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  • Methods, compositions, and systems for detecting coronavirus neutralizing antibodies
    Patent number: 12366581
    Abstract: The present disclosure relates to methods, compositions, and systems for detecting whether a subject exposed to a coronavirus has developed a neutralizing antibody response. Also disclosed are methods for determining whether a patient infected by a coronavirus is likely to respond to treatment with an antibody preparation. Also disclosed are methods for detecting the level of neutralizing antibody response in a sample of serum from a subject exposed to a coronavirus or to a coronavirus vaccine.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: July 22, 2025
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Christos J. Petropoulos, Mary T. Wrin, Danielle DiTirro
  • Methods, Compositions, and Systems for Detecting Coronavirus Neutralizing Antibodies
    Publication number: 20220065869
    Abstract: The present disclosure relates to methods, compositions, and systems for detecting whether a subject exposed to a coronavirus has developed a neutralizing antibody response. Also disclosed are methods for determining whether a patient infected by a coronavirus is likely to respond to treatment with an antibody preparation. Also disclosed are methods for detecting the level of neutralizing antibody response in a sample of serum from a subject exposed to a coronavirus or to a coronavirus vaccine.
    Type: Application
    Filed: June 25, 2021
    Publication date: March 3, 2022
    Inventors: Christos J. Petropoulos, Mary T. Wrin, Danielle DiTirro
  • Nucleocapsid-independent specific viral RNA packaging and uses thereof
    Publication number: 20040175829
    Abstract: The present invention shows that expressed coronavirus envelope protein M specifically interacted with co-expressed non-coronavirus RNA transcripts containing the short viral packaging signal in the absence of coronavirus N protein. Furthermore, this M protein-packaging signal interaction led to specific packaging of the packaging-signal-containing RNA transcripts into coronavirus-like particles in the absence of N protein. These findings highlight a novel RNA packaging mechanism for an enveloped virus, and a novel coronavirus-based expression system can be developed based on the data presented herein.
    Type: Application
    Filed: March 5, 2004
    Publication date: September 9, 2004
    Inventors: Shinji Makino, Krishna Narayanan
  • ANTIBODIES
    Publication number: 20240043507
    Abstract: The present invention relates to antibodies capable of binding to the spike protein of coronavirus SARS-CoV-2, and methods and uses thereof in the prevention, treatment and/or diagnosis of coronavirus infections, and diseases and/or complications associated with coronavirus infections, including COVID-19.
    Type: Application
    Filed: February 4, 2022
    Publication date: February 8, 2024
    Inventors: Gavin SCREATON, Juthathip MONGKOLSAPAYA
  • PD-1-BASED VACCINES AGAINST CORONAVIRUS INFECTION
    Publication number: 20210261644
    Abstract: Disclosed soluble PD-1 (sPD-1) proteins and nucleic acids, and therapeutic compositions comprising sPD-1 proteins and nucleic acids, for enhancing immunity of a subject against coronavirus infection. Disclosed are soluble PD-1 fusion proteins that include a soluble PD-1 protein fragment and an antigenic protein fragment, preferably where the antigenic protein fragment comprises a coronavirus protein fragment. In some forms, the coronavirus protein fragment is derived from a coronavirus receptor binding domain (RBD) or a coronavirus nucleoprotein (N). In some forms, the sPD-1 proteins, nucleic acids, and compositions are formulated as a vaccine composition. Also disclosed are methods for treating a subject at risk of or suffering a coronavirus infection.
    Type: Application
    Filed: February 26, 2021
    Publication date: August 26, 2021
    Inventors: Zhiwei Chen, Kwok Yung Yuen, Honglin Chen, Yik Chun Wong, Li Liu
  • ANTI-CORONAVIRUS POLYPEPTIDE AS WELL AS DERIVATIVE AND APPLICATION THEREOF
    Publication number: 20240398893
    Abstract: The invention relates to an anti-coronavirus polypeptide as well as derivatives and application thereof, provides the anti-coronavirus polypeptide, and provides cholesterol-containing derivatives of the polypeptide on the basis of the anti-coronavirus polypeptide. Particularly, the original strain and the variant strain of the SARS-COV-2 have an unexpected inhibition effect, can be used for preparing medicines or vaccines for preventing or treating the new coronavirus, and have great prevention or treatment potential.
    Type: Application
    Filed: June 27, 2024
    Publication date: December 5, 2024
    Applicants: Institute of Microbiology, Chinese Academy of Sciences, Hybio Pharmaceutical Co., Ltd.
    Inventors: Fu GAO, Shaogui ZENG, Qihui WANG, Yangming TANG, Jiantao CHEN, Lili WU, Anqi ZHENG
  • CORONAVIRUS ANTIBODIES AND USES THEREOF
    Publication number: 20250188154
    Abstract: Recombinant monoclonal antibodies (mAbs) and fragments that bind specifically to coronavirus spike protein. Herein, monoclonal antibodies were recombinantly derived from isolated B cell from coronavirus infected individuals. Such antibodies bind various epitopes on the coronavirus spike protein and are neutralizing. The invention provides methods for using the inventive antibodies in prophylactic and/or therapeutic methods to prevent or treat coronavirus infection.
    Type: Application
    Filed: September 15, 2021
    Publication date: June 12, 2025
    Inventors: Gregory Sempowski, Barton F. Haynes, Kevin Saunders, Dapeng Li, Xiaozhi Lu, Robert J. Edwards, Priyamvada Acharya, Kartik Manne, Sophie Gobeil, John R. Mascola, Barney S. Graham, Tongqing Zhou
  • PEPTIDE FOR SUPPRESSING CORONAVIRUS AND USE THEREOF
    Publication number: 20230181681
    Abstract: The present invention relates to: a therapeutic composition for coronavirus comprising, as an active ingredient, one peptide selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 6, and SEQ ID NO: 8 that binds to a coronavirus N-protein, a coronavirus-derived spike protein, or a fragment of the spike protein; and a composition that binds to a coronavirus N-protein comprising, as an active ingredient, the coronavirus-derived spike protein or the fragment of the spike protein. It is suggested that the peptides of the present invention, based on the understanding and targeting of the interaction of the coronavirus S protein and N protein of the present invention, have an effect that can be helpful in the treatment of coronaviruses including MERS-CoV, SARS-CoV-2, SARS-CoV, and HCoV-OC43.
    Type: Application
    Filed: May 3, 2021
    Publication date: June 15, 2023
    Inventors: Hyung Joo KWON, Byoung Kwon PARK, Dong Bum KIM, Jin Soo KIM
  • BINDING MOLECULE HAVING NEUTRALIZING ACTIVITY AGAINST SARS-CORONAVIRUS-2
    Publication number: 20230113734
    Abstract: The present invention relates to a binding molecule that binds to SARS-coronavirus-2 (SARS-CoV-2). More particularly, the binding molecule of the present invention has strong ability to bind to a spike protein (S protein) on the surface of SARS-coronavirus-2 and high neutralizing activity against SARS-coronavirus-2 and is thus very useful in the diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19).
    Type: Application
    Filed: March 22, 2021
    Publication date: April 13, 2023
    Inventors: Cheol-Min KIM, Ji-Min SEO, Min-Soo KIM, Soo-Young LEE, Dong-Kyun RYU, Sung-Soon KIM, Joo-Yeon LEE, Kyung-Chang KIM, Jeong-Sun YANG, Han-Saem LEE, Hye-Min WOO, Jun-Won KIM
  • Coronavirus (COVID-19) air sanitization/isolation system with anti-virus curtain walls
    Patent number: 12053562
    Abstract: Various embodiments are directed to a coronavirus air sanitization/isolation system with anti-virus curtain. The system may include a group of anti-virus strips with attached separation magnets coupled to an air inlet housing mounted above (e.g., in an attic ceiling) in an enclosed space. The anti-virus strips may be coated with a saline and soap solution that attracts airborne droplets contaminated with the coronavirus and dissolves a fatty layer of coronavirus cell membranes to prevent cell replication of the coronavirus, thereby destroying the coronavirus. The air inlet housing may include exhaust ventilation fans, salt filters, a wick saturated with the saline and soap solution, an electro-static air filter, and a distribution air duct. The fans may be utilized to circulate an airstream containing the coronavirus through the anti-virus strips, the filters, the saturated wick, and the distribution air duct to remove the coronavirus while protecting occupants with uncontaminated air.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: August 6, 2024
    Assignee: FLORIDA A&M UNIVERSITY
    Inventor: Charles Magee
  • PEPTIDE COMPOUNDS FOR DETECTING OR INHIBITING SARS CORONAVIRUS AND APPLICATION THEREOF
    Publication number: 20100304363
    Abstract: Disclosed herein are peptide compounds and the application thereof to the detection and inhibition of SARS coronavirus. Composed of dipeptides, the compounds for detecting and inhibiting SARS coronavirus can be readily synthesized and produced at low cost. In addition, they can be stored safely for a long period of time. The dipeptide compounds are useful as inhibitors of SARS coronavirus as well as acting as excellent capturing materials of SARS coronavirus.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 2, 2010
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Soo-Hyung LEE, Hyo-Bong Hong, Tao-Wan Kim, Myung-Ae Chung, Sung-Woo Sohn, Seoung-Min Yoo
  • CORONAVIRUS NANOBODIES AND METHODS FOR THEIR USE AND IDENTIFICATION
    Publication number: 20240043505
    Abstract: Disclosed herein are coronavirus neutralizing antibodies and uses thereof for treating and preventing a coronavirus infection in a subject.
    Type: Application
    Filed: August 19, 2021
    Publication date: February 8, 2024
    Inventors: Yi SHI, I, Yufei XIANG
  • BROADLY NEUTRALIZING NANOBODIES FOR CORONAVIRUS AND USES THEREOF
    Publication number: 20250002563
    Abstract: Disclosed herein are coronavirus neutralizing antibodies and uses thereof for treating and/or preventing a coronavirus infection in a subject.
    Type: Application
    Filed: September 12, 2022
    Publication date: January 2, 2025
    Inventors: Yi SHI, Yufei XIANG
  • CORONAVIRUS (COVID-19) AIR SANITIZATION/ISOLATION SYSTEM WITH ANTI-VIRUS CURTAIN WALLS
    Publication number: 20220040354
    Abstract: Various embodiments are directed to a coronavirus air sanitization/isolation system with anti-virus curtain. The system may include a group of anti-virus strips with attached separation magnets coupled to an air inlet housing mounted above (e.g., in an attic ceiling) in an enclosed space. The anti-virus strips may be coated with a saline and soap solution that attracts airborne droplets contaminated with the coronavirus and dissolves a fatty layer of coronavirus cell membranes to prevent cell replication of the coronavirus, thereby destroying the coronavirus. The air inlet housing may include exhaust ventilation fans, salt filters, a wick saturated with the saline and soap solution, an electro-static air filter, and a distribution air duct. The fans may be utilized to circulate an airstream containing the coronavirus through the anti-virus strips, the filters, the saturated wick, and the distribution air duct to remove the coronavirus while protecting occupants with uncontaminated air.
    Type: Application
    Filed: August 3, 2021
    Publication date: February 10, 2022
    Inventor: Charles Magee
  • CORONAVIRUS IRNA COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20220127615
    Abstract: The present invention relates to RNAi agents, e.g., dsRNA agents, targeting the coronavirus genome. The invention also relates to methods of using such RNAi agents to inhibit expression of a coronavirus genome and to methods of treating or preventing a coronavirus-associated disease in a subject.
    Type: Application
    Filed: November 10, 2021
    Publication date: April 28, 2022
    Inventors: Akin Akinc, James D. McIninch, Yesseinia Anglero-Rodriguez, Mark K. Schlegel, Christy M. Hebner, Florian A. Lempp
  • CELL ENTRY-MODULATING AGENTS AND USES THEREFOR
    Publication number: 20250195501
    Abstract: The present disclosure relates generally to the use of compounds that inhibit coronavirus entry into an angiotensin converting enzyme 2 (ACE2)-expressing cell, in methods and compositions for inhibiting the interaction of coronavirus to an ACE2-expressing cell and for treating or inhibiting the development of coronavirus infections.
    Type: Application
    Filed: May 7, 2021
    Publication date: June 19, 2025
    Inventors: Michael Paul Jennings, Christopher James Day, Milton Kiefel, Thomas Haselhorst
  • COMPOSITION FOR DIAGNOSING SARS-COV-2, KIT, AND METHOD FOR DIAGNOSING SARS-COV-2 BY USING SAME
    Publication number: 20230057087
    Abstract: The present invention relates to a composition for diagnosing whether someone has been infected with a novel coronavirus (SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2), a kit comprising the composition, and a method for diagnosing whether someone has been infected with the novel coronavirus by using same. Particularly, the present invention relates to a composition for diagnosing whether someone has been infected with a novel coronavirus, comprising a nucleic acid oligomer capable of specifically amplifying by targeting a leader sequence most abundantly present in cells infected with the novel coronavirus, a kit comprising the composition, and a method for diagnosing whether someone has been infected with the novel coronavirus by using same.
    Type: Application
    Filed: March 5, 2021
    Publication date: February 23, 2023
    Inventors: Sunghwan AN, Myung Soon KIM
  • APPLICATION OF GOSSYPOL AND ITS OPTICAL ISOMERS TO PREPARATION OF CORONAVIRUS 3CL PROTEASE INHIBITOR
    Publication number: 20240074990
    Abstract: The present invention relates to application of gossypol and its optical isomers to preparation of an anti-Coronavirus drug. Specifically disclosed is application of pharmaceutically acceptable salts, solvates, isotopes, stereoisomers, stereoisomer mixtures, and tautomers of the gossypol and its optical isomers to preparation of a drug for preventing and/or treating a disease caused by a Coronavirus. The Coronavirus is MERS-CoV, SARS-CoV, or SARS-CoV-2. It is found in the present invention for the first time that the gossypol and its optical isomers can inhibit the activity of Coronavirus 3CL proteases to achieve an anti-Coronavirus effect. The half maximal inhibitory concentrations of gossypol and (?)-gossypol to SARS-CoV proteases and SARS-CoV-2 3CL proteases are all lower than 10 ?M. The anti-Coronavirus 3CL protease effect is good. Therefore, the gossypol and its optical isomers have the potential for use in the preparation of a drug for preventing and/or treating novel Coronavirus infections.
    Type: Application
    Filed: March 18, 2023
    Publication date: March 7, 2024
    Inventors: Xiaolin XIE, Dezhu ZHANG, Zhao MA, Boyang LI, Xuhua ZHOU, Lei TIAN, Chengyuan LIANG, Taotao QIANG, Jingyi LI, Liang XIN, Shaojun ZHANG, Kangxiong WU, Xiuding YANG, Sundian LIU, Yuting LIU
  • CORONAVIRUS MUTATION DETERMINATION DEVICE COMPRISING METAMATERIAL ARRAY AND ELECTROMAGNETIC WAVE IRRADIATION UNIT
    Publication number: 20240044787
    Abstract: The present specification relates to a device and method capable of determining a coronavirus mutation using a highly sensitive label-free terahertz electromagnetic wave metamaterial sensor, and a device for diagnosing a coronavirus disease-19, amd the device can specify the amino acids of a virus belonging to the genus coronavirus having an excellent absorption in a terahertz band, and the metamaterial can amplify the corresponding signal, and the problem of coffee ring formation, which hinders the measurement and analysis in the conventional measurement and analysis of solution-based samples, can be solved by the method in which a sample containing coronavirus is applied to the surface of a metamaterial, and the optical constant value of the sample is analyzed, so that it is possible to more quickly and accurately determine the coronavirus mutation, and furthermore, there is an excellent effect in diagnosing a coronavirus disease-19.
    Type: Application
    Filed: August 4, 2023
    Publication date: February 8, 2024
    Inventors: Minah SEO, Hyun Seok SONG, Hyun Gyu SONG, Jeongmin JANG, Yeonkyung LEE, Soohyun LEE
  • FUSION PROTEINS OF RECOMBINANT SARS CORONAVIRUS STRUCTURAL PROTEINS, THEIR PRODUCTION AND USES
    Publication number: 20100150923
    Abstract: Fusion proteins of recombinant SARS coronavirus structural proteins, their production and uses are provided. An optimized SARS coronavirus S protein gene which can be highly expressed in the mammalian cell strains and SARS coronavirus S protein variants comprising deletion, modification or mutation amino acids 318-510 corresponding to SARS coronavirus S protein are also provided.
    Type: Application
    Filed: June 13, 2006
    Publication date: June 17, 2010
    Applicant: Chinese Academy of Medical Sciences, Institute of Basic Medical Sciences
    Inventors: Chengyu Jiang, Feng Guo, Shuan Rao, Bing Guan, Yi Huan, Peng Yang
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