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  • INHIBITORS OF HIF PROLYL HYDROXYLASE
    Publication number: 20170233412
    Abstract: The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
    Type: Application
    Filed: September 23, 2015
    Publication date: August 17, 2017
    Applicants: MERCK SHARP & DOHME CORP., MSD R&D (CHINA) CO., LTD.
    Inventors: JIAQIANG CAI, ALEJANDRO CRESPO, XIAOXING DU, BYRON GABRIEL DUBOIS, DEODIALSINGH GUIADEEN, SHANKARAN KOTHANDARAMAN, PING LIU, RONGQIANG LIU, WEIGUO QUAN, CHRISTOPHER SINZ, LIPING WANG
  • Use of S-119 in lithographic fountain solutions
    Patent number: 4347289
    Abstract: Polysaccharide S-119 is used as a desensitizer in lithographic fountain solutions to maintain non-image areas on a lithographic printing plate in a hydrophilic condition in order to prevent scumming or ink pickup in said areas. S-119 is prepared in aqueous solution which is added to phosphoric acid etch in water plus alcohol to provide a gum concentration of 20-1000 ppm by weight in the fountain solution.
    Type: Grant
    Filed: August 3, 1981
    Date of Patent: August 31, 1982
    Assignee: Merck & Co., Inc.
    Inventor: George T. Colegrove
  • 2-Amino-3,5-dicyano-6-(substituted)pyrazine antimicrobial compounds
    Patent number: 4517186
    Abstract: Antimicrobial compounds of the formula: ##STR1## wherein: R is mono- or di-substituted mono- or diloweralkylamino wherein the loweralkyl substituents are hydroxy or loweralkanoyloxy; 4-morpholino; thiocyano; mercapto; straight or branched chain C.sub.1-8 alkylthio; mono- or di-substituted lower alkylthio wherein the substituents are hydroxy, amino, loweralkanoylamino, or loweralkoxycarbonyl; arylthio; loweralkylsulfoxy; or loweralkylsulfonyl; are useful in various agricultural and industrial areas.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: May 14, 1985
    Assignee: Merck & Co., Inc.
    Inventor: David B. R. Johnston
  • Particulate UV protection agent
    Patent number: 8753684
    Abstract: The present invention relates to particulate UV protection agents which are obtainable by hydrothermal treatment of a particulate metal oxide and subsequent application of a manganese oxide coating, and to the preparation and use thereof. The present invention furthermore relates to novel compositions, in particular for topical application, which are intended, in particular, for light protection of the skin and/or hair against UV radiation and free-radical-induced stress, and to the use thereof in the above-mentioned cosmetic application.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: June 17, 2014
    Assignees: Merck Patent GmbH, Sachtleben Chemie GmbH
    Inventors: Frank Pfluecker, Bernd Hirthe
  • COMPOUNDS FOR A LIQUID-CRYSTALLINE MEDIUM, AND USE FOR HIGH-FREQUENCY COMPONENTS
    Publication number: 20120273724
    Abstract: The present invention relates to compounds of the formula (I) where one or more of the radicals A1-5 denote a 1,4-naphthylene or 1,4-anthracenylene radical, and the other parameters are as defined in Claim 1. The invention additionally includes liquid-crystalline media which comprise the title compounds, components for high-frequency technology which comprise these media, in particular phase shifters and microwave array antennae.
    Type: Application
    Filed: October 1, 2010
    Publication date: November 1, 2012
    Applicant: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Christian Jasper, Elvira Montenegro, Detlef Pauluth, Volker Reiffenrath, Atsutaka Manabe
  • PYRANYL ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
    Publication number: 20120157438
    Abstract: The present invention is directed to pyranyl aryl methyl benzoquinazolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
    Type: Application
    Filed: August 26, 2010
    Publication date: June 21, 2012
    Applicant: Merck Sharp & Dohme Corp
    Inventors: Scott D. Kuduk, Ronald K. Chang, Thomas J. Greshock
  • Dichloroamino acid derivatives useful as potent germicidal and fungicidal agents
    Patent number: 4386103
    Abstract: Dichloroamino acid derivatives other than .alpha.-dichloroamino acids are prepared from chlorination of corresponding amino acids, and are found to be potent germicidal and fungicidal agents.
    Type: Grant
    Filed: January 30, 1981
    Date of Patent: May 31, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Stefano A. Pogany, Takeru Higuchi
  • Difficidin and derivative antibacterials
    Patent number: 4545991
    Abstract: Difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: October 8, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Sheldon B. Zimmerman, Kenneth E. Wilson, Richard L. Monaghan, Sagrario M. Del Val, Maria I. M. Fernandez, Otto D. Hensens, James E. Flor, Cheryl Deriso
  • 2-(Substitutedpiperidylmethyl)propene and propane nitriles
    Patent number: 4247700
    Abstract: Antimicrobial agents suitable for use in aqueous systems for their preservation against biodeterioration include substitutedpiperidinomethyl-propenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine with cyano acetic acid and formaldehyde: the propane derivatives therefrom by nucleophilic addition. spThis application is a continuation-in-part of Ser. No. 795,693, filed May 11, 1977, now abandoned.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: January 27, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Bruce E. Witzel
  • Process for the stereoselective reduction of steroid enelactams
    Patent number: 5470976
    Abstract: The novel process of this invention involves the reduction of certain .DELTA.-5 steroidal alkenes to selectively produce either the 5.alpha. or 5.beta. reduction products. Particularly, this invention involves reduction of .DELTA.-5 steroidal alkenes using a rhodium based catalyst in the presence of hydrogen to selectively yield 5.alpha. steroids or alternatively reduction of .DELTA.-5 steroidal alkenes in an ionizing medium with a trialkylsilane to selectively yield 5.beta. steroids.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: November 28, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Guy R. Humphrey, Ross A. Miller
  • Conjugated polymers
    Patent number: 9178166
    Abstract: The invention relates to novel conjugated polymers containing repeating units comprising a halogenated benzene ring, a silolobithiophene moiety, and a benzofused heteroaromatic moiety, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as organic semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to OE, OPV and OPD devices comprising these polymers, polymer blends, mixtures or formulations.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: November 3, 2015
    Assignee: MERCK PATENT GMBH
    Inventors: David P. Waller, Kap-Soo Cheon
  • Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
    Patent number: 5990132
    Abstract: Compounds of Formula (I) have been shown to enhance the release of the neurotransmitter acetylcholine, and thus may be useful in the treatment of diseases of man where subnormal levels of this neurochemical are found, such as in Alzheimer's disease, and other conditions involving learning and cognition.
    Type: Grant
    Filed: June 17, 1996
    Date of Patent: November 23, 1999
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Christopher Allan Teleha, Wendell Wilkie Wilkerson, Richard Alan Earl
  • Antibody neutralizing human respiratory syncytial virus
    Patent number: 10323079
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 18, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su
  • Oxazolidines as 5-HT2A-antagonists
    Patent number: 6462056
    Abstract: The invention relates to novel oxazolidine derivatives of the formula in which R1, R2 and R3 have the meanings stated in claim 1, their salts and processes for preparing the compounds according to the invention. The compounds of the formula I act as 5-HT2A antagonists with a 5-HT reuptake-inhibiting, antidepressant or anxiolytic effect and can be used to produce pharmaceuticals.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: October 8, 2002
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Henning Böttcher, Helmut Prücher, Hartmut Greiner, Gerd Bartoszyk, Christoph Seyfried
  • HPV VACCINE
    Publication number: 20230123584
    Abstract: The present disclosure provides, among other things, a pharmaceutical composition that includes a lipid nanoparticle adjuvant and an anti-human papillomavirus (HPV) comprising HPV virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82.
    Type: Application
    Filed: February 9, 2021
    Publication date: April 20, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Marian E. Gindy, John P. Bilello, Amy S. Espeseth, Andrew J. Bett, Tong-Ming Fu
  • Peptides
    Patent number: 6130204
    Abstract: Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise such oligopeptides useful for determining free PSA protease activity in vitro and in vivo. Therapeutic agents which comprise conjugates of such oligopeptides and known cytotoxic agents are also described.
    Type: Grant
    Filed: April 6, 1998
    Date of Patent: October 10, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Deborah DeFeo-Jones, Dong-Mei Feng, Victor M. Garsky, Raymond E. Jones, Allen I. Oliff
  • Gastric cytoprotection with L-363,586
    Patent number: 4470974
    Abstract: The somatostatin analog L-363,586 is a cyclic hexapeptide having the structure; cyclo-(N-methyl-Ala-Tyr-d-Trp-Lys-Val-Phe). L-363,586 has been found to be useful for inducing gastric cytoprotection via a mechanism not involving the inhibition of gastric acid secretions. Specific therapeutic utilities include, erosive gastritis, erosive esophagitis, inflammatory bowel disease and ethanol induced hemorrhagic gastric erosions.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: September 11, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Marvin M. Goldenberg, Doris L. Keller
  • Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5
    Patent number: 7371767
    Abstract: Pyrrole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorder and panic, as well as in the treatment of pain, circadian rhythm disorders, and other diseases.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: May 13, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Nicholas D. P. Cosford, Dehua Huang, Nicholas D. Smith
  • Factor XIa inhibitors
    Patent number: 9868727
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: January 16, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Weiguo Liu, Scott D. Edmondson, Zhuyan Guo, Sung-Sau So, Anthony K. Ogawa, Rongze Kuang, Heping Wu, Amjad Ali, Ying-Duo Gao, Yu Jiang, Chunsing Li, Tingting Yu
  • CONJUGATED POLYMERS
    Publication number: 20150349256
    Abstract: The invention relates to novel conjugated polymers containing one or more thieno[3,2-b]thiophene based polycyclic repeating units, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as organic semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to OE, OPV and OPD devices comprising these polymers, polymer blends, mixtures or formulations.
    Type: Application
    Filed: June 4, 2013
    Publication date: December 3, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: William MITCHELL, Mansoor D'LAVARI, Changsheng WANG, Steven TIERNEY, David SPARROWE
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