Search Patents
  • ANTI-CD96 ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20200199227
    Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD96 receptor protein (hu-CD96) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD96. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD96 binding to CD155, including effects arising from CD96 interactions with CD226 and/or TIGIT.
    Type: Application
    Filed: December 18, 2019
    Publication date: June 25, 2020
    Applicant: 23andMe, Inc.
    Inventors: Yu CHEN, Chingwei Vivian LEE, Germaine FUH-KELLY, Zuoan YI, Yao-ming HUANG, Valentine YEUNG, Krista Maureen MCCUTCHEON, Samuel NALLE, Augusta Eleanor BROUGHTON, Louise SCHARF, Navneet SINGH, Tina THAI, Shouhua XIAO
  • ANTI-CD96 ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20230183343
    Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD96 receptor protein (hu-CD96) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD96. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD96 binding to CD155, including effects arising from CD96 interactions with CD226 and/or TIGIT.
    Type: Application
    Filed: November 18, 2022
    Publication date: June 15, 2023
    Applicant: 23andMe, Inc.
    Inventors: Yu CHEN, Chingwei Vivian LEE, Germaine FUH-KELLY, Zuoan YI, Yao-ming HUANG, Valentine YEUNG, Krista Maureen MCCUTCHEON, Samuel NALLE, Augusta Eleanor BROUGHTON, Louise SCHARF, Navneet SINGH, Tina THAI, Shouhua XIAO
  • De-identification and sharing of genetic data
    Patent number: 8589437
    Abstract: A system for separating identifying data from personal data is disclosed. The system includes: a first set of stored data comprising a plurality of identifying data structures containing identifying data; a second set of stored data comprising a plurality of personal data structures containing personal data; a set of mapping data comprising a plurality of mappings, wherein each mapping is between an identifying data structure and a personal data structure; and an application configured to receive mapping data associated with a mapping, determine a mapping associated with the mapping data, and obtain a personal data structure based on the mapping. The set of mapping data is logically separate from the first set of stored data, the second set of stored data, and the application.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: November 19, 2013
    Assignee: 23andMe, Inc.
    Inventors: Oleksiy Khomenko, Alexander Wong, Anne Wojcicki, Linda Avey
  • Anti-CD200R1 antibodies and methods of use thereof
    Patent number: 11787861
    Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD200R1 receptor protein (hu-CD200R1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD200R1. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD200 binding to CD200R1.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: October 17, 2023
    Assignee: 23andMe, Inc.
    Inventors: Yu Chen, Jilean Beth Fenaux, Germaine Fuh-Kelly, Yao-Ming Huang, Wei-Jen Chung, Erik Edward Karrer, Cecilia Lay, Steven J. Pitts, Louise Scharf
  • Finding relatives in a database
    Patent number: 11776662
    Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.
    Type: Grant
    Filed: March 28, 2023
    Date of Patent: October 3, 2023
    Assignee: 23andMe, Inc.
    Inventors: Lawrence Hon, Serge Saxonov, Brian Thomas Naughton, Joanna Louise Mountain, Anne Wojcicki, Linda Avey
  • Learning system for pangenetic-based recommendations
    Patent number: 11514085
    Abstract: An embodiment may involve storing, by a computing device and in a database, a set of pangenetic attributes of a set of individuals, wherein the pangenetic attributes of the set are respectively and statistically associated with products; based on the statistical associations between the pangenetic attributes and the products, determining, by the computing device, product recommendations for a second set of individuals; receiving, by the computing device and from the second set of individuals, a plurality of measures of satisfaction with the product recommendations; based on the plurality of measures of satisfaction, learning, by the computing device, an association between a subset of the pangenetic attributes and a particular product; and storing, by the computing device and in the database, the learned association, wherein the learned association provides a basis for subsequent recommendations of the particular product when a subsequent individual exhibits the subset of the pangenetic attributes.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: November 29, 2022
    Assignee: 23andMe, Inc.
    Inventors: Andrew Alexander Kenedy, Charles Anthony Eldering
  • Finding relatives in a database
    Patent number: 11935628
    Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.
    Type: Grant
    Filed: November 2, 2022
    Date of Patent: March 19, 2024
    Assignee: 23andMe, Inc.
    Inventors: Lawrence Hon, Serge Saxonov, Brian Thomas Naughton, Joanna Louise Mountain, Anne Wojcicki, Linda Avey
  • SUMMARIZING AN AGGREGATE CONTRIBUTION TO A CHARACTERISTIC FOR AN INDIVIDUAL
    Publication number: 20130345988
    Abstract: Summarizing an aggregate contribution to a phenotypic characteristic for an individual includes: receiving information pertaining to the phenotypic characteristic of an individual; identifying, using one or more computer processors, a set of one or more markers associated with the phenotypic characteristic; obtaining a set of one or more marker measurements of the individual that corresponds to the set of one or more markers; obtaining a set of one or more statistical factors that measure associations between the set of one or more markers and the phenotypic characteristic; determining an aggregate contribution to the phenotypic characteristic of the individual based at least in part on the retrieved set of one or more statistical factors; and outputting a display characteristic to be displayed that is associated with the aggregate contribution to the phenotypic characteristic for the individual.
    Type: Application
    Filed: July 1, 2013
    Publication date: December 26, 2013
    Applicant: 23andMe, Inc.
    Inventors: Linda Avey, Andro Rene Hsu, Oleksiy Khomenko, John Michael Macpherson, Joanna Louise Mountain, Brian Thomas Naughton, Serge Saxonov, Anne Wojcicki, Alexander Wong
  • Anti-CD96 antibodies and methods of use thereof
    Patent number: 11555073
    Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD96 receptor protein (hu-CD96) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD96. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD96 binding to CD155, including effects arising from CD96 interactions with CD226 and/or TIGIT.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: January 17, 2023
    Assignee: 23andMe, Inc.
    Inventors: Yu Chen, Chingwei Vivian Lee, Germaine Fuh-Kelly, Zuoan Yi, Yao-ming Huang, Valentine Yeung, Krista Maureen McCutcheon, Samuel Nalle, Augusta Eleanor Broughton, Louise Scharf, Navneet Singh, Tina Thai, Shouhua Xiao
  • Processing data from genotyping chips
    Patent number: 9218451
    Abstract: Processing genetic data includes receiving two or more genetic data sets for an individual from one or more genetic data sources, wherein the genetic data sets comprises data pertaining to the individual's deoxyribonucleic acid (DNA); merging the genetic data sets from the one or more genetic data sources to obtain a set of merged genetic data for the individual, including: identifying data in the genetic data sets that is conflicting, the identified data corresponding to a genetic marker associated with a variation that occurs at a region in the individual's genome; analyzing the identified data to resolve a discrepancy attributed to the identified conflicting data and automatically determine an appropriate value that corresponds to the genetic marker, the analysis and the determination being based at least in part on contextual information; and storing the appropriate value in the set of merged genetic data.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: December 22, 2015
    Assignee: 23andMe, Inc.
    Inventors: Alexander Wong, Oleksiy Khomenko, Serge Saxonov, Brian Thomas Naughton, Lawrence Hon
  • PROCESSING DATA FROM GENOTYPING CHIPS
    Publication number: 20140156605
    Abstract: Processing genetic data includes receiving two or more genetic data sets for an individual from one or more genetic data sources, wherein the genetic data sets comprises data pertaining to the individual's deoxyribonucleic acid (DNA); merging the genetic data sets from the one or more genetic data sources to obtain a set of merged genetic data for the individual, including: identifying data in the genetic data sets that is conflicting, the identified data corresponding to a genetic marker associated with a variation that occurs at a region in the individual's genome; analyzing the identified data to resolve a discrepancy attributed to the identified conflicting data and automatically determine an appropriate value that corresponds to the genetic marker, the analysis and the determination being based at least in part on contextual information; and storing the appropriate value in the set of merged genetic data.
    Type: Application
    Filed: December 9, 2013
    Publication date: June 5, 2014
    Applicant: 23andMe, Inc.
    Inventors: Alexander Wong, Oleksiy Khomenko, Serge Saxonov, Brian Thomas Naughton, Lawrence Hon
  • Database and data processing system for use with a network-based personal genetics services platform
    Patent number: 10936626
    Abstract: Databases and data processing systems for use with a network-based personal genetics services platform may include member information pertaining to a plurality of members of the network-based personal genetics services platform. The member information may include genetic information, family history information, environmental information, and phenotype information of the plurality of members. A data processing system may determine, based at least in part on the member information, a model for predicting a phenotype from genetic information, family history information, and environmental information, wherein determining the model includes training the model using the member information pertaining to a set of the plurality of members.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: March 2, 2021
    Assignee: 23andMe, Inc.
    Inventors: Brian Thomas Naughton, Chuong Do, John Michael Macpherson
  • Database and data processing system for use with a network-based personal genetics services platform
    Patent number: 10437858
    Abstract: Databases and data processing systems for use with a network-based personal genetics services platform may include member information pertaining to a plurality of members of the network-based personal genetics services platform. The member information may include genetic information, family history information, environmental information, and phenotype information of the plurality of members. A data processing system may determine, based at least in part on the member information, a model for predicting a phenotype from genetic information, family history information, and environmental information, wherein determining the model includes training the model using the member information pertaining to a set of the plurality of members.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: October 8, 2019
    Assignee: 23andMe, Inc.
    Inventors: Brian Thomas Naughton, Chuong Do, John Michael Macpherson
  • Database and data processing system for use with a network-based personal genetics services platform
    Patent number: 10691725
    Abstract: Databases and data processing systems for use with a network-based personal genetics services platform may include member information pertaining to a plurality of members of the network-based personal genetics services platform. The member information may include genetic information, family history information, environmental information, and phenotype information of the plurality of members. A data processing system may determine, based at least in part on the member information, a model for predicting a phenotype from genetic information, family history information, and environmental information, wherein determining the model includes training the model using the member information pertaining to a set of the plurality of members.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: June 23, 2020
    Assignee: 23andMe, Inc.
    Inventors: Brian Thomas Naughton, Chuong Do, John Michael Macpherson
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