Abstract: The present invention provides a use of a phillyrin/phillygenin composition which targets and inhibits 3CLpro protein of COVID-19 virus, in preparation of an anti-coronavirus drug or a drug for treating a disease caused by the coronavirus, wherein the coronavirus is COVID-19 virus, and the disease caused by the coronavirus is COVID-19.
Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.
Type:
Application
Filed:
March 18, 2022
Publication date:
March 9, 2023
Inventors:
Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
Abstract: The present invention discloses a drug for treating severe acute respiratory syndrome caused by coronavirus and the complications thereof and the use of the drug, and specifically the use of an agent in the preparation of a drug for treating severe acute respiratory syndrome caused by coronavirus and the complications thereof. The above-mentioned agent is at least one of hyaluronic acid synthesis inhibitor, hyaluronidase, hyaluronidase inhibitor, hyaluronic acid receptor inhibitor, and anticoagulant.
Type:
Application
Filed:
November 4, 2021
Publication date:
May 4, 2023
Applicants:
SHANGHAI PUBLIC HEALTH CLINICAL CENTER, Shanghai Yizhe Biotechnology Co., Ltd.
Abstract: Disclosed herein is a method for inhibiting coronavirus infection, including administering to a subject in need thereof an effective amount of pioglitazone or a pharmaceutically acceptable salt thereof. Also disclosed is a method for inhibiting coronavirus replication, including contacting a coronavirus with pioglitazone or a pharmaceutically acceptable salt thereof.
Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.
Type:
Grant
Filed:
May 15, 2020
Date of Patent:
September 14, 2021
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Inventors:
Ralph A. Tripp, Jackelyn Murray, Robert Jeff Hogan
Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.
Type:
Application
Filed:
November 16, 2022
Publication date:
March 7, 2024
Inventors:
Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
Abstract: Disclosed herein is a method for inhibiting coronavirus infection, including administering to a subject in need thereof an effective amount of rosiglitazone or a pharmaceutically acceptable salt thereof. Also disclosed is a method for inhibiting coronavirus replication, including contacting a coronavirus with rosiglitazone or a pharmaceutically acceptable salt thereof.
Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.
Type:
Application
Filed:
March 18, 2022
Publication date:
March 9, 2023
Inventors:
Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.
Type:
Grant
Filed:
April 16, 2021
Date of Patent:
January 10, 2023
Assignee:
BioNTech SE
Inventors:
Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
Abstract: The invention relates to coronavirus peptides, and the use of such peptides for the diagnosis, treatment and prevention of coronavirus infection.
Type:
Application
Filed:
June 2, 2021
Publication date:
June 29, 2023
Inventors:
Thomas RADEMACHER, Richard PERRINS, Laurens RADEMACHER
Abstract: The present invention provides a method for preparing a coronavirus-targeting universal DC cell vaccine, and belongs to the technical field of virus vaccine preparation. The preparation method includes the following steps: ligating a fusion gene including a HLA gene and a coronavirus antigen gene onto an expression vector to obtain a recombinant vector; then transferring the recombinant vector into antigen-presenting cells to be transfected to obtain the coronavirus-targeting universal DC cell vaccine. The universal DC cell vaccine of the present invention has a targeting property against a coronavirus, can effectively stimulate a CTL, and has a killing effect on a target cell.
Type:
Grant
Filed:
August 10, 2020
Date of Patent:
July 11, 2023
Assignees:
Beijing DCTY Biotech Co., Ltd.
Inventors:
Shunchang Jiao, Rong Zhang, Zishan Zhou
Abstract: Methods for treating one or more symptoms associated with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and/or coronavirus disease 2019 (COVID-19), including lingering dysgeusia, by administering a lipoxin analog, such as BLXA4, to a subject in need of treatment, including post-COVID-19 subjects.
Type:
Application
Filed:
February 18, 2022
Publication date:
May 23, 2024
Inventors:
Christopher R. Schuster, Wesley D. Blakeslee
Abstract: The benzisoselazole derivative of formula (I) can be used for preparing an anti-coronavirus drug or a drug for treating diseases caused by coronaviruses. The benzisoselazole derivatives can effectively inhibit the activity of 2019-nCoV 3CLpro proteolytic enzyme, thus inhibiting the activation of 2019-nCoV RNA polymerase, inhibiting virus replication, while also effectively treating interstitial lung disease (ILD) caused by coronavirus.
Abstract: The present application relates to a compositions and methods comprising or expressing a MOMO30 protein derived from Momordica balsamina. The MOMO30 protein is about 30 kDa in size, binds coronavirus S protein, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to coronavirus spike (S) protein, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by a coronavirus or alleviating symptoms in coronavirus infected patients and comprises the amino acid sequence of SEQ ID NO: 1. The MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for preventing or treating viral infections by coronaviruses and others.
Type:
Grant
Filed:
August 18, 2020
Date of Patent:
November 9, 2021
Assignee:
MOREHOUSE SCHOOL OF MEDICINE
Inventors:
Michael Powell, Erick Vidjin′ Agnih Gbodossou
Abstract: The present application provides a novel coronavirus antibody detection kit based on magnetic particle chemiluminescence. The detection kit includes: streptavidin magnetic particles, biotin-labeled novel coronavirus antigens, an acridine sulfonamide-labeled secondary antibody, a sample diluent and a quality control material; wherein the biotin-labeled novel coronavirus antigens include a recombinant nucleocapsid protein and a recombinant spike protein S1. The sample to be tested, the biotin-labeled antigens and the streptavidin magnetic particles are mixed, incubated and washed, and then the acridine sulfonamide-labeled antibody is added to form a magnetic particle-streptavidin-biotin-antigen-novel coronavirus antibody-secondary antibody complex, and then the luminous intensity is detected to qualitatively determine the sample to be tested.
Type:
Application
Filed:
March 24, 2021
Publication date:
September 21, 2023
Inventors:
Chunlong Liu, Zhou Zhang, Shaohua Ma, Jiashun Wang, Yan Su, Zeqi Zhou
Abstract: Provided are a kit for detecting Coronavirus using magnetic nanoparticles and a method detecting Coronavirus using the same. The kit for detecting Coronavirus includes a reactor having an opening on one side and provided with a sample containing Coronavirus, at least one magnetic nanoparticle part provided in the reactor, a conductive substrate provided to cover the opening of the reactor, and a magnetic field applying part for applying a magnetic field to the reactor, in which the magnetic nanoparticle part includes a magnetic nanoparticle including a core portion made of iron oxide and a shell portion made of gold and provided to surround the core portion, and a primer attached to the shell portion of the magnetic nanoparticle.
Type:
Application
Filed:
November 4, 2022
Publication date:
August 31, 2023
Applicants:
Korea University Research and Business Foundation, Industry-University Cooperation Foundation Hanyang University ERICA Campus
Inventors:
Young Keun KIM, Ju Hun LEE, Bum Chul PARK, Hyeon Su PARK, Jeong Ook SOH
Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.
Type:
Grant
Filed:
September 3, 2021
Date of Patent:
February 20, 2024
Assignee:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Inventors:
Ralph A. Tripp, Jackelyn Murray, Robert Jeff Hogan
Abstract: Provided herein are methods and systems for detecting coronavirus. Methods and systems as described herein comprise using antibodies with improved specificity and sensitivity for accurately detecting coronavirus.
Abstract: Disclosed herein are methods of treating a coronavirus infection by administration of ethyl mercury or thiol derivative thereof in an amount effective to treat the coronavirus infection.
Abstract: The present disclosure relates in some aspects to immunogenic compositions including recombinant peptides and proteins comprising coronavirus viral antigens and immunogens, e.g., coronavirus S protein peptides. In some aspects, the immunogenic composition comprises a secreted fusion protein comprising a soluble coronavirus viral antigen joined by in-frame fusion to a C-terminal portion of a collagen which is capable of self-trimerization to form a disulfide bond-linked trimeric fusion protein. In some aspects, the immunogenic compositions provided herein are useful for generating an immune response, e.g., for treating or preventing a coronavirus infection. In some aspects, the immunogenic compositions provided herein may be used in a vaccine composition, e.g., as part of a prophylactic and/or therapeutic vaccine. Also provided herein are methods for producing the recombinant peptides and proteins, prophylactic, therapeutic, and/or diagnostic methods, and related kits.
Type:
Application
Filed:
September 29, 2021
Publication date:
January 20, 2022
Applicant:
Sichuan Clover Biopharmaceuticals, Inc.