Search Patents
  • Signaling Pathway of Cannabidiol (CBD) for Prevention and Treatment of COVID-19
    Publication number: 20220170119
    Abstract: The invention relates to the technical field of medicine, and provides a method of screening and identifying small molecule with antiviral properties. The invention has screened and identified Cannabidiol (CBD), which can be used for prevention of viral infections. The invention also examined and verified that CBD can be used for prevention of COVID-19 disease, by a key signaling pathway of upregulating the expression of the TRIB3 gene. The invention also determined that the optimal dosage of CBD treatment for prevention of COVID-19 disease is 5 ?M-10 ?M.
    Type: Application
    Filed: December 2, 2021
    Publication date: June 2, 2022
    Inventors: Zhongjun Zhou, Sheung Kin Ken Wong, Hin Chu, Xuelai Wang, Jie Zhou, Cun Li, Leung Kris Ying, Jian Zhang
  • Indigenous and improved bacterially fermented CBD, CBG and related cannabinoid oral dosage forms
    Patent number: 11547669
    Abstract: The present invention is a cannabidiol oral dosage form including predominantly or exclusively bacterially fermented hemp pomace, compounded as a tablet or formulated within a capsule generally without the addition of synthetic excipients, fillers or other additives, not including the inevitable presence of some moisture. The dosage forms contain dietary fiber, important to activity as the desired delivery system, having a ratio of one part soluble dietary fiber to 30 parts insoluble dietary fiber and delivers desirable/non hallucinogenic cannabinoids (CBD, CBG, etc.) in a ratio of 60:1 up to 120:1 to hallucinogenic cannabinoids (THC).
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: January 10, 2023
    Assignee: Fermented Farmer, LLC.
    Inventor: Jordan Seth Rubin
  • TOPICAL SKIN FORMULATIONS AND WOUND CARE PRODUCTS WITH INTEGRATED CBD DELIVERY MECHANISMS
    Publication number: 20210275441
    Abstract: Cannabidiol (CBD) is one of the most abundant and physiologically active phytocannabinoids in Cannabis plants. The chemical has well-known mechanisms that have been the potential to treat and prevent numerous inflammatory, immunologic, anti-infectious, sun-damaged, age-related (wrinkling, drying, hair loss), and neurogenic-related (anti-pain, anti-itch) diseases as well as heal traumatized skin. The incorporation of CBD on or within topically applied formulations or within wound care dressings, biomaterials skin substitutes, or skin adhesives is a novel approach to alleviate, prevent and cure acute and chronic skin disease, and promote normal healing and recovery after injury.
    Type: Application
    Filed: May 24, 2021
    Publication date: September 9, 2021
    Inventor: Adam M. Rotunda
  • Introducing a metal layer between SiN and TiN to improve CBD contact resistance for P-TSV
    Patent number: 7633165
    Abstract: The present disclosure provide an integrated circuit. The integrated circuit includes a through-silicon-via (TSV) trench configured in a semiconductor substrate; a conductive pad formed on the semiconductor substrate, the conductive pad being adjacent the TSV trench; a silicon nitride layer disposed over the conductive pad and in the TSV trench; a titanium layer disposed on the silicon nitride layer; a titanium nitride layer disposed on the titanium layer; and a copper layer disposed on the titanium nitride layer.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: December 15, 2009
    Assignee: Taiwan Semiconductor Manfacturing Company, Ltd.
    Inventors: Kuo-Ching Hsu, Chen-Shien Chen, Boe Su, Hon-Lin Huang
  • TOPICAL SKIN FORMULATIONS AND WOUND CARE PRODUCTS WITH INTEGRATED CBD DELIVERY MECHANISMS FOR SKIN REJUVENATION
    Publication number: 20210275442
    Abstract: Cannabidiol (CBD) is one of the most abundant and physiologically active phytocannabinoids in Cannabis plants. The chemical has well-known mechanisms that have been the potential to treat and prevent numerous inflammatory, immunologic, anti-infectious, sun-damaged, age-related (wrinkling, drying, hair loss), and neurogenic-related (anti-pain, anti-itch) diseases as well as heal traumatized skin. The incorporation of CBD on or within topically applied formulations or within wound care dressings, biomaterials skin substitutes, or skin adhesives is a novel approach to alleviate, prevent and cure acute and chronic skin disease, and promote normal healing and recovery after injury.
    Type: Application
    Filed: May 24, 2021
    Publication date: September 9, 2021
    Inventor: Adam M. Rotunda
  • Novel synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV
    Publication number: 20050124540
    Abstract: The present invention relates to peptides, referred to as CBD-1, CBD-2, CBM-1/TH-1, CBM-1/TH-2, CBM-2/TH-1, CBM-2/TH-2 and C-20 peptides, which are antigenic and elicit a protective immune response against HIV infection. Compositions, pharmaceutical compositions and vaccines comprising these antigenic peptides are also encompassed by the present invention, as well as neutralizing antibodies which inhibit infection of primary CD4+ T lymphocytes by various HIV isolates. Methods for diagnosis of HIV are also disclosed.
    Type: Application
    Filed: April 9, 2004
    Publication date: June 9, 2005
    Inventors: Ara Hovanessian, Jean-Paul Briand, Sylviane Muller, Bernard Krust, Josette Svab, Elias Said
  • REDUCTION OF SILICA
    Publication number: 20110182795
    Abstract: A process for producing silicon comprising reacting silica with a reducing gas comprising carbon monoxide, wherein the reducing gas does not contain elemental carbon. A reactor for producing silicon comprising a carbon combustion chamber for reacting carbon with oxygen to generate a reducing gas comprising carbon monoxide, wherein the reducing gas contains no elemental carbon; a reaction chamber for reacting the reducing gas containing no elemental carbon with silica, the reaction chamber communicating with the carbon combustion chamber; a temperature controller for controlling the temperature of the reaction chamber; a silica inlet port communicating with the reaction chamber for admitting the silica to the reaction chamber; and a silicon outlet port communicating with the reaction chamber for allowing the silicon to leave the reaction chamber.
    Type: Application
    Filed: February 19, 2009
    Publication date: July 28, 2011
    Applicant: CBD Energy Limited
    Inventor: Robert Lloyd
  • Anti-tumor halo bicyclo alkanones
    Patent number: 4689349
    Abstract: Potent tumor inhibitors are prepared which are compounds of the formula: ##STR1## wherein Q is CO, CH(OH) or C(OH)CH.sub.3,M.sub.1 is halogen,M.sub.2 is halogen or hydrogen,c is one or twop is 0 or 1, andone of X and X' is H and the other is hydroxy-C.sup.2-9 alkyl, methoxy-C.sup.2-9 -alkyl, ethoxy-C.sup.2-9 -alkyl, oxo-C.sup.2-9 -alkyl, formyl-C.sup.2-9 -alkyl, carboxy-C.sup.2-9 -alkyl or (C.sub.1-2 -alkyl)oxycarbonyl-C.sup.2-9 -alkyl.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: August 25, 1987
    Assignee: CBD Corporation
    Inventors: Walter J. Kasha, Chantal S. Burnison
  • Elastomeric Skin Contact Material that Contains and Releases CBD Oil
    Publication number: 20220401237
    Abstract: An improved composition for a thermoplastic elastomer that is used in a product that touches the skin. The thermoplastic elastomer contains a styrene block copolymer, a plasticizing oil, and CBD oil. The plasticizing oil and the CBD oil, in combination, comprise at least eighty percent of the thermoplastic elastomer by weight. The plasticizing oil and the CBD oil have the same, or similar, molecular weights. In that manner, the plasticizing oil and the CBD oil can form a homogenous mixture. The CBD oil saturates the thermoplastic elastomer and will slowly bloom out of the thermoplastic elastomer over time. The migration of the CBD oil brings the CBD oil to the exposed surfaces of the thermoplastic elastomer, therein enabling the CBD oil to be absorbed by the skin.
    Type: Application
    Filed: June 5, 2022
    Publication date: December 22, 2022
    Inventor: Gregory S. Bernhardt
  • INDIGENOUS CBD ORAL DOSAGE FORMS
    Publication number: 20210106532
    Abstract: The present invention is a cannabidiol oral dosage form including predominantly or exclusively hemp pomace, compounded as a tablet or formulated within a capsule without the addition of synthetic excipients, fillers or other additives, not including the inevitable presence of some moisture and the optional presence of fungal or bacterial probiotics introduced prior to or during dosage form manufacturing, and with or without fermentation of the hemp pomace prior to the dosage form manufacturing process. The dosage forms contain dietary fiber, important to activity as the desired delivery system, having a ratio of one part soluble dietary fiber to 30 parts insoluble dietary fiber and delivers desirable/non hallucinogenic cannabinoids (CBD, CBG) in a ratio of 30:1 up to 120:1 to hallucinogenic cannabinoids (THC).
    Type: Application
    Filed: February 4, 2020
    Publication date: April 15, 2021
    Applicant: Beyond Hemp, LLC
    Inventor: Jordan Seth Rubin
  • TOPICAL MASSAGE OIL AND CREAM CONTAINING CBD, CBN, CURCUMIN AND BOSWELLIA RESIN
    Publication number: 20200016115
    Abstract: An example method of treating a medical issue includes applying a composition to a skin area corresponding to a location afflicted with the medical issue. The composition includes a blend of Cannabidiol (CBD) oil and Cannabinol (CBN) oil fortified with curcumin from turmeric, Boswellic acid, and polycyclic terpenes from Boswellia serrata. The medical issue includes at least one of osteoarthritis, joint pain associated with natural causes or injury, reduced joint function and flexibility after injury or other causes, and photo-aging. A composition including a blend of pure CBD oil and CBN oil fortified with curcumin from turmeric and Boswellic acid along with polycyclic terpenes from Boswellia serrata is also disclosed.
    Type: Application
    Filed: July 12, 2019
    Publication date: January 16, 2020
    Inventors: V. Hari, John Stockwell
  • Method for the enrichment of target cells by use of CBDs
    Publication number: 20040197833
    Abstract: The present invention concerns a method for the enrichment of target cells by binding, wherein cell wall binding domains are used. Specifically, the present invention concerns a method for the specific recognition of target cells by binding wherein the CBDs are covalently bound to a solid phase and wherein said solid phase consists of beads, preferably magnetic latex beads. The invention also relates to the use of said method for detection, diagnosis, immobilisation or enrichment of cells. The invention furthermore relates to a reaction kit for a method as described above, wherein said kit comprises additionally to conventional detection means one or more CBDs. Finally, the present invention also relates to biochips, comprising CBDs, specifically biochips comprising two or more different CBDs in defined locations.
    Type: Application
    Filed: April 3, 2003
    Publication date: October 7, 2004
    Applicant: Danisco A/S
    Inventor: Martin Loessner
  • Topical Skin Formulations and Wound Care Products with Integrated CBD Delivery Mechanisms for Skin Rejuvenation, Wound Care and Healing, Pain and Itch Relief, and Scar Prevention and Treatment
    Publication number: 20200352849
    Abstract: Cannabidiol (CBD) is one of the most abundant and physiologically active phytocannabinoids in Cannabis plants. The chemical has well-known mechanisms that have been the potential to treat and prevent numerous inflammatory, immunologic, anti-infectious, sun-damaged, age-related (wrinkling, drying, hair loss), and neurogenic-related (anti-pain, anti-itch) diseases as well as heal traumatized skin. The incorporation of CBD on or within topically applied formulations or within wound care dressings, biomaterials skin substitutes, or skin adhesives is a novel approach to alleviate, prevent and cure acute and chronic skin disease, and promote normal healing and recovery after injury.
    Type: Application
    Filed: May 6, 2020
    Publication date: November 12, 2020
    Inventor: Adam M. Rotunda
  • Modified CBD/RGD recombinant attachment factor for improving cell-attachment efficiency and the manufacturing method thereof
    Publication number: 20040005690
    Abstract: A modified CBD/RGD recombinant attachment factor for improving cell attachment efficiency and the manufacturing method thereof, wherein the Arg-Gly-Asp (RGD) amino acid sequence is grafted on the C-terminal having a cellulose binding domain (CBD), thus the CBD-RGD polypeptide is capable of promoting the cell to attach onto the cellulose culturing plate; and as an RGD sequence is added, it can be accommodated in a stable annular structure built up by disulfide bonds, and is grafted on the N-terminal of said cellulose binding domain (CBD); thus, a CBD/RGD recombinant attachment factor for improving the promotion capability of cell-attachment is composed, and therefore the promotion capability of cell-attachment can be enhanced conspicuously.
    Type: Application
    Filed: June 27, 2002
    Publication date: January 8, 2004
    Applicant: Bio999 Inc.
    Inventor: Chia-Hui Lin
  • Pharmaceutical Composition Comprising Cannabinoids Having Reduced Psychoactivity through the Combination of CBD and Non-decarboxylated THC
    Publication number: 20140302086
    Abstract: The present invention relates to a pharmaceutical composition comprising non-decarboxylated ?9 Tetrahydrocannabinol (THC), Cannabidiol (CBD), and at least one small molecule selected from Citric Acid, Ascorbic Acid, Citrus Essential Oil(s), Lecithin, one or more sugar(s), Resvertrol, and combinations thereof, wherein the composition exhibits an increased but negated psychoactivity with concurrent enhancement in therapeutic potency of THC and/or CBD. The present invention is further directed to methods of treating one or more disease(s) or disorder(s) modulated by the activation of the Cannabinoid CB1 and/or CB2 receptors, by administering a therapeutically effective amount of the composition of the present invention to a subject in need thereof.
    Type: Application
    Filed: January 1, 2014
    Publication date: October 9, 2014
    Applicant: BROOKS KELLY RESEARCH, LLC
    Inventor: Brooks J. Kelly
  • Synthetic peptides corresponding to overlapping neutralizing determinants in the CBD1 epitope induce broadly neutralizing antibodies
    Patent number: 8790898
    Abstract: The present invention relates to chimeric peptides having a caveolin-1 binding domain of an HIV-1 gp41 (CBD1) peptide or a variant of said CBD1, fused to a T helper epitope. In one aspect, the T epitope is from a peptide selected from the group consisting of a tetanus toxin, an HIV-1 Gag p24 and an HIV-1 Env-gp120. Compositions containing these chimeric peptides and pharmaceutical and immunogenic compositions as well as vaccines comprising these chimeric peptides also are part of the present invention. Methods to induce neutralizing antibodies against HIV-1 activity and uses of the chimeric peptides to treat or to prevent HIV-1 infection are also disclosed.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: July 29, 2014
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Ara Hovanessian, Bernard Krust
  • Indigenous CBD oral dosage forms
    Patent number: 11590186
    Abstract: The present invention is a cannabidiol oral dosage form including predominantly or exclusively hemp pomace, compounded as a tablet or formulated within a capsule without the addition of synthetic excipients, fillers or other additives, not including the inevitable presence of some moisture and the optional presence of fungal or bacterial probiotics introduced prior to or during dosage form manufacturing, and with or without fermentation of the hemp pomace prior to the dosage form manufacturing process. The dosage forms contain dietary fiber, important to activity as the desired delivery system, having a ratio of one part soluble dietary fiber to 30 parts insoluble dietary fiber and delivers desirable/non hallucinogenic cannabinoids (CBD, CBG) in a ratio of 30:1 up to 120:1 to hallucinogenic cannabinoids (THC).
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: February 28, 2023
    Assignee: Fermented Farmer, LLC
    Inventor: Jordan Seth Rubin
  • 7-HYDROXY CANNABIDIOL (7-OH-CBD) FOR USE IN THE TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
    Publication number: 20170128385
    Abstract: The liver plays a key role in regulating total body energy homeostasis and its ability to do so is greatly affected by the occurrence of pathological conditions such as hepatosteatosis or non-alcoholic fatty liver disease (NAFLD), which contributes to hepatic insulin resistance and potentially end-stage liver disease-related mortality. Triglyceride accumulation in hepatocytes of steatotic livers results from the incorporation of plasma free fatty acids as well as de novo fat synthesis. The present invention relates to the use of 7-hydroxy-cannabidiol (7-OH-CBD) in the treatment of non-alcoholic fatty liver disease (NAFLD). Treatment of NAFLD involves lowering the triglyceride levels in a patient's blood stream.
    Type: Application
    Filed: June 29, 2015
    Publication date: May 11, 2017
    Inventors: Colin Stott, Marnie Duncan, Vincenzo Di Marzo, Cristoforo Silvestri, Andrea Martella
  • Systems and Methods for Adaptive CBD Estimation in a Storage Device
    Publication number: 20100182718
    Abstract: Various embodiments of the present invention provide systems and methods for adaptive channel bit density estimation. For example, various embodiments of the present invention provide methods for adaptively estimating channel bit density. Such methods include providing a storage medium (178) that includes information corresponding to a process data set, and accessing the process data set from the storage medium (505). A first channel bit density estimate (535) is computed based at least in part on a first portion of the process data set (520-530), and a second channel bit density estimate (535) is calculated based at least in part on the first portion of the process data set, a second portion of the process data set (520-530) and the first channel bit density estimate (535).
    Type: Application
    Filed: October 20, 2008
    Publication date: July 22, 2010
    Inventors: George Mathew, Yuan Xing Lee, Hongwei Song, Jefferson E. Singleton
  • Topical massage oil and cream containing CBD, CBN, curcumin and Boswellia resin
    Patent number: 10668045
    Abstract: An example method of treating a medical issue includes applying a composition to a skin area corresponding to a location afflicted with the medical issue. The composition includes a blend of Cannabidiol (CBD) oil and Cannabinol (CBN) oil fortified with curcumin from turmeric, Boswellic acid, and polycyclic terpenes from Boswellia serrata. The medical issue includes at least one of osteoarthritis, joint pain associated with natural causes or injury, reduced joint function and flexibility after injury or other causes, and photo-aging. A composition including a blend of pure CBD oil and CBN oil fortified with curcumin from turmeric and Boswellic acid along with polycyclic terpenes from Boswellia serrata is also disclosed.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: June 2, 2020
    Inventors: V. Hari, John Stockwell
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