Search Patents
  • Coronavirus vaccine
    Patent number: 11878055
    Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses.
    Type: Grant
    Filed: June 26, 2023
    Date of Patent: January 23, 2024
    Assignee: BioNTech SE
    Inventors: Alexander Muik, Kena Anne Swanson, Qi Yang, Hui Cai, Ugur Sahin, Kayvon Modjarrad
  • METHODS AND KITS FOR DETECTING OR DETERMINING AN AMOUNT OF AN ANTI-B-CORONAVIRUS ANTIBODY IN A SAMPLE
    Publication number: 20230258638
    Abstract: Disclosed herein are methods, kits, systems, algorithms and improvements for detecting the presence of or determining an amount, quantity, concentration and/or level of an antibody against at least one type of ?-coronavirus, such as, for example, an antibody against SARS-CoV or SARS-CoV-2, in one or more samples obtained from a subject. In some aspects, the methods, kits and systems relate to detecting the presence of or determining an amount, quantity, concentration and/or level of at least one type of anti-?-coronavirus antibody, such as an IgG and/or IgM antibody, in one or more samples obtained from a subject.
    Type: Application
    Filed: October 12, 2022
    Publication date: August 17, 2023
    Inventors: A. Scott Muerhoff, John C. Prostko, James L. Stewart, Mary A. RODGERS, Gavin A. CLOHERTY, James Hartnett, Jeff Moore, Kathy Otis, Alak Kar, Bailin Tu, Bryan Tieman, Carolyn Strobel, David Hawksworth, Robert Ziemann, Zhihong Lin, Chris Marohnic, Peter Wiebe, Todd Meyer, Weijie Jiao, Gangamani S. Beligere, Saminathan X. Muthusamy, Jessica L. Grieshaber, Sandra K. Pearce, Edwin C. Frias, Russell E. Taylor, Kelly Coller, Yangrong E. Zhang, Thomas T. Biegalski, David J. Daghfal, Claudio Galli, Sergey Y. Tetin, Qiaoqiao Ruan, Patrick MacDonald, Michael S. Cassidy, Mary E. Gardiner, Mary Ann P. Palafox, Matthew S. Matias, Melissa B. Brennan, Philip W. Schultz, Beth C. Trudeau
  • VACCINES AGAINST CORONAVIRUS AND METHODS OF USE
    Publication number: 20230338515
    Abstract: Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
    Type: Application
    Filed: May 2, 2023
    Publication date: October 26, 2023
    Inventors: Jian Yan, Kate Broderick, David Weiner, Kar Muthumani, Ami Patel
  • VACCINES AGAINST CORONAVIRUS AND METHODS OF USE
    Publication number: 20210268102
    Abstract: Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
    Type: Application
    Filed: February 25, 2021
    Publication date: September 2, 2021
    Inventors: Jian Yan, Kate Broderick, David Weiner, Kar Muthumani, Ami Patel
  • Live Attenuated Nidovirus Vaccines
    Publication number: 20070286872
    Abstract: The present invention is directed live, attenuated Nidovirus vaccines, and in a particular embodiment, to coronavirus vaccines. The vaccine comprises a viral genome encoding a replicase polyprotein having at least one proteinase cleavage site that exhibits reduced or no cleavage. Such viruses show reduced.
    Type: Application
    Filed: April 22, 2004
    Publication date: December 13, 2007
    Applicant: Vanderbilt University
    Inventor: Mark Denison
  • Vaccine based on TGEV for protection of canines against canine coronavirus
    Patent number: 6074651
    Abstract: A method for preventing canine coronavirus in dogs is disclosed which comprises administering to a dog a live or inactivated vaccine prepared from transmissible gastroenteritis virus of swine (a TGEV vaccine). An inactivated vaccine composition for use in such a method and a process for the manufacture of the inactivated vaccine composition are described.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: June 13, 2000
    Assignee: Pfizer, Inc.
    Inventors: Dale Bordt, Hans Draayer
  • VACCINE COMPOSITION FOR PREVENTION OR TREATMENT OF SARS-CORONAVIRUS-2 INFECTION
    Publication number: 20240042008
    Abstract: The present invention provides a recombinant antigen protein for preventing SARS-coronavirus-2 infection, comprising a polypeptide derived from an S1 subunit of a spike protein of SARS-coronavirus-2 and a polypeptide constituting a tetanus toxin (TT) epitope P2 domain, and a vaccine composition comprising the same.
    Type: Application
    Filed: October 27, 2021
    Publication date: February 8, 2024
    Applicant: SK BIOSCIENCE CO., LTD.
    Inventors: Ki-weon SEO, Teawoo KWON, Eun-som KIM, Chi-Yong KIM, Yoonjae LEE, Seung-hye HONG
  • CANINE CORONAVIRUS VACCINE
    Publication number: 20140205621
    Abstract: A new pantropic canine coronavirus (CCoV) strain, having reduced pathogenicity, and capable of eliciting an immune response, is described.
    Type: Application
    Filed: June 26, 2012
    Publication date: July 24, 2014
    Inventors: Nicola Decaro, Vito Martella, Gabriella Elia, Canio Buonavoglia
  • Vaccine based on TGEV for protection of dogs against canine coronavirus
    Patent number: 5911999
    Abstract: A method for preventing canine coronavirus in dogs is disclosed which comprises administering to a dog a live or inactivated vaccine prepared from transmissible gastroenteritis virus of swine (a TGEV vaccine). An inactivated vaccine composition for use in such a method and a process for the manufacture of the inactivated vaccine composition are described.
    Type: Grant
    Filed: March 27, 1991
    Date of Patent: June 15, 1999
    Assignee: Pfizer, Inc.
    Inventors: Dale Bordt, Hans Draayer
  • VACCINE COMPOSITION FOR PREVENTING OR TREATING INFECTION OF SARS-COV-2
    Publication number: 20230257425
    Abstract: Provided is a recombinant protein for preventing or treating infection of SARS-Coronavirus-2 antigen comprising an extended receptor binding domain (RBD) of a spike protein of SARS-Coronavirus-2, and a vaccine composition comprising thereof. Also the present invention relates to a method for preventing infection of SARS-Coronavirus-2 by administering the recombinant antigen protein to a subject. The present invention can prevent COVID-19 infection. The present invention can be used as a vaccine.
    Type: Application
    Filed: April 29, 2021
    Publication date: August 17, 2023
    Inventors: Teawoo KWON, YoonJae LEE, Eun-som KIM, Seung-hye HONG, Ki-weon SEO, Sujeen LEE
  • Canine coronavirus vaccine
    Patent number: 9200259
    Abstract: A new pantropic canine coronavirus (CCoV) strain, having reduced pathogenicity, and capable of eliciting an immune response, is described.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: December 1, 2015
    Inventors: Nicola Decaro, Vito Martella, Gabriella Elia, Canio Buonavoglia
  • VACCINES, ADJUVANTS, AND METHODS OF GENERATING AN IMMUNE RESPONSE
    Publication number: 20230149537
    Abstract: Provided herein are vaccines including coronavirus antigens and E6020, as well as methods of mitigation of coronavirus infection by administering those vaccines.
    Type: Application
    Filed: April 6, 2021
    Publication date: May 18, 2023
    Applicants: Eisai R&D Management Co., Ltd., Variation Biotechnologies Inc.
    Inventors: Fabian GUSOVSKY, Lynn HAWKINS, Sally ISHIZAKA, David Evander ANDERSON, Anne-Catherine FLUCKIGER
  • Vaccines against coronavirus and methods of use
    Patent number: 11660335
    Abstract: Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: May 30, 2023
    Assignees: Inovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and Biology
    Inventors: Jian Yan, Kate Broderick, David Weiner, Kar Muthumani, Ami Patel
  • CORONAVIRUS VACCINES
    Publication number: 20230241201
    Abstract: The invention relates to polynucleotides comprising a sequence of a live, infectious, attenuated Flavivirus wherein a nucleotide sequence encoding the S1 and S2 subunits of a coronavirus Spike protein is located, such that a chimeric virus is expressed.
    Type: Application
    Filed: March 1, 2021
    Publication date: August 3, 2023
    Inventors: Kai DALLMEIER, Johan NEYTS, Lorena SANCHEZ FELIPE, Hendrik, Jan THIBAUT, Dominique VAN LOOVEREN, Thomas VERCRUYSSE
  • SARS-COV-2 MRNA DOMAIN VACCINES
    Publication number: 20230346914
    Abstract: The disclosure relates to coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The RNA vaccines encode domains and subunits of coronavirus.
    Type: Application
    Filed: February 6, 2021
    Publication date: November 2, 2023
    Applicant: ModernaTX, Inc.
    Inventors: Guillaume Stewart-Jones, Andrea Carfi, Sayda Mahgoub Elbashir, Mihir Metkar
  • Compositions And Methods For Detecting Severe Acute Respiratory Syndrome Coronavirus
    Publication number: 20110223659
    Abstract: The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.
    Type: Application
    Filed: December 7, 2010
    Publication date: September 15, 2011
    Inventors: David R. Scholl, Joseph D. Jollick, Laura Gillim-Ross, Jill Taylor, David E. Wentworth
  • STABLE CORONAVIRUS PROTEINS AND VACCINE COMPOSITIONS THEREOF
    Publication number: 20220325279
    Abstract: Provided herein are compositions and methods comprising mutated coronavirus “S” spike proteins or receptor binding domains thereof that have an increased expression level, yield and stability compared to its corresponding native or wild-type coronavirus spike protein under the same expression, culture or storage conditions. These mutated spike proteins can be used for generating a protein-based vaccine against one or more coronaviruses.
    Type: Application
    Filed: December 28, 2021
    Publication date: October 13, 2022
    Applicants: UNIVERSITY OF WASHINGTON, FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Daniel ELLIS, Neil KING, Jesse BLOOM, Tyler STARR, Allison GREANEY
  • Compositions and methods for detecting severe acute respiratory syndrome coronavirus
    Publication number: 20050095582
    Abstract: The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.
    Type: Application
    Filed: November 3, 2003
    Publication date: May 5, 2005
    Applicants: Diagnostic Hybrids, Inc., Health Research Incorporated
    Inventors: Laura Gillim-Ross, Jill Taylor, David Scholl, David Wentworth, Joseph Jollick
  • Compositions and Methods for Detecting Severe Acute Respiratory Syndrome Coronavirus
    Publication number: 20080076115
    Abstract: The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.
    Type: Application
    Filed: November 3, 2004
    Publication date: March 27, 2008
    Inventors: David R. Scholl, Joseph D. Jollick, Laura Gillim-Ross, Jill Taylor, David E. Wentworth
  • ANTI-CORONAVIRUS VACCINES
    Publication number: 20220047696
    Abstract: The invention provides stable coronavirus spike proteins. Immunogenic compositions comprising same and the methods of using these immunogenic compositions are also provided.
    Type: Application
    Filed: July 30, 2021
    Publication date: February 17, 2022
    Inventors: Eric Todd Baima, Yulia Burakova, Paul Joseph Dominowski, Steven Alan Dunham, Nicole Lynn Hainer, John Morgan Hardham, Mahesh Kumar, Jason John Millership, Duncan M. Mwangi, Sharath K. Rai, Sharon Marie Wappel, Dennis Lee Foss
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