Search Patents
  • Isolated human transporter cofactor proteins, nucleic acid molecules encoding human transporter cofactor proteins, and uses thereof
    Patent number: 6485939
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter cofactor peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter cofactor peptides, and methods of identifying modulators of the transporter cofactor peptides.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: November 26, 2002
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Multi-site mutagenesis
    Patent number: 8067556
    Abstract: The present invention provides compositions and improved methods for multi-site directed mutagenesis and DNA shuffling. The present compositions and methods provide increased mutation frequency and increased number of transformants which allow one to sequence only a few clones in order to identify the correct mutants and to obtain the desired mutant by screening large number of transformants in a short time. Moreover, the inclusion of FEN-1, PEF and optimized buffer and cycling conditions provided in the present invention should also facilitate random mutagenized library construction and the mutagenesis of large or difficult templates.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: November 29, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: Holly H. Hogrefe, Janice M. Cline
  • Soybean mutant strain and soybean oil therefrom
    Patent number: 7326547
    Abstract: A soybean oil of a decreased content of polyunsaturated fatty acids is produced by hybridizing, selecting and raising a soybean mutant KK21 characterized by a gene having a sequence of base given by the sequence No. 1 of the sequence listing, a soybean mutant M23 characterized by deletion of a gene having a sequence of base given by the sequence No. 2 of the sequence listing, a soybean mutant M24 characterized by a gene having a sequence of base given by the sequence No. 3 of the sequence listing, a soybean mutant M5 characterized by a gene having a sequence of base given by the sequence No. 4 of the sequence listing, a soybean mutant J18 characterized by deletion of a gene having a sequence of base given by the sequence No. 5 of the sequence listing, and one or two kinds or more of these soybean mutants.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: February 5, 2008
    Assignee: Saga Prefectural Regional Industry Support Center
    Inventors: Toyoaki Anai, Yutaka Takagi
  • Alternatively Transcribed Genes Associated with Memory Consolidation
    Publication number: 20110165174
    Abstract: Methods of identifying gene targets associated with learning and memory and with memory consolidation, as well as to specific nucleic acid molecules that have been discovered to be associated with memory consolidation are provided. Accordingly, the invention also relates to methods of modulating learning and memory function, methods of diagnosing learning and memory disorders, and methods of identifying compounds that modulate learning and memory function via manipulations of the nucleic acid molecules and their products.
    Type: Application
    Filed: February 11, 2009
    Publication date: July 7, 2011
    Applicant: University College Dublin, National University of Ireland, Dublin
    Inventors: Keith J. Murphy, Ciaran M. Regan, Robert H. Ring, David Von Schack
  • Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
    Publication number: 20030027998
    Abstract: The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: March 1, 2001
    Publication date: February 6, 2003
    Inventors: Douglas A. Holtzman, Thomas M. Barnes
  • Antisense modulation of inhibitor-kappa B kinase-alpha expression
    Patent number: 6395545
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Inhibitor-kappa B Kinase-alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Inhibitor-kappa B Kinase-alpha. Methods of using these compounds for modulation of Inhibitor-kappa B Kinase-alpha expression and for treatment of diseases associated with expression of Inhibitor-kappa B Kinase-alpha are provided.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: May 28, 2002
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Brett P. Monia, Lex M. Cowsert
  • Susceptability and resistance genes for bipolar affective disorder
    Patent number: 6897022
    Abstract: Chromosomal regions comprising loci associated with susceptibility and resistance to bipolar affective disorder have been identified. Methods and compositions are provided for determining the contribution of these chromosomal regions to bipolar affective disorder in an affected family, for determining in an affected family a genotype associated with increased or decreased susceptibility or resistance to bipolar illness, and for assessing an increased or decreased risk of developing bipolar illness for a tested individual from an affected family.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: May 24, 2005
    Assignees: University of Miami, The United States of America as represented by the Secretary of Health & Human Services
    Inventors: Edward I. Ginns, Janice A. Egeland, Steven M. Paul
  • Cystic fibrosis gene
    Patent number: 6902907
    Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: June 7, 2005
    Assignees: HSC Research Development Corporation, The Board of Regents Acting for and on Behalf of The University of Michigan
    Inventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
  • MSP-5 nucleic acid molecules and uses therefor
    Patent number: 6204013
    Abstract: The invention provides isolated nucleic acid molecules, designated MSP-5 nucleic acid molecules, which encode novel myocardium secreted proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MSP-5 nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for producing MSP-5 polypeptides.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: March 20, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Mehran M. Khodadoust
  • Use of a baculovirus to express an exogenous gene in a mammalian cell
    Patent number: 7192933
    Abstract: Disclosed is a method of expressing an exogenous gene in a mammalian cell, involving infecting the cell with a baculovirus whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Also disclosed is a method of treating a gene deficiency disorder in a mammal by providing to a cell a therapeutically effective amount of a baculovirus whose genome carries an exogenous gene and growing the cell under conditions such that the exogenous gene is expressed in the mammal.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: March 20, 2007
    Assignee: The Massachusetts General Hospital
    Inventor: Frederick M. Boyce
  • Antisense modulation of fibroblast growth factor receptor 2 expression
    Patent number: 6900053
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding fibroblast growth factor receptor 2. Methods of using these compounds for modulation of fibroblast growth factor receptor 2 expression and for treatment of diseases associated with expression of fibroblast growth factor receptor 2 are provided.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: May 31, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventor: Susan M. Freier
  • Nucleic acid molecules encoding a subunit of a human calcium/calmodulin-dependent protein kinase
    Patent number: 6716604
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: April 6, 2004
    Assignee: Applera Corporation
    Inventors: Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • FLUORESCENT PROBES FOR MONITORING VOLTAGE BY PHOTO-INDUCED ELECTRON TRANSFER
    Publication number: 20140093907
    Abstract: Compounds and methods for determining transmembrane potential, monitoring changes in transmembrane potential, and/or drug screening are provided. In one aspect, compounds of the invention have a structure according to the formula: E-M-A, wherein A is a fluorophore, selected from xanthenes, eoumarins, cyanines, bimanes, and difluoroboradizaindacenes, charged at physiological pH; M is a molecular wire; and E is a hydrophobic moiety, wherein A and E are capable of being involved in a photo-induced, intramolecular electron transfer that quenches the fluorescence of A in response to a voltage condition. When in use, compounds of the invention are membrane-impermeant and oriented within the cell membrane such that the charged moiety localizes at the outer leaflet of the lipid bilayer and the hydrophobic moiety and molecular wire associate with the hydrophobic portion of the lipid bilayer.
    Type: Application
    Filed: May 21, 2012
    Publication date: April 3, 2014
    Applicant: The Regents of the University of California
    Inventors: Evan Walker Miller, Roger Y. Tsien
  • Cortistatin Polypeptides
    Patent number: 6232100
    Abstract: The present invention relates to novel cortistatin polypeptides, and to polynucleotides encoding these polypeptides. More specifically, isolated nucleic acid molecules are provided encoding a Human Cortistatin polypeptide. Cortistatin polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting variations in Human Cortistatin gene expression and therapeutic methods for treating individuals in need of an increased level of Human Cortistatin activity.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: May 15, 2001
    Assignee: Human Genome Sciences, Inc.
    Inventors: Henrik S. Olsen, Steven M. Ruben
  • Genes encoding sulfate assimilation proteins
    Patent number: 6696292
    Abstract: This invention relates to an isolated nucleic acid fragment encoding a sulfate assimilation protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the sulfate assimilation protein, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the sulfate assimilation protein in a transformed host cell.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: February 24, 2004
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Stephen M. Allen, Saverio Carl Falco, Catherine J. Thorpe
  • Isolated nucleic acid molecules encoding human lanosterol synthase proteins, and related products and processes
    Patent number: 6737261
    Abstract: The present invention provides amino acid sequences of human lanosterol synthase proteins and nucleic acid sequences encoding these lanosterol synthase proteins. The present invention provides isolated lanosterol synthase proteins and encoding nucleic acid molecules, vectors and host cells containing these nucleic acid molecules, and processes for producing the lanosterol synthase proteins.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: May 18, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Regulatable growth of filamentous fungi
    Patent number: 8304221
    Abstract: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: November 6, 2012
    Assignee: Danisco US Inc.
    Inventors: Ali R. Akin, Elizabeth A. Bodie, Shirley M. Burrow, Nigel Dunn-Coleman, Geoffrey Turner, Michael Ward
  • Fusion proteins of
    Patent number: 7982025
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: July 19, 2011
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Raymond L. Houghton, Patricia D. McNeill, Davin C. Dillon, Michael J. Lodes
  • Three component chimeric antisense oligonucleotides
    Patent number: 7691996
    Abstract: This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a complementary region and 3? and 5? ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: April 6, 2010
    Assignees: Lakewood-Amedex, Sequitur, Inc.
    Inventors: Amy Arrow, Roderic M. K. Dale, Tod Mitchell Woolf
  • NOVEL TRAF FAMILY PROTEINS
    Publication number: 20100324267
    Abstract: In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention TPBDs. Such TPBDs and/or anti-TPBD antibodies are useful for discovery of drugs that suppress autoimmunity, inflammation, allergy, allograph rejection, sepsis, and other diseases.
    Type: Application
    Filed: December 18, 2009
    Publication date: December 23, 2010
    Applicant: Burnham Institute for Medical Research
    Inventors: Juan M. Zapata, John C. Reed