Search Patents
  • Method for importing biologically active molecules into cells
    Patent number: 7576058
    Abstract: The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: August 18, 2009
    Assignee: Vanderbilt University
    Inventors: Yao-Zhong Lin, Jack J. Hawiger
  • Methods of monitoring treatment of BAFF-R related disease
    Patent number: 7709220
    Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: May 4, 2010
    Assignee: Biogen Idec MA Inc.
    Inventors: Christine M. Ambrose, Jeffrey S. Thompson
  • oocyst protein
    Patent number: 7741063
    Abstract: Recombinant proteins have been developed for the detection of Toxoplasma gondii oocyst proteins for example in biological fluids. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: June 22, 2010
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Dolores Hill, Dante S Zarlenga, Cathleen Coss, Jitender P Dubey
  • Silk proteins
    Patent number: 8481681
    Abstract: The present invention provides silk proteins, as well as nucleic acids encoding these proteins. The present invention also provides recombinant cells and/or organisms which synthesize silk proteins. Silk proteins of the invention can be used for a variety of purposes such as in the manufacture of personal care products, plastics, textiles, and biomedical products.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: July 9, 2013
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Tara D. Sutherland, Victoria S. Haritos, Holly Trueman, Alagacone Sriskantha, Sarah Weisman, Peter M. Campbell
  • BACTERIOPHAGE LYSINS FOR BACILLUS ANTHRACIS
    Publication number: 20100120673
    Abstract: The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and S. cereus bacteria and spores, and related conditions. The disclosure further relates to compositions comprising various phage associated lytic enzyme that rapidly and specifically detect and kill Bacillus anthracis and other bacteria. Related articles of manufacture, methods of degrading spores and methods of treatment of infections or bacteria populations of, or subjects exposed to or at risk for exposure to Bacillus anthracis are also provided.
    Type: Application
    Filed: May 31, 2006
    Publication date: May 13, 2010
    Inventors: Pauline Yoong, Raymond Schuch, Daniel Nelson, Vincent A. Fischetti
  • Materials and methods for the control of calliphoridae pests
    Patent number: 5888503
    Abstract: Methods and compositions for the control of pests of the family Calliphoridae are described. Specifically, Bacillus thuringiensis (B.t.) isolates having anti-calliphorid activity are disclosed. Also described are recombinant hosts which express B.t. genes coding for pesticidal toxins. The B.t. isolates and recombinant proteins are shown to be useful in a method for controlling calliphorids including screw-worms and the sheep blowfly.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: March 30, 1999
    Assignee: Mycogen Corporation
    Inventors: Leslie A. Hickle, Jewel Payne
  • Response regulator
    Patent number: 6140061
    Abstract: The invention provides response regulator polypeptides and polynucleotides encoding response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing response regulator polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: October 31, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Nicola Gail Wallis, Magdalena Zalacain, John Throup, Sanjoy Biswas
  • ANTI-ANGIOGENIC COMPOSITIONS AND THERAPEUTIC APPLICATIONS THEREOF
    Publication number: 20110142918
    Abstract: There is described the use of the Human herpesvirus type 6 (HHV-6) U94 gene and its product, the protein Rep, expression vectors and pharmaceutical compositions suitable for the delivery of the U94 gene or the protein encoded therefrom to the therapeutic sites, to inhibit angiogenic and lymphangiogenic processes in a subject in need thereof.
    Type: Application
    Filed: June 10, 2009
    Publication date: June 16, 2011
    Applicant: PHOEBUS S.R.L.
    Inventors: Arnaldo Caruso, Dario Di Luca
  • Materials and methods for immunocontraception
    Patent number: 5989550
    Abstract: A method for specifically inducing transient infertility or permanent sterility in a host animal by selective vaccination with specific zona pellucida proteins or immunocontraceptively active fragments thereof. Novel zona pellucida DNA sequences encoding specific zona pellucida proteins are disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 23, 1999
    Assignee: Zonagen, Inc.
    Inventors: Jeffrey D. Harris, Kuang T. Hsu, Joseph S. Podolski
  • BIOMARKER
    Publication number: 20120020888
    Abstract: Described are bladder cancer specific biomarkers and lung cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are uses of the biomarkers in the treatment, diagnosis, monitoring and imaging of bladder cancer and lung cancer.
    Type: Application
    Filed: December 21, 2009
    Publication date: January 26, 2012
    Applicant: THE UNIVERSITY OF SURREY
    Inventors: Richard Morgan, Hardev S. Pandha
  • Neutropohil inhibitors
    Patent number: 6756211
    Abstract: Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
    Type: Grant
    Filed: May 11, 1993
    Date of Patent: June 29, 2004
    Assignee: Corvas International, Inc.
    Inventors: Matthew Moyle, David L. Foster, George P. Vlasuk
  • Peptide inhibitor of TGF-? growth factors
    Patent number: 7402566
    Abstract: A potent peptide inhibitor (SuperSog) of TGF-? family growth factor signaling, peptide variants thereof and nucleotide coding sequences therefore are provided by the invention. The Super-Sog peptide comprises a fragment of the Drosophilia short gastrulation (Sog) gene which includes the CR-1 cysteine-rich repeat of Sog. Methods and compositions for use of Super-Sog in therapeutic and diagnostic applications are also provided.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: July 22, 2008
    Assignee: The Regents of the University of California
    Inventors: Ethan Bier, Kweon Yu
  • Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
    Patent number: 8143021
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: July 7, 2010
    Date of Patent: March 27, 2012
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Junxin Duan, Ye Liu, Lan Tang, Wenping Wu, Jason Quinlan, Randall Kramer
  • Methods for enhancing bacterial cell display of proteins and peptides
    Patent number: 8293685
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: October 23, 2012
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Jeffrey Rice
  • Alzheimer's disease-associated proteins
    Publication number: 20040102612
    Abstract: The invention provides human Alzheimer's disease-associated proteins (ADP) and polynucleotides which identify and encode ADP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ADP.
    Type: Application
    Filed: April 3, 2003
    Publication date: May 27, 2004
    Applicant: Incyte Corporation
    Inventors: Yuming Xu, Kavitha Thangavelu, Vicki S Elliott, Y Tom Tang, Henry Yue, Narinder K Chawla
  • Glycoconjugates and their use as potential vaccines against infection by
    Patent number: 8124380
    Abstract: A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: February 28, 2012
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Armelle Phalipon, Farida Nato, Laurence Mulard, Philippe Sansonetti, Françoise Baleux, Frédéric Belot, Cyrille Grandjean
  • ENHANCED CAPACITY AND PURIFICATION OF PROTEIN BY MIXED MODE CHROMATOGRAPHY IN THE PRESENCE OF AQUEOUS-SOLUBLE NONIONIC ORGANIC POLYMERS
    Publication number: 20110263823
    Abstract: This invention relates to the use of mixed mode chromatography for purification of a protein from a mixture containing other materials, including fragmented or aggregated antibodies, host cell proteins, DNA, endotoxin, and/or virus. This invention further relates to the integration of such a method into a multi-step procedure with other fractionation methods for purification of antibodies or other proteins suitable for in vivo applications.
    Type: Application
    Filed: July 8, 2011
    Publication date: October 27, 2011
    Applicant: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon
  • Protease-stable, cell wall-lysing enzymes
    Patent number: 8492519
    Abstract: The present invention relates to a modified polypeptide with a biological activity to lyse cell walls of bacteria, wherein the polypeptide has no caspase, clostripain, enterokinase, factor Xa, granzyme B, staphylococcus peptidase I (V8 Protease), plasmin, streptopain, bacillolysin and/or thrombin cleavage site. The invention further relates to nucleic acids with a sequence encoding a polypeptide according to the present invention.
    Type: Grant
    Filed: August 19, 2008
    Date of Patent: July 23, 2013
    Assignees: Hyglos Invest GmbH, bioMérieux S.A.
    Inventors: Holger Grallert, Michael Forchheim
  • Compositions and methods for enhancing osseous growth, repair and regeneration
    Patent number: 6350867
    Abstract: Novel human DLX3 genes and their encoded proteins are provided herein. The proteins encoded by the disclosed DLX3 and DLX3&Dgr; genes play a pivotal role in craniofacial growth and development. DLX3 genes and their encoded proteins provide valuable therapeutic targets for the design of proliferative agents which augment bone growth and repair.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: February 26, 2002
    Assignee: Wake Forest University
    Inventors: Thomas C. Hart, Jennifer A. Price
  • Methods of modulating apoptosis by administration of relaxin agonists or antagonists
    Patent number: 8119136
    Abstract: The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: February 21, 2012
    Assignee: Molecular Medicine Research Institute
    Inventors: Edward P. Amento, Christian S. Samuel