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  • Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds
    Patent number: 7317034
    Abstract: Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds, processes for their preparation, medicaments and pharmaceutical compositions containing them, and their use in treatment methods and in the preparation of analgesics, in the preparation of a local anaesthetic, an antiarrhythmic, an antiemetic, a nootropic agent and/or a medicament for the treatment and/or prophylaxis of cardiovascular diseases, urinary incontinence, diarrhea, pruritus and/or inflammations, and/or a medicament for the treatment of depression and/or alcohol and/or drug and/or medicament abuse, and/or a medicament for increasing vigilance.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: January 8, 2008
    Assignee: Gruenenthal GmbH
    Inventors: Corrina Sundermann, Michael Przewosny
  • Aqueous coating composition with low VOC content
    Patent number: 7858682
    Abstract: The present invention aqueous coating compositions comprising (a) an acrylate-based binder comprising 1% to 10% by weight of at least one hydroxy-functional comonomer of the general formula (I) A-[B]n-C where A is a polymerizable group, B is a spacer, C is a hydroxy-functional radical, and n is 0 or 1, (b) at least one pigment, (c) water, (d) less than 3% by weight of antifrost agent, and if appropriate, further, customary auxiliaries.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: December 28, 2010
    Assignee: BASF Aktiengesellschaft
    Inventors: Konrad Roschmann, Joerg Leuninger, Rolf Dersch
  • Cylinder head gasket having reinforced combustion seal
    Publication number: 20030178788
    Abstract: A gasket body has a combustion opening and a coolant opening close to the combustion opening to define a narrow region of the gasket between the openings. An inner armor layer has an inner C-shaped section folded over an edge of the combustion opening adjacent to the coolant opening. The inner armor layer has top and bottom portions extending over the top and bottom surfaces of the narrow region of the gasket body. An outer armor layer has an outer C-shaped section folded over the inner C-shaped section. The outer armor layer has top and bottom portions extending over the top and bottom portions of the inner armor layer. The bottom portion of the outer armor layer extends across the entire width of the bottom surface of the narrow region of the gasket body and has a second C-shaped section folded up and over an edge of the coolant opening adjacent to the combustion opening.
    Type: Application
    Filed: March 25, 2002
    Publication date: September 25, 2003
    Applicant: Federal-Mogul World Wide, Inc.
    Inventors: Richard M. Larson, Gregory C. West
  • 1-[2',3' -Dideoxy-3' C-(Hydroxymethyl) - Beta-D-Erythro-Pentofuranosyl] Cytosine Derivatives as Hiv
    Publication number: 20080221140
    Abstract: Compounds of the formula (I) wherein: R1 is independently H1—OR3, —NHR4; C1-C4 alkyl; or, when n is 2, adjacent R1 together define an olefinic bond; R2 is H; or when the gem R1 is C1-C4 alkyl, that R2 may also be C1-C4 alkyl; or when the gem R1 is —OR3, that R2 may also be —C(?O)OH or a pharmaceutically acceptable ester thereof; R3 is independently H, or a pharmaceutically acceptable ester thereof; R4 is independently H or a pharmaceutically acceptable amide thereof; R5 and R6 are H or an amine prodrug moiety n is 1, 2 or 3; and pharmaceutically acceptable salts thereof; have utility in the treatment or prophylaxis of HIV, especially reverse transcriptase mutants which allow an obligate chain terminating nucleoside- or nucleotide phosphate to be excised from the nascent DNA strand by ATP- or pyrophosphate-mediated excision.
    Type: Application
    Filed: July 5, 2006
    Publication date: September 11, 2008
    Inventors: Xiao-Xiong Zhou, Christer Sahlberg
  • C2-substituted alpha olefins produced by dimerization of branched Colefins
    Patent number: 11174205
    Abstract: Disclosed herein are compositions containing branched C20 2-substituted alpha olefins and processes for making the compositions by dimerization reaction of a C10 olefin composition.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: November 16, 2021
    Assignee: Chevron Phillips Chemical Company, LP
    Inventor: Jeffrey C. Gee
  • Process for isolating polycarbonates with CO.sub.2 under pressure
    Patent number: 5221731
    Abstract: A continuous process for the isolation of polycarbonates from a solution of polycarbonate in methylene chloride at temperatures of 30.degree. to 80.degree. C. is disclosed. The process which yields polycarbonate in powder form having residual solvent content of less than 5% by weight, is characterized in that it entails the following steps:a) obtaining a solution of polycarbonate in methylene chloride containing 10 to 40 percent polycarbonate, said percent being relative to the total weight of the polycarbonate solution,b) mixing into said solution under pressures of 10 to 50 bar and at temperatures of 30.degree. to 50.degree. C. a fluid containing carbon dioxide resulting in a non-gelling polycarbonate/methylene/chloride/dioxide pressurized system, in which between 10 and 12% CO.sub.2 are dissolved,c) mixing said pressurized system in a two-component nozzle with additional fluid containing carbon dioxide under a pressure of 50 to 300 bar and at temperatures of 40.degree. to 150.degree. C.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: June 22, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunther Weymans, Jurgen Kirsch, Wolfgang Herrig, Hanns-Ingolf Paul, Rolf Treckmann
  • C-BASED SINGLE DOMAIN ANTIBODY FOR NEUTRALIZING RESPIRATORY SYNCYTIAL VIRUS AND APPLICATION THEREOF
    Publication number: 20250042977
    Abstract: The invention discloses a C-based single domain antibody that neutralizes respiratory syncytial virus (RSV) and its application thereof. The C-based single domain antibody of the present invention is a neutralizing antibody against RSV F protein, can inhibit the viral entry into host cells, and can be used for the prevention, treatment and diagnosis of RSV, as well as for further studying the mechanism of RSV infection. The C-based single domain antibody has a smaller molecular weight, better tissue permeability and the ability to bind to antigenic epitope with steric hindrance effect; it can be expressed in multiple expression systems, including prokaryotic, yeast, and mammalian cells. The C-based single domain antibody has a low production cost and a short production cycle; it has a wide range of administration routes and can be administered through nasal drops, nasal spray, spray, aerosol inhalation, intramuscular injection, intravenous injection, subcutaneous injection, etc.
    Type: Application
    Filed: July 19, 2024
    Publication date: February 6, 2025
    Inventors: RUI GONG, HAIWEI ZHANG, YE QIN
  • Pressure sensitive adhesive composition which is water dispersible under alkaline pH conditions
    Patent number: 5397614
    Abstract: A pressure sensitive adhesive which is dispersible at an alkaline pH but not at an acidic or a neutral pH is disclosed. The adhesive is essentially free from plasticizers (i.e., it contains less than 0.1 part of plasticizer per part of polymer).The polymer is formed from A, B and C monomers. The A monomer is hydrophobic and is an acrylic or methacrylic ester of a non-tertiary C.sub.2 -C.sub.14 alcohol. It comprises from 50 to 80 weight % of the polymer.The B monomer contains .beta.-carboxyethyl acrylate (BCEA) or a salt thereof or a mixture of BCEA or a salt thereof with a vinyl carboxylic acid or a salt thereof. The polymer contains from 10 to 30 weight % of B monomer. The acid groups of the polymer have been neutralized with from 0.5 to 2 equivalents of an alkali metal hydroxide.The C monomer is an X--Y--Z macromer. X is copolymerizable with the A and B monomers. Y is a divalent linking group.
    Type: Grant
    Filed: July 16, 1993
    Date of Patent: March 14, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Gregg A. Patnode, Donald R. Battles, Francois C. D'Haese
  • Two-component polyurethane binders as primers
    Patent number: 6756464
    Abstract: The invention relates to a primer containing a solvent-containing two-component polyurethane binder comprising I) a curing component (A), comprising an addition product of at least one organic polyisocyanate (B) with an average NCO functionality of 2.5 to 5.0 and an isocyanate content of 8 to 27 wt. % and an alkoxysilane (C) of formula (I) with at least one isocyanate-reactive group, Q—Z—SiXaY3−a  (I), in which Q represents an isocyanate-reactive group, Z represents a linear or branched C1-C12 alkylene group, X represents a hydrolyzable group, Y represents identical or different C1-C4 alkyl groups and a is an integer from 1 to 3, and II) a lacquer resin (D) which can react with isocyanate groups as adhesion promoter.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: June 29, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Steffen Hofacker, Markus Mechtel, Wieland Hovestadt, Claus Kobusch
  • Thermal print head
    Patent number: 7629990
    Abstract: A thermal printhead (A1) includes a substrate (1), and a plurality of heating portions (2) aligned on the substrate in a primary scanning direction (X) . A plurality of electrodes (31, 32, 33) are connected to the heating portions (2). Each of the heating portions (2) has a width in the primary scanning direction (X) which is smaller than that of each of the electrodes (31, 32, 33). Each of the electrodes (31, 32, 33) includes a tapered portion (31C, 32C, 33C) having a width which reduces as progressing toward a corresponding one of the heating portions 2.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: December 8, 2009
    Assignee: Rohm Co., Ltd.
    Inventor: Koji Nishi
  • L-ascorbic acid production in microorganisms
    Patent number: 5001059
    Abstract: Improved production of ascorbic acid is obtained empolying Chlorella as a microorganism source and growing the culture under a controlled pattern of carbon source supply. Greatly improved ratios of ascorbic acid to total carbon supplied as well as enhanced ascorbic acid concentrations in the fermentor are obtained.C. pyrenoidosa UV101-158 was deposited at the A.T.C.C. on June 27, 1985 and given Accession No. 53170.
    Type: Grant
    Filed: July 1, 1985
    Date of Patent: March 19, 1991
    Assignee: Bio-Technical Resources, Inc.
    Inventors: Thomas J. Skatrud, Ronald J. Huss
  • Class I sequence based typing of HLA-A, -B, and -C alleles by direct DNA sequencing
    Publication number: 20030017458
    Abstract: There is provided a method for directly typing or sequencing HLA-A, -B, or -C alleles from a tissue sample wherein exons 2 and 3 of the HLA-A, -B, or -C alleles from the sample are amplified together in a locus specific manner and then separated out and individually amplified in a locus specific manner. After the two amplifications, the amplified exons are directly sequenced, the sequences are recombined, and a comparison is made between the derived HLA allele sequence and an HLA allele database, thereby giving an exact HLA-A, -B, or -C type for the sample being tested.
    Type: Application
    Filed: May 1, 2001
    Publication date: January 23, 2003
    Inventors: William H. Hildebrand, Mary Ellexson, Pierre Chretien, R. Scott Duthie
  • Fluoropolymer-based conductive composition
    Patent number: 6762245
    Abstract: The present invention relates to a conductive composition comprising (i) a fluoropolymer, (ii) an electrically conductive product and (iii) a triblock copolymer ABC, the three blocks A, B and C being linked together in this order, each block being either a homopolymer or a copolymer obtained from two or more monomers, block A being linked to block B and block B to block C by means of a covalent bond or an intermediate molecule linked to one of these blocks via a covalent bond and to the other block via another covalent bond, and such that: block A is compatible with the fluoropolymer, block B is incompatible with the fluoropolymer and is incompatible with block A, block C is incompatible with the fluoropolymer, block A and block B. The invention also relates to the components manufactured with the above composition. These components may be plates, films, tubes, rods, centrifugal pump components and containers.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: July 13, 2004
    Assignee: ATOFINA
    Inventors: Anthony Bonnet, Francois Court, Ludwik Leibler
  • Process for producing N,N-dimethyl-N-alkylamine or N,N-dimethyl-N-alkenylamine
    Patent number: 5696294
    Abstract: N,N-Dimethyl-N-alkylamine or -alkenylamine is prepared by reacting a higher alcohol and dimethylamine by passing hydrogen gas and dimethylamine into a reactor containing a catalyst for the reaction at a pressure of atmospheric pressure to 100 atm. at 150.degree. C. to 250.degree. C. and removing water produced in the reaction as a component of the mixed hydrogen and unreacted dimethylamine gas which is discharged from the reactor, wherein at the point in the reaction at which from 90 to 99% of the higher alcohol has reacted with dimethylamine, one of the following procedures is followed: i) the introduction of only dimethylamine gas into the reactor is stopped, and the reaction is allowed to continue at a temperature 20.degree. to 150.degree. C. lower than the reaction temperature recited above; ii) the introduction of only dimethylamine gas into the reactor is stopped while the temperature is decreased to a level of 20.degree. to 150.degree. C.
    Type: Grant
    Filed: September 19, 1996
    Date of Patent: December 9, 1997
    Assignee: Kao Corporation
    Inventors: Hiroshi Abe, Hideki Taniguchi, Tetsuaki Fukushima
  • C-ARM RETENTION LOCKS, SYSTEMS CONTAINING THE SAME, AND METHODS FOR USING THE SAME
    Publication number: 20150071412
    Abstract: C-arm retention locks allowing users to secure and unsecure C-arm positioning devices of an X-ray machine, systems containing such locks, and methods of using such locks are described. The C-arm retention lock comprises a latch bail and a latching assembly. The latching assembly comprises a latch base having an ear and a generally flat engagement surface at an end of the latch base proximate the ear, a latch having an arm, the latch being pivotally connected to the latch base so the latch is rotatable between closed and open positions, and a tensioning device engaging the latch and latch base such that the tensioning device pulls the latch toward either of the closed or open positions. The latching assembly or latch bail is configured to be connected to a C-arm and the latching assembly retains the latch bail between the ear and the arm when the latch is closed.
    Type: Application
    Filed: September 6, 2013
    Publication date: March 12, 2015
    Applicant: General Electric Company
    Inventors: John Matthew Simmons, David Ellis Barker, Krishnanand Prabhu Bailur, Allen Michael Collins
  • Process of refining C-Caliphatic diols
    Patent number: 8143457
    Abstract: A process of refining a crude C6-C16 aliphatic diol, preferably, a C6-C16 monocyclic aliphatic diol, more preferably, an isomeric mixture of cis/trans-(1,3)(1,4)-cyclohexanedimethanol, containing in addition to the diol one or more impurities selected from phenols, and aliphatic mono-ols, esters, carboxylic acids, and hemiacetals, and mixtures thereof. The refining process involves distilling the crude C6-C16 aliphatic diol in the presence of an alkali or alkaline earth metal compound, preferably, an excess thereof relative to acid equivalents present in the diol.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: March 27, 2012
    Inventors: Glenn A. Miller, Edward H. Yonemoto, Rainer Potthast
  • Generator of a.c. signals, such as reference signals, and aircraft equipped with such a generator
    Patent number: 8415992
    Abstract: An a.c. signal generator is provided with a first circuit (B1) capable of generating alternations of a first a.c. signal (S1) between a first potential (V+) formed by a first voltage source and a second potential (V?). A second circuit (B2) is capable of generating alternations of a second a.c. signal (S2), phase-shifted relative to the first signal (S1), between the first potential (V+) formed by the first voltage source and the second potential (V?). Such a generator can be used, for example, in a flight control calculator of an aircraft.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: April 9, 2013
    Assignee: Airbus Operations SAS
    Inventor: Olivier Rieux-Lopez
  • METHOD OF TREATING C-KIT POSITIVE RELAPSED ACUTE MYELOID LEUKEMIA
    Publication number: 20110281813
    Abstract: The present invention relates to a method of treating c-kit positive relapsed acute myeloid leukemia (AML) in a human patient population using a combination comprising a c-kit inhibitor, daunorubicin and cytarabine.
    Type: Application
    Filed: December 3, 2009
    Publication date: November 17, 2011
    Applicant: CLEVELAND CLINIC
    Inventors: Anjali Advani, Matt Kalaycio
  • COMBINATION THERAPY USING A FACTOR XII INHIBITOR AND A C-1 INHIBITOR
    Publication number: 20200129600
    Abstract: Methods and compositions are disclosed for treating disorders of the contact activation system, comprising the administration of at least one C1-Inhibitor (C1-INH) and at least one Factor XII (FXII) inhibitor.
    Type: Application
    Filed: October 31, 2019
    Publication date: April 30, 2020
    Inventors: Marc NOLTE, Ingo PRAGST
  • Method for the preparation of fibrous insoluble calcium sulfate anhydrite
    Patent number: 4029512
    Abstract: A process is described for the formation of fibrous insoluble calcium sulfate anhydrite, the fibers thereof having specified dimensions. A dilute aqueous suspension of gypsum and, if desired, a crystal habit modifier suitable for the formation of fibrous calcium sulfate hemihydrate, is first formed. The gypsum in this suspension is then converted to the fibrous hemihydrate by reaction in the presence of saturated steam at 120.degree. C to 155.degree. C for 0.5 to 2.5 hours, thereby forming fibrous calcium sulfate hemihydrate of the desired dimensions. The fibrous hemihydrate is thereafter calcined at 500.degree. C to 750.degree. C for 0.5 to 3.0 hours to convert the fibrous hemihydrate to fibrous insoluble calcium sulfate anhydrite having substantially the same crystalline shape and dimensions.
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: June 14, 1977
    Assignee: Johns-Manville Corporation
    Inventors: Karlis L. Jaunarajs, Julie C. Yang
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