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  • RNA SCAFFOLDS
    Publication number: 20230203502
    Abstract: The present invention discloses an RNA scaffold comprising a tracrRNA; and a recruiting RNA motif with an extension sequence for targeted gene editing and related uses. The method enables precise modifications to be made to the genome whilst minimizing the possibility of off-target effects, making the method particularly suitable for therapeutic applications.
    Type: Application
    Filed: July 9, 2021
    Publication date: June 29, 2023
    Inventors: MICHAEL RUSHTON, MICHAEL ANBAR, KEVIN HEMPHILL
  • MODIFIED CELLULASES WITH ENHANCED THERMOSTABILITY
    Publication number: 20130084619
    Abstract: The present invention relates to modified family-8 cellulases that exhibit enhanced thermostability compared to the corresponding wild-type enzyme, polynucleotides encoding the modified cellulases, compositions comprising same and uses thereof. The variant family-8 cellulases are advantageous for the bioconversion process of cellulosic substrates.
    Type: Application
    Filed: June 6, 2011
    Publication date: April 4, 2013
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Edward A. Bayer, Michael Anbar
  • HIGHLY POTENT CELLULOLYTIC ENZYME PREPARATIONS AND PROCESSES FOR PRODUCING SAME
    Publication number: 20170218354
    Abstract: Compositions comprising unprocessed cell pellets of a cellulosome-producing microorganism grown on cellulosic biomass are provided. Further provided are methods for producing the compositions and uses thereof in hydrolysis of cellulosic substrates. In particular, the compositions advantageously contain extracellular beta-glucosidase, either expressed on the cells themselves or extrinsically added to the cell pellets.
    Type: Application
    Filed: April 11, 2017
    Publication date: August 3, 2017
    Applicant: DESIGNER ENERGY LTD.
    Inventors: Ely MORAG, Tal BARAK, Alon KARPOL, Michael ANBAR
  • HIGHLY POTENT CELLULOLYTIC ENZYME PREPARATIONS AND PROCESSES FOR PRODUCING SAME
    Publication number: 20150344867
    Abstract: Compositions comprising unprocessed cell pellets of a cellulosome-producing microorganism grown on cellulosic biomass are provided. Further provided are methods for producing the compositions and uses thereof in hydrolysis of cellulosic substrates. In particular, the compositions advantageously contain extracellular beta-glucosidase, either expressed on the cells themselves or extrinsically added to the cell pellets.
    Type: Application
    Filed: January 9, 2014
    Publication date: December 3, 2015
    Applicant: DESIGNER ENERGY LTD.
    Inventors: Ely MORAG, Tal BARAK, Alon KARPOL, Michael ANBAR
  • Fusion proteins comprising type-II cohesin modules, multi-enzyme complexes comprising same and uses thereof
    Patent number: 9371520
    Abstract: Fusion proteins including a type-II cohesin module that are capable of integrating into native and designer cellulosomes. ?-glucosidases modified to include a type-II cohesin module and polynucleotides encoding same. Multi-enzyme complexes including the fusion proteins, and methods for biomass degradation utilizing same.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: June 21, 2016
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Edward A. Bayer, Gilad Gefen, Michael Anbar
  • Fusion Proteins Comprising Type-II Cohesin Modules, Multi-Enzyme Complexes Comprising Same and Uses Thereof
    Publication number: 20140335573
    Abstract: Fusion proteins including a type-II cohesin module that are capable of integrating into native and designer cellulosomes. ?-glucosidases modified to include a type-II cohesin module and polynucleotides encoding same. Multi-enzyme complexes including the fusion proteins, and methods for biomass degradation utilizing same.
    Type: Application
    Filed: July 30, 2014
    Publication date: November 13, 2014
    Inventors: Edward A. Bayer, Gilad Gefen, Michael Anbar
  • Method and apparatus for electrochemical generation of power from hydrogen
    Patent number: 4042755
    Abstract: Method and apparatus for the pollution-free generation of electrical power from hydrogen in which molten lead is electrochemically oxidized to produce lead oxide and electricity in a single cell in which the resulting lead oxide is simultaneously converted back to lead metal by thermochemical reduction with hydrogen fuel, the entire process being carried out in a single cell using a molten salt as electrolyte in a temperature range of 500.degree. to 900.degree. C. The entire cycle consumes only hydrogen and oxygen, while producing electricity.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: August 16, 1977
    Inventor: Michael Anbar
  • Detection of cancerous lesions by measuring nitric oxide concentrations in tissue
    Patent number: 6035225
    Abstract: The present invention involves the measurement of nitric oxide in interstitial fluid extracted by a thin needle from a body tissue, and particularly a human breast. The diffuse nature of nitric oxide means that the sample of body fluid does not need to be taken directly from the lesion to indicate that cancerous cells are present in the vicinity. Therefore, the presence of nitric oxide in the extracted body fluid is a direct indicator of the presence of a cancerous lesion in the vicinity.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: March 7, 2000
    Assignee: Omnicorder Technologies
    Inventor: Michael Anbar
  • Method of detection of cancerous lesions by their effect on the spatial distribution of modulation of temperature and homogeneity of tissue
    Patent number: 5961466
    Abstract: A method for measuring the periodicity of changes in blood perfusion over large regions of skin so as to identify a locally impaired neuronal control, thereby providing a quick and inexpensive screening test for relatively shallow neoplastic lesions, such as breast cancer, is described. The present method is predicated on infrared imaging of the skin to detect changes in the spectral structure and spatial distribution of thermoregulatory frequencies (TRFs) over different areas of the skin.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: October 5, 1999
    Assignee: Omnicorder Technologies, Inc.
    Inventor: Michael Anbar
  • Detection of cancerous lesions by their effect on the periodic modulation of perfusion in the surrounding tissues
    Patent number: 5810010
    Abstract: The present invention comprises methods and apparatus for cancer detection involving the measurement of temporal periodic changes in blood perfusion associated with immune response, occurring in neoplastic lesions and their surrounding tissues. Particularly, the method for cancer detection involves the detection of non-neuronal thermoregulation of blood perfusion, aberrant modulation of blood perfusion, aberrant temperature oscillations associated with blood perfusion, aberrant thermoregulatory frequencies associated with blood perfusion, and periodic changes in the spatial homogeneity of skin temperature.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: September 22, 1998
    Inventor: Michael Anbar
  • Detection of cancerous lesions by their effect on the spatial homogeneity of skin temperature
    Patent number: 5999843
    Abstract: The present invention comprises methods for cancer detection involving the measurement of temporal periodic changes in blood perfusion, associated with immune response, occurring in neoplastic lesions and their surrounding tissues. Particularly, the method for cancer detection involves the detection of non-neuronal thermoregulation of blood perfusion, periodic changes in the spatial homogeneity of skin temperature, aberrant oscillations of spatial homogeneity of skin temperature and aberrant thermoregulatory frequencies associated with periodic changes in the spatial homogeneity of skin temperature.
    Type: Grant
    Filed: April 20, 1998
    Date of Patent: December 7, 1999
    Assignee: OmniCorder Technologies, Inc.
    Inventor: Michael Anbar
  • Method for detecting and quantifying carbon isotopes
    Patent number: 4427884
    Abstract: A method for detecting and quantifying a carbon isotope at quantities of less than 1.times.10.sup.-12 gram at a statistical precision of better than 5% in a time period of less than 5 minutes by producing a carbon compound, selected from CO,CS.sub.2,CO.sub.2 and elemental carbon, from the carbon containing composition to be analyzed; and producing and detecting sufficient C.sup.- ions from the carbon compound at a known efficiency to provide at least 80 counts of carbon isotope ions per minute by mass spectrometry.
    Type: Grant
    Filed: January 25, 1982
    Date of Patent: January 24, 1984
    Assignee: The Research Foundation of State University of New York
    Inventors: Michael Anbar, Robert C. Abbott
  • Mass spectrometric immunoassay
    Patent number: 4022876
    Abstract: A method and means of making an immunological assay is provided whereby stable isotopes of certain elements, or long-lived radioisotopes of these elements are used to tag antigens or antibodies. A known amount of the tagged antibodies or antigens are then mixed with the unknown number of antigens or antibodies forming an antigen-antibody complex, (bound) and free tagged antigens, or antibodies, (unbound). The bound antigens or antibodies are separated from the unbound, and their quantity is determined by negative ion mass spectrometry. An aliquot of the unbound or bound antigens or antibodies is taken and dried in a metal crucible, for example, which is then inserted into a negative ion mass spectrometer where the sample is vaporized, ionized and the number of tagging atoms is then counted. From the information provided by the count, an immunoassay can be established.
    Type: Grant
    Filed: June 21, 1973
    Date of Patent: May 10, 1977
    Assignee: Stanford Research Institute
    Inventor: Michael Anbar
  • Method and apparatus for electrochemical generation of power from carbonaceous fuels
    Patent number: 3970474
    Abstract: Method and apparatus for the pollution-free generation of electrical power from carbonaceous fuels in which molten lead is electrochemically oxidized to produce lead oxide and electricity in a single integrated cell in which the resulting lead oxide is simultaneously converted back to lead metal by carbothermic reduction with a carbonaceous fuel, the entire process being carried out in a single cell using a molten carbonate as electrolyte in a temperature range of 500.degree. to 900.degree. C. The entire cycle thus consumes only carbon and oxygen and produces electricity. It is found that by thus coupling the electrochemical cell and the thermochemical regeneration system, the resulting integrated carbon-lead-air cell will maintain a voltage well above that provided by a simple lead-air cell approaching that of a hypothetical carbon-air cell.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: July 20, 1976
    Assignee: Stanford Research Institute
    Inventors: Michael Anbar, Donald F. McMillen, Robert D. Weaver, Paul J. Jorgensen
  • Infrared imaging system for simultaneous generation of temperature, emissivity and fluorescence images
    Patent number: 5272340
    Abstract: The present invention comprises a method and apparatus for determining actual temperature, reflectivity and fluorescence of a surface and comprises in the preferred embodiment a two-dimensional focal plane array of rapidly tunable infrared detectors, 11, adapted to detect the emitted infrared flux from a surface of interest, 10, across pre-selected spectral segments in the 4-15 .mu.m range. The invention further comprises a computer having deconvolution algorithms, 13, for isolating the effects of reflectivity, fluorescence and environmental factors affecting infrared emission for each pixel of the generated image at various spectral segments in the 4-15 .mu.m range. The device further includes means for generating images of temperature, emissivity and fluorescence for diagnostic use.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: December 21, 1993
    Assignee: Amara, Inc.
    Inventor: Michael Anbar
  • Telethermometric psychological evaluation by monitoring of changes in skin perfusion induced by the autonomic nervous system
    Patent number: 5771261
    Abstract: The present invention comprises methods and apparatus for assessment of the effects mental stress involving the measurement of periodic changes in skin perfusion. Using a remotely mounted infrared camera, dynamic area telethermometry (DAT) measures the autonomic nervous activity by monitoring and quantitatively analyzing the modulation of cutaneous perfusion. When people gets "nervous" their sympathetics "act up" and they blush (vasodilates) or becomes pale (vasoconstricts). A DAT test of the face proves to be a superior "lie detector" test since emotional stress is reflected in an autonomic nervous response that can be measured remotely. DAT is much more sensitive than any visual assessment of skin color or than instrumental measurement of diaphoresis. Not only is it more reliable than currently used polygraph tests, but its non-contact administration is so simple and innocuous that it could be done without the subject's awareness.
    Type: Grant
    Filed: September 13, 1995
    Date of Patent: June 23, 1998
    Inventor: Michael Anbar
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