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  • Method for automatic tissue segmentation of medical images
    Patent number: 10157466
    Abstract: A method to segment images that contain multiple objects in a nested structure including acquiring an image; defining the multiple objects by layers, each layer corresponding to one region, where a region contains an innermost object and all the objects nested within the innermost object; stacking the layers in an order of the nested structure of the multiple objects, the stack of layers having at least a top layer and a bottom layer; extending each layer with padded nodes; connecting the top layer to a sink and the bottom layer to a source, wherein each intermediate layer between the top layer and the bottom layer are connected only to the adjacent layer by undirected links; and measuring a boundary length for each layer.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: December 18, 2018
    Assignees: Riverside Research Institute, New York University
    Inventors: Jen-wei Kuo, Jonathan Mamou, Xuan Zhao, Jeffrey A. Ketterling, Orlando Aristizabal, Daniel H. Turnbull, Yao Wang
  • System of therapeutic ultrasound and real-time ultrasonic scanning
    Patent number: 4932414
    Abstract: A system is described for obtaining in real-time cross-sectional and 3-dimensional images of a body under study using ultrasonic energy. A piezoelectric transducer is positioned to emit ultrasonic energy and receive echo pulses. The transducer is electronically swept or physically rotated to produce a series of sectored scan planes which are separated by a known angular distance. The echo pulses are processed to produce an ultrasonic image in pseudo 3-dimensional display. By using data from one scan plane, processed as a B-scan image, cross-sectional data can be obtained. Such is combined in a display with an overlay to visually portray the object and positioning information or comparative data. The system is combined with a computer for data analysis and a therapeutic transducer for treatment.
    Type: Grant
    Filed: November 2, 1987
    Date of Patent: June 12, 1990
    Assignees: Cornell Research Foundation, Inc., Riverside Research Institute
    Inventors: D. Jackson Coleman, Frederic L. Lizzi
  • ASSURED COMPUTER ARCHITECTURE -VOLATILE MEMORY DESIGN AND OPERATION
    Publication number: 20190005249
    Abstract: A method and apparatus providing computer system cryptographic protection including a processor, a trusted platform module, trusted bus devices, a first secure memory and a second secure memory, wherein the first and second memory each have a first and second shadow copy, an external bus controller, and a system bus. The system bus contains trusted data and connects with the processor, the trusted platform module, trusted bus devices, the first and second secure memory and the external bus controller. The first and second secure memory separating code and data via physically distinct memory components. The contents of the distinct memory components being replicated into two shadow copies for each component, wherein during a write operation, simultaneously updating the shadow copies with the contents of the distinct components, and during a read operation, sending the two shadow copies and the memory component to a majority function.
    Type: Application
    Filed: August 13, 2018
    Publication date: January 3, 2019
    Applicant: Riverside Research Institute
    Inventor: Rusty Baldwin
  • Ultrasonic tissue-type classification and imaging methods and apparatus
    Patent number: 6238342
    Abstract: Clinical data, ultrasonic radio frequency (RF) backscatter spectral data and histological results of corresponding biopsy sites are stored in a database and are used to train a classifier suitable for real-time tissue classification and imaging. In clinical use, clinical data and ultrasonic RF backscatter data are applied as input variables to the trained classifier which assigns a likelihood of cancer (LOC) score to each pixel location in an ultrasound image. The LOC scores are then categorized by ranges, which can be established by user selected threshold values, to apply different colors or grey scale values distinguishing varying levels of suspicion (LOS) to each pixel position in real-time. This classification and display technique is especially valuable for guiding a person performing a needle biopsy of the prostate.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: May 29, 2001
    Assignee: Riverside Research Institute
    Inventors: Ernest Joseph Feleppa, Frederic Louis Lizzi, Tian Liu
  • ASSURED COMPUTER ARCHITECTURE-VOLATILE MEMORY DESIGN AND OPERATION
    Publication number: 20170076098
    Abstract: A method and apparatus providing computer system cryptographic protection including a processor, a trusted platform module, trusted bus devices, a first secure memory and a second secure memory, wherein the first and second memory each have a first and second shadow copy, an external bus controller, and a system bus. The system bus contains trusted data and connects with the processor, the trusted platform module, trusted bus devices, the first and second secure memory and the external bus controller. The first and second secure memory separating code and data via physically distinct memory components. The contents of the distinct memory components being replicated into two shadow copies for each component, wherein during a write operation, simultaneously updating the shadow copies with the contents of the distinct components, and during a read operation, sending the two shadow copies and the memory component to a majority function.
    Type: Application
    Filed: September 12, 2016
    Publication date: March 16, 2017
    Applicant: Riverside Research Institute
    Inventor: Rusty Baldwin
  • System and method for ultrasonic harmonic imaging for therapy guidance and monitoring
    Patent number: 6533726
    Abstract: An ultrasound system is provided which includes a therapy ultrasound transducer and a diagnostic ultrasound transducer and operates in accordance with a method to direct the application of the therapy ultrasound. The method includes operating the diagnostic ultrasound transducer to acquire a first ultrasound image; simultaneously operating the diagnostic ultrasound transducer and therapy ultrasound transducer for a second interval to acquire a second ultrasound image; and determining a difference in the first and second images indicative of the pattern of the therapy ultrasound transducer signal. The difference in the images, which result from enhanced non-linearities and propagation distortions induced by the high intensity therapy ultrasound, can be obtained by subtracting the two images.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: March 18, 2003
    Assignee: Riverside Research Institute
    Inventors: Frederic Louis Lizzi, Cheri Xiaoyu Deng
  • System and method for ultrasonic harmonic imaging for therapy guidance and monitoring
    Patent number: 6726627
    Abstract: An ultrasound system is provided which includes a therapy ultrasound transducer and a diagnostic ultrasound transducer and operates in accordance with a method to direct the application of the therapy ultrasound. The method includes operating the diagnostic ultrasound transducer to acquire a first ultrasound image; simultaneously operating the diagnostic ultrasound transducer and therapy ultrasound transducer for a second interval to acquire a second ultrasound image; and determining a difference in the first and second images indicative of the pattern of the therapy ultrasound transducer signal. The difference in the images, which result from enhanced non-linearities and propagation distortions induced by the high intensity therapy ultrasound, can be obtained by subtracting the two images.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: April 27, 2004
    Assignee: Riverside Research Institute
    Inventors: Frederic Louis Lizzi, Cheri Xiaoyu Deng
  • System and method for ultrasonic harmonic imaging for therapy guidance and monitoring
    Patent number: 8152723
    Abstract: An ultrasound system is provided which includes a therapy ultrasound transducer and a diagnostic ultrasound transducer and operates in accordance with a method to direct the application of the therapy ultrasound. The method includes operating the diagnostic ultrasound transducer to acquire a first ultrasound image; simultaneously operating the diagnostic ultrasound transducer and therapy ultrasound transducer for a second interval to acquire a second ultrasound image; and determining a difference in the first and second images indicative of the pattern of the therapy ultrasound transducer signal. The difference in the images, which result from enhanced non-linearities and propagation distortions induced by the high intensity therapy ultrasound, can be obtained by subtracting the two images.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: April 10, 2012
    Assignee: Riverside Research Institute
    Inventors: Frederic Louis Lizzi, Cheri Xiaoyu Deng
  • Processor for two-dimensional array antenna
    Patent number: 6255990
    Abstract: Signal processors that support transmit or receive beams of two dimensional array antennas generate an appropriate distribution of phase shifts and/or time delays for each of the elements in the antenna array. The signals are processed by row and by column, where corresponding elements are grouped using intermediate frequency tagging, i.e., the elements of a first column are translated to a first intermediate frequency, the elements of a second column are translated to a second intermediate frequency, etc. Signals from elements of like rows are then summed and subjected to a row delay. The delayed signals are then summed and passed through a filter bank, where the summed signal is partitioned in accordance with the plurality of intermediate frequencies into a plurality of column signals. The column signals are subjected to a respective column delays, are translated to a common intermediate or baseband frequency and are summed to establish a received beam signal.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: July 3, 2001
    Assignee: Riverside Research Institute
    Inventor: Marvin King
  • System for ultrasonically determining corneal layer thicknesses and shape
    Patent number: 5293871
    Abstract: An ultrasound system that enables determination of layer thicknesses and contours of a multi-layer organic body includes a transmitter/receiver for obtaining a radio frequency signal from echoes over a plurality of points on the organic surface. Each radio frequency signal is then deconvolved to remove apparatus generated noise and filtered to create an analytic signal that exhibits a magnitude related to an instantaneous rate of arrival of total echo energy received by the transmitter/receiver. Analytic signals from adjacent parallel scans are then cross-correlated and magnitude detected to determine energy peaks to enable accurate determination of echo producing surfaces of each layer of the multi-layer organic body across the plurality of interrogation points. In the application of the invention to Corneal Epithelium Mapping, a pupil monitoring system is included that disables the measurement system if the pupil's gaze wanders so as to cause a diversion of the optical axis.
    Type: Grant
    Filed: July 9, 1993
    Date of Patent: March 15, 1994
    Assignees: Cornell Research Foundation Inc., Riverside Research Institute
    Inventors: Dan Z. Reinstein, Ronald H. Silverman, Donald J. Coleman, Frederic L. Lizzi
  • CURVED LINEAR ARRAY TRANSDUCER, SYSTEM AND METHOD
    Publication number: 20110295123
    Abstract: A focused ultrasound beam is created using a probe having a curved linear array. The curved linear array is asymmetric and two dimensional comprising individual parallel circumferential, linear sub-arrays disposed at a distal end of a probe. A first sub-array is disposed proximate a distal end and a final sub-array is disposed proximate a proximal end with subsequent sub-arrays disposed between the first and final array. In practice, the first sub-array transmits a set of pulses of ultrasound radiation for a period of time then an adjacent array transmits a set of pulses of ultrasound radiation after a lag. The transmissions by each sub-array continue with a lag between each array transmission until the final sub-array transmits a final set of pulses of ultrasound radiation. The pulse is generated by each transmission is steered and focused depending on the phases and amplitudes of the pulses of ultrasound radiation transmitted by the full set of elements in the transmitting sub-arrays.
    Type: Application
    Filed: June 1, 2010
    Publication date: December 1, 2011
    Applicant: RIVERSIDE RESEARCH INSTITUTE
    Inventor: Ernest J. Feleppa
  • Frequency diversity for image enhancement
    Patent number: 4561019
    Abstract: Methods for improving the availability of information derived from signals received from an object irradiated with coherent pulses of any form of radiation that exhibits a wave nature are disclosed. A method for reducing speckle derives separate component noncoherent signals from the received signals, and combines these separate noncoherent signals to form improved composite noncoherent signals. Weighting and processing of component signals can be applied as a function of time, frequency, and signal amplitude to optimize speckle reduction in all or a critical part of the signal by compensating for the range and frequency dependence of attenuation and the frequency dependence of scattering phenomena. In a method for enhancing resolution, separate component coherent signals are derived from the received signals, weighted and processed, and combined to form improved composite coherent signals; then noncoherent signals are derived from the improved composite coherent signals.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: December 24, 1985
    Assignee: Riverside Research Institute
    Inventors: Frederic L. Lizzi, Marek Elbaum, Ernest J. Feleppa
  • METHOD FOR GESTATIONAL AGE ESTIMATION AND EMBRYONIC MUTANT DETECTION
    Publication number: 20180336681
    Abstract: A method to characterize shape variations in brain ventricles during embryonic growth in mammals, the method including extracting a brain ventricle skeleton from one or more images, calculating a volume profile for the skeleton using the extracted images, partitioning the brain ventricle based on the volume profile along the skeleton, the brain ventricle being partitioned into two lateral ventricles and a main ventricle, the main ventricle being further partitioned into three sub regions, determining volume vectors of the two lateral ventricles and the three sub regions, computing a means square error between the determined computed volume vectors and a pretrained mean volume vector of embryos during different gestational stages, and classifying the embryo to the gestational stage having the lowest mean square error.
    Type: Application
    Filed: July 9, 2018
    Publication date: November 22, 2018
    Applicants: Riverside Research Institute, New York University
    Inventors: Jen-wei Kuo, Jonathan Mamou, Jeffrey A. Ketterling, Orlando Aristizabal, Daniel H. Turnbull, Yao Wang
  • Method for gestational age estimation and embryonic mutant detection
    Patent number: 10140708
    Abstract: A method to characterize shape variations in brain ventricles during embryonic growth in mammals, the method including extracting a brain ventricle skeleton from one or more images, calculating a volume profile for the skeleton using the extracted images, partitioning the brain ventricle based on the volume profile along the skeleton, the brain ventricle being partitioned into two lateral ventricles and a main ventricle, the main ventricle being further partitioned into three sub regions, determining volume vectors of the two lateral ventricles and the three sub regions, computing a means square error between the determined computed volume vectors and a pretrained mean volume vector of embryos during different gestational stages, and classifying the embryo to the gestational stage having the lowest mean square error.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: November 27, 2018
    Assignee: Riverside Research Institute
    Inventors: Jen-wei Kuo, Jonathan Mamou, Jeffrey A. Ketterling, Orlando Aristizabal, Daniel H. Turnbull, Yao Wang
  • METHOD FOR GESTATIONAL AGE ESTIMATION AND EMBRYONIC MUTANT DETECTION
    Publication number: 20170213340
    Abstract: A method to characterize shape variations in brain ventricles during embryonic growth in mammals, the method including extracting a brain ventricle skeleton from one or more images, calculating a volume profile for the skeleton using the extracted images, partitioning the brain ventricle based on the volume profile along the skeleton, the brain ventricle being partitioned into two lateral ventricles and a main ventricle, the main ventricle being further partitioned into three sub regions, determining volume vectors of the two lateral ventricles and the three sub regions, computing a means square error between the determined computed volume vectors and a pretrained mean volume vector of embryos during different gestational stages, and classifying the embryo to the gestational stage having the lowest mean square error.
    Type: Application
    Filed: January 23, 2017
    Publication date: July 27, 2017
    Applicants: Riverside Research Institute, New York University
    Inventors: Jen-wei Kuo, Jonathan Mamou, Jeffrey A. Ketterling, Orlando Aristizabal, Daniel H. Turnbull, Yao Wang
  • Method for gestational age estimation and embryonic mutant detection
    Patent number: 10354380
    Abstract: A method to characterize shape variations in brain ventricles during embryonic growth in mammals, the method including extracting a brain ventricle skeleton from one or more images, calculating a volume profile for the skeleton using the extracted images, partitioning the brain ventricle based on the volume profile along the skeleton, the brain ventricle being partitioned into two lateral ventricles and a main ventricle, the main ventricle being further partitioned into three sub regions, determining volume vectors of the two lateral ventricles and the three sub regions, computing a means square error between the determined computed volume vectors and a pretrained mean volume vector of embryos during different gestational stages, and classifying the embryo to the gestational stage having the lowest mean square error.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 16, 2019
    Assignees: Riverside Research Institute, New York University
    Inventors: Jen-wei Kuo, Jonathan Mamou, Jeffrey A. Ketterling, Orlando Aristizabal, Daniel H. Turnbull, Yao Wang
  • Method for enhancement of ultrasonic image data
    Patent number: 4858124
    Abstract: Methods for enhancement of data obtained from scanning objects such as body tissue with ultrasonic wideband pulses to detect characteristics of the tissue and to identify the tissue. The methods include performing spectral analysis on selected time portions of signals obtained from ultrasonic scanning to derive spectral data which is representative of the received signal characteristics for spatial samples of a particular region of interest in the body. The characteristic values are selected to correlate with significant characteristics of the material. A display of the selected body region is generated, with the display characteristic for each of the spatial samples being selected in accordance with the derived spectral characteristic values. Examples of the spectral characteristic values include spectral amplitude, spectral slope, and spectral amplitude uncertainty.
    Type: Grant
    Filed: August 11, 1987
    Date of Patent: August 15, 1989
    Assignee: RiverSide Research Institute
    Inventors: Frederic L. Lizzi, Mykola M. Yaremko, Ronald H. Silverman, D. Jackson Coleman
  • AUTOREGRESSIVE SIGNAL PROCESSING APPLIED TO HIGH-FREQUENCY ACOUSTIC MICROSCOPY OF SOFT TISSUES
    Publication number: 20200088687
    Abstract: A method to create a parameter map depicting acoustical and mechanical properties of biological tissue at microscopic resolutions to identify potential health related issues.
    Type: Application
    Filed: September 12, 2019
    Publication date: March 19, 2020
    Applicant: Riverside Research Institute
    Inventors: Daniel Rohrbach, Jonathan Mamou
  • Frequency diversity for image enhancement
    Patent number: RE35148
    Abstract: Methods for improving the availability of information derived from signals received from an object irradiated with coherent pulses of any form of radiation that exhibits a wave nature are disclosed. A method for reducing speckle derives separate component noncoherent signals from the received signals, and combines these separate noncoherent signals to form improved composite noncoherent signals. Weighting and processing of component signals can be applied as a function of time, frequency, and signal amplitude to optimize speckle reduction in all or a critical part of the signal by compensating for the range and frequency dependence of attenuation and the frequency dependence of scattering phenomena. In a method for enhancing resolution, separate component coherent signals are derived from the received signals, weighted and processed, and combined to form improved composite coherent signals; then noncoherent signals are derived from the improved composite coherent signals.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: January 23, 1996
    Assignee: Riverside Research Institute
    Inventors: Frederic L. Lizzi, Marek Elbaum, Ernest J. Feleppa
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