Search Patents
  • Aircraft network cybersecurity apparatus and methods
    Patent number: 11889392
    Abstract: Mapping of an avionic network is obfuscated by interposing a network module between an external-access node and a bus of an avionics network. First and second network maps are generated and loaded on the network module. The network map accessible to the external-access node is changed from the first network map to the second network map, to disrupt any reconnaissance of the avionics network.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: January 30, 2024
    Assignee: The Boeing Company
    Inventors: Daniel Nguyen, Michael Vanguardia, Adonis Williams
  • AIRCRAFT NETWORK CYBERSECURITY APPARATUS AND METHODS
    Publication number: 20200396250
    Abstract: A method of obfuscating mapping of an avionic network is disclosed, including operatively coupling a network module between an external-access node and an avionics bus, with all communications between the external-access node and the avionics bus passing through the network module. The method further includes generating a first network map identifying network addresses for a first set of components on at least a first portion of the avionics bus, loading the first network map on the network module, and making the first network map accessible to the external access node. The method further includes generating at least a second network map different from the first network map and loading the second network map on the network module. The method further includes changing the network map accessible to the external-access node from the first network map to the second network map.
    Type: Application
    Filed: June 14, 2019
    Publication date: December 17, 2020
    Applicant: The Boeing Company
    Inventors: Daniel Nguyen, Michael Vanguardia, Adonis Williams
  • BLOCKCHAIN FORTIFIED AIRCRAFT COMMUNICATIONS ADDRESSING AND REPORTING SYSTEM (ACARS) COMMUNICATION
    Publication number: 20190281026
    Abstract: Systems for and methods of securely communicating between a ground station and an aircraft are presented. The communications are among a plurality of nodes, including a ground based node and a plurality of aircraft based nodes. Each node stores at least a respective portion of a blockchain representing interactions among at least some of the nodes. Control nodes may initiate a privileged network action by: broadcasting to the plurality of control nodes a blockchain record representing the privileged network action, receiving from control nodes a plurality of votes representing validation results of the privileged network action, determining that a consensus from the control node votes indicates that the privileged action is permissible, and publishing to respective blockchain portions of each of the plurality of nodes a derivation of the blockchain record representing the privileged action, where the system implements the privileged action based on the determining.
    Type: Application
    Filed: March 12, 2018
    Publication date: September 12, 2019
    Inventors: Timothy M. Mitchell, Daniel Nguyen, Adonis X. Williams, Michael R. Vanguardia
  • Blockchain fortified aircraft communications addressing and reporting system (ACARS) communication
    Patent number: 10681020
    Abstract: Systems for and methods of securely communicating between a ground station and an aircraft are presented. The communications are among a plurality of nodes, including a ground based node and a plurality of aircraft based nodes. Each node stores at least a respective portion of a blockchain representing interactions among at least some of the nodes. Control nodes may initiate a privileged network action by: broadcasting to the plurality of control nodes a blockchain record representing the privileged network action, receiving from control nodes a plurality of votes representing validation results of the privileged network action, determining that a consensus from the control node votes indicates that the privileged action is permissible, and publishing to respective blockchain portions of each of the plurality of nodes a derivation of the blockchain record representing the privileged action, where the system implements the privileged action based on the determining.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: June 9, 2020
    Assignee: THE BOEING COMPANY
    Inventors: Timothy M. Mitchell, Daniel Nguyen, Adonis X. Williams, Michael R. Vanguardia
  • PREPARATION AND USE OF PLATELET PRODUCTS
    Publication number: 20180185484
    Abstract: The present disclosure relates to improved methods for the preparation and platelet products for administration to subjects in need thereof
    Type: Application
    Filed: January 15, 2016
    Publication date: July 5, 2018
    Inventors: William GREENMAN, Lily LIN, Adonis STASSINOPOULOS
  • COMPOSITIONS AND METHODS FOR IMPROVED NK CELL THERAPIES
    Publication number: 20190134095
    Abstract: The present disclosure relates to the preparation and use of CAR-NK cells which are modified by a nucleic acid targeting compound.
    Type: Application
    Filed: May 1, 2017
    Publication date: May 9, 2019
    Applicant: CERUS CORPORATION
    Inventors: Adonis STASSINOPOULOS, William GREENMAN
  • COMPOSITIONS AND METHODS FOR PATHOGEN INACTIVATION OF PLATELETS
    Publication number: 20190085289
    Abstract: Provided are methods, kits, and compositions for preparing platelet compositions suitable for infusion, including improved methods, compositions, and kits for pathogen inactivation of an apheresis-derived preparation of platelets.
    Type: Application
    Filed: September 20, 2018
    Publication date: March 21, 2019
    Inventors: William GREENMAN, Adonis STASSINOPOULOS, Elan WEINER, Peter BRINGMANN, Felicia SANTA MARIA
  • COMPOSITIONS AND METHODS FOR PATHOGEN INACTIVATION OF PLATELETS
    Publication number: 20240271094
    Abstract: Provided are methods, kits, and compositions for preparing platelet compositions suitable for infusion, including improved methods, compositions, and kits for pathogen inactivation of an apheresis-derived preparation of platelets.
    Type: Application
    Filed: January 18, 2024
    Publication date: August 15, 2024
    Inventors: William GREENMAN, Adonis STASSINOPOULOS, Elan WEINER, Peter BRINGMANN, Felicia SANTA MARIA
  • COMPOSITIONS AND METHODS FOR IMPROVED CAR-T CELL THERAPIES
    Publication number: 20170354724
    Abstract: The present invention relates to the preparation and use in recipients of CAR-T cell-derived effector cells which are modified to limit their proliferation within the recipient. This is accomplished through the introduction of adducts into the nucleic acids of CAR-T cell-derived effector cells following expansion in vitro to provide expanded and activated CAR-T cell-derived effector cells that retain immunologic function, including the expression of one ore more cytokines.
    Type: Application
    Filed: November 2, 2015
    Publication date: December 14, 2017
    Inventors: Adonis STASSINOPOULOS, William Mariner GREENMAN
  • Compositions and methods for improved car-T cell therapies
    Patent number: 10688166
    Abstract: The present invention relates to the preparation and use in recipients of CAR-T cell-derived effector cells which are modified to limit their proliferation within the recipient. This is accomplished through the introduction of adducts into the nucleic acids of CAR-T cell-derived effector cells following expansion in vitro to provide expanded and activated CAR-T cell-derived effector cells that retain immunologic function, including the expression of one ore more cytokines.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: June 23, 2020
    Assignee: CERUS CORPORATION
    Inventors: Adonis Stassinopoulos, William Mariner Greenman
  • Continuing playback of advertisements across multiple devices based on monitoring user active viewing duration
    Patent number: 10636054
    Abstract: A computer-implemented method comprising: presenting, by a computing device, an advertisement on a first device; monitoring, by the computing device, viewing activity by a user of the advertisement, wherein the monitoring comprises tracking an amount of time that the user actively views the advertisement on the first device; and continuing, by the computing device, playback of the advertisement on one or more second devices until the user has actively viewed the advertisement for a target impression time based on the monitoring.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: April 28, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Siddique M. Adoni, Gregory J. Boss, Norbert Herman, Shubhadip Ray, Dhandapani Shanmugam
  • METHODS AND PRODUCTS
    Publication number: 20230174965
    Abstract: A method of producing a biofilm-like microorganism-polymer complex, the method comprising the step of exposing, in an aqueous medium, cells of a microorganism to a polymer comprising groups as defined by formula (la) or formula (lb), wherein: Y comprises an imine; and R2 comprises a CI-30 group. A biofilm-like microorganism-polymer complex comprising cells of a microorganism and a polymer comprising groups as defined by formula (la) and/or formula (lb). A method for producing a chemical and/or biological product using the microorganism-polymer complex, and the chemical and/or biological products obtained therefrom. A method of dispersing the microorganism-polymer complex. Polymers of formula (la) and of formula (lb).
    Type: Application
    Filed: April 16, 2021
    Publication date: June 8, 2023
    Inventors: Francisco FERNANDEZ-TRILLO, Timothy William OVERTON, Pavan Rao ADONI, Omar Nicholas Edward HUNEIDI
  • Determining advertisement content based on cluster density within dynamic visibility fence
    Patent number: 10769660
    Abstract: Systems and methods for determining advertisement content based on cluster density analysis of advertisement targets within a dynamic visibility fence are disclosed. A computer-implemented method includes determining, by an advertisement determination device, a dynamic visibility fence for a time, the dynamic visibility fence defining a first set of advertisement targets, determining, by the advertisement determination device, an advertisement to display based on cluster analysis of the first set of advertisement targets, and displaying, by the advertisement determination device, the determined advertisement.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: September 8, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Siddique M. Adoni, Gregory J. Boss, Norbert Herman, Shubhadip Ray, Dhandapani Shanmugam
  • Frangible compounds for pathogen inactivation
    Patent number: 6514987
    Abstract: Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell preparations and plasma. The compounds and methods may be used to treat materials intended for in vitro or in vivo use, such as clinical testing or transfusion. The compounds are designed to specifically bind to and react with nucleic acid, and then to degrade to form breakdown products. The degradation reaction is preferably slower than the reaction with nucleic acid.
    Type: Grant
    Filed: July 2, 2000
    Date of Patent: February 4, 2003
    Assignee: Cerus Corporation
    Inventors: David Cook, John E. Merritt, Aileen Nerio, Henry Rapoport, Adonis Stassinopoulos, Susan Wollowitz, Jan Matejovic, William A. Denny
  • Headgear with safety light
    Patent number: 5353008
    Abstract: A motorcycle helmet with a brake light includes a duty cycled receiver circuit for receiving a radio frequency (RF) signal from a transmitter located on the motorcycle. The receiver circuit is generally turned off if the RF signal is not present. When the receiver detects the RF signal, the receiver is turned on. The brake light is illuminated when the receiver receives the RF signal. The brake light includes LEDs for providing light. The lens is a plastic lens which provides superior performance having spherical indentations on an interior surface.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: October 4, 1994
    Assignee: Adonis Incorporated
    Inventors: Michael G. Eikenberry, Richard Stants, William Baker, Raymond G. Benson, Jr.
  • Optically and fluidically enhanced in vitro dianostic test chamber
    Publication number: 20040071596
    Abstract: An enclosed chamber is used in a system for screening of a liquid specimen through binding assays. The enclosed chamber includes an inlet, an outlet, and a plurality of discrete reactant containing wells communicated by a common reagent flow path between the inlet and the outlet. A transparent member or coverslip defines on an inside thereof the plurality of wells. Each well has a bottom for receiving an allergent/antigen/reactant, which emits light upon reacting. The coverslip can optionally define at least one lens at each well. A bottom encloses the plurality of wells and defines between the inlet and the outlet a common reagent flow path between the inlet and the outlet. This bottom defines for each of the plurality of wells a flow-diverting member. An opaque partition is disclosed for surrounding the individual lenses and generally isolating the light path from each well.
    Type: Application
    Filed: March 5, 2003
    Publication date: April 15, 2004
    Inventors: Dianna Innerst, Adonis Kassinos, C Benjamin Wooley, Brett Wilmarth, William J Sell, Emi Zychlinsky, Donald Marino, Sandy Yamada, Renee Ryan, Karen Ding, Michael Zatzke
  • Optically and fluidically enhanced in vitro diagnostic test chamber
    Patent number: 7189354
    Abstract: An enclosed chamber is used in a system for screening of a liquid specimen through binding assays. The enclosed chamber includes an inlet, an outlet, and a plurality of discrete reactant containing wells communicated by a common reagent flow path between the inlet and the outlet. A transparent member or coverslip defines on an inside thereof the plurality of wells. Each well has a bottom for receiving an allergent/antigen/reactant, which emits light upon reacting. The coverslip can optionally define at least one lens at each well. A bottom encloses the plurality of wells and defines between the inlet and the outlet a common reagent flow path between the inlet and the outlet. This bottom defines for each of the plurality of wells a flow-diverting member. An opaque partition is disclosed for surrounding the individual lenses and generally isolating the light path from each well.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: March 13, 2007
    Assignee: Hitachi Chemical Diagnostics, Inc.
    Inventors: Dianna Innerst, Adonis Kassinos, C. Benjamin Wooley, Brett Wilmarth, William J. Sell, Emi Zychlinsky, Donald Marino, Sandy Yamada, Renee Ryan, Karen Ding, Michael Zatzke
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