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  • System for producing chemical compounds via a baric electromagnetic thermal process
    Publication number: 20070065553
    Abstract: A baric electromagnetic thermal system for manufacturing disaccharide sweetener compounds is provided and permits baric and thermal processing, at low temperatures, to effect the retrocycloaddition, chemoselective promiscuous ligation, and cycloaddition reactions. A method for selecting base and adjunct components for the manufacture of a disaccharide sweetener compound having an equivalent functionality as a natural sweetener and/or derivative thereof as required for a specific food processing application is presented.
    Type: Application
    Filed: September 13, 2006
    Publication date: March 22, 2007
    Inventor: Gregory Robbins
  • System for producing chemical compounds via a baric electromagnetic thermal process
    Patent number: 7799292
    Abstract: A baric electromagnetic thermal system for manufacturing disaccharide sweetener compounds is provided and permits baric and thermal processing, at low temperatures, to effect the retrocycloaddition, chemoselective promiscuous ligation, and cycloaddition reactions. A method for selecting base and adjunct components for the manufacture of a disaccharide sweetener compound having an equivalent functionality as a natural sweetener and/or derivative thereof as required for a specific food processing application is presented.
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: September 21, 2010
    Assignee: Quantum Food Design, LLC.
    Inventor: Gregory C. Robbins
  • EXTRA-CARDIAC DIFFERENTIAL VENTRICULAR ACTUATION BY INERTIAL AND BARIC PARTITIONING
    Publication number: 20110196189
    Abstract: A device for extra-cardiac actuation for the support of a failing heart is provided that utilizes the inertial component of a driving fluid to provide separately adjustable quantities of supportive energy to the left and right ventricles. By partitioning the inertial and baric forms of energy delivered to a single chamber, heart encircling assist device, and by localizing the heart to minimize lateral and axial displacement a device and method for achieving balanced left-right flow is disclosed that restores the Frank-Starling mechanism to a failing heart and assists recovery by enabling the heart to achieve physiologic cardiovascular equilibrium.
    Type: Application
    Filed: February 9, 2010
    Publication date: August 11, 2011
    Applicant: MyoCardioCare, Inc.
    Inventor: Michael Milbocker
  • Pasteurizable wide-mouth container
    Publication number: 20040173565
    Abstract: A wide-mouth blow-molded plastic container capable of accommodating, without undesirable distortion, super-baric pressures when filled with volatile food products and pasteurized, and sub-baric pressures after cooling to ambient temperatures. A method of packaging a food product in the container is also disclosed.
    Type: Application
    Filed: March 15, 2004
    Publication date: September 9, 2004
    Inventors: Frank Semersky, John W. Tobias, Robert A. Stewart
  • Process for manufacturing a polysaccharide sweetener compound
    Publication number: 20070077339
    Abstract: A method of forming a compound such as a polysaccharide sweetener compound is obtained via a process of cycloelimination of a macromolecule, for example, a glycoside, chemoselective promiscuous ligation of a first component constituent such as a constituent disaccharide fraction derived from the macromolecule with a second component such as a base monosaccharide, such as fructose, and cycloaddition of the base monosaccharide with a the constituent disaccharide fraction. Subsequent addition of fortifiers such as vitamins and minerals may be accomplished via baric processing to effect cross-linking or cross-bonding with the polysaccharide sweetener compound. A process for manufacturing polysaccharide sweetener compounds is provided and permits baric, electromagnetic, and thermal processing, at low temperatures, to effect the cycloelimination, chemoselective promiscuous ligation, and cycloaddition reactions.
    Type: Application
    Filed: September 13, 2006
    Publication date: April 5, 2007
    Inventor: Gregory Robbins
  • Disaccharide sweetener compounds, process for manufacture, and method of selecting components for dissacaride sweetener compounds based on user specific sweetener applications
    Publication number: 20070059422
    Abstract: A disaccharide sweetener compound is obtained via a process of cycloelimination of a polysaccharide, for example, a glycoside, chemoselective promiscuous ligation of the constituent monosaccharides derived from the polysaccharide with a base monosaccharide, such as fructose, and cycloaddition of the base monosaccharide with a constituent monosaccharide derived from the polysaccharide. Subsequent addition of fortifiers such as vitamins and minerals may be accomplished via baric processing to effect cross-linking or cross-bonding with the disaccharide. A process for manufacturing such disaccharide sweetener compounds is provided and permits baric and thermal processing, at low temperatures, to effect the cycloelimination, chemoselective promiscuous ligation, and cycloaddition reactions.
    Type: Application
    Filed: June 23, 2006
    Publication date: March 15, 2007
    Inventor: Gregory Robbins
  • Polysaccharide sweetener compounds, process for manufacture, and method of selecting components for polysaccharide sweetener compounds based on user specific sweetener applications
    Publication number: 20070082105
    Abstract: A polysaccharide sweetener compound is obtained via a process of cycloelimination of a macromolecule, for example, a glycoside, chemoselective promiscuous ligation of a constituent disaccharide fraction derived from the macromolecule with a base monosaccharide, such as fructose, and cycloaddition of the base monosaccharide with the constituent disaccharide fraction. Subsequent addition of fortifiers such as vitamins and minerals may be accomplished via baric processing to effect cross-linking or cross-bonding with the polysaccharide sweetener compound. A process for manufacturing polysaccharide sweetener compounds is provided and permits baric, electromagnetic, and thermal processing, at low temperatures, to effect the cycloelimination, chemoselective promiscuous ligation, and cycloaddition reactions.
    Type: Application
    Filed: September 13, 2006
    Publication date: April 12, 2007
    Inventor: Gregory Robbins
  • METHODS AND COMPOSITIONS FOR CORONAVIRUS DIAGNOSTICS AND THERAPEUTICS
    Publication number: 20160238601
    Abstract: The present invention provides methods and compositions for detecting a coronavirus in a sample and identifying the subgroup of the coronavirus in the sample.
    Type: Application
    Filed: October 14, 2014
    Publication date: August 18, 2016
    Inventors: Ralph Baric, Sudhakar Agnihothram, Boyd Yount
  • HUMAN ANTI-DENGUE ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20230078330
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing dengue virus and methods for use thereof.
    Type: Application
    Filed: January 19, 2021
    Publication date: March 16, 2023
    Inventors: James E. CROWE, JR., Ralph BARIC, Eva HARRIS
  • METHODS AND COMPOSITIONS FOR CHIMERIC CORONAVIRUS SPIKE PROTEINS
    Publication number: 20170096455
    Abstract: The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.
    Type: Application
    Filed: March 20, 2015
    Publication date: April 6, 2017
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Sudhakar Agnihothram, Boyd Yount
  • METHODS AND COMPOSITIONS FOR NOROVIRUS VACCINES AND DIAGNOSTICS
    Publication number: 20210371468
    Abstract: The present invention is directed to methods and compositions for norovirus therapeutics, such as vaccines, and diagnostics.
    Type: Application
    Filed: October 18, 2018
    Publication date: December 2, 2021
    Inventors: Lisa Chon Lindesmith, Ralph Steven Baric, Kari Moore Debbink, Eric Francis Donaldson
  • METHODS AND COMPOSITIONS FOR TREATMENT OF CORONAVIRUS INFECTION
    Publication number: 20230137667
    Abstract: The present invention provides methods and compositions for treating coronavirus infection and diseases and disorders associated with or caused by coronavirus infection.
    Type: Application
    Filed: March 19, 2021
    Publication date: May 4, 2023
    Inventors: Ralph Baric, Amy Sims, Hugh D. Mitchell, Katrina M. Waters
  • CHIMERIC CORONAVIRUS S PROTEIN COMPOSITIONS AND METHODS OF USE
    Publication number: 20240018191
    Abstract: This invention relates to chimeric coronavirus S proteins and methods of their use, for example, to treat and/or prevent diseases or disorders caused by infection by a coronavirus.
    Type: Application
    Filed: October 27, 2021
    Publication date: January 18, 2024
    Inventors: Ralph S. Baric, David R. Martinez
  • Container for a consumable good, coated with a resveratrol containing layer
    Publication number: 20180148223
    Abstract: The present invention relates to a container for a consumable good, wherein the container has an inner coating layer including resveratrol, and process for preparing the container.
    Type: Application
    Filed: December 23, 2014
    Publication date: May 31, 2018
    Inventors: Gregory John Charles Stokes, Steven John Anthony Barics
  • Methods and compositions for chimeric coronavirus spike proteins
    Patent number: 9884895
    Abstract: The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: February 6, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Sudhakar Agnihothram, Boyd Yount
  • CONTAINER FOR A CONSUMABLE GOOD, COATED WITH A RESVERATROL CONTAINING LAYER
    Publication number: 20190135489
    Abstract: The present invention relates to a container for a consumable good, wherein the container has an inner coating layer including resveratrol, and process for preparing the container.
    Type: Application
    Filed: December 28, 2018
    Publication date: May 9, 2019
    Inventors: Gregory John Charles Stokes, Steven John Anthony Barics
  • Methods and compositions for norovirus vaccines and diagnostics
    Patent number: 11566050
    Abstract: The present invention is directed to methods and compositions for norovirus therapeutics, such as vaccines, and diagnostics.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: January 31, 2023
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Lisa Chon Lindesmith, Ralph Steven Baric, Kari Moore Debbink, Eric Francis Donaldson
  • Container for a consumable good, coated with antioxidant-containing layer
    Publication number: 20180118954
    Abstract: The present invention relates to a container for a consumable good having an inner coating layer comprising an antioxidant other than resveratrol, and a process for preparing the container.
    Type: Application
    Filed: December 23, 2015
    Publication date: May 3, 2018
    Inventors: Steven John Anthony Barics, Gregory John Charles Stokes
  • Cutting tool insert package
    Patent number: D353095
    Type: Grant
    Filed: August 31, 1992
    Date of Patent: December 6, 1994
    Assignee: Kennametal Inc.
    Inventors: Robert T. Kendra, Philip H. Weihl, Thomas J. Baric, Kent W. Murphy, Edward L. Bejster, Harry C. Dundore
  • Track body for linear modules
    Patent number: D726988
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: April 14, 2015
    Assignee: Parker-Hannifin Corporation
    Inventors: Thomas J. Baric, Michael D. Bridges, Adis Halimic
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