Search Patents
  • Patent number: 3999553
    Abstract: An improved cerebrospinal fluid anti-syphoning device for insertion into the human body to provide control and regulation of fluid being transported from the lateral ventricles to another portion of the body. The improved fluid anti-syphoning device includes a fluid housing member which is adapted to contain a pair of check valves which control fluid flow through the housing member and prevents back flow from a downstream area to an upstream area. A central chamber within the fluid housing member encloses a combination fluid egress conduit and flexible diaphragm which in cooperative relation provide for a substantial termination of fluid flow when the down stream pressure becomes too low with respect to the upstream pressure.Specific construction of the fluid egress conduit and the flexible diaphragm provides for negation of possible terminal closure of the flow path through the anti-syphoning device under a wide range of conditions.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: December 28, 1976
    Assignee: Bio-Medical Research, Ltd.
    Inventors: Eugene B. Spitz, Richard E. Brenz, Charles C. Hansford
  • Patent number: 4712558
    Abstract: A method and apparatus are disclosed for the electrotrophic stimulation of muscle, that is, stimulation using pulses trains onto which information which will cause long-term functional and/or structural changes in the muscle tissue. This information is coded onto the interval between successive pulses of the series. Also disclosed is a method and apparatus for acquiring trophic data from motor unit action potential series.
    Type: Grant
    Filed: March 12, 1985
    Date of Patent: December 15, 1987
    Assignee: Bio Medical Research Ltd.
    Inventors: Geoffrey Kidd, Daniel V. Maher, Jozef Cywinski
  • Patent number: 6728577
    Abstract: A method for stimulating abdominal muscles of a subject, comprising the steps of providing at least three electrodes, one of the at least three electrodes being a central electrode and the other two of the at least three electrodes being side electrodes located on the subject spaced apart from the central electrode on respective sides thereof, and passing at least one pulsed signal subcutaneously through the subject between selected electrodes of the at least three electrodes.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: April 27, 2004
    Assignee: Bio-Medical Research Ltd.
    Inventors: Michael Conor Minogue, Michael Louis Crowe
  • Publication number: 20120116477
    Abstract: A method and apparatus for stimulating the lower back and abdominal muscles in a patient comprising applying a first electrode A1/A2 substantially centrally to the lower lumbar region of the patient's body, and applying second and third electrodes B, C respectively to opposite side flanks of the patient's body. The electrodes are energised to apply a first group of muscular stimulation current pulses which flow between the second and third electrodes and a second group of muscular stimulation current pulses which flow between the first electrode and the second and third electrodes alternately.
    Type: Application
    Filed: June 16, 2010
    Publication date: May 10, 2012
    Applicant: BIO-MEDICAL RESEARCH LTD.
    Inventors: Louis Crowe, Brian Caulfield, Conor Minogue
  • Patent number: 9675802
    Abstract: A method and apparatus for stimulating the lower back and abdominal muscles in a patient comprising applying a first electrode A1/A2 substantially centrally to the lower lumbar region of the patient's body, and applying second and third electrodes B, C respectively to opposite side flanks of the patient's body. The electrodes are energized to apply a first group of muscular stimulation current pulses which flow between the second and third electrodes and a second group of muscular stimulation current pulses which flow between the first electrode and the second and third electrodes alternately.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: June 13, 2017
    Assignees: University College Dublin, National University of Ireland, Dublin, Bio-Medical Research Ltd.
    Inventors: Louis Crowe, Brian Caulfield, Conor Minogue
  • Patent number: 7069089
    Abstract: A device for attaching at least three electrodes to a subject for stimulating abdominal muscles of the subject, comprising an attachment mechanism for extending around the torso of the subject and a main locating element provided on the attachment mechanism for locating a central electrode of the at least three electrodes adjacent the umbilicus of the subject. Two secondary locating elements are also provided on the attachment mechanism disposed on respective opposite sides of the main locating element for locating two corresponding side electrodes of the at least three electrodes spaced apart from the central electrode. Application of at least one pulsed signal to the subject through the respective central and side electrodes stimulates the abdominal muscles of the subject.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: June 27, 2006
    Assignee: Bio-Medical Research Ltd.
    Inventors: Michael Conor Minogue, Michael Louis Crowe
  • Patent number: 6760629
    Abstract: A device for attaching at least three electrodes to a subject for stimulating abdominal muscles of the subject. The device comprises an attachment mechanism that further comprises a main locating element for locating a central electrode of the at least three electrodes, and two secondary locating elements disposed on respective opposite sides of the main locating element for locating two corresponding side electrodes of the at least three electrodes spaced apart from the central electrode. A receiver is also provided for receiving a signal generated by a signal generator for generating at least one pulsed signal. A selector is also provided for selecting one or more of the electrodes through which a pulsed signal is to be applied.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: July 6, 2004
    Assignee: Bio-Medical Research Ltd.
    Inventors: Michael Conor Minogue, Michael Louis Crowe
  • Patent number: 6885896
    Abstract: A device for attaching at least three electrodes to a subject for stimulating abdominal muscles of the subject. The device comprises an attachment mechanism for extending around the torso of the subject and a main locating element on the attachment mechanism for locating a central electrode of the at least three electrodes adjacent the umbilicus of the subject. Two secondary locating elements are also provided on the attachment mechanism disposed on respective opposite sides of the main locating element for locating two corresponding side electrodes of the at least three electrodes spaced apart from the central electrode in a general direction towards a corresponding one of the right and left mid-axillary lines of the torso intermediate the rib cage and corresponding right and left iliac crests. By applying at least one pulsed signal to the subject through the respective central and side electrodes, abdominal muscles of the subject are stimulated.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: April 26, 2005
    Assignee: Bio-Medical Research Ltd.
    Inventors: Michael Conor Minogue, Michael Louis Crowe
  • Patent number: 3999551
    Abstract: A subcutaneous guide assembly for use by surgeons during an operation where surgical elements must be passed through an elongated path internal to a human body. The guide assembly includes an elongated rod of predetermined contour and length which is secured on opposing ends to a handle member and to one of a variety of surgical elements which may be releasably secured to the rod through threaded engagement. Additionally, a plurality of rod members of differing lengths and contours may be easily secured to the handle section of the subcutaneous guide assembly. The handle section includes an internal chamber where various surgical elements may be contained for use in particular portions or phases of an operation. The handle further includes a mechanism whereby the contained surgical elements within the handle internal chamber may be easily sterilized.
    Type: Grant
    Filed: January 7, 1975
    Date of Patent: December 28, 1976
    Assignee: Bio-Medical Research, Ltd.
    Inventors: Eugene B. Spitz, Richard E. Brenz, Charles C. Hansford
  • Publication number: 20140341952
    Abstract: A method for treating a disease comprising administering to a mammal in need thereof an effective dosage of an extract of a plant of the genus Hoodia, wherein the disease is selected from the group consisting of immune-mediated disorders, immune-associated disorders, inflammatory diseases, coronary disease, insulin resistance and liver-related diseases. In a preferred embodiment, the Hoodia is Hoodia parviflora. Also disclosed is a pharmaceutical composition for treating the above diseases comprising an effective dosage of an extract of a plant of the genus Hoodia.
    Type: Application
    Filed: December 19, 2013
    Publication date: November 20, 2014
    Applicants: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD., BIO-MASS LTD., DESERT LABS AGRICULTURE COOPERATIVE ASSOCIATION LTD.
    Inventors: Refael Aharon, Yaron Ilan
  • Patent number: 9170187
    Abstract: A flow cytometer and a fluid system are provided. The fluid system comprises a flow cell, a sample providing unit, a waste container, a sheath container, a negative pressure source, a quantitative unit and a sample flow monitoring unit, the negative pressure source, the waste container and the flow cell are connected, a negative pressure source, which provides a negative pressure relative to the sample providing unit for the flow cell so that the sample providing unit causes the sample to flow into the flow cell under the negative pressure, a sample flow monitoring unit monitors a flow of the sample fluid transported from the sample providing unit to the flow cell and outputs a feedback signal reflecting flow changes of the sample fluid in real-time; wherein the controller receives the feedback signal and controls the quantitative unit to adjust a flow of the sheath fluid according to the feedback signal.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: October 27, 2015
    Assignees: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD.
    Inventors: Baohua Yan, Chuixin Liao, William Li, Huawen Yan, Wenheng Guo
  • Publication number: 20060246095
    Abstract: Disclosed are recombinant multiple epitope polypeptides (MEPs) consisting of T cell epitopes derived from tumor-associated antigens capable of being presented by an antigen presenting cell (APC), the recombinant nucleic acid sequences and expression vectors encoding them, and host cells transfected with said expression vectors. Further described are LTB-MEP fusion proteins comprising the E. Coli heat labile enterotoxin subunit B (LTB) peptide fused to a MEP by a synthetic linker, the recombinant nucleic acid sequences and expression vectors encoding them and host cell transfected with said expression vectors. Further included are compositions for inducing an immune response against malignancies, pharmaceutical compositions and a transdermal drug delivery system for the treatment of malignant disorders. Also disclosed are methods for conferring immunity against malignancies and for the treatment of malignant disorders.
    Type: Application
    Filed: March 24, 2006
    Publication date: November 2, 2006
    Applicants: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, GAVISH-GALILEE-BIO APPLICATIONS LTD.
    Inventors: Tamar Peretz, Michal Lotem, Shoshana Frankenburg, Jacob Pitcovski, Adva Levi, Hanah Margalit, Yael Altuvia
  • Patent number: 5784162
    Abstract: According to the present invention there are provided spectral imaging methods for biological research, medical diagnostics and therapy comprising the steps of (a) preparing a sample to be spectrally imaged; (b) viewing the sample through an optical device, the optical device being optically connected to an imaging spectrometer, the optical device and the imaging spectrometer obtaining a spectrum of each pixel of the sample by: (i) collecting incident light simultaneously from all pixels of the sample using collimating optics; (ii) passing the incident collimated light through an interferometer system having a number of elements, to form an exiting light beam; (iii) passing the exiting light beam through a focusing optical system which focuses the exiting light beam on a detector having a two-dimensional array of detector elements, so that at each instant each of the detector elements is the image of one pixel of the sample, so that the real image of the sample is stationary on the plane of the detector array
    Type: Grant
    Filed: December 12, 1995
    Date of Patent: July 21, 1998
    Assignee: Applied Spectral Imaging Ltd.
    Inventors: Dario Cabib, Robert A. Buckwald, Zvi Malik, Yuval Garini, Nir Katzir, Dirk G. Soeknsen
  • Publication number: 20110123629
    Abstract: The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.
    Type: Application
    Filed: January 25, 2009
    Publication date: May 26, 2011
    Applicants: GAVISH-GALILEE BIO APPLIACTIONS LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPEMENT LTD.
    Inventors: Jacob Pitcovski, Ehud Shahar, Raphael Gorodetsky
  • Patent number: 9358307
    Abstract: The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.
    Type: Grant
    Filed: January 25, 2009
    Date of Patent: June 7, 2016
    Assignees: GAVISH-GALILEE BIO APPLICATIONS LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Jacob Pitcovski, Ehud Shahar, Raphael Gorodetsky
  • Publication number: 20080213237
    Abstract: The invention relates to a method for the isolation of T cell lymphocyte, preferably, CD8+ cytotoxic T lymphocyte, which is capable of specifically recognizing an antigen related to a pathologic disorder. The method of the invention is base on ability of the CTL's to capture membrane from labeled target cells. The invention further provides compositions comprising said specific lymphocytes and methods for the treatment of said pathologic disorder using the specific lymphocytes isolated and prepared by the method of the invention.
    Type: Application
    Filed: March 9, 2006
    Publication date: September 4, 2008
    Applicants: Hadasit Medical Research Services and Development Ltd., Gavish Galilee Bio Applications Ltd.
    Inventors: Shoshana Frankenburg, Jacob Pitcovski, Tamar Peretz, Michal Lotem, Arthur Machlenkin, Ronny Uzana
  • Publication number: 20160082051
    Abstract: The present invention discloses use of sea cucumber glycosaminoglycan in the preparation of drugs. In particular, the present invention relates to use of medical use of sea cucumber glycosaminoglycan, and more particularly to use of depolymerized sea cucumber glycosaminoglycan or natural molecular segments of sea cucumber glycosaminoglycan with a weight average molecular weight greater than 54,500 Da in the preparation of a drug for the prevention and treatment of thromboembolic diseases. Thromboembolic diseases include atherosclerotic thrombotic diseases, venous thromboembolic diseases, hypercoagulable states and postoperative thrombosis or treatment of postoperative thrombi. The present invention has a wide treatment window for thromboembolic diseases, has a higher level of safety, and has good development and research value.
    Type: Application
    Filed: May 7, 2014
    Publication date: March 24, 2016
    Applicants: Shanghai Kairun Biology Medicine Limited Liability Company, Harbin Hongdoushan Bio-Pharm Co., Ltd., Heilongjiang Hongdoushan Pharmaceutical Co., Ltd.
    Inventors: Zhiguo Wang, Quanhai Liu, Xuehai Wu
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