Search Patents
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Patent number: 3999553Abstract: An improved cerebrospinal fluid anti-syphoning device for insertion into the human body to provide control and regulation of fluid being transported from the lateral ventricles to another portion of the body. The improved fluid anti-syphoning device includes a fluid housing member which is adapted to contain a pair of check valves which control fluid flow through the housing member and prevents back flow from a downstream area to an upstream area. A central chamber within the fluid housing member encloses a combination fluid egress conduit and flexible diaphragm which in cooperative relation provide for a substantial termination of fluid flow when the down stream pressure becomes too low with respect to the upstream pressure.Specific construction of the fluid egress conduit and the flexible diaphragm provides for negation of possible terminal closure of the flow path through the anti-syphoning device under a wide range of conditions.Type: GrantFiled: June 18, 1975Date of Patent: December 28, 1976Assignee: Bio-Medical Research, Ltd.Inventors: Eugene B. Spitz, Richard E. Brenz, Charles C. Hansford
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Patent number: 4712558Abstract: A method and apparatus are disclosed for the electrotrophic stimulation of muscle, that is, stimulation using pulses trains onto which information which will cause long-term functional and/or structural changes in the muscle tissue. This information is coded onto the interval between successive pulses of the series. Also disclosed is a method and apparatus for acquiring trophic data from motor unit action potential series.Type: GrantFiled: March 12, 1985Date of Patent: December 15, 1987Assignee: Bio Medical Research Ltd.Inventors: Geoffrey Kidd, Daniel V. Maher, Jozef Cywinski
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Patent number: 6728577Abstract: A method for stimulating abdominal muscles of a subject, comprising the steps of providing at least three electrodes, one of the at least three electrodes being a central electrode and the other two of the at least three electrodes being side electrodes located on the subject spaced apart from the central electrode on respective sides thereof, and passing at least one pulsed signal subcutaneously through the subject between selected electrodes of the at least three electrodes.Type: GrantFiled: July 10, 2001Date of Patent: April 27, 2004Assignee: Bio-Medical Research Ltd.Inventors: Michael Conor Minogue, Michael Louis Crowe
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Publication number: 20120116477Abstract: A method and apparatus for stimulating the lower back and abdominal muscles in a patient comprising applying a first electrode A1/A2 substantially centrally to the lower lumbar region of the patient's body, and applying second and third electrodes B, C respectively to opposite side flanks of the patient's body. The electrodes are energised to apply a first group of muscular stimulation current pulses which flow between the second and third electrodes and a second group of muscular stimulation current pulses which flow between the first electrode and the second and third electrodes alternately.Type: ApplicationFiled: June 16, 2010Publication date: May 10, 2012Applicant: BIO-MEDICAL RESEARCH LTD.Inventors: Louis Crowe, Brian Caulfield, Conor Minogue
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Patent number: 9675802Abstract: A method and apparatus for stimulating the lower back and abdominal muscles in a patient comprising applying a first electrode A1/A2 substantially centrally to the lower lumbar region of the patient's body, and applying second and third electrodes B, C respectively to opposite side flanks of the patient's body. The electrodes are energized to apply a first group of muscular stimulation current pulses which flow between the second and third electrodes and a second group of muscular stimulation current pulses which flow between the first electrode and the second and third electrodes alternately.Type: GrantFiled: June 16, 2010Date of Patent: June 13, 2017Assignees: University College Dublin, National University of Ireland, Dublin, Bio-Medical Research Ltd.Inventors: Louis Crowe, Brian Caulfield, Conor Minogue
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Patent number: 6760629Abstract: A device for attaching at least three electrodes to a subject for stimulating abdominal muscles of the subject. The device comprises an attachment mechanism that further comprises a main locating element for locating a central electrode of the at least three electrodes, and two secondary locating elements disposed on respective opposite sides of the main locating element for locating two corresponding side electrodes of the at least three electrodes spaced apart from the central electrode. A receiver is also provided for receiving a signal generated by a signal generator for generating at least one pulsed signal. A selector is also provided for selecting one or more of the electrodes through which a pulsed signal is to be applied.Type: GrantFiled: July 10, 2001Date of Patent: July 6, 2004Assignee: Bio-Medical Research Ltd.Inventors: Michael Conor Minogue, Michael Louis Crowe
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Patent number: 7069089Abstract: A device for attaching at least three electrodes to a subject for stimulating abdominal muscles of the subject, comprising an attachment mechanism for extending around the torso of the subject and a main locating element provided on the attachment mechanism for locating a central electrode of the at least three electrodes adjacent the umbilicus of the subject. Two secondary locating elements are also provided on the attachment mechanism disposed on respective opposite sides of the main locating element for locating two corresponding side electrodes of the at least three electrodes spaced apart from the central electrode. Application of at least one pulsed signal to the subject through the respective central and side electrodes stimulates the abdominal muscles of the subject.Type: GrantFiled: July 10, 2001Date of Patent: June 27, 2006Assignee: Bio-Medical Research Ltd.Inventors: Michael Conor Minogue, Michael Louis Crowe
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Patent number: 6885896Abstract: A device for attaching at least three electrodes to a subject for stimulating abdominal muscles of the subject. The device comprises an attachment mechanism for extending around the torso of the subject and a main locating element on the attachment mechanism for locating a central electrode of the at least three electrodes adjacent the umbilicus of the subject. Two secondary locating elements are also provided on the attachment mechanism disposed on respective opposite sides of the main locating element for locating two corresponding side electrodes of the at least three electrodes spaced apart from the central electrode in a general direction towards a corresponding one of the right and left mid-axillary lines of the torso intermediate the rib cage and corresponding right and left iliac crests. By applying at least one pulsed signal to the subject through the respective central and side electrodes, abdominal muscles of the subject are stimulated.Type: GrantFiled: July 10, 2001Date of Patent: April 26, 2005Assignee: Bio-Medical Research Ltd.Inventors: Michael Conor Minogue, Michael Louis Crowe
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Patent number: 3999551Abstract: A subcutaneous guide assembly for use by surgeons during an operation where surgical elements must be passed through an elongated path internal to a human body. The guide assembly includes an elongated rod of predetermined contour and length which is secured on opposing ends to a handle member and to one of a variety of surgical elements which may be releasably secured to the rod through threaded engagement. Additionally, a plurality of rod members of differing lengths and contours may be easily secured to the handle section of the subcutaneous guide assembly. The handle section includes an internal chamber where various surgical elements may be contained for use in particular portions or phases of an operation. The handle further includes a mechanism whereby the contained surgical elements within the handle internal chamber may be easily sterilized.Type: GrantFiled: January 7, 1975Date of Patent: December 28, 1976Assignee: Bio-Medical Research, Ltd.Inventors: Eugene B. Spitz, Richard E. Brenz, Charles C. Hansford
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Patent number: 11959911Abstract: The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or HGB measurement. A blood sample may be tested in one reaction cell through time-division multiplexing technology to obtain four groups leukocytes classification result and HGB result by single detection channel. Thus, the structure of the analyzer may be greatly simplified on the premise of guaranteeing the performance of the analyzer, the size and cost of the analyzer may reduce and a performance-price ratio of the analyzer may increase.Type: GrantFiled: December 24, 2021Date of Patent: April 16, 2024Assignees: CHENGDU SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD., SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Wenjun Tong, Yijie Yang, Huaming Xu, Xing Shi
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Publication number: 20140341952Abstract: A method for treating a disease comprising administering to a mammal in need thereof an effective dosage of an extract of a plant of the genus Hoodia, wherein the disease is selected from the group consisting of immune-mediated disorders, immune-associated disorders, inflammatory diseases, coronary disease, insulin resistance and liver-related diseases. In a preferred embodiment, the Hoodia is Hoodia parviflora. Also disclosed is a pharmaceutical composition for treating the above diseases comprising an effective dosage of an extract of a plant of the genus Hoodia.Type: ApplicationFiled: December 19, 2013Publication date: November 20, 2014Applicants: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD., BIO-MASS LTD., DESERT LABS AGRICULTURE COOPERATIVE ASSOCIATION LTD.Inventors: Refael Aharon, Yaron Ilan
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Publication number: 20200355676Abstract: A fully automated chemilumiescence immunoassay analyzer, including a sample and reagent receiving device for receiving a sample and a reagent, a dispensing device for aspirating and discharging the sample and the reagent, a mixing device for mixing the sample and the reagent in a reaction vessel, an incubation and luminescence detection device for incubation and luminescence detection, a magnetic separation cleaning device for separation cleaning an analyte and impurities in the reaction vessel, a reaction vessel grasping device for transferring the reaction vessel, and a liquid path device. The fully automated chemiluminescence immunoassay analyzer has a simple structure and is convenient to operate, and also reduce the overall size such that the footprint thereof is small and the production cost is reduced, so that the analyzer is easy to achieve miniaturization, and is convenient for an operator to use.Type: ApplicationFiled: July 24, 2020Publication date: November 12, 2020Applicants: CHENGDU SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD., SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Huaming XU, Yundong QI, Wangfu CHEN, Meng XIAN, Gansong SHEN, Zhibin CHENG, Jianjun PENG
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Patent number: 11215609Abstract: The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or HGB measurement. A blood sample may be tested in one reaction cell through time-division multiplexing technology to obtain four groups leukocytes classification result and HGB result by single detection channel. Thus, the structure of the analyzer may be greatly simplified on the premise of guaranteeing the performance of the analyzer, the size and cost of the analyzer may reduce and a performance-price ratio of the analyzer may increase.Type: GrantFiled: February 15, 2019Date of Patent: January 4, 2022Assignees: CHENGDU SHEN MIDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD, SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Wenjun Tong, Yijie Yang, Huaming Xu, Xing Shi
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Publication number: 20060246095Abstract: Disclosed are recombinant multiple epitope polypeptides (MEPs) consisting of T cell epitopes derived from tumor-associated antigens capable of being presented by an antigen presenting cell (APC), the recombinant nucleic acid sequences and expression vectors encoding them, and host cells transfected with said expression vectors. Further described are LTB-MEP fusion proteins comprising the E. Coli heat labile enterotoxin subunit B (LTB) peptide fused to a MEP by a synthetic linker, the recombinant nucleic acid sequences and expression vectors encoding them and host cell transfected with said expression vectors. Further included are compositions for inducing an immune response against malignancies, pharmaceutical compositions and a transdermal drug delivery system for the treatment of malignant disorders. Also disclosed are methods for conferring immunity against malignancies and for the treatment of malignant disorders.Type: ApplicationFiled: March 24, 2006Publication date: November 2, 2006Applicants: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, GAVISH-GALILEE-BIO APPLICATIONS LTD.Inventors: Tamar Peretz, Michal Lotem, Shoshana Frankenburg, Jacob Pitcovski, Adva Levi, Hanah Margalit, Yael Altuvia
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Patent number: 9170187Abstract: A flow cytometer and a fluid system are provided. The fluid system comprises a flow cell, a sample providing unit, a waste container, a sheath container, a negative pressure source, a quantitative unit and a sample flow monitoring unit, the negative pressure source, the waste container and the flow cell are connected, a negative pressure source, which provides a negative pressure relative to the sample providing unit for the flow cell so that the sample providing unit causes the sample to flow into the flow cell under the negative pressure, a sample flow monitoring unit monitors a flow of the sample fluid transported from the sample providing unit to the flow cell and outputs a feedback signal reflecting flow changes of the sample fluid in real-time; wherein the controller receives the feedback signal and controls the quantitative unit to adjust a flow of the sheath fluid according to the feedback signal.Type: GrantFiled: February 10, 2015Date of Patent: October 27, 2015Assignees: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD.Inventors: Baohua Yan, Chuixin Liao, William Li, Huawen Yan, Wenheng Guo
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Patent number: 5784162Abstract: According to the present invention there are provided spectral imaging methods for biological research, medical diagnostics and therapy comprising the steps of (a) preparing a sample to be spectrally imaged; (b) viewing the sample through an optical device, the optical device being optically connected to an imaging spectrometer, the optical device and the imaging spectrometer obtaining a spectrum of each pixel of the sample by: (i) collecting incident light simultaneously from all pixels of the sample using collimating optics; (ii) passing the incident collimated light through an interferometer system having a number of elements, to form an exiting light beam; (iii) passing the exiting light beam through a focusing optical system which focuses the exiting light beam on a detector having a two-dimensional array of detector elements, so that at each instant each of the detector elements is the image of one pixel of the sample, so that the real image of the sample is stationary on the plane of the detector arrayType: GrantFiled: December 12, 1995Date of Patent: July 21, 1998Assignee: Applied Spectral Imaging Ltd.Inventors: Dario Cabib, Robert A. Buckwald, Zvi Malik, Yuval Garini, Nir Katzir, Dirk G. Soeknsen
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Patent number: 10617697Abstract: A vitamin D2-enriched biomass of an edible fungus, extracts and compositions thereof are provided, for use in delaying onset of, treating, ameliorating or protecting from an immune-related or inflammatory related disease, disorder or condition, wherein the level of vitamin D2 in said biomass is at least 80 IU/gr.Type: GrantFiled: January 17, 2016Date of Patent: April 14, 2020Assignees: GAVISH-GALILEE BIO APPLICATIONS, LTD., HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTDInventors: Dan Levanon, Yaron Ilan, Ofer Danai
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Publication number: 20110123629Abstract: The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.Type: ApplicationFiled: January 25, 2009Publication date: May 26, 2011Applicants: GAVISH-GALILEE BIO APPLIACTIONS LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPEMENT LTD.Inventors: Jacob Pitcovski, Ehud Shahar, Raphael Gorodetsky
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Patent number: 10188741Abstract: The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.Type: GrantFiled: May 4, 2016Date of Patent: January 29, 2019Assignees: GAVISH-GALILEE BIO APPLICATIONS, LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.Inventors: Jacob Pitcovski, Ehud Shahar, Raphael Gorodetsky
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Patent number: 9358307Abstract: The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.Type: GrantFiled: January 25, 2009Date of Patent: June 7, 2016Assignees: GAVISH-GALILEE BIO APPLICATIONS LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.Inventors: Jacob Pitcovski, Ehud Shahar, Raphael Gorodetsky
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