Search Patents
  • cDNAs associated with ataxia-telangiectasia
    Patent number: 5777093
    Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia.
    Type: Grant
    Filed: July 28, 1995
    Date of Patent: July 7, 1998
    Assignee: RAMOT-University Authority for Applied Research & Industrial Development Ltd.
    Inventors: Yosef Shiloh, Danilo A. Tagle, Francis S. Collins
  • Mutated proteins associated with ataxia-telangiectasia
    Patent number: 5728807
    Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia.
    Type: Grant
    Filed: June 21, 1995
    Date of Patent: March 17, 1998
    Assignee: Ramot-University Authority For Applied Research and Industrial Development, Ltd.
    Inventors: Yosef Shiloh, Danilo A. Tagle, Francis S. Collins
  • Markers for detection of chromosome 16 rearrangements
    Patent number: 5869611
    Abstract: The breakpoints of the pericentric inversion of chromosome 16 have been cloned. Two genes, one at each breakpoint, have also been identified, as well as several forms of the inversion 16 fusion gene. Diagnostic applications for chromosome 16 abnormalities and, particularly acute myeloid leukemia are also within the scope of the present invention.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: February 9, 1999
    Assignees: The Regents Of The University Of Michigan and The Board of Regents, University of Texas System
    Inventors: Pu Liu, Francis S. Collins, Michael J. Siciliano, David Claxton
  • Cystic fibrosis gene
    Patent number: 6730777
    Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 4, 2004
    Assignees: HSC Research Development Corporation, University of Michigan
    Inventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
  • Neurofibromatosis gene
    Patent number: 6238861
    Abstract: The invention relates to the gene involved in the von Recklinghausen neurofibromatosis (NF1) disease process and to the identification, isolation and cloning of a nucleic acid sequence corresponding to the gene. The invention further relates to the NF1 gene product and sequence and antibodies raised thereto. The invention also relates to methods of screening for NF1 and NF1 diagnosis, as well as conventional treatment and gene therapy utilizing recombinant technologies.
    Type: Grant
    Filed: August 2, 1993
    Date of Patent: May 29, 2001
    Assignee: The Regents of the University of Michigan
    Inventors: Francis S. Collins, Margaret R. Wallace, Douglas A. Marchuk, Lone B. Andersen, David H. Gutmann
  • Cystic fibrosis gene
    Patent number: 6984487
    Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: January 10, 2006
    Assignees: HSC Research Development Corporation, The Board of Regents Acting For and on Behalf of The University of Michigan
    Inventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
  • Cystic fibrosis gene
    Patent number: 6902907
    Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: June 7, 2005
    Assignees: HSC Research Development Corporation, The Board of Regents Acting for and on Behalf of The University of Michigan
    Inventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
  • Neurofibromatosis gene
    Patent number: 5859195
    Abstract: The entire coding region of the gene involved in von Recklinghausen neurofibromatosis (NF1) and a ubiquitously expressed large transcript (NF1LT) of the gene have been identified, cloned and sequenced. With the identification of the NF1 gene and its gene product, nucleic acid probes and antibodies raised to the gene product can be used in a variety of hybridization and immunological assays to screen for NF1 and detect it in its early stages. Conventional and gene therapies can also be developed to treat those afflicted with the disease.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: January 12, 1999
    Assignee: The Regents of the University of Michigan
    Inventors: Francis S. Collins, Margaret R. Wallace, Douglas A. Marchuk, Lone B. Andersen, David H. Gutmann