Search Patents
  • Process for renaturing fish growth hormone
    Patent number: 4985544
    Abstract: Reactivation of cysteine-containing protein in a process, in which a reduced and denatured cysteine-containing protein such as salmon growth hormone I or eel growth hormone I can be efficiently reactivated.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: January 15, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yoshiharu Yokoo, Seiji Sugimoto
  • Process for the isolation and purification of hirudin
    Patent number: 5095092
    Abstract: The invention relates to a process for the isolation and purification of hirudin from complex and salt-containing solutions by hydrophobic chromatography, using as stationary phase porous adsorber resins and as mobile phase organic solvents which are miscible with water.
    Type: Grant
    Filed: September 27, 1990
    Date of Patent: March 10, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Badziong, Peter Crause, Paul Habermann, Dominique Tripier
  • Antibiotic, cammunocin, a process for the preparation thereof, and the use thereof as a pharmaceutical
    Patent number: 5271935
    Abstract: Cammunocin, an active substance which can be obtained by cultivation of Streptomyces species Y-84,36210 (DSM 4329), has antibiotic and immunosuppressant activity.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: December 21, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Christopher M. M. Franco, Sugata Chatterjee, Erra K. S. Vijayakumar, Bimal N. Ganguli, Richard H. Rupp
  • Enrichment and concentration of proteins by ultrafiltration
    Patent number: 4897465
    Abstract: Disclosed are ultrafiltration processes for the enrichment and concentration of selected proteins from protein conaining fluids. Illustratively, IgG is concentrated from whey by means of multiple ultrafiltration "passes", using a metallic oxide ultrafiltration membrane, which are characterized by differing pH's.
    Type: Grant
    Filed: October 12, 1988
    Date of Patent: January 30, 1990
    Assignee: Abbott Laboratories
    Inventors: Christopher T. Cordle, Larry G. Criswell, Ronald L. Thomas
  • Brazzein sweetener
    Patent number: 5326580
    Abstract: Disclosed herein is a protein sweetener that has been isolated from Pentadiplandra brazzeana Baillon. The sweetener is thermostable, lysine rich, and has a relative long lasting taste. Also disclosed is a recombinant host capable of producing the sweetener in large quantities. Compositions of this sweetener with other sweeteners are also disclosed.
    Type: Grant
    Filed: February 16, 1993
    Date of Patent: July 5, 1994
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bengt G. Hellekant, Ding Ming
  • Functional polypeptide containing a cell binding domain and a heparin binding domain of fibronectin
    Patent number: 5198423
    Abstract: This invention relates to a functional polypeptide containing the binding domain of human fibronectin and the heparin-binding domain of human fibronectin.
    Type: Grant
    Filed: May 22, 1990
    Date of Patent: March 30, 1993
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Yuki Taguchi, Yoh'ichi Ohdate, Yasutoshi Kawase, Shouichi Goto, Fusao Kimizuka, Ikunoshin Kato, Ikuo Saiki, Ichiro Azuma
  • Protein active in humoral hypercalcemia of malignancy-PTHRP
    Patent number: 5116952
    Abstract: Substantially pure proteins active in humoral hypercalcemia of malignancy (PTHrP) and sub-units and fragments thereof. Antibody reagents capable of binding to epitopes of PTHrP. Methods and kits for the detection of PTHrP.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: May 26, 1992
    Assignee: The University of Melbourne
    Inventors: Thomas J. Martin, Jane M. Moseley, Bruce E. Kemp, Richard E. H. Wettenhall
  • Therapeutic uses of bactericidal/permeability increasing protein products
    Patent number: 5348942
    Abstract: The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: September 20, 1994
    Assignee: Xoma Corporation
    Inventors: Roger G. Little, II, Helene Gazzano-Santoro, James B. Parent
  • Characterization and method of isolation of factor J, an inhibitor of complement C1
    Patent number: 5264549
    Abstract: A purified protein, factor J, which has inhibitory properties which prevent the formation or the dissociation of Cl complex and a method of purification for said protein. The method including the following sequential chromatography steps: anion exchange, QAE-"SEPHADEX", heparin-"SEPHAROSE" affinity, "MONO Q" and hydroxylapatite.
    Type: Grant
    Filed: April 27, 1992
    Date of Patent: November 23, 1993
    Assignee: The Beth Israel Hospital Association
    Inventor: Anne Nicholson-Weller
  • Substrate for the epidermal growth factor receptor kinase
    Patent number: 5717067
    Abstract: A new substrate of epidermal growth factor receptor and certain other tyrosine kinase receptors denominated eps15, polynucleotides encoding epsl5, antisense eps15 polynucleotide, triple helix eps15 polynucleotide, antibodies to eps15, and assays for determining eps15.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 10, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Pier Paolo DiFiore, Francesca Fazioli
  • Method to achieve solubilization of spider silk proteins
    Patent number: 5245012
    Abstract: A recombinant spider silk protein can be obtained in a commercially useful form by cloning and the expression in a host cell of a polynucleotide encoding an endogenous spider silk protein or variant thereof. The sequencing of a spider silk protein is made possible by a method for solubilizing a spider silk protein.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: September 14, 1993
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Stephen J. Lombari, David L. Kaplan
  • Protein size marker ladder
    Patent number: 5449758
    Abstract: The invention relates to a multidomain protein comprising sites for cleavage of the protein into at least 3 polypeptide domains; nucleic acid encoding the multidomain protein; a protein ladder comprising a collection of protein fragments obtained by the partial cleavage of one or more multidomain proteins by one or more cleaving agents; and methods of using and preparing the protein ladder.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: September 12, 1995
    Assignee: Life Technologies, Inc.
    Inventor: James L. Hartley
  • Strains of Bacillus thuringiensis insecticidal compositions containing the same
    Patent number: 5147640
    Abstract: The present invention provides novel strains of Bacillus thuringiensis containing genes that code for P1 endotoxin proteins. The invention also provides methods and compositions for controlling insects or protecting plants from insect attack with a novel strain of Bacillus thuringiensis.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: September 15, 1992
    Assignee: Ecogen Inc.
    Inventors: Ivan E. Gard, Jr., Jose M. Gonzalez, Jr., Dennis R. Ciarlante
  • Modified HIL-6
    Patent number: 5264209
    Abstract: Provided are PEGylated "interleukin-6" derivatives (PEG IL-6) having an extended plasma half-life, as well as enhanced in-vivo IL-6 biological activities.Methods for producing the modified glycosylated and unglycosylated IL-6 proteins or polypeptides, as well as, for their use in treating hematopoietic disorders and difficiencies, particularly acute thrombocytopenia, are also provided.
    Type: Grant
    Filed: December 21, 1990
    Date of Patent: November 23, 1993
    Assignee: Kirin-Amgen, Inc.
    Inventors: Toshihumi Mikayama, Toshihiko Kadoya, Makoto Kakitani, Hideo Inoue
  • Purified trichosanthin and method of preparation
    Patent number: 5077390
    Abstract: A substantially pure, hemagglutinin-free composition of trichosanthin, and a method of producing the composition is disclosed. A plant extract from Trichosanthes kirilowii is contacted with an anionic exchange resin to remove contaminating hemagglutinins, and trichosanthin is further purified from the extract by cation exchange chromatography to a purity of greater than 95%.
    Type: Grant
    Filed: September 7, 1989
    Date of Patent: December 31, 1991
    Assignee: Genelabs, Incorporated
    Inventors: Paul S. Wu, Susan B. Wade, Raul R. Soikes
  • Protein with bone formation ability and process for its production
    Patent number: 5756664
    Abstract: The present invention provides the sequence of the novel bone-related protein OSF-2 which can be obtained from mammalian bone tissues. The invention further provides a method of production of OSF-2 by recombinant techniques.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: May 26, 1998
    Assignee: Hoechst Japan Limited
    Inventors: Egon Amann, Yoko Otawara-Hamamoto, Reiko Kikuno, Sunao Takeshita, Kenichi Tezuka
  • Self incompatibility protein
    Patent number: 5037959
    Abstract: A class of proteins associated with self-incompatibility alleles of plants, preferably of gametophytic self-incompatibility type, are provided. These proteins inhibit pollen tube growth in a plant style having the associated self-incompatibility allele, and have defined amino acid homologies and cross-reactivities.
    Type: Grant
    Filed: May 15, 1987
    Date of Patent: August 6, 1991
    Assignee: Lubrizol Genetics, Inc.
    Inventors: Adrienne E. Clarke, Elizabeth G. Williams, Marilyn A. Anderson, Shaio-Lim Mau, Rosslyn Hoggart, Edwina Cornish
  • Method of treatment to inhibit the undesirable activation of the complement cascade with factor J, an inhibitor of complement C1
    Patent number: 5268363
    Abstract: A purified protein, factor J, which has inhibitory properties which prevent the formation or the dissociation of Cl complex and a method of purification for said protein. The method including the following sequential chromatography steps: anion exchange QAE-"SEPHADEX", heparin-"SEPHAROSE" affinity, "MONO Q" and hydroxylapatite.
    Type: Grant
    Filed: April 27, 1992
    Date of Patent: December 7, 1993
    Assignee: The Beth Israel Hospital Association
    Inventor: Anne Nicholson-Weller
  • PDGF receptor blocking peptides
    Patent number: 5268358
    Abstract: Methods and compositions are provided for treating several acute disease states associated with smooth muscle cell proliferation as well as the chronic process of atherogenesis utilizing oligopeptides corresponding to regions of the PDGF receptor protein. The oligopeptides can be used to block PDGF binding and activation for numerous applications, and can serve as immunogens to raise receptor-specific antibodies.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: December 7, 1993
    Assignee: Cor Therapeutics, Inc.
    Inventor: Larry J. Fretto
  • Class of low calorie protein sweeteners
    Patent number: 5478923
    Abstract: Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.
    Type: Grant
    Filed: March 25, 1994
    Date of Patent: December 26, 1995
    Assignees: The Regents of the University of California, Lucky, Ltd.
    Inventors: Sung-Hou Kim, Joong M. Cho
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