Search Patents
  • Remote magnetic manipulation of nervous systems
    Patent number: 6238333
    Abstract: Apparatus and method for remote manipulation of nervous systems by the magnetic dipole field of a rotating bar magnet. Reliance on modulation of spontaneous spiking patterns of sensory nerve receptors, and exploitation of a resonance mechanism of certain neural circuits, allows the use of very weak magnetic fields. This, together with the large magnetic moments that can be obtained with a permanent bar magnet, makes it possible to effectively manipulate the nervous system of a subject over a distance of several hundred meters, using a small portable battery-powered device. The method can be used in law enforcement for standoff situations.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: May 29, 2001
    Inventor: Hendricus G. Loos
  • Pulse variability in electric field manipulation of nervous systems
    Patent number: 6167304
    Abstract: Apparatus and method for manipulating the nervous system of a subject by applying to the skin a pulsing external electric field which, although too weak to cause classical nerve stimulation, modulates the normal spontaneous spiking patterns of certain kinds of afferent nerves. For certain pulse frequencies the electric field stimulation can excite in the nervous system resonances with observable physiological consequences. Pulse variability is introduced for the purpose of thwarting habituation of the nervous system to the repetitive stimulation, or to alleviate the need for precise tuning to a resonance frequency, or to control pathological oscillatory neural activities such as tremors or seizures. Pulse generators with stochastic and deterministic pulse variability are disclosed, and the output of an effective generator of the latter type is characterized.
    Type: Grant
    Filed: June 17, 1999
    Date of Patent: December 26, 2000
    Inventor: Hendricus G. Loos
  • Manipulation of nervous systems by electric fields
    Patent number: 5899922
    Abstract: Apparatus and method for manipulating the nervous system of a subject through afferent nerves, modulated by an externally applied weak electric field. The field frequency is to be chosen such that the modulation causes excitation of a sensory resonance. The resonances found so far include one near 1/2 Hz which affects the autonomic nervous system, and a resonance near 2.4 Hz that causes slowing of certain cortical processes. Excitation of the 1/2 Hz autonomic resonance causes relaxation, sleepiness, ptosis of the eyelids, or sexual excitement, depending on the precise frequency used. The weak electric field for causing the excitation is applied to skin areas away from the head of the subject, such as to avoid substantial polarization current densities in the brain. Very weak fields suffice for bringing about the physiological effects mentioned. This makes it possible to excite sensory resonances with compact battery powered devices that have a very low current consumption.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: May 4, 1999
    Inventor: Hendricus G. Loos
  • Subliminal acoustic manipulation of nervous systems
    Patent number: 6017302
    Abstract: In human subjects, sensory resonances can be excited by subliminal atmospheric acoustic pulses that are tuned to the resonance frequency. The 1/2 Hz sensory resonance affects the autonomic nervous system and may cause relaxation, drowsiness, or sexual excitement, depending on the precise acoustic frequency near 1/2 Hz used. The effects of the 2.5 Hz resonance include slowing of certain cortical processes, sleepiness, and disorientation. For these effects to occur, the acoustic intensity must lie in a certain deeply subliminal range. Suitable apparatus consists of a portable battery-powered source of weak subaudio acoustic radiation. The method and apparatus can be used by the general public as an aid to relaxation, sleep, or sexual arousal, and clinically for the control and perhaps treatment of insomnia, tremors, epileptic seizures, and anxiety disorders.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: January 25, 2000
    Inventor: Hendricus G. Loos
  • Pulsative manipulation of nervous systems
    Patent number: 6091994
    Abstract: Method and apparatus for manipulating the nervous system by imparting subliminal pulsative cooling to the subject's skin at a frequency that is suitable for the excitation of a sensory resonance. At present, two major sensory resonances are known, with frequencies near 1/2 Hz and 2.4 Hz. The 1/2 Hz sensory resonance causes relaxation, sleepiness, ptosis of the eyelids, a tonic smile, a "knot" in the stomach, or sexual excitement, depending on the precise frequency used. The 2.4 Hz resonance causes the slowing of certain cortical activities, and is characterized by a large increase of the time needed to silently count backward from 100 to 60, with the eyes closed. The invention can be used by the general public for inducing relaxation, sleep, or sexual excitement, and clinically for the control and perhaps a treatment of tremors, seizures, and autonomic system disorders such as panic attacks.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: July 18, 2000
    Inventor: Hendricus G. Loos
  • NERVOUS SYSTEM MANIPULATION BY ELECTROMAGNETIC FIELDS FROM MONITORS
    Publication number: 20020188164
    Abstract: Physiological effects have been observed in a human subject in response to stimulation of the skin with weak electromagnetic fields that are pulsed with certain frequencies near ½ Hz or 2.4 Hz, such as to excite a sensory resonance. Many computer monitors and TV tubes, when displaying pulsed images, emit pulsed electromagnetic fields of sufficient amplitudes to cause such excitation. It is therefore possible to manipulate the nervous system of a subject by pulsing images displayed on a nearby computer monitor or TV set. For the latter, the image pulsing may be imbedded in the program material, or it may be overlaid by modulating a video stream, either as an RF signal or as a video signal. The image displayed on a computer monitor may be pulsed effectively by a simple computer program. For certain monitors, pulsed electromagnetic fields capable of exciting sensory resonances in nearby subjects may be generated even as the displayed images are pulsed with subliminal intensity.
    Type: Application
    Filed: June 1, 2001
    Publication date: December 12, 2002
    Inventor: Hendricus G. Loos
  • Nervous system manipulation by electromagnetic fields from monitors
    Patent number: 6506148
    Abstract: Physiological effects have been observed in a human subject in response to stimulation of the skin with weak electromagnetic fields that are pulsed with certain frequencies near ½ Hz or 2.4 Hz, such as to excite a sensory resonance. Many computer monitors and TV tubes, when displaying pulsed images, emit pulsed electromagnetic fields of sufficient amplitudes to cause such excitation. It is therefore possible to manipulate the nervous system of a subject by pulsing images displayed on a nearby computer monitor or TV set. For the latter, the image pulsing may be imbedded in the program material, or it may be overlaid by modulating a video stream, either as an RF signal or as a video signal. The image displayed on a computer monitor may be pulsed effectively by a simple computer program. For certain monitors, pulsed electromagnetic fields capable of exciting sensory resonances in nearby subjects may be generated even as the displayed images are pulsed with subliminal intensity.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: January 14, 2003
    Inventor: Hendricus G. Loos
  • Minimally invasive surgical techniques for implanting devices that deliver stimulant to the nervous system
    Patent number: 6360750
    Abstract: Devices are currently implanted in patients to treat pain and other conditions including incontinence by delivering stimulants to the nervous system. Surgical methods are improved for implanting the devices. The soft tissues of the body are dilated above the site of device implantation, for example, above the sacrum, to create an annulus of dilated soft tissues. The tissues are dilated by introducing into the soft tissue sequentially larger cannulated dilating devices. A tubular retractor is then passed over the largest introduced dilating device and at least a number of the dilating devices are retracted. This establishes a tubular device insertion corridor through the dilated soft tissues to the site of implantation, for example, the foramen of the sacrum. The device to be implanted, such as an electrical lead, is then inserted through the corridor. The device is tested in situ. Finally, such other method steps are performed, including closing the corridor, as implantation requires.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: March 26, 2002
    Assignee: Medtronic, Inc.
    Inventors: Martin Theodore Gerber, Michael C. Sherman
  • MANIPULATION OF MENINGEAL LYMPHATIC VASCULATURE FOR BRAIN AND CNS TUMOR THERAPY
    Publication number: 20220008510
    Abstract: A method of inducing lymphangiogenesis in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of inducing lymphangiogenesis in a tumor in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of treating a cancer of the brain or central nervous system is also provided in which an effective amount of a lymphangiogenesis inducer is administered. An example of a lymphangiogenesis inducer is VEGFC. The lymphangiogenesis inducer can be in the form of a protein or a polynucleotide encoding the protein, such as an mRNA or AAV. The lymphangiogenesis inducer can be administered to the cistemamagna or directly into the lymphatic system. An immunotherapeutic agent, such as a checkpoint inhibitor, may also be administered.
    Type: Application
    Filed: November 15, 2019
    Publication date: January 13, 2022
    Applicant: Yale University
    Inventors: Akiko IWASAKI, Jean-Leon THOMAS, Eric SONG
  • Apparatus for evaluating manual dexterity
    Publication number: 20040177686
    Abstract: An apparatus for evaluating manual dexterity in humans and in particular to an apparatus for evaluating the manual dexterity of humans with an impaired nervous system and/or musculoskeletal system is provided. Manual dexterity and object manipulation is a three dimensional activity and any attempt to evaluate it should take this fact into consideration. A method and apparatus for evaluating manual dexterity and object manipulation in humans comprises a structure to receive a hand and a unit to measure and record omnidirectional forces applied to the hand. Additionally, a connection structure to connect two hands is provided, wherein each hand is capable of transmitting a force onto the other hand via the connection structure. The apparatus may also include a unit to measure and record forces applied by each hand.
    Type: Application
    Filed: March 25, 2004
    Publication date: September 16, 2004
    Inventor: Roland Sixten Johansson
  • MULTI-COMPONENT SYSTEM FOR MANIPULATION OF BONE AND SOFT TISSUES
    Publication number: 20180132899
    Abstract: The present invention relates to devices for manipulation of bones and their associated soft-tissue structures including joints, muscles, tendons, ligaments, and nervous tissues. The devices use articulated arms that attach to bone and soft tissue to properly align bone and soft tissue for fixation. Locking members attached to the articulated arms are activated by buttons or switches to unlock the articulated arms for adjustment of the position of an attached bone and to lock the articulated arms for holding an attached bone in a stable position.
    Type: Application
    Filed: November 13, 2017
    Publication date: May 17, 2018
    Inventor: Nelson F. SooHoo
  • Multi-component system for manipulation of bone and soft tissues
    Patent number: 11191569
    Abstract: The present invention relates to devices for manipulation of bones and their associated soft-tissue structures including joints, muscles, tendons, ligaments, and nervous tissues. The devices use articulated arms that attach to bone and soft tissue to properly align bone and soft tissue for fixation. Locking members attached to the articulated arms are activated by buttons or switches to unlock the articulated arms for adjustment of the position of an attached bone and to lock the articulated arms for holding an attached bone in a stable position.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: December 7, 2021
    Assignee: The Regents of the University of California
    Inventor: Nelson F. SooHoo
  • Genetic manipulation of brain serotonin using the pet-1 transcriptional control region
    Publication number: 20080118913
    Abstract: Serotonin neurons modulate most homeostatic Central Nervous System (CNS) functions while influencing the expression of behavioral traits such as mood, aggression and anxiety. Serotonin neuron dysfunction has been implicated in depression, addiction, autism and sudden infant death syndrome. This disclosure describes a straightforward, highly reproducible method for genetically accessing serotonin neurons and a sub-population of intestinal enterocytes, in vivo, using BAC-based transgenes that can be constructed using simple subcloning procedures. Compositions described herein include these transgenes and methods for making and using them to create transgenic mouse strains and identify serotonin and intestinal enterocytes without immunostaining.
    Type: Application
    Filed: November 1, 2005
    Publication date: May 22, 2008
    Inventors: Michael M. Scott, Evan S. Deneris
  • Controlled drug delivery system for treatment of neural disorders
    Patent number: 4883666
    Abstract: The present invention is a method and composition for treatment of ischemic, metabolic, congenital, or degenerative disorders of the central or peripheral nervous system. The composition is formed by encapsulation within an implantable biocompatible polymeric device of one or more compounds which have the effect or replacing or stimulating functions of the nervous system. A variety of biocompatible polymers including both biodegradable and non-degradable polymers can be used to form the implants. An essential feature of the composition is linear release, achieved through manipulation of the polymer composition and form. The selection of the shape, size, drug, polymer, and method for implantation are determined on an individual basis according to the disorder to be treated and the individual patient response.
    Type: Grant
    Filed: April 29, 1987
    Date of Patent: November 28, 1989
    Assignee: Massachusetts Institute of Technology
    Inventors: Bernhard A. Sabel, Andrew Freese, William M. Saltzman
  • System and methods for stress release and associated nitric oxide release for treatment of pain in specific parts of the body
    Publication number: 20090124865
    Abstract: This invention provides unique technology, systems and methods of treatment of stress induced afflictions in the musculoskeletal system, the vascular system or the nervous tissue. More specifically, the systems comprise diagnosis of a stress-induced consistent tightness on the right side of the cranial, cervical, thoracic, lumbar, sacral spine, referred herein as “The Twist”, and utilize “Stress Relief Methods” to reduce The Twist to resolve any afflictions associated with it. The invention comprises a coordinated series of untwisting dynamic motions, spinal manipulation and/or motion palpations that result in release of nitric oxide and relief from pain. The systems and methods of the invention therefore provide the benefits of increased nitric oxide release to maintain homeostasis in pulmonary vasculature. The invention also provides methods of training others in the correct use of the Stress Relief Methods to prevent and treat afflictions associated with the Twist.
    Type: Application
    Filed: November 14, 2007
    Publication date: May 14, 2009
    Inventor: James E. Kiernan
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