Abstract: Provided herein are antigen-binding protein constructs capable of specifically binding MET or an epitope of MET presented on surface of a target mammalian cell, wherein said antigen binding is pH-dependent. Provided are also uses of said antigen-binding protein constructs.
Type:
Application
Filed:
July 30, 2020
Publication date:
September 8, 2022
Applicant:
Mythic Therapeutics, Inc.
Inventors:
Alexander J. Nichols, Brian P. Fiske, Nimish Gera
Abstract: Provided herein are antigen-binding protein constructs capable of specifically binding FOLR1 or an epitope of FOLR1 presented on the surface of a target mammalian cell, wherein said antigen binding is pH-dependent. Provided are also uses of said antigen-binding protein constructs.
Type:
Application
Filed:
June 5, 2020
Publication date:
September 22, 2022
Applicant:
Mythic Therapeutics, Inc.
Inventors:
Alexander J. Nichols, Brian P. Fiske, Nimish Gera
Abstract: Provided herein are antigen-binding protein constructs capable of specifically binding CD33 or an epitope of CD33 presented on the surface of a target mammalian cell, wherein said antigen binding is pH-dependent. Provided are also uses of said antigen-binding protein constructs.
Type:
Application
Filed:
June 5, 2020
Publication date:
October 13, 2022
Applicant:
Mythic Therapeutics, Inc.
Inventors:
Alexander J. Nichols, Brian P. Fiske, Nimish Gera
Abstract: Provided herein are antigen-binding protein constructs capable of specifically binding CD22 or an epitope of CD22 presented on the surface of a target mammalian cell, wherein said antigen binding is pH-dependent. Provided are also uses of said antigen-binding protein constructs.
Type:
Application
Filed:
July 8, 2020
Publication date:
September 15, 2022
Applicant:
Mythic Therapeutics, Inc.
Inventors:
Alexander J. Nichols, Brian P. Fiske, Nimish Gera
Abstract: Provided herein are antigen-binding protein constructs capable of specifically binding DLL3 or an epitope of DLL3 presented on the surface of a target mammalian cell, wherein said antigen binding is pH-dependent. Provided are also uses of said antigen-binding protein constructs.
Type:
Application
Filed:
June 5, 2020
Publication date:
October 6, 2022
Applicant:
Mythic Therapeutics, Inc.
Inventors:
Alexander J. Nichols, Brian P. Fiske, Nimish Gera
Abstract: Provided is a single-action trigger assembly that includes a pivoting trigger member, a sear/disconnector mechanism, and a trigger bar operably connecting the trigger member and the sear/disconnector mechanism. The sear/disconnector mechanism includes a slider assembly longitudinally reciprocated by the trigger bar. The slider assembly includes a tripper member carried on a slider frame that, when the trigger is pulled, moves a sear trip member to allow displacement of a sear and release a striker.
Abstract: A system for allowing a person to experience systems of mythology. It includes an existential analyzer module (EAM), for assessing a portion of a person's meaningful experiential world. The EAM generates an existential descripter (EXD) data structure describing the assessments. A facilitator module (FAM) utilizes the assessment from the EXD data structure for determining at least one appropriate enactment. The FAM generates at least one enactment descripter (END) data structure describing the enactment chosen from the FAM. An enactor module (ENM) utilizes information from the EXD data structure and from the END data structure to generate a mythic virtual reality that incorporates the chosen enactment.
Abstract: Systems and methods of implementing a mixed-signal integrated circuit includes sourcing, by a reference signal source, a plurality of analog reference signals along a shared signal communication path to a plurality of local accumulators; producing an electrical charge, at each of the plurality of local accumulators, based on each of the plurality of analog reference signals; adding or subtracting, by each of the plurality of local accumulators, the electrical charge to an energy storage device of each of the plurality of local accumulators over a predetermined period; summing along the shared communication path the electrical charge from the energy storage device of each of the plurality of local accumulators at an end of the predetermined period; and generating an output based on a sum of the electrical charge from each of the plurality of local accumulators.
Type:
Grant
Filed:
February 20, 2019
Date of Patent:
October 11, 2022
Assignee:
Mythic, Inc.
Inventors:
Laura Fick, Manar El-Chammas, Skylar Skrzyniarz, David Fick
Abstract: Systems and methods of implementing a mixed-signal integrated circuit includes sourcing, by a reference signal source, a plurality of analog reference signals along a shared signal communication path to a plurality of local accumulators; producing an electrical charge, at each of the plurality of local accumulators, based on each of the plurality of analog reference signals; adding or subtracting, by each of the plurality of local accumulators, the electrical charge to an energy storage device of each of the plurality of local accumulators over a predetermined period; summing along the shared communication path the electrical charge from the energy storage device of each of the plurality of local accumulators at an end of the predetermined period; and generating an output based on a sum of the electrical charge from each of the plurality of local accumulators.
Type:
Grant
Filed:
September 11, 2018
Date of Patent:
April 9, 2019
Assignee:
Mythic, Inc.
Inventors:
Laura Fick, Manar El-Chammas, Skylar Skrzyniarz, David Fick
Abstract: Systems and methods of implementing a mixed-signal integrated circuit includes sourcing, by a reference signal source, a plurality of analog reference signals along a shared signal communication path to a plurality of local accumulators; producing an electrical charge, at each of the plurality of local accumulators, based on each of the plurality of analog reference signals; adding or subtracting, by each of the plurality of local accumulators, the electrical charge to an energy storage device of each of the plurality of local accumulators over a predetermined period; summing along the shared communication path the electrical charge from the energy storage device of each of the plurality of local accumulators at an end of the predetermined period; and generating an output based on a sum of the electrical charge from each of the plurality of local accumulators.
Type:
Grant
Filed:
August 31, 2022
Date of Patent:
August 15, 2023
Assignee:
Mythic, Inc.
Inventors:
Laura Fick, Manar El-Chammas, Skylar Skrzyniarz, David Fick
Abstract: Systems and methods of configuring a fixed memory array of an integrated circuit with coefficients of one or more applications includes identifying a utilization constraint type of the fixed memory array from a plurality of distinct utilization constraint types based on computing attributes of the one or more applications; identifying at least one coefficient mapping technique from a plurality of distinct coefficient mapping techniques that addresses the utilization constraint type; configuring the fixed memory array according to the at least one coefficient mapping technique, wherein configuring the array includes at least setting within the array the coefficients of the one or more applications in an arrangement prescribed by the at least one coefficient mapping technique that optimizes a computational utilization of the fixed memory array.
Type:
Grant
Filed:
November 14, 2019
Date of Patent:
April 13, 2021
Assignee:
Mythic, Inc.
Inventors:
David Fick, Michael Henry, Laura Fick, Malav Parikh, Skylar Skrzyniarz, Scott Johnson, Pei-Ci Wu, Andrew Morten
Abstract: Systems and methods of configuring a fixed memory array of an integrated circuit with coefficients of one or more applications includes identifying a utilization constraint type of the fixed memory array from a plurality of distinct utilization constraint types based on computing attributes of the one or more applications; identifying at least one coefficient mapping technique from a plurality of distinct coefficient mapping techniques that addresses the utilization constraint type; configuring the fixed memory array according to the at least one coefficient mapping technique, wherein configuring the array includes at least setting within the array the coefficients of the one or more applications in an arrangement prescribed by the at least one coefficient mapping technique that optimizes a computational utilization of the fixed memory array.
Type:
Grant
Filed:
April 24, 2019
Date of Patent:
October 22, 2019
Assignee:
Mythic, Inc.
Inventors:
David Fick, Michael Henry, Laura Fick, Malav Parikh, Skylar Skrzyniarz, Scott Johnson, Pei-Ci Wu, Andrew Morten
Abstract: Systems and methods of configuring a fixed memory array of an integrated circuit with coefficients of one or more applications includes identifying a utilization constraint type of the fixed memory array from a plurality of distinct utilization constraint types based on computing attributes of the one or more applications; identifying at least one coefficient mapping technique from a plurality of distinct coefficient mapping techniques that addresses the utilization constraint type; configuring the fixed memory array according to the at least one coefficient mapping technique, wherein configuring the array includes at least setting within the array the coefficients of the one or more applications in an arrangement prescribed by the at least one coefficient mapping technique that optimizes a computational utilization of the fixed memory array.
Type:
Grant
Filed:
May 2, 2019
Date of Patent:
December 24, 2019
Assignee:
Mythic, Inc.
Inventors:
David Fick, Michael Henry, Laura Fick, Malav Parikh, Skylar Skrzyniarz, Scott Johnson, Pei-Ci Wu, Andrew Morten
Abstract: An integrated circuit and method are provided for performing weighted sum computations. The circuit includes: a plurality of current generators interconnected and arranged into pairs, a positive summation node, a negative summation node, and an input generation circuit. For each pair of current generators, the control terminal of each element is electrically connected to an input node. One of the current generators has its drain connected to the positive summation node while the other current generation element has its drain connected to the negative summation node. The remaining terminals on both current generators are connected to a reference, which may be shared. Each pair of current generator source predetermined amounts of current onto the two summation nodes when the following conditions occur: the input node is at an activation voltage, and the two summation nodes are at a predetermined target voltage.
Type:
Grant
Filed:
February 7, 2018
Date of Patent:
April 9, 2019
Assignees:
The Regents of The University of Michigan, Mythic, Inc.
Inventors:
David Alan Fick, Laura E. Fick, Skylar J. Skrzyniarz, Manar El-Chammas
Abstract: Systems and methods of configuring a fixed memory array of an integrated circuit with coefficients of one or more applications includes identifying a utilization constraint type of the fixed memory array from a plurality of distinct utilization constraint types based on computing attributes of the one or more applications; identifying at least one coefficient mapping technique from a plurality of distinct coefficient mapping techniques that addresses the utilization constraint type; configuring the fixed memory array according to the at least one coefficient mapping technique, wherein configuring the array includes at least setting within the array the coefficients of the one or more applications in an arrangement prescribed by the at least one coefficient mapping technique that optimizes a computational utilization of the fixed memory array.
Type:
Grant
Filed:
March 5, 2021
Date of Patent:
March 28, 2023
Assignee:
Mythic, Inc.
Inventors:
David Fick, Michael Henry, Laura Fick, Malav Parikh, Skylar Skrzyniarz, Scott Johnson, Pei-Ci Wu, Andrew Morten