Search Patents
  • Micro-cavity-based force sensor
    Patent number: 11719686
    Abstract: A system for measuring cellular forces exerted on a surface comprising: a deformable sensor that has a deformable surface adapted to deform on application of a cellular force, and an optical detector for optically detecting deformation of the surface.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: August 8, 2023
    Assignee: UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS
    Inventors: Malte C. Gather, Nils Kronenberg, Philipp Liehm
  • Transgenic non-human animals for producing chimeric antibodies
    Patent number: 8293480
    Abstract: The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: October 23, 2012
    Assignee: Genpharm International
    Inventors: Nils Lonberg, Robert M. Kay
  • HUMAN ANTIBODIES
    Publication number: 20030091995
    Abstract: The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expresing human immunoglobulins. Such screening produces unlimited numbers of high affinity human antibodies to any target of interest.
    Type: Application
    Filed: December 1, 1999
    Publication date: May 15, 2003
    Inventors: JOE BUECHLER, GUNARS VALKIRS, JEFF GRAY, NILS LONBERG
  • Human antibodies as detection reagents
    Publication number: 20030165993
    Abstract: The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the samples. The methods can be effected using a sandwich format among others.
    Type: Application
    Filed: June 6, 2002
    Publication date: September 4, 2003
    Inventors: Joe Buechler, Gunars Valkirs, Jeff Gray, Nils Lonberg
  • Diagnosis of acute coronary syndrome, myocardial infarction, or angina pectoris by means of neurophysin II
    Patent number: 9261517
    Abstract: The invention relates to methods for in vitro diagnosis of acute coronary syndrome (ACS), acute myocardial infarction (AMI) or angina pectoris (AP) by determining the level of neurophysin II in a sample from a patient.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: February 16, 2016
    Assignee: B.R.A.H.M.S GmbH
    Inventors: Andreas Bergmann, Nils Morgenthaler, Jana Papassotiriou, Joachim Struck, Leong L. Ng
  • Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker
    Patent number: 7108983
    Abstract: The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: September 19, 2006
    Assignee: Rigshospitalet
    Inventors: Mads N. Holten-Andersen, Ross W. Stephens, Hans Jorgen Nielsen, Ib Jarle Christensen, Nils Brünner
  • Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker
    Patent number: 7807379
    Abstract: The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: October 5, 2010
    Assignee: Rigshospitalet
    Inventors: Mads Holten-Andersen, Ross Stephens, Hans Jørgen Nielsen, Ib Jarle Christensen, Nils Brünner
  • Human antibodies
    Patent number: 7135287
    Abstract: The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expressing human immunoglobulins. Such screening produces unlimited numbers of high affinity human antibodies to any target of interest.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: November 14, 2006
    Assignees: Biosite, Inc., Medarex, Inc.
    Inventors: Nils Lonberg, Joe Buechler, Jeff Gray, Gunars Valkirs
  • Human antibodies
    Patent number: 6794132
    Abstract: The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expresing human immunoglobulins. Such screening produces unlimited numbers of high affinity human antibodies to any target of interest.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: September 21, 2004
    Assignees: Biosite, Inc., GenPharm International, Inc.
    Inventors: Joe Buechler, Gunars Valkirs, Jeff Gray, Nils Lonberg
  • DIAGNOSIS AND RISK ASSESSMENT OF PANCREATIC DIABETES USING MR-PROADM
    Publication number: 20100035275
    Abstract: The invention relates to a method for diagnosis and/or risk assessment of pancreatic diabetes, in particular of diabetic sequelae, wherein a determination of the marker mid-regional proAdrenomedullin (MR-proADM: SEQ ID No. 2) or a partial peptide or fragment thereof or if contained in a marker combination (Panel, Cluster) is carried out on a patient under investigation. The invention further relates to a diagnostic device and a kit for carrying out said method.
    Type: Application
    Filed: November 8, 2007
    Publication date: February 11, 2010
    Applicant: Brahms Aktiengesellschaft
    Inventors: Andreas Bergmann, Nils Morgenthaler, Jana Papassotiriou, Joachim Struck
  • Process for preparation of coated polymer particles containing superparamagnetic crystals
    Patent number: 8227262
    Abstract: A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting surface-functionalized, superparamagnetic crystal-containing polymer particles of diameter less than 0.5 ?m with at least one polyisocyanate and at least one diol.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: July 24, 2012
    Assignee: Invitrogen Dynal AS
    Inventors: Geir Fonnum, Lars Kilaas, Arvid Trygve Berge, Tom-Nils Nilsen, Ruth Schmid, Grete Irene Modahl
  • Hybrid molecules having Factor VII/VIIa activity
    Patent number: 7432352
    Abstract: The present invention relates to novel human coagulation Factor VII/VIIa proteins having coagulant potential/activity as well as pharmaceutical compositions comprising the proteins, uses thereof, and methods of treatment therewith. In particular, the present invention relates to novel, semi synthetic analogues of human coagulation Factor VII and VIIa (FVII and FVIIa) as well as to a method of their production.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: October 7, 2008
    Assignee: Novo Nordisk Healthcare AG
    Inventor: Nils Langeland Johansen
  • Human antibodies as detection reagents
    Patent number: 7189515
    Abstract: The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the samples. The methods can be effected using a sandwich format among others.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: March 13, 2007
    Assignees: Biosite, Inc., Medarex, Inc.
    Inventors: Joe Buechler, Gunars Valkirs, Jeff Gray, Nils Lonberg
  • METHOD AND DEVICE FOR SMALL SCALE REACTIONS
    Publication number: 20100035273
    Abstract: The present invention relates to a method and a device for small scale reactions, such as sample preparation of a desired substance in a sample. In the method using the device samples mixed with functionalized magnetic particles are magnetically transferred between different working stations on the device. The method uses a hydrophobic surface, such as a Petri dish, provided with hydrophilic spots of, for example, agarose beads located on said hydrophobic surface and provided with buffers, reactants or ligands.
    Type: Application
    Filed: September 24, 2007
    Publication date: February 11, 2010
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Andreas Axen, Anders Larsson, Nils Norrman
  • DIAGNOSIS AND RISK STRATIFICATION OF INFECTIONS AND CHRONIC DISEASES OF THE RESPIRATORY TRACT AND LUNGS BY MEANS OF PROVASOPRESSIN, PARTICULARLY COPEPTIN OR NEUROPHYSIN II
    Publication number: 20100041064
    Abstract: The invention relates to a method for diagnosing and/or stratifying the risk of infections or chronic diseases of the respiratory tract and lungs, particularly lower respiratory tract infections and chronic obstructive pulmonary disease. In said method, provasopressin (proAVP) or fragments or partial peptides thereof, especially copeptin or neurophysin II, is/are determined. The invention further relates to suitable biomarker combinations for in-vitro diagnosis.
    Type: Application
    Filed: November 11, 2007
    Publication date: February 18, 2010
    Applicant: BRAHMS Aktiengesellschaft
    Inventors: Andreas Bergmann, Nils Morgenthaler, Jana Papassotiriou, Joachim Struck, Beat Müller
  • METHOD FOR DETECTING, SCREENING, AND/OR MONITORING CANCER IN AN INDIVIDUAL
    Publication number: 20090035794
    Abstract: The invention relates to a method for screening and/or detecting and/or monitoring a cancer in an individual, said method comprising determining a first parameter represented by the concentration of TIMP-1 in at least one excreta, e.g. saliva, from the individual. The invention provides a method that without the need to use a blood sample is suitable for facilitating the early diagnosis of a cancer, monitoring the recurrence of a cancer, and/or monitoring the status of a cancer or the effect of cancer treatment in an individual.
    Type: Application
    Filed: August 7, 2008
    Publication date: February 5, 2009
    Applicant: Rigshospitalet, Public University Hospital
    Inventors: Lasse L. Hessel, Jesper Malling, Nils Brunner, Mads Holten-Andersen, Hans Jorgen Nielsen
  • Diagnosis and risk stratification of cardiac insufficiency by means of natriuretic peptides for NYHA I patients
    Patent number: 8252544
    Abstract: The invention relates to a method for the diagnosis, and/or risk stratification, and/or outcome prognosis of cardiac insufficiency for NYHA I patients, wherein a determination of the proANP marker, NT-proANP marker, or fragments or partial peptides thereof is carried out parallel to a determination of BNP, proBNP, and/or NT-proBNP on patients to be examined.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: August 28, 2012
    Assignee: B.R.A.H.M.S GmbH
    Inventors: Andreas Bergmann, Nils Morgenthaler, Jana Papassotiriou, Joachim Struck, Stefan Anker
  • Diagnosis and risk stratification of infections and chronic diseases of the respiratory tract and lungs by means of provasopressin, particularly copeptin or neurophysin II
    Patent number: 8158368
    Abstract: The invention relates to a method for diagnosing and/or stratifying the risk of infections or chronic diseases of the respiratory tract and lungs, particularly lower respiratory tract infections and chronic obstructive pulmonary disease. In said method, provasopressin (proAVP) or fragments or partial peptides thereof, especially copeptin or neurophysin II, is/are determined. The invention further relates to suitable biomarker combinations for in-vitro diagnosis.
    Type: Grant
    Filed: November 11, 2007
    Date of Patent: April 17, 2012
    Assignee: B.R.A.H.M.S. GmbH
    Inventors: Andreas Bergmann, Nils Morgenthaler, Jana Papassotiriou, Joachim Struck, Beat Müller
  • Diagnosis and risk classification of acute coronary syndrome by means of CT-proET-1 in combination with NT-proBNP
    Patent number: 8524463
    Abstract: The invention relates to a method for diagnosis and/or risk classification for acute coronary syndrome (ACS), in particular for acute myocardial infarct (AMI) and angina pectoris (AP) and/or a post-myocardial infarct, wherein a determination of the C-terminal pro-endothelin (CT-proET-1) or fragments and partial peptides therefrom, is carried out in combination with NT-proBNP.
    Type: Grant
    Filed: December 22, 2007
    Date of Patent: September 3, 2013
    Assignee: B.R.A.H.M.S GmbH
    Inventors: Andreas Bergmann, Nils Morgenthaler, Jana Papassotiriou, Joachim Struck, Leong L. Ng
  • Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin
    Patent number: 9012151
    Abstract: The invention provides methods for the diagnosis and risk stratification of adverse events in post-myocardial infarction patients by means of proADM, whereby a determination of the marker pro-adrenomedullin or partial sequence or a fragment thereof or contained in a marker combination (panel, cluster) is carried out on a post-myocardial infarction patient. The invention also provides a diagnostic device and a kit for the performance of the method of the method of the invention.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: April 21, 2015
    Assignee: B.R.A.H.M.S. GmbH
    Inventors: Leong Loke Ng, Andreas Bergmann, Joachim Struck, Nils Morgenthaler, Jana Papassotiriou