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  • Treatments for obesity and methods for identifying compounds useful for treating obesity
    Patent number: 6451783
    Abstract: The present invention provides a method of treating obesity, sexual dysfunction (including erectile dysfunction), diabetes, insulin resistance, hyperinsulinemia, Syndrome X, adrenal dysfunction, hypertension, hypercholesterolemia, atherosclerosis, hyperlipoproteinemia, hypertriglyceridemia, or substance abuse, the method comprising the step of administering to a patent having or at risk of having one of the above-mentioned diseases a therapeutically effective amount of a compound that attenuates the binding of agouti-related protein to melanocortin receptors, but does not attenuate the binding of &agr;-melanocyte stimulating hormone to melanocortin receptors.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: September 17, 2002
    Assignee: Pfizer Inc.
    Inventors: John R. Hadcock, Andrew G. Swick
  • Treatments for obesity and methods for identifiying compounds useful for treating obesity
    Patent number: 6734175
    Abstract: The present invention provides a method of treating obesity, sexual dysfunction (including erectile dysfunction), diabetes, insulin resistance, hyperinsulinemia, Syndrome X, adrenal dysfunction, hypertension, hypercholesterolemia, atherosclerosis, hyperlipoproteinemia, hypertriglyceridemia, or substance abuse, the method comprising the step of administering to a patent having or at risk of having one of the above-mentioned diseases a therapeutically effective amount of a compound that attenuates the binding of agouti-related protein to melanocortin receptors, but does not attenuate the binding of &agr;-melanocyte stimulating hormone to melanocortin receptors.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: May 11, 2004
    Assignee: Pfizer Inc.
    Inventors: John R. Hadcock, Andrew G. Swick
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