Search Patents
  • ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF
    Publication number: 20160075708
    Abstract: Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.
    Type: Application
    Filed: April 9, 2014
    Publication date: March 17, 2016
    Applicants: GUANGZHOU HUI BO RUI BIOLOGICAL PHARMACEUTICAL TECHNOLOGY CO., LTD., ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN UNIVERSITY
    Inventors: Rui Hou, Kang Zhang
  • METHODS AND COMPOSITIONS FOR NANOPORE SEQUENCING
    Publication number: 20210132032
    Abstract: Disclosed herein are methods and compositions relating to synthesized nanopores. The synthesized nanopores can be used for detecting a target molecule (e.g. RNA, DNA, or peptide).
    Type: Application
    Filed: January 17, 2018
    Publication date: May 6, 2021
    Inventors: Kang ZHANG, Rui HOU
  • LENS REGENERATION USING ENDOGENOUS STEM/PROGENITOR CELLS
    Publication number: 20180353645
    Abstract: The disclosure herein includes uses and systems for cataract removal and lens regeneration using endogenous stem cells that results in improved outcomes.
    Type: Application
    Filed: December 8, 2016
    Publication date: December 13, 2018
    Inventors: Kang ZHANG, Rui HOU
  • METHYLATION MARKERS FOR DIAGNOSING CANCER
    Publication number: 20200277677
    Abstract: Disclosed herein are methods, probes, and kits for diagnosing the presence of cancer and/or a cancer type in a subject.
    Type: Application
    Filed: October 5, 2018
    Publication date: September 3, 2020
    Applicants: YouHealth Oncotech, Limited, The Regents of the University of California
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG, Gen LI
  • Methods and compositions for nanopore sequencing
    Patent number: 11531020
    Abstract: Disclosed herein are methods and compositions relating to synthesized nanopores. The synthesized nanopores can be used for detecting a target molecule (e.g. RNA, DNA, or peptide).
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: December 20, 2022
    Inventors: Kang Zhang, Rui Hou
  • COLON CANCER METHYLATION MARKERS AND USES THEREOF
    Publication number: 20190300964
    Abstract: Disclosed herein are methods and kits for identifying a subject as having colon cancer. Also provided herein are methods and kits for determining the prognosis of a subject having colon cancer and for determining the progression of colon cancer in a subject.
    Type: Application
    Filed: July 6, 2017
    Publication date: October 3, 2019
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • BREAST AND OVARIAN CANCER METHYLATION MARKERS AND USES THEREOF
    Publication number: 20190360052
    Abstract: Disclosed herein are methods and kits for identifying a subject as having breast cancer. Also provided herein are methods and kits for determining the prognosis of a subject having breast cancer and for determining the progression of breast cancer in a subject.
    Type: Application
    Filed: July 6, 2017
    Publication date: November 28, 2019
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • LIVER CANCER METHYLATION MARKERS AND USES THEREOF
    Publication number: 20190300965
    Abstract: Disclosed herein are methods and kits for identifying a subject as having liver cancer. Also provided herein are methods and kits for determining the prognosis of a subject having liver cancer and for determining the progression of liver cancer in a subject.
    Type: Application
    Filed: July 6, 2017
    Publication date: October 3, 2019
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • LEUKEMIA METHYLATION MARKERS AND USES THEREOF
    Publication number: 20190136327
    Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.
    Type: Application
    Filed: August 3, 2018
    Publication date: May 9, 2019
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • LUNG CANCER METHYLATION MARKERS AND USES THEREOF
    Publication number: 20190345560
    Abstract: Disclosed herein are methods and kits for identifying a subject as having lung cancer. Also provided herein are methods and kits for determining the prognosis of a subject having lung cancer and for determining the progression of lung cancer in a subject.
    Type: Application
    Filed: July 6, 2017
    Publication date: November 14, 2019
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • COMPOSITIONS AND METHODS TO TREAT AND/OR PREVENT VISION DISORDERS OF THE LENS OF THE EYE
    Publication number: 20170239273
    Abstract: The disclosure generally relates to compositions and uses thereof to treat vision disorders that affect the normal function of the lens in the eye in a subject having or at risk of developing such vision disorders.
    Type: Application
    Filed: August 22, 2015
    Publication date: August 24, 2017
    Inventors: Kang ZHANG, Stanley KIM, Jie ZHU, Rui HOU, J Jefferson PERRY
  • LEUKEMIA METHYLATION MARKERS AND USES THEREOF
    Publication number: 20210115518
    Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.
    Type: Application
    Filed: June 22, 2020
    Publication date: April 22, 2021
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • COMPOUNDS FOR TREATING EYE DISORDERS OR DISEASES
    Publication number: 20170218009
    Abstract: Described herein are compounds that inhibit or prevent protein aggregation, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with protein aggregation.
    Type: Application
    Filed: February 2, 2017
    Publication date: August 3, 2017
    Inventors: Rui HOU, Kang ZHANG
  • LEUKEMIA METHYLATION MARKERS AND USES THEREOF
    Publication number: 20180010192
    Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.
    Type: Application
    Filed: February 16, 2017
    Publication date: January 11, 2018
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • DEEP LEARNING-BASED DIAGNOSIS AND REFERRAL OF OPHTHALMIC DISEASES AND DISORDERS
    Publication number: 20190110753
    Abstract: Disclosed herein are systems, methods, devices, and media for carrying out medical diagnosis of ophthalmic diseases and conditions. Deep learning algorithms enable the automated analysis of ophthalmic images to generate predictions of comparable accuracy to clinical experts.
    Type: Application
    Filed: October 15, 2018
    Publication date: April 18, 2019
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • SOLID TUMOR METHYLATION MARKERS AND USES THEREOF
    Publication number: 20180094325
    Abstract: Disclosed herein are methods and kits for identifying a subject as having esophagus cancer, pancreatic cancer, or stomach cancer. Also provided herein are methods and kits for generating the methylation profile of a biomarker associated with esophagus cancer, pancreatic cancer, or stomach cancer.
    Type: Application
    Filed: December 12, 2017
    Publication date: April 5, 2018
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • METHOD AND SYSTEM FOR DETERMINING CANCER STATUS
    Publication number: 20180341745
    Abstract: Disclosed herein are methods, systems, platforms, non-transitory computer-readable medium, services, and kits for determining a cancer type in an individual. Also described herein include methods, systems, platforms, non-transitory computer-readable medium, and compositions for generating a CpG methylation profile database.
    Type: Application
    Filed: January 8, 2018
    Publication date: November 29, 2018
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • SOLID TUMOR METHYLATION MARKERS AND USES THEREOF
    Publication number: 20200299776
    Abstract: Disclosed herein are methods and kits for identifying a subject as having esophagus cancer, pancreatic cancer, or stomach cancer. Also provided herein are methods and kits for generating the methylation profile of a biomarker associated with esophagus cancer, pancreatic cancer, or stomach cancer.
    Type: Application
    Filed: December 26, 2019
    Publication date: September 24, 2020
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • Breast and ovarian cancer methylation markers and uses thereof
    Patent number: 11396678
    Abstract: Disclosed herein are methods and kits for identifying a subject as having breast cancer. Also provided herein are methods and kits for determining the prognosis of a subject having breast cancer and for determining the progression of breast cancer in a subject.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: July 26, 2022
    Assignees: The Regent of the University of California, YouHealth Oncotech, Limited
    Inventors: Kang Zhang, Rui Hou, Lianghong Zheng
  • Deep learning-based diagnosis and referral of ophthalmic diseases and disorders
    Patent number: 10722180
    Abstract: Disclosed herein are systems, methods, devices, and media for carrying out medical diagnosis of ophthalmic diseases and conditions. Deep learning algorithms enable the automated analysis of ophthalmic images to generate predictions of comparable accuracy to clinical experts.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: July 28, 2020
    Inventors: Kang Zhang, Rui Hou, Lianghong Zheng
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