Abstract: Compound of formula (I):
wherein:
n represents 2 or 3,
R1 represents optionally substituted alkyl, cycloalkyl or optionally substituted phenyl,
R2 represents amino, optionally substituted amidino, optionally substituted guanidino or optionally substituted isothioureido,
Ar represents aryl or heteroaryl,
X1 represents hydroxy or optionally substituted amino,
isomers thereof, and also salts thereof with a pharmaceutically acceptable acid or base, and which
medicinal products containing the same/are useful as trypsin-related serine protease inhibitors.
Type:
Grant
Filed:
May 2, 2000
Date of Patent:
September 11, 2001
Assignee:
Adir et Compagnie
Inventors:
Guillaume De Nanteuil, Philippe Gloanec, Tony Verbeuren, Alain Rupin
Abstract: Compound of formula (I):
in which:
n is 1 or 2,
X represents alkylene, alkenylene, alkynylene or optionally substituted arylene or heteroarylene,
R10 represents hydrogen or alkyl and R11 and R12 together form a bond, or alternatively R12 represents hydrogen or alkyl and R10 and R11 together form a bond,
R2, R3 and R4 each independently of the others represents hydrogen, alkyl, hydroxyalkyl, alkoxy, alkoxycarbonyl, aryl, arylalkyl or aryloxyalkyl, or two of R2, R3 and R4 form a cycloalkyl radical.
Medicinal products containing the same are useful in the treatment of cardiovascular diseases.
Type:
Grant
Filed:
November 16, 2000
Date of Patent:
October 9, 2001
Assignee:
Adir et Compagnie
Inventors:
Pascal Bousquet, Jean-Daniel Ehrhardt, Véronique Bruban, Josiane Feldman, Stephan Schann, Elisabeth Scalbert, Bruno Pfeiffer, Pierre Renard
Abstract: Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): Application in the synthesis of perindopril and its pharmaceutically acceptable salts.
Abstract: The present invention relates to a new salt of perindopril and to pharmaceutical compositions containing it, and Medicaments for treatment of hypertension and heart failure.
Type:
Grant
Filed:
February 21, 2003
Date of Patent:
February 24, 2004
Assignee:
Les Laboratoires Servier
Inventors:
Gérard Damien, François Lefoulon, Bernard {acute over (M)}archand
Abstract: A ? crystalline form of the compound of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.
Type:
Grant
Filed:
February 4, 2005
Date of Patent:
August 21, 2007
Assignee:
Les Laboratoires Servier
Inventors:
Bruno Pfeiffer, Yves-Michel Ginot, Gérard Coquerel, Stéphane Beilles
Abstract: Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): Application in the synthesis of perindopril and its pharmaceutically acceptable salts.
Abstract: Process for the synthesis of compounds of formula (I): wherein R represents hydrogen or a protecting group. Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.
Abstract: ?-crystalline form of the compound of formula (I): characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.
Abstract: Process for the synthesis of compounds of formula (I): wherein R represents a hydrogen atom or a protecting group for the amino function. Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.
Abstract: Process for the industrial synthesis of the compounds of formula (I): wherein R1 represents a hydrogen atom or an alkyl or benzyl group, and R2 represents a group that protects the amino function.
Type:
Grant
Filed:
July 23, 2002
Date of Patent:
June 13, 2006
Assignee:
Les Laboratoires Servier
Inventors:
Tibor Mezei, Marta Porcs-Makkay, Gyula Simig