Search Patents
  • Patent number: 6288077
    Abstract: Compound of formula (I): wherein: n represents 2 or 3, R1 represents optionally substituted alkyl, cycloalkyl or optionally substituted phenyl, R2 represents amino, optionally substituted amidino, optionally substituted guanidino or optionally substituted isothioureido, Ar represents aryl or heteroaryl, X1 represents hydroxy or optionally substituted amino, isomers thereof, and also salts thereof with a pharmaceutically acceptable acid or base, and which medicinal products containing the same/are useful as trypsin-related serine protease inhibitors.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: September 11, 2001
    Assignee: Adir et Compagnie
    Inventors: Guillaume De Nanteuil, Philippe Gloanec, Tony Verbeuren, Alain Rupin
  • Patent number: 6300366
    Abstract: Compound of formula (I): in which: n is 1 or 2, X represents alkylene, alkenylene, alkynylene or optionally substituted arylene or heteroarylene, R10 represents hydrogen or alkyl and R11 and R12 together form a bond, or alternatively R12 represents hydrogen or alkyl and R10 and R11 together form a bond, R2, R3 and R4 each independently of the others represents hydrogen, alkyl, hydroxyalkyl, alkoxy, alkoxycarbonyl, aryl, arylalkyl or aryloxyalkyl, or two of R2, R3 and R4 form a cycloalkyl radical. Medicinal products containing the same are useful in the treatment of cardiovascular diseases.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: October 9, 2001
    Assignee: Adir et Compagnie
    Inventors: Pascal Bousquet, Jean-Daniel Ehrhardt, Véronique Bruban, Josiane Feldman, Stephan Schann, Elisabeth Scalbert, Bruno Pfeiffer, Pierre Renard
  • Patent number: 7534896
    Abstract: Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: May 19, 2009
    Assignee: Les Laboratories Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Patent number: 7208607
    Abstract: Process for the synthesis of perindopril of formula (I): and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: April 24, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry DuBuffet, Pascal Langlois
  • Patent number: 7358372
    Abstract: Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: April 15, 2008
    Assignee: Les Laboratories Servier
    Inventors: Claude Fugier, Thierry Dubuffet, Pascal Langlois
  • Patent number: 7183308
    Abstract: A process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: February 27, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Patent number: 7223872
    Abstract: A process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: May 29, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Patent number: 6835843
    Abstract: The invention concerns a method for synthesis of perindopril of formula (I) and its pharmaceutically acceptable salts
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: December 28, 2004
    Assignee: Les Laboratoires Servier
    Inventors: Pascal Langlois, Hugues Turbe
  • Patent number: 7279583
    Abstract: Process for the industrial synthesis of perindopril of formula (I): and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: October 9, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Patent number: 7368580
    Abstract: Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: May 6, 2008
    Assignee: Les Laboratories Servier
    Inventors: Claude Fugier, Thierry Dubuffet, Pascal Langlois
  • Patent number: 7179833
    Abstract: Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: February 20, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Patent number: 7166633
    Abstract: Process for the synthesis of perindopril of formula (I): and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: January 23, 2007
    Assignee: Les Laboratories Servier
    Inventors: Thierry Dubuffet, Pascal Langlois
  • Patent number: 7323575
    Abstract: Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): Application in the synthesis of perindopril and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: January 29, 2008
    Assignee: Les Laboratories Servier
    Inventors: Jean-Claude Souvie, Jean-Pierre Lecouve
  • Patent number: 6696481
    Abstract: The present invention relates to a new salt of perindopril and to pharmaceutical compositions containing it, and Medicaments for treatment of hypertension and heart failure.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: February 24, 2004
    Assignee: Les Laboratoires Servier
    Inventors: Gérard Damien, François Lefoulon, Bernard {acute over (M)}archand
  • Patent number: 7259181
    Abstract: A ? crystalline form of the compound of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: August 21, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Bruno Pfeiffer, Yves-Michel Ginot, Gérard Coquerel, Stéphane Beilles
  • Patent number: 7196204
    Abstract: Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): Application in the synthesis of perindopril and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: March 27, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Claude Souvie, Jean-Pierre Lecouve
  • Patent number: 7157484
    Abstract: Process for the synthesis of compounds of formula (I): wherein R represents hydrogen or a protecting group. Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: January 2, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Pascal Langlois
  • Patent number: 7923569
    Abstract: ?-crystalline form of the compound of formula (I): characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.
    Type: Grant
    Filed: February 26, 2007
    Date of Patent: April 12, 2011
    Assignee: Les Laboratoires Servier
    Inventors: Gérard Coquerel, Loïc Lefebvre, Jean-Claude Souvie, Pascale Authouart
  • Patent number: 7288661
    Abstract: Process for the synthesis of compounds of formula (I): wherein R represents a hydrogen atom or a protecting group for the amino function. Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: October 30, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Thierry Dubuffet, Jean-Pierre Lecouve
  • Patent number: 7060842
    Abstract: Process for the industrial synthesis of the compounds of formula (I): wherein R1 represents a hydrogen atom or an alkyl or benzyl group, and R2 represents a group that protects the amino function.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: June 13, 2006
    Assignee: Les Laboratoires Servier
    Inventors: Tibor Mezei, Marta Porcs-Makkay, Gyula Simig