Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
Type:
Grant
Filed:
March 28, 2003
Date of Patent:
July 26, 2005
Assignee:
Sloan-Kettering Institute for Cancer Research
Inventors:
Samuel J. Danishefsky, Alexy Rivkin, Fumikiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda
Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
Type:
Grant
Filed:
May 9, 2003
Date of Patent:
January 19, 2010
Assignee:
Sloan-Kettering Institute for Cancer Research
Inventors:
Samuel J. Danishefsky, Alexey Rivkin, Yoshimura Fumikiko, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
Type:
Grant
Filed:
October 12, 2006
Date of Patent:
July 20, 2010
Assignee:
Sloan-Kettering Institute for Cancer Research
Inventors:
Samuel J. Danishefsky, Alexey Rivkin, Fumikiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong
Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
Type:
Grant
Filed:
August 18, 2004
Date of Patent:
June 10, 2008
Assignee:
Sloan-Kettering Institute for Cancer Research
Inventors:
Samuel J. Danishefsky, Alexey Rivkin, Fumihiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong, Kaida Wu, Malcolm A. S. Moore, David Dorn
Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
Type:
Grant
Filed:
February 25, 2003
Date of Patent:
April 20, 2004
Assignee:
Sloan-Kettering Institute for Cancer Research
Inventors:
Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J Sorensen, Aaron Balog, Kenneth A. Savin