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  • Publication number: 20030026852
    Abstract: This invention describes a non-aqueous oral composition of molecular iodine in a stabilized hydrophobic environment containing a hydrophobe or combination of hydrophobes for treating different disease states.
    Type: Application
    Filed: March 27, 2001
    Publication date: February 6, 2003
    Applicant: SYMBOLLON CORPORATION
    Inventors: Yongjun Duan, Jack Kessler
  • Patent number: 6248335
    Abstract: A stabilized solid oral pharmaceutical composition comprised of iodide and iodate as the active agents in the presence of one or more pharmaceutical excipients and a method for preparing these stabilized compositions.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: June 19, 2001
    Assignee: Symbollon Corporation
    Inventors: Yongjun Duan, Kirk Dinehart, John Hickey, Jack Kessler
  • Patent number: 5772971
    Abstract: A microbial decontamination system includes a chamber for housing items to be decontaminated as well as a source of one or more iodine-containing fluids that are conveyed to the chamber as necessary. The system also includes a detector element for monitoring the concentration of free iodine within the chamber. A signal representative of the free iodine concentration is conveyed to a controller element which communicates with receptacles for housing the iodine-containing fluids so that additional iodine-containing fluids may be added to maintain the free iodine concentration within the chamber at a desired level.
    Type: Grant
    Filed: July 5, 1996
    Date of Patent: June 30, 1998
    Assignee: Symbollon Corporation
    Inventors: Joseph Murphy, John Hickey, Yongjun Duan
  • Patent number: 5962029
    Abstract: A method for forming an iodine disinfecting solution that continuously generates free molecular iodine at a controlled average rate of at least 0.2 ppm per hour over a sustained and extended time period. The method involves combining persulfate anions and iodide anions in sufficient quantity in an aqueous medium having a resulting pH of less than about 6.5 so as to create an iodine generating capacity in said aqueous medium of between 1.5 and 6.5 with a generated concentration of at least 5 ppm of free molecular iodine and maintaining this concentration over the course of the extended time period.
    Type: Grant
    Filed: July 5, 1996
    Date of Patent: October 5, 1999
    Assignee: Symbollon Corporation
    Inventors: Yongjun Duan, Jack Howard Kessler
  • Patent number: 5885592
    Abstract: The invention is a method of administering therapeutic iodine for treating a disorder in a mammal. The invention comprises a step of feeding said mammal an effective amount of an oxidant for an iodine species and an iodine reductant which will cause oxidation-reduction reactions upon contact with the gastric juices present in the stomach of the mammal. This is done such that molecular iodine is generated in vivo at a ratio of molecular iodine to total iodine of above at least about 0.65. The invention also discloses a non-aqueous pharmaceutically acceptable carrier with said oxidant and reductant having the ability to cause oxidation-reduction reactions upon contact with the gastric juices present in the stomach of said mammal and in an amount sufficient to generate molecular iodine, in vivo, at a ratio of molecular iodine to total iodine of above at least about 0.65.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: March 23, 1999
    Assignee: Symbollon Corporation
    Inventors: Yongjun Duan, John Hickey, Rick Panicucci, Jack Kessler
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