Search Patents
  • Benzene derivatives and pharmaceutical use thereof
    Publication number: 20050165114
    Abstract: The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: March 24, 2005
    Publication date: July 28, 2005
    Applicant: AJINOMOTO CO. INC
    Inventors: Yukio Iino, Kohichi Fujita, Takashi Tsuji, Ariko Kodaira, Kenji Takehana, Tsuyoshi Kobayashi, Takashi Yamamoto
  • Benzene derivatives and Pharmaceutical use thereof
    Publication number: 20010018441
    Abstract: The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: March 12, 2001
    Publication date: August 30, 2001
    Applicant: Ajinomoto Co., Inc.
    Inventors: Yukio Iino, Kohichi Fujita, Takashi Tsuji, Ariko Kodaira, Kenji Takehana, Tsuyoshi Kobayashi, Takashi Yamamoto
  • Benzene derivatives and pharmaceutical use thereof
    Publication number: 20030166693
    Abstract: The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: March 14, 2003
    Publication date: September 4, 2003
    Applicant: AJINOMOTO CO., INC
    Inventors: Yukio Iino, Kohichi Fujita, Takashi Tsuji, Ariko Kodaira, Kenji Takehana, Tsuyoshi Kobayashi, Takashi Yamamoto
  • Benzene derivatives and pharmaceutical use thereof
    Patent number: 6703379
    Abstract: The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: March 9, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yukio Iino, Kohichi Fujita, Takashi Tsuji, Ariko Kodaira, Kenji Takehana, Tsuyoshi Kobayashi, Takashi Yamamoto
  • Benzene derivatives and pharmaceutical use thereof
    Patent number: 7459585
    Abstract: The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: December 2, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yukio Iino, Kohichi Fujita, Takashi Tsuji, Ariko Kodaira, Kenji Takehana, Tsuyoshi Kobayashi, Takashi Yamamoto
  • Process for preparing aminostilbene derivatives
    Publication number: 20040176642
    Abstract: The present invention relates to a novel process for preparing an aminostilbene derivative, which is important as an active component of anticancer drugs or an intermediate for preparation thereof, as well as methods of producing the same.
    Type: Application
    Filed: December 22, 2003
    Publication date: September 9, 2004
    Applicant: AJINOMOTO CO. INC
    Inventors: Takashi Yamamoto, Hiroyuki Matsueda, Masaki Naito, Isao Arai, Masanobu Yatagai
  • NOVEL DIARYLALKENE DERIVATIVES AND NOVEL DIARYLALKANE DERIVATIVES
    Publication number: 20080058311
    Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH?CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C?C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.
    Type: Application
    Filed: October 26, 2007
    Publication date: March 6, 2008
    Applicant: AJINOMOTO CO., INC.
    Inventors: Takashi YAMAMOTO, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
  • Diarylalkene derivatives and novel diarylalkane derivatives
    Patent number: 8278329
    Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH?CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C?C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: October 2, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takashi Yamamoto, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
  • Process for preparing aminostilbene derivatives
    Patent number: 6930205
    Abstract: The present invention relates to a novel process for preparing an aminostilbene derivative, which is important as an active component of anticancer drugs or an intermediate for preparation thereof, as well as methods of producing the same.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: August 16, 2005
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takashi Yamamoto, Hiroyuki Matsueda, Masaki Naito, Isao Arai, Masanobu Yatagai
  • Diarylalkene derivatives and novel diarylalkane derivatives
    Patent number: 7462630
    Abstract: The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH?CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C?C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: December 9, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takashi Yamamoto, Seiji Niwa, Kayo Otani, Seiji Ohno, Hajime Koganei, Satoshi Iwayama, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Shinichi Fujita, Keiko Moki
  • Dihydropyridine derivatives
    Publication number: 20020147222
    Abstract: Compounds having a selective N-type calcium channel antagonistic activity are provided.
    Type: Application
    Filed: December 20, 2001
    Publication date: October 10, 2002
    Applicant: AJINOMOTO CO. INC
    Inventors: Chika Nakanishi, Yoko Masuzawa, Masako Hagihara, Takashi Yamamoto, Hiroyuki Matsueda, Seiji Ohno, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei
  • SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
    Publication number: 20160244451
    Abstract: Provided is a sulfonamide derivative represented by the following general formula (1) and having an ?4 integrin inhibitory effect with high selectivity with a low effect on ?4?1 and a high effect on ?4?7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).
    Type: Application
    Filed: April 29, 2016
    Publication date: August 25, 2016
    Applicant: Ajinomoto Co., Inc.
    Inventors: Hirokazu UENO, Takashi YAMAMOTO, Tomoko MIYAZAWA, Kenji SHINKAI, Harumi ARISAKA, Toshiyuki TAKANOHASHI
  • Lactam compounds and pharmaceutical use thereof
    Publication number: 20060189597
    Abstract: An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
    Type: Application
    Filed: April 6, 2006
    Publication date: August 24, 2006
    Applicant: Ajinomoto Co., Inc.
    Inventors: Yukio Ilno, Takao Ikenoue, Nobuo Kondo, Hiroyuki Matsueda, Toshihiro Hatanaka, Ryusuke Hirama, Yoko Masuzawa, Fumio Ohta, Akiyo Yamazaki, Seiji Niwa, Takashi Yamamoto
  • Heterocyclic compounds and medical use thereof
    Publication number: 20020133005
    Abstract: The present invention provides an AP-1 activation inhibitor, a NF-kappaB activation inhibitor, an inflammatory cytokine production inhibitor, a production inhibitor for matrix metalloprotease or an inflammatory cell adhesion factor expression inhibitor, which contains a heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: December 31, 2001
    Publication date: September 19, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Yukio Iino, Koichi Fujita, Ariko Kodaira, Toshihiro Hatanaka, Kenji Takehana, Tsuyoshi Kobayashi, Atsushi Konishi, Takashi Yamamoto
  • Biscyclopropanecarboxamide compounds and pharmaceutical use thereof
    Publication number: 20020161053
    Abstract: The present invention discloses biscyclopropanecarboxamide compounds and pharmaceutically acceptable salts thereof; and also NF-kappa B activation inhibitors, Inflammatory cytokine production inhibitors, matrix metalloprotease production inhibitors, inflammatory cell adhesion molecules incidence inhibitors, antiinflammatory agents, antirheumatic agents, immunosuppressive agents, cancerous metastasis inhibitors or antiviral agents each containing such a compound as the active ingredient.
    Type: Application
    Filed: March 1, 2002
    Publication date: October 31, 2002
    Applicant: AJINOMOTO CO. INC.
    Inventors: Yukio Iino, Kohichi Fujita, Takashi Yamamoto, Kenji Takehana, Tsuyoshi Kobayashi
  • Curdlan sulfate
    Patent number: 5512672
    Abstract: A beta-1,3-glucan of sulfated curdlan having a sulfur content of 12.4 to 17% and an average molecular weight of 27,000 to 330,000 daltons. Sulfate curdlan exhibits strong HIV inhibitory activity with little anticoagulant activity and little toxicity.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: April 30, 1996
    Assignees: Ajinomoto Co., Inc., Fujirebio, Inc.
    Inventors: Naoki Yamamoto, Hideki Nakashima, Toshiyuki Uryu, Takashi Yoshida, Kei Matsuzaki, Yutaro Kaneko, Toru Mimura
  • Lactam compounds and pharmaceutical use thereof
    Patent number: 7326701
    Abstract: An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: February 5, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yukio Iino, Takao Ikenoue, Nobuo Kondo, Hiroyuki Matsueda, Toshihiro Hatanaka, Ryusuke Hirama, Yoko Masuzawa, Fumio Ohta, Akiyo Yamazaki, Seiji Niwa, Takashi Yamamoto
  • Process for producing piperidinecarboxylic acid amide derivatives
    Patent number: 6207834
    Abstract: A process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them, which comprises the step of reacting a 2-oxazoline compound with a piperidine derivative in the presence of an acid is provided. This process is an industrially excellent process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: March 27, 2001
    Assignee: Ajinomoto Co., Inc.
    Inventors: Isao Arai, Takashi Yamamoto, Hirokazu Naora
  • POLY(AMINO ACID) COMPOUND HAVING INHIBITORY ACTIVITY ON ABSORPTION OF PHOSPHORUS AND PHOSPHORUS ABSORPTION INHIBITOR
    Publication number: 20100093973
    Abstract: Herein disclosed is a water-soluble compound represented by the following general formula (I) or a salt thereof. The compound is a novel water-soluble compound having an inhibitory effect on the absorption of phosphorus in vivo. where the structural variables are defined herein.
    Type: Application
    Filed: August 27, 2009
    Publication date: April 15, 2010
    Applicant: AJINOMOTO CO., INC.
    Inventors: Tadakiyo Nakagawa, Hironobu Tsugeno, Naomi Matsutani, Masayuki Sugiki, Haruko Hirashima, Tatsuya Okuzumi, Tatsuya Kasahara, Wataru Miyanaga, Takashi Yamamoto, Masatsugu Noguchi, Kayo Matsumoto, Hideyuki Tanaka, Tomoyuki Konda
  • Process for producing piperidinecarboxylic acid amide derivatives
    Patent number: 6355804
    Abstract: A process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them, which comprises the step of reacting a 2-oxazoline compound with a piperidine derivative in the presence of an acid is provided. This process is an industrially excellent process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: March 12, 2002
    Assignee: Ajinomoto Co., Inc.
    Inventors: Isao Arai, Takashi Yamamoto, Hirokazu Naora
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