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  • MIR27B IS A NOVEL TARGET FOR TREATMENT OF LIVER FIBROSIS
    Publication number: 20130150428
    Abstract: Methods are provided for treating fibrosis of a tissue, including fibrosis of the liver, using combinations of antagomirs and/or locked nucleic acids. Compositions therefor are also provided.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 13, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Albert Einstein College of Medicine of Yeshiva University
  • METHODS FOR QUANTITATIVE ASSESSMENT OF VOLUMETRIC IMAGE FROM A SUBJECT AND USES THEROF
    Publication number: 20130223714
    Abstract: Methods and systems are disclosed for assessing a quantitative image volume from an individual subject comprising comparing the image from the subject to images from a control group of subjects using voxel-wise comparison. The methods allow detection of pathologies or lesions in the individual subject being assessed.
    Type: Application
    Filed: February 25, 2013
    Publication date: August 29, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Albert Einstein College of Medicine of Yeshiva University
  • MODULATION OF AMINO ACID METABOLISM IN THE HYPOTHALAMUS
    Publication number: 20130209433
    Abstract: Methods for reducing peripheral blood glucose levels, food intake, glucose production, gluconeogenesis, triglyceride levels, and low density lipoprotein (VLDL) levels in mammals are provided. Also provided are methods of increasing glucose production and food intake in mammals. Further provided are methods of treating a disorder selected from the group consisting of obesity, type 2 diabetes, type 1 diabetes, hyperglycemia, insulin resistance, glucose intolerance, leptin resistance, metabolic syndrome, heart failure, ischemia, coronary heart disease, familial lipoprotein lipase deficiency, hypopituitarism, hyperlipidemia, hypertriglyceridemia, hyper-VLDLemia, atherosclerosis, hypercholesterolemia, hypertension, and any combination of the foregoing. The methods involve manipulations of amino acid presence or metabolism in the hypothalamus of the mammal.
    Type: Application
    Filed: December 12, 2012
    Publication date: August 15, 2013
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Albert Einstein College of Medicine of Yeshiva University
  • Purified human CSF-1
    Patent number: 5792450
    Abstract: The present invention relates to the purification of proteins, to the products of such purification, and to DNA probes constructed therefrom. More specifically, the invention relates to the purification and sequencing of murine and human colony stimulating factor-1 (CSF-1).
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: August 11, 1998
    Assignees: Chiron Corporation, Albert Einstein College of Medicine
    Inventors: Kenneth J. Wilson, E. Richard Stanley, Albert Boosman, Mary Kim Warren, James E. Strickler, Judit Csejtey
  • Bloodbag and method of making same
    Patent number: 5300059
    Abstract: The interior surface of a container, such as a bloodbag, is primed and subsequently coated with a time-releasable viricide against HIV absorbed in a hydrogel polymer. The viricides of this invention are derivatives of urea, and upon release into the blood, have no adverse effects on the red blood cell functions of the blood.
    Type: Grant
    Filed: November 19, 1991
    Date of Patent: April 5, 1994
    Assignees: Hydro Slip Technologies Inc., Albert Einstein College of Medicine
    Inventors: Arye Rubinstein, Albert Goldstein, Howard I. Podell
  • ALTERNATIVELY SPLICED mRNA ISOFORMS AS PROGNOSTIC INDICATORS FOR METASTATIC CANCER
    Publication number: 20140066319
    Abstract: The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
    Type: Application
    Filed: February 24, 2012
    Publication date: March 6, 2014
    Applicants: Massachusetts Institute of Technology, Montefiore Medical Center, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Frank B. Gertler, Christopher Boyce Burge, Irina M. Shapiro, Wu Albert Cheng, John S. Condeelis, Maja H. Oktay
  • Alternatively spliced mRNA isoforms as prognostic indicators for metastatic cancer
    Patent number: 9926601
    Abstract: The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 27, 2018
    Assignees: Massachusetts Institute of Technology, Montefiore Medical Center, Albert Einstein College of Medicine, Inc.
    Inventors: Frank B. Gertler, Christopher Boyce Burge, Irina M. Shapiro, Wu Albert Cheng, John S. Condeelis, Maja H. Oktay
  • NUCLEIC ACID-SCAFFOLDED SMALL MOLECULE LIBRARIES
    Publication number: 20160266133
    Abstract: Methods and compositions are provided for identifying novel ligands for a protein target.
    Type: Application
    Filed: October 28, 2014
    Publication date: September 15, 2016
    Applicant: Albert Einstein College of Medicine, Inc.
    Inventor: Matthew Levy
  • RESIDUE-BASED PHARMACOPHORE METHOD FOR IDENTIFYING COGNATE PROTEIN LIGANDS
    Publication number: 20190369097
    Abstract: A system and a method for identifying a cognate ligand molecules for known proteins.
    Type: Application
    Filed: January 4, 2017
    Publication date: December 5, 2019
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
    Inventors: Andras Fiser, Enghui Yap
  • MICROBIAL HYPERSWARMERS AND USES THEREOF
    Publication number: 20220080002
    Abstract: Bacterial hyperswarmers are disclosed for treatment, prevention and diagnosis of conditions such as intestinal inflammation.
    Type: Application
    Filed: October 8, 2021
    Publication date: March 17, 2022
    Applicant: Albert Einstein College of Medicine
    Inventors: Sridhar Mani, Libusha Kelly, Hao Li
  • MICROBIAL HYPERSWARMERS AND USES THEREOF
    Publication number: 20180289753
    Abstract: Bacterial hyperswarmers are disclosed for treatment, prevention and diagnosis conditions such as intestinal inflammation.
    Type: Application
    Filed: September 21, 2016
    Publication date: October 11, 2018
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
    Inventors: Sridhar Mani, Libusha Kelly, Hao Li
  • PISTON DEVICE FOR MAGNETIC RESONANCE ELASTOGRAPHY AND USES THEREOF
    Publication number: 20160287130
    Abstract: Disclosed are piston actuator devices and their uses for magnetic resonance elastography (MRE).
    Type: Application
    Filed: March 31, 2016
    Publication date: October 6, 2016
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
    Inventor: Mark Elliot Wagshul
  • METHOD FOR MEASURING DNA METHYLATION PROFILES
    Publication number: 20140329692
    Abstract: Methods are provided for determining epimutations in a nucleic acid sequence of a cell.
    Type: Application
    Filed: April 16, 2014
    Publication date: November 6, 2014
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Jan Vijg, Silvia Gravina
  • Method of rapid isolation of aptamer beacons
    Patent number: 10144926
    Abstract: Methods and compositions are provided for rapidly identifying novel structure-switching aptamers.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: December 4, 2018
    Assignee: Albert Einstein College of Medicine, Inc.
    Inventors: Matthew Levy, Simon G. Trevino
  • MONOCLONAL ANTIBODIES AGAINST HUMAN TIM-3
    Publication number: 20210198357
    Abstract: Provided are anti-human Tim-3 IgV domain-specific antibodies and fragments thereof, as well as methods of use employing such antibodies and/or fragments.
    Type: Application
    Filed: August 21, 2019
    Publication date: July 1, 2021
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventor: Xingxing ZANG
  • Piston device for magnetic resonance elastography and uses thereof
    Patent number: 10694973
    Abstract: Disclosed are piston actuator devices and their uses for magnetic resonance elastography (MRE).
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: June 30, 2020
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventor: Mark Elliott Wagshul
  • BAX ACTIVATORS AND USES THEREOF IN CANCER THERAPY
    Publication number: 20220313665
    Abstract: Activators of BAX and their uses in cancer therapy are disclosed.
    Type: Application
    Filed: June 7, 2022
    Publication date: October 6, 2022
    Applicant: Albert Einstein College of Medicine
    Inventors: Evripidis Gavathiotis, Denis E. Reyna, Felix Kopp, Ulrich Steidl
  • TREATMENT OF OBESITY AND PULMONARY ARTERIAL HYPERTENSION
    Publication number: 20160113933
    Abstract: Disclosed are methods and compositions for treating pulmonary arterial hypertension and/or obesity using inhibitors of prostaglandin transporter (PGT) activity.
    Type: Application
    Filed: June 17, 2014
    Publication date: April 28, 2016
    Applicant: Albert Einstein College of Medicine, Inc.
    Inventors: Victor L. Schuster, Yuling Chi
  • Residue-based pharmacophore method for identifying cognate protein ligands
    Patent number: 11435355
    Abstract: A system and a method for identifying a cognate ligand molecules for known proteins.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: September 6, 2022
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventors: Andras Fiser, Enghui Yap
  • Therapeutic weight transfer sling
    Patent number: D377833
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: February 4, 1997
    Assignee: Albert Einstein Healthcare Network
    Inventor: L. Matthew Schwartz
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