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  • C-TYPE NATRIURETIC PEPTIDE ENGRAFTED ANTIBODIES
    Publication number: 20210079056
    Abstract: The present invention relates to an antibody or a fragment thereof comprising at least one heterologous amino acid sequence incorporated within at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Ntls), a C-Type Natriuretic Peptide (CNP) and a C-terminal linker sequence (Ctls). Optionally, at least a portion of said at least one CDR region is replaced by said at least one heterologous amino acid sequence incorporated therein. The present invention further relates to such antibody or fragment thereof for use in a method for treatment, a composition comprising such antibody or fragment thereof, a nucleic acid or a mixture of nucleic acids encoding such antibody or fragment thereof, a host cell comprising such nucleic acid or such mixture of nucleic acids and to a process for producing such antibody or fragment thereof.
    Type: Application
    Filed: April 10, 2019
    Publication date: March 18, 2021
    Applicant: Bayer Aktiengesellschaft
    Inventors: Damian BROCKSCHNIEDER, Lucas Hudson HOFMEISTER, Claudia NOACK, Jan TEBBE, Stuart WALSH, Andreas WILMEN, Frank WUNDER
  • Method for Controlling a Hydraulic System and Hydraulic Control System
    Publication number: 20230332630
    Abstract: A method for controlling a hydraulic system of a machine having a machine control system is disclosed. The hydraulic system includes at least one hydraulic output having an output element which can be controlled by way of activation variables and whose state can be described by state variables. The method includes registering the at least one hydraulic output, wherein registration data of the at least one hydraulic output is captured, wherein the registration data includes data concerning the activation variables and the state variables, and wherein the state variables include output state variables which describes the state of the output element of the at least one hydraulic output. The method further includes transmitting one or more data concerning the output state variables of the at least one hydraulic output to the machine control system.
    Type: Application
    Filed: April 10, 2023
    Publication date: October 19, 2023
    Inventors: Andreas Guender, Henning Noack, Jan Lukas Bierod, Marc Weigand
  • METHOD FOR PREPARATION OF HOMOGENOUS CATALYST FOR SELECTIVE 1-HEXENE PRODUCTION
    Publication number: 20190314798
    Abstract: A method for preparing a homogenous catalyst for the production of linear alpha olefins includes: preparing a first pre-catalyst solution comprising a modifier and an organoaluminum compound in a first solvent wherein the first pre-catalyst solution is reacted and stored in a first vessel for a period of time of 1 hour to 90 days; preparing a second pre-catalyst solution comprising a second solvent, a ligand, and a chromium containing compound, wherein the second pre-catalyst solution is stored in a second vessel for a period of time of 1 hour to 90 days; and after a period of time, adding the first pre-catalyst solution to a catalyst pre-formation unit; after the same period of time, adding the second pre-catalyst solution to the catalyst pre-formation unit; forming a homogenous catalyst by mixing the first pre-catalyst solution and the second pre-catalyst solution; adding the homogeneous catalyst to a reaction vessel, wherein the reaction vessel comprises an alpha olefin; and forming the linear alpha olefin
    Type: Application
    Filed: December 21, 2017
    Publication date: October 17, 2019
    Inventors: Abdullah Saad Al-Dughaither, Shahid Azam, Abdulmajeed Mohammed Al-Hamdan, Dafer Mubarak Alshahrani, Sebastiano Licciulli, Anina Wohl, Wolfgang Muller, Heinz Bolt, Andreas Meiswinkel, Tobias Meier, Ralf Noack
  • ATRIAL NATRIURETIC PEPTIDE ENGRAFTED ANTIBODIES
    Publication number: 20210139555
    Abstract: The present invention relates to an antibody or a fragment thereof comprising at least one heterologous amino acid sequence incorporated within at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Nils), an Atrial Natriuretic Peptide (ANP) and a C-terminal linker sequence (Ctls). Optionally, at least a portion of said at least one CDR region is replaced by said at least one heterologous amino acid sequence incorporated therein. The present invention further relates to such antibody or fragment thereof for use in a method for treatment, a composition comprising such antibody or fragment thereof, a nucleic acid or a mixture of nucleic acids encoding such antibody or fragment thereof, a host cell comprising such nucleic acid or such mixture of nucleic acids and to a process for producing such antibody or fragment thereof.
    Type: Application
    Filed: April 10, 2019
    Publication date: May 13, 2021
    Applicant: Bayer Aktiengesellschaft
    Inventors: Anke MAYER-BARTSCHMID, Damian BROCKSCHNIEDER, Marcel GEERTZ, Simone GREVEN, Lucas Hudson HOFMEISTER, Hannah JÖRISSEN, Christoph MAHLERT, Tobias MARQUARDT, Ilka MATHAR, Thomas MONDRITZKI, Claudia NOACK, Jan TEBBE, Stuart WALSH, Ernst WEBER, Andreas WILMEN, Frank WUNDER
  • Method for preparation of homogenous catalyst for selective 1-hexene production
    Patent number: 11331655
    Abstract: A method for preparing a homogenous catalyst for the production of linear alpha olefins includes: preparing a first pre-catalyst solution comprising a modifier and an organoaluminum compound in a first solvent wherein the first pre-catalyst solution is reacted and stored in a first vessel for a period of time of 1 hour to 90 days; preparing a second pre-catalyst solution comprising a second solvent, a ligand, and a chromium containing compound, wherein the second pre-catalyst solution is stored in a second vessel for a period of time of 1 hour to 90 days; and after a period of time, adding the first pre-catalyst solution to a catalyst pre-formation unit; after the same period of time, adding the second pre-catalyst solution to the catalyst pre-formation unit; forming a homogenous catalyst by mixing the first pre-catalyst solution and the second pre-catalyst solution; adding the homogeneous catalyst to a reaction vessel, wherein the reaction vessel comprises an alpha olefin; and forming the linear alpha olefin
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: May 17, 2022
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Abdullah Saad Al-Dughaither, Shahid Azam, Abdulmajeed Mohammed Al-Hamdan, Dafer Mubarak Alshahrani, Sebastiano Licciulli, Anina Wohl, Wolfgang Muller, Heinz Bolt, Andreas Meiswinkel, Tobias Meier, Ralf Noack
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