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  • Brain implant device
    Patent number: 8862235
    Abstract: A brain implant device includes a housing containing communication and control electronics coupled to a conduit configured for monitoring signals from a brain's motor cortex and providing stimulation signals to the brain's sensory cortex. The brain implant device is capable of wireless communication with an external communication and control signal source by means of an antenna provided in the housing. The conduit is flexible and may contain upwards of 128 electrical conductors providing electrical connections between the device electronics and related sites on the motor and/or sensory cortex by means of a plurality of electrically conductive protuberances extending from the conduit and adapted for contact with such sites.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: October 14, 2014
    Assignee: Alfred E. Mann Foundation for Scientific Research
    Inventors: Howard H. Stover, John C. Gord, Charles L. Byers, Joseph H. Schulman, Guangqiang Jiang, Ross Davis
  • Brain implant device
    Patent number: 9622677
    Abstract: A brain implant device includes a housing containing communication and control electronics coupled to a conduit configured for monitoring signals from a brain's motor cortex and providing stimulation signals to the brain's sensory cortex. The brain implant device is capable of wireless communication with an external communication and control signal source by means of an antenna provided in the housing. The conduit is flexible and may contain upwards of 128 electrical conductors providing electrical connections between the device electronics and related sites on the motor and/or sensory cortex by means of a plurality of electrically conductive protuberances extending from the conduit and adapted for contact with such sites.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: April 18, 2017
    Assignee: Alfred E. Mann Foundation for Scientific Research
    Inventors: Howard H. Stover, John C. Gord, Charles L. Byers, Joseph H. Schulman, Guangqiang Jiang, Ross Davis
  • DEEP BRAIN STIMULATION IMPLANT WITH MICROCOIL ARRAY
    Publication number: 20090254146
    Abstract: An implant for deep brain stimulation (DBS) has an array of electromagnetic microcoils dispersed over the length of the implant. The microcoils produce magnetic fields that are directed into, and induce current in, the adjacent brain tissue. The microcoils may be selectively operated to direct and focus electrical stimulation to targeted areas of the brain. The implant is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain such as Parkinson's disease, drug addiction, and depression.
    Type: Application
    Filed: April 3, 2009
    Publication date: October 8, 2009
    Inventors: Giorgio Bonmassar, Matti S. Hamalainen, Bruce Rosen
  • Deep brain stimulation implant with microcoil array
    Patent number: 8944985
    Abstract: An implant for deep brain stimulation (DBS) has an array of electromagnetic microcoils dispersed over the length of the implant. The microcoils produce magnetic fields that are directed into, and induce current in, the adjacent brain tissue. The microcoils may be selectively operated to direct and focus electrical stimulation to targeted areas of the brain. The implant is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain such as Parkinson's disease, drug addiction, and depression.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: February 3, 2015
    Assignee: The General Hospital Corporation
    Inventors: Giorgio Bonmassar, Matti S. Hamalainen, Bruce Rosen
  • Systems and methods of multi-implant patterned brain imaging and stimulation
    Patent number: 11412932
    Abstract: The present disclosure is directed to instruments and methods that provide one or more stimulations with multiple fibers and multiple imaging implants inserted in a subject for capturing images from one or more regions of the subject's brain. The microendoscope can include a single spatial light modulator or multiple spatial light modulators, a furcated imaging fiber bundle with multiple fibers, multi-implants coupled to a subject for multi-implant patterned brain imaging and stimulation. Both the single spatial light modulator and multiple spatial light modulators are capable to project optical patterns to different imaging fibers and thereby stimulate multiple regions of the brain.
    Type: Grant
    Filed: November 18, 2018
    Date of Patent: August 16, 2022
    Assignee: PHOTONEDGE, INC.
    Inventor: Song Peng
  • Biodegradable Implant for Sustained Trans-Nasal Delivery of Therapeutic Agents to the Brain
    Publication number: 20210378947
    Abstract: A method of delivering a therapeutic agent into the central nervous system through the blood-brain barrier includes implanting an implant within the submucosal space of the olfactory epithelium. The implant can provide sustained drug delivery to the brain. The implant can be placed using a minimally invasive surgical approach.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 9, 2021
    Inventors: Mansoor M. AMIJI, Smrithi PADMAKUMAR, Benjamin S. BLEIER
  • PIVOTING SURGICAL IMPLANT PLACEMENT TOOL
    Publication number: 20230157779
    Abstract: Disclosed is a brain implant placement apparatus, which includes a base member contoured to rest against a cranium of a patient. The brain implant apparatus including a pivot arm hingedly coupled to the base member and configured to rotate from a first configuration to a second configuration. The brain implant placement apparatus including an implant attachment member coupled to the pivot arm via a rotating attachment mechanism and further comprising a receiving portion configured to removably couple with a brain implant and rotate the brain implant. In the first configuration, the pivot arm is positioned such that the receiving portion of the implant attachment member is facing upward. In the second configuration, the pivot arm is positioned such that the receiving portion of the implant attachment member is facing substantially downwards.
    Type: Application
    Filed: November 19, 2021
    Publication date: May 25, 2023
    Applicant: Neuralink Corp.
    Inventors: Russell N. Ohnemus, Robin E. Young
  • SYSTEMS AND METHODS FOR REDUCING SCAR FORMATION ABOUT A NEURAL IMPLANT
    Publication number: 20160354034
    Abstract: Systems, devices, and methods are provided for reducing scar formation about a neural implant due to brain tissue and neural implant movement. In an embodiment, a neural implant is provided which has a surface coating that matches one or more mechanical properties, such as elastic modulus, of the brain tissue, thereby reduce scar formation about the neural implant due to normal brain micromotion.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 8, 2016
    Inventors: Kevin C. Spencer, Jay Christopher Sy, Michael J. Cima
  • Surgical implant and method of accessing cerebrospinal fluid
    Publication number: 20050027234
    Abstract: A surgical implant and method of gaining access to cerebrospinal fluid in the brain. The implant includes an upper housing part which is positioned subcutaneously on the skull and a lower cage-like member which depends downwardly from the housing part. The housing part defines a chamber or reservoir therein which communicates with openings defined in the lower member. The implant is embedded between portions of the brain so that the lower member projects between the cerebellum and the cerebrum and holds same apart in order to access cerebrospinal fluid which pools in this area. The cerebrospinal fluid is accessed for sampling or dosing purposes through a septum provided within the upper housing part.
    Type: Application
    Filed: June 17, 2004
    Publication date: February 3, 2005
    Inventors: Donna Waggoner, Allen Buhl, Steven Kuhlman, Matthew Flegal
  • Implant compositions for the unidirectional delivery of therapeutic compounds to the brain
    Patent number: 9956172
    Abstract: The present invention provides, in some aspects, bilayered and trilayered pharmaceutical implant compositions for the unidirectional delivery of anti-cancer compounds to the brain over a period of time (e.g., several weeks, 1, 2, 3, 4, 5, 6, 7 days, or 1, 2, 3, weeks, or any range derivable therein) following the removal of glioblastoma multiforme or other malignant tumors in the brain.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: May 1, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael J. McGinity, Feng Zhang, John R. Floyd, James W. McGinity
  • Implant compositions for the unidirectional delivery of therapeutic compounds to the brain
    Patent number: 10434063
    Abstract: The present invention provides, in some aspects, bilayered and trilayered pharmaceutical implant compositions for the unidirectional delivery of anti-cancer compounds to the brain over a period of time (e.g., several weeks, 1, 2, 3, 4, 5, 6, 7 days, or 1, 2, 3, weeks, or any range derivable therein) following the removal of glioblastoma multiforme or other malignant tumors in the brain.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: October 8, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael J. McGinity, Feng Zhang, John R. Floyd, James W. McGinity
  • IMPLANT COMPOSITIONS FOR THE UNIDIRECTIONAL DELIVERY OF THERAPEUTIC COMPOUNDS TO THE BRAIN
    Publication number: 20200138707
    Abstract: The present invention provides, in some aspects, bilayered and trilayered pharmaceutical implant compositions for the unidirectional delivery of anti-cancer compounds to the brain over a period of time (e.g., several weeks, 1, 2, 3, 4, 5, 6, 7 days, or 1, 2, 3, weeks, or any range derivable therein) following the removal of glioblastoma multiforme or other malignant tumors in the brain.
    Type: Application
    Filed: October 4, 2019
    Publication date: May 7, 2020
    Applicant: Board of Regents, the University of Texas System
    Inventors: Michael J. McGINITY, Feng ZHANG, John R. FLOYD, James W. McGINITY
  • IMPLANT COMPOSITIONS FOR THE UNIDIRECTIONAL DELIVERY OF THERAPEUTIC COMPOUNDS TO THE BRAIN
    Publication number: 20170027864
    Abstract: The present invention provides, in some aspects, bilayered and trilayered pharmaceutical implant compositions for the unidirectional delivery of anti-cancer compounds to the brain over a period of time (e.g., several weeks, 1, 2, 3, 4, 5, 6, 7 days, or 1, 2, 3, weeks, or any range derivable therein) following the removal of glioblastoma multiforme or other malignant tumors in the brain.
    Type: Application
    Filed: July 28, 2016
    Publication date: February 2, 2017
    Applicant: Board of Regents, the University of Texas System
    Inventors: Michael J. McGINITY, Feng ZHANG, John R. FLOYD, James W. McGINITY
  • Implant compositions for the unidirectional delivery of therapeutic compounds to the brain
    Patent number: 11229599
    Abstract: The present invention provides, in some aspects, bilayered and trilayered pharmaceutical implant compositions for the unidirectional delivery of anti-cancer compounds to the brain over a period of time (e.g., several weeks, 1, 2, 3, 4, 5, 6, 7 days, or 1, 2, 3, weeks, or any range derivable therein) following the removal of glioblastoma multiforme or other malignant tumors in the brain.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: January 25, 2022
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael J. McGinity, Feng Zhang, John R. Floyd, James W. McGinity
  • IMPLANT COMPOSITIONS FOR THE UNIDIRECTIONAL DELIVERY OF THERAPEUTIC COMPOUNDS TO THE BRAIN
    Publication number: 20180311157
    Abstract: The present invention provides, in some aspects, bilayered and trilayered pharmaceutical implant compositions for the unidirectional delivery of anti-cancer compounds to the brain over a period of time (e.g., several weeks, 1, 2, 3, 4, 5, 6, 7 days, or 1, 2, 3, weeks, or any range derivable therein) following the removal of glioblastoma multiforme or other malignant tumors in the brain.
    Type: Application
    Filed: March 21, 2018
    Publication date: November 1, 2018
    Applicant: Board of Regents, the University of Texas System
    Inventors: Michael J. McGINITY, Feng ZHANG, John R. FLOYD, James W. McGINITY
  • Systems and methods of rotation compensation for brain optical imaging and stimulation
    Patent number: 11944270
    Abstract: Embodiments of the present disclosure are directed to microendoscope instruments and methods that allows the imaging fiber to freely rotate with the animal while capturing images and projecting stimulation patterns with correct orientations. The microendoscope includes a first spatial light modulator for sourcing a first light source and generating a stimulated pattern to a fiber coupled to an imaging implant for attaching to the brain of the subject. A rotary joint is disposed between the microendoscope and the imaging implant to facilitate the movements and rotations of the imaging implant that is attached to the subject, thereby provides an essentially frictionless contact to brain of the subject so that the subject can freely moves and rotates without feeling the cumbersome imaging implant and fiber that are attached to the subject. A camera captures images obtained from the imaging implant with the specimen taken from the subject.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: April 2, 2024
    Inventor: Song Peng
  • APPARATUS AND METHOD FOR BRAIN FIBER BUNDLE MICROSCOPY
    Publication number: 20150265153
    Abstract: An intracranial implant to position a fiber bundle to a specified region of a brain of an animal. The implant may include a base support to be fixed to a skull of the animal over an orifice drilled in the skull, a hollow conduit arranged through the base support to guide the fiber bundle to the brain of the animal through the drilled orifice and a first locking member arranged on the base support, to cooperate with a ferrule of the fiber bundle, the first locking member configured to lock the fiber bundle to the specified region of the brain of the animal.
    Type: Application
    Filed: June 5, 2015
    Publication date: September 24, 2015
    Applicant: Mauna Kea Technologies
    Inventors: Nicolas Boularot, Arnaud Cressant
  • Stereotaxic brain implant system for large animals
    Patent number: 10251722
    Abstract: A stereotactic system with customizable and interoperable components for implantation of intracranial implants is provided. The stereotactic system can include a NeuroHat stereotactic device that attaches directly to the skull of an animal subject to protect chronic intracranial implants without interfering with the normal activities of the animal subject. The stereotactic system can also include a drill guide for accurate placement of burr holes and implant shuttles designed to be interoperable with other components of the NeuroHat stereotactic device for accurate placement and secureability.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: April 9, 2019
    Assignee: The Florida International University Board of Trustees
    Inventors: Timothy Allen, Adam Draper, Aaron Mattfeld
  • Apparatus and method for brain fiber bundle microscopy
    Patent number: 9730586
    Abstract: An intracranial implant to position a fiber bundle to a specified region of a brain of an animal. The implant may include a base support to be fixed to a skull of the animal over an orifice drilled in the skull, a hollow conduit arranged through the base support to guide the fiber bundle to the brain of the animal through the drilled orifice and a first locking member arranged on the base support, to cooperate with a ferrule of the fiber bundle, the first locking member configured to lock the fiber bundle to the specified region of the brain of the animal.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: August 15, 2017
    Assignee: Mauna Kea Technologies
    Inventors: Nicolas Boularot, Arnaud Cressant
  • KINETIC INTELLIGENT WIRELESS IMPLANT/NEURONS ON AUGMENTED HUMAN
    Publication number: 20210263589
    Abstract: Embodiments may provide a general-purpose, relatively inexpensive, AI-driven implant that is able to adapt to and modulate any given region in the brain. For example, in an embodiment, an implant device adapted to be implanted within a body of a person for interacting with brain tissue may comprise a plurality of fibers adapted to receive electrical and optical signals from electrophysiological neural signals of the brain tissue and to transmit electrical and optical signals to provide electrophysiological stimulation of the brain tissue, the fibers electrically and optically coupled to at least one readout integrated circuit.
    Type: Application
    Filed: February 14, 2021
    Publication date: August 26, 2021
    Inventor: Newton Howard
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