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  • AVIAN ONCOLYTIC VIRUS HAVING MODIFIED SEQUENCES AND USES THEREOF
    Publication number: 20200190538
    Abstract: The present disclosure relates to one or more modified avian-virus based agents, therapies, treatments, and methods of use of the modified avian-virus based agents and/or therapies and/or treatments for cancer. The disclosure also provides for methods of generating modified avian-virus based agents.
    Type: Application
    Filed: December 14, 2018
    Publication date: June 18, 2020
    Inventors: Robert KOZAK, Byram BRIDLE, Eva NAGY, Bradley THOMPSON
  • Method of Vaccination Comprising a Histone Deacetylase Inhibitor
    Publication number: 20180064805
    Abstract: A vaccination method is provided. The method comprises administering to a mammal a histone deacytelase inhibitor in conjunction with a vaccine that expresses an antigen to which the mammal has a pre-existing immunity.
    Type: Application
    Filed: October 16, 2017
    Publication date: March 8, 2018
    Inventors: Byram Bridle, Brian Lichty, Yonghong Wan, Jean-Simon Diallo, Chantal Lemay, John Bell
  • Avian oncolytic virus having modified sequences and uses thereof
    Patent number: 10829786
    Abstract: The present disclosure relates to one or more modified avian-virus based agents, therapies, treatments, and methods of use of the modified avian-virus based agents and/or therapies and/or treatments for cancer. The disclosure also provides for methods of generating modified avian-virus based agents.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: November 10, 2020
    Assignee: ARV Pharma Inc.
    Inventors: Robert Kozak, Byram Bridle, Eva Nagy, Bradley Thompson
  • METHOD OF VACCINATION COMPRISING A HISTONE DEACETYLASE INHIBITOR
    Publication number: 20140193458
    Abstract: A vaccination method is provided. The method comprises administering to a mammal a histone deacytelase inhibitor in conjunction with a vaccine that expresses an antigen to which the mammal has a pre-existing immunity.
    Type: Application
    Filed: March 9, 2012
    Publication date: July 10, 2014
    Inventors: Byram Bridle, Brian Lichty, Yonghong Wan, Jean-Simon Diallo, Chantal Lemay, John Bell
  • Method of vaccination comprising a histone deacetylase inhibitor
    Patent number: 9821054
    Abstract: A vaccination method is provided. The method comprises administering to a mammal a histone deacytelase inhibitor in conjunction with a vaccine that expresses an antigen to which the mammal has a pre-existing immunity.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: November 21, 2017
    Assignee: Turnstone Limited Partnership
    Inventors: Byram Bridle, Brian Lichty, Yonghong Wan, Jean-Simon Diallo, Chantal Lemay, John Bell
  • ENGINEERED NEWCASTLE DISEASE VIRUS VECTOR AND USES THEREOF
    Publication number: 20220396809
    Abstract: An engineered Newcastle Disease Virus (NDV) vector is provided. In particular, the present disclosure provides methods of treating or preventing a disease such as cancer, or an infectious disease, or methods for eliciting an immune response, with the engineered NDV vector. The engineered NDV vector provided herein is useful as an immunogenic composition, an oncolytic agent, or a vaccine.
    Type: Application
    Filed: June 3, 2022
    Publication date: December 15, 2022
    Inventors: Sarah Wootton, Leonardo Susta, Byram Bridle, Pierre Major, Lisa Santry, Yanlong Pei
  • VACCINATION METHODS
    Publication number: 20120014990
    Abstract: In one aspect, a method of treating cancer in a mammal is provided. The method comprises administering to the mammal an oncolytic vector that expresses a tumour antigen to which the mammal has a pre-existing immunity. In another aspect, a method of boosting immune response in a mammal having a pre-existing immunity to an antigen is provided comprising intravenous administration to the mammal of a B-cell infecting vector that expresses the antigen.
    Type: Application
    Filed: March 16, 2010
    Publication date: January 19, 2012
    Inventors: Brian Lichty, Byram Bridle, Yonghong Wan, Jonathan Bramson
  • Vaccination methods
    Patent number: 9707285
    Abstract: In one aspect, a method of treating cancer in a mammal is provided. The method comprises administering to the mammal an oncolytic vector that expresses a tumor antigen to which the mammal has a pre-existing immunity. In another aspect, a method of boosting immune response in a mammal having a pre-existing immunity to an antigen is provided comprising intravenous administration to the mammal of a B-cell infecting vector that expresses the antigen.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: July 18, 2017
    Assignee: Turnstone Limited Partnership
    Inventors: Brian Lichty, Byram Bridle, Yonghong Wan, Jonathan Bramson
  • Vaccination methods
    Patent number: 10925946
    Abstract: In one aspect, a method of treating cancer in a mammal is provided. The method comprises administering to the mammal an oncolytic vector that expresses a tumour antigen to which the mammal has a pre-existing immunity. In another aspect, a method of boosting immune response in a mammal having a pre-existing immunity to an antigen is provided comprising intravenous administration to the mammal of a B-cell infecting vector that expresses the antigen.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: February 23, 2021
    Assignee: Turnstone Limited Partnership
    Inventors: Brian Lichty, Byram Bridle, Yonghong Wan, Jonathan Bramson
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