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  • Publication number: 20200190538
    Abstract: The present disclosure relates to one or more modified avian-virus based agents, therapies, treatments, and methods of use of the modified avian-virus based agents and/or therapies and/or treatments for cancer. The disclosure also provides for methods of generating modified avian-virus based agents.
    Type: Application
    Filed: December 14, 2018
    Publication date: June 18, 2020
    Inventors: Robert KOZAK, Byram BRIDLE, Eva NAGY, Bradley THOMPSON
  • Publication number: 20180064805
    Abstract: A vaccination method is provided. The method comprises administering to a mammal a histone deacytelase inhibitor in conjunction with a vaccine that expresses an antigen to which the mammal has a pre-existing immunity.
    Type: Application
    Filed: October 16, 2017
    Publication date: March 8, 2018
    Inventors: Byram Bridle, Brian Lichty, Yonghong Wan, Jean-Simon Diallo, Chantal Lemay, John Bell
  • Patent number: 10829786
    Abstract: The present disclosure relates to one or more modified avian-virus based agents, therapies, treatments, and methods of use of the modified avian-virus based agents and/or therapies and/or treatments for cancer. The disclosure also provides for methods of generating modified avian-virus based agents.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: November 10, 2020
    Assignee: ARV Pharma Inc.
    Inventors: Robert Kozak, Byram Bridle, Eva Nagy, Bradley Thompson
  • Publication number: 20140193458
    Abstract: A vaccination method is provided. The method comprises administering to a mammal a histone deacytelase inhibitor in conjunction with a vaccine that expresses an antigen to which the mammal has a pre-existing immunity.
    Type: Application
    Filed: March 9, 2012
    Publication date: July 10, 2014
    Inventors: Byram Bridle, Brian Lichty, Yonghong Wan, Jean-Simon Diallo, Chantal Lemay, John Bell
  • Patent number: 10925946
    Abstract: In one aspect, a method of treating cancer in a mammal is provided. The method comprises administering to the mammal an oncolytic vector that expresses a tumour antigen to which the mammal has a pre-existing immunity. In another aspect, a method of boosting immune response in a mammal having a pre-existing immunity to an antigen is provided comprising intravenous administration to the mammal of a B-cell infecting vector that expresses the antigen.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: February 23, 2021
    Assignee: Turnstone Limited Partnership
    Inventors: Brian Lichty, Byram Bridle, Yonghong Wan, Jonathan Bramson
  • Patent number: 9821054
    Abstract: A vaccination method is provided. The method comprises administering to a mammal a histone deacytelase inhibitor in conjunction with a vaccine that expresses an antigen to which the mammal has a pre-existing immunity.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: November 21, 2017
    Assignee: Turnstone Limited Partnership
    Inventors: Byram Bridle, Brian Lichty, Yonghong Wan, Jean-Simon Diallo, Chantal Lemay, John Bell
  • Patent number: 9707285
    Abstract: In one aspect, a method of treating cancer in a mammal is provided. The method comprises administering to the mammal an oncolytic vector that expresses a tumor antigen to which the mammal has a pre-existing immunity. In another aspect, a method of boosting immune response in a mammal having a pre-existing immunity to an antigen is provided comprising intravenous administration to the mammal of a B-cell infecting vector that expresses the antigen.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: July 18, 2017
    Assignee: Turnstone Limited Partnership
    Inventors: Brian Lichty, Byram Bridle, Yonghong Wan, Jonathan Bramson
  • Publication number: 20120014990
    Abstract: In one aspect, a method of treating cancer in a mammal is provided. The method comprises administering to the mammal an oncolytic vector that expresses a tumour antigen to which the mammal has a pre-existing immunity. In another aspect, a method of boosting immune response in a mammal having a pre-existing immunity to an antigen is provided comprising intravenous administration to the mammal of a B-cell infecting vector that expresses the antigen.
    Type: Application
    Filed: March 16, 2010
    Publication date: January 19, 2012
    Inventors: Brian Lichty, Byram Bridle, Yonghong Wan, Jonathan Bramson
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