Search Patents
  • ENCAPSULATED CANNABINOID FORMULATIONS FOR ORAL DELIVERY
    Publication number: 20190216869
    Abstract: Preparation of cannabinoid formulations containing: ?9-tetrahydrocannabinol (?9-THC), ?8-tetrahydrocannabinol (?8-THC), ?9-tetrahydrocannabinolic acid (THCa), cannabidiol (CBD), cannabidiolic acid (CBDa), cannabigerol (CBG), cannabichromene (CBC) and cannabinol (CBN), either alone or in combinations henceforth known as Cannabis, have been created using an emulsification process to encapsulate cannabinoids. The aqueous-based method involves micellular encapsulation of cannabinoids, a method that has been used to increase the bioavailability of poorly permeable, lipophilic drugs. These preparations demonstrates the viability of sublingual, buccal, or oral delivery using an aqueous-based encapsulation method, including as a beverage or drink.
    Type: Application
    Filed: January 11, 2019
    Publication date: July 18, 2019
    Applicant: Nutrae, LLC
    Inventors: Jacqueline L. Salm, Christopher G. Witowski
  • Medicinal cannabis fatty foodstuff
    Publication number: 20120043242
    Abstract: The invention is a product and a process wherein Medicinal Delta-9 tetrahydrocannabinol (?9-THC) and potentially other cannabinoids (medicinal cannabis substances) associated with decarboxylated cannabis, including yet not necessarily limited to cannbidiols, and cannabigerol are rendered into a fatty foodstuff and then molded into a mold that also acts as a package. The best mode of the invention is a blister pack containing a plurality of voids or receptacles of desired sizes. A product that is characterized by a controlled amount of medicinal cannabis per unit volume of a fatty foodstuff base material is inserted into the mold, then cooled, and finally sealed. Each void or receptacle contains a known amount of medicinal cannabis that are independently dispensable.
    Type: Application
    Filed: April 4, 2011
    Publication date: February 23, 2012
    Inventor: Andrew David Hospodor
  • ANTIBIOTIC CANNABINOID-TERPENE FORMULATIONS
    Publication number: 20230355573
    Abstract: Pharmaceutical formulations are provided that include at least two antibiotically active ingredients: a cannabinoid that is one or more of cannabichromene (CBC), cannabidiol (CBD) and/or cannabigerol (CBG); a sesquiterpene that is one or both of a-humulene and/or ?-caryophyllene; and a lipopeptide antibiotic that is daptomycin or an analogue thereof. The antibiotically active ingredients may be provided in relative amounts that amplify their individual activities, including amounts that are synergistically effective in an assay to inhibit growth and/or reproduction of an Enterococcus faecium or an Enterococcus faecalis. Therapies are provided that utilize these formulations as anti-microbials, and provide for the combined use of two or more of the antibiotically active compounds.
    Type: Application
    Filed: July 13, 2023
    Publication date: November 9, 2023
    Inventors: Charles J. Thompson, Mark C. Pryjma, Dana M. Lambert, Manisha Dosanjh
  • ANTIBIOTIC CANNABINOID-TERPENE FORMULATIONS
    Publication number: 20220233494
    Abstract: Pharmaceutical formulations are provided that include at least two antibiotically active ingredients: a cannabinoid that is one or more of cannabichromene (CBC), cannabidiol (CBD) and/or cannabigerol (CBG); a sesquiterpene that is one or both of a-humulene and/or ?-caryophyllene; and a lipopeptide antibiotic that is daptomycin or an analogue thereof. The antibiotically active ingredients may be provided in relative amounts that amplify their individual activities, including amounts that are synergistically effective in an assay to inhibit growth and/or reproduction of an Enterococcus faecium or an Enterococcus faecalis. Therapies are provided that utilize these formulations as anti-microbials, and provide for the combined use of two or more of the antibiotically active compounds.
    Type: Application
    Filed: January 31, 2022
    Publication date: July 28, 2022
    Inventors: Charles J. Thompson, Mark C. Pryjma, Dana M. Lambert, Manisha Dosanjh
  • Topical composition with active compounds from and for reduction of skin lesions
    Patent number: 11364273
    Abstract: Disclosed is a topical composition including essential combination of synergistically acting phyto-active materials, non-psychotropic phytocannabinoids from the plant of Cannabis sativa: Cannabidiol, Cannabidiolic acid, Cannabivarin Cannabigerol in combination with extract of Calendula flower and the formulation of the base to ensure the features of anti-inflammation, anti-oxidation, emollient, and bactericidal components. The topical composition is an emollient dedicated for reduction of skin lesions caused by atopic dermatitis, urticaria, radiotherapy and UV induced skin damage and acne. In addition the topical composition could reduce secretion of fats, facilitate deep skin hydration, reduce pores and exert soothing effect.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: June 21, 2022
    Assignee: UAB STAIMED
    Inventors: Juozas Siurkus, Rimantas Peciura
  • Antibiotic cannabinoid-terpene formulations
    Patent number: 11744819
    Abstract: Pharmaceutical formulations are provided that include at least two antibiotically active ingredients: a cannabinoid that is one or more of cannabichromene (CBC), cannabidiol (CBD) and/or cannabigerol (CBG); a sesquiterpene that is one or both of a-humulene and/or ?-caryophyllene; and a lipopeptide antibiotic that is daptomycin or an analogue thereof. The antibiotically active ingredients may be provided in relative amounts that amplify their individual activities, including amounts that are synergistically effective in an assay to inhibit growth and/or reproduction of an Enterococcus faecium or an Enterococcus faecalis. Therapies are provided that utilize these formulations as anti-microbials, and provide for the combined use of two or more of the antibiotically active compounds.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: September 5, 2023
    Assignee: The University of British Columbia
    Inventors: Charles J. Thompson, Mark C. Pryjma, Dana M. Lambert, Manisha Dosanjh
  • Anti-microbial composition comprising cannabinoids
    Patent number: 10441552
    Abstract: This invention discloses anti-bacterial and anti-fungal compositions in spray form, in cream form, in liquid form, and in powder form. The anti-bacterial and anti-fungal compositions comprise cannabinoids, specifically cannabidiol, cannabigerol, tetrahydrocannabinol, tetracannabidivarin, and/or cannabidivarin for anti-bacterial and anti-fungal activities. The anti-bacterial and anti-fungal compositions may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: October 15, 2019
    Assignee: Axim Biotechnologies, Inc.
    Inventors: George E. Anastassov, Lekhram Changoer, Philippus Anne Van Damme
  • Anti-microbial compositions comprising cannabinoids
    Patent number: 11058646
    Abstract: This invention discloses anti-bacterial and anti-fungal compositions in spray form, in cream form, in liquid form, and in powder form. The anti-bacterial and anti-fungal compositions comprise cannabinoids, specifically cannabidiol, cannabigerol, tetrahydrocannabinol, tetracannabidivarin, and/or cannabidivarin for anti-bacterial and anti-fungal activities. The anti-bacterial and anti-fungal compositions may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: July 13, 2021
    Assignee: APIRx Pharmaceutical USA, LLC
    Inventors: George E. Anastassov, Lekhram Changoer, Philippus Anne Van Damme
  • METHODS OF SYNTHESIZING CANNABIGERGOL, CANNABIGEROLIC ACID, AND ANALOGS THEREOF
    Publication number: 20220024843
    Abstract: Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides highly purity CBG, CBGA, and analogs thereof.
    Type: Application
    Filed: October 6, 2021
    Publication date: January 27, 2022
    Applicant: Canopy Growth Corporation
    Inventors: Daniel BRUMAR, Mahmood Azizpour FARD, Ben GEILING, Mohammadmehdi HAGHDOOST MANJILI
  • METHODS OF SYNTHESIZING CANNABIGERGOL, CANNABIGEROLIC ACID, AND ANALOGS THEREOF
    Publication number: 20240002320
    Abstract: Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides high purity CBG, CBGA, and analogs thereof.
    Type: Application
    Filed: September 15, 2023
    Publication date: January 4, 2024
    Applicant: Canopy Growth Corporation
    Inventors: Daniel BRUMAR, Mahmood Azizpour FARD, Ben GEILING, Mohammadmehdi HAGHDOOST MANJILI
  • Encapsulated cannabinoid formulations for transdermal delivery
    Patent number: 10709748
    Abstract: Preparation of cannabinoid formulations containing: ?9-tetrahydrocannabinol (?9-THC), ?8-tetrahydrocannabinol (?8-THC), ?9-tetrahydrocannabinolic acid (THCa), cannabidiol (CBD), cannabidiolic acid (CBDa), cannabigerol (CBG), cannabichromene (CBC) and cannabinol (CBN), either alone or in combinations henceforth known as cannabis, have been created using an emulsification process to encapsulate cannabinoids. The aqueous-based method involves micellular encapsulation of cannabinoids, a method that has been used to increase the bioavailability of poorly permeable, lipophilic drugs. The present invention demonstrates the viability of transdermal delivery with gels and patches for consistent and sustained cannabinoid dosing.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: July 14, 2020
    Assignee: NUTRAE, LLC
    Inventors: Christopher G. Witowski, Jacqueline L. Salm
  • Cannabinoid composition for treating pain
    Patent number: 10117891
    Abstract: A combination of THC, CBD and Cobalamin (in a ratio of about 63%, 27% and 10%, respectively) is used with a topical carrier such as Shea butter cream to relieve pain. The THC and CBD mixture is extracted from a Cannabis Indica dominant strain using high pressure and carbon dioxide (CO2) as a solvent and comprises: Tetrahydrocannabinol “THC” (9-Tetrahydrocannabinol (delta-9 THC), 8-Tetrahydrocannabinol (Delta-8 THC) and 9-THC Acid), Cannabidiol “CBD”, Cannabinol “CBN”, Cannabichromene (“CBC”), Cannabigerol (“CBG”), terpenoids and flavonoids. The Shea butter is an extract from the Shea nut from the Shea tree (Vitellaria paradoxa).
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: November 6, 2018
    Assignee: India Globalization Capital, Inc.
    Inventors: Ramachandra Mukunda, Ranga Chelva Krishna
  • CANNABIS COMPOSITIONS AND METHODS
    Publication number: 20220054447
    Abstract: Provided are pharmaceutical compositions comprising cannabis such that when combusted produces cannabidiolic acid (CBDA) for inhalation. Also provided are pharmaceutical composition for inhalation by a subject comprising tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabigerol (CBG). Also provided are methods of enhancing cannabidiolic acid (CBDA) in a pharmaceutical composition for inhalation. Methods of use of embodiments of the pharmaceutical composition and kits comprising embodiments of the pharmaceutical composition are provided herein. Unit dosage form medicaments and compositions for vaporization by a subject comprising cannabinoids are also disclosed herein.
    Type: Application
    Filed: December 17, 2019
    Publication date: February 24, 2022
    Applicant: Tetra Bio-Pharma Inc.
    Inventors: Guy Chamberland, Charles Campbell, Randy Ringguette, Jenniver Dorothy Bassett, Ofer Yifrach-Stav, Andrien Rackov, Peter Ford
  • Parenteral formulations
    Patent number: 11229612
    Abstract: The present invention relates to parenteral cannabinoid formulations, and more particularly to cannabinoid containing intravenous (IV) formulations. Preferably the parenteral containing formulation comprises a cannabinoid; an isotonic agent; a surfactant; and one or more stability enhancers. Furthermore the cannabinoid may be selected from one or more of cannabichromene (CBC), cannabichromenic acid (CBCV), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabigerol (CBG), cannabigerolpropyl variant (CBGV), cannabicyclol (CBL), cannabinol (CBN), cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV) and tetrahydrocannabivarinic acid (THCVA).
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: January 25, 2022
    Assignee: GW Research Limited
    Inventors: Stephen Wright, Jitinder Wilkhu
  • Medicinal cannabis uniform in food
    Publication number: 20120095088
    Abstract: The invention is a product and a process wherein cannabinoids such as Medicinal ?9-THC and/or other substances associated with medicinal cannabis, including yet not necessarily limited to cannbidiols, cannabigerol are contained or processed into foodstuffs or medicinal compounds in controlled ways and with specific characteristics. First a medicinal substance with a known about of medicinal cannabis is mixed into a foodstuff such that the medicinal cannabis is distributed uniformly in the foodstuff. Foodstuffs consistent with this invention include baked goods, hard candies, ice cream, bases, ice cream, and yogurt. The product is characterized by a controlled amount of cannabinoids per unit volume of the foodstuff. Another provision of the invention is providing controlled amounts or ratios of ?9-THC as compared to CBD in a foodstuff.
    Type: Application
    Filed: August 19, 2011
    Publication date: April 19, 2012
    Inventor: Andrew David Hospodor
  • OLIVETOL SYNTHASE VARIANTS AND METHODS FOR PRODUCTION OF OLIVETOLIC ACID AND ITS ANALOG COMPOUNDS
    Publication number: 20220177858
    Abstract: Described herein are non-natural olivetol synthase (OLS) variants, nucleic acids, engineered cells, method s for preparing cannabinoids, and compositions thereof. The non-natural olivetol OLS variants form desired cannabinoid precursor and products at increased rates, have higher affinity for pathway substrates, and/or byproducts are formed in lower amounts in their presence, as compared to wild type OLS. The OLS variants can be used to form linear polyketides, and can be expressed in an engineered cell having a pathway to form cannabinoids, which include CBGA, its analogs and derivatives. CBGA can be used for the preparation of cannabigerol (CBG), which can be used in therapeutic compositions.
    Type: Application
    Filed: April 17, 2020
    Publication date: June 9, 2022
    Inventors: Michael A. Noble, Russell Scott Komor, Jingyi Li
  • SYNTHESIS OF CANNABIDIOL AND ANALOGS THEREOF, AND RELATED COMPOUNDS, FORMULATIONS, AND METHODS OF USE
    Publication number: 20230357177
    Abstract: Methods are provided for the synthesis of cannabinoids, including cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidivarin (CBDV), cannabidibutol (CBD-C4), dihydrocannabidiol (DCBD), tetrahydrocannabivarin (THCV), analogs thereof, and precursors to the foregoing. One method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((-)-trans-?9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.
    Type: Application
    Filed: June 20, 2023
    Publication date: November 9, 2023
    Inventors: Glenn M. SAMMIS, Markus ROGGEN, Matthew ROBERTS, Caitlyn KREBS
  • Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof
    Patent number: 11384040
    Abstract: Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides highly purity CBG, CBGA, and analogs thereof.
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: July 12, 2022
    Inventors: Daniel Brumar, Mahmood Azizpour Fard, Ben Geiling, Mohammadmehdi Haghdoost Manjili
  • Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof
    Patent number: 11306050
    Abstract: Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides highly purity CBG, CBGA, and analogs thereof.
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: April 19, 2022
    Inventors: Daniel Brumar, Mahmood Azizpour Fard, Ben Geiling, Mohammadmehdi Haghdoost Manjili
  • CANNABIDIOL-DOMINANT FORMULATIONS, METHODS OF MANUFACTURING, AND USES THEREOF
    Publication number: 20220347152
    Abstract: Stable liquid formulations dominant in cannabidiol (CBD) can be manufactured by a sequential process of purification to create a formulation that does not crystallize under a variety of storage and use conditions, and without the use of potentially harmful additives. For example, the formulation may be used in vaporization devices (i.e., electronic cigarettes) that typically require formulations to remain in a non-crystalline, non-solid, or non-partially solid state. The liquid formulations dominant in CBD may further contain other phytocannabinoids, including, but not limited to, tetrahydrocannabinol (THC), cannabigerol (CBG), cannabichromene (CBC), cannabinol (CBN), and cannabidivarin (CBDV) in higher concentrations than unrefined and refined cannabis extracts obtained via existing methods.
    Type: Application
    Filed: April 29, 2022
    Publication date: November 3, 2022
    Inventors: Christopher Adair, Steven Nazarian
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