Abstract: Methods of converting cannabidiol to ?8-tetrahydrocannabinol or ?9-tetrahydrocannabinol are described. The described methods produce higher yields and higher purity compared to prior art methods.
Type:
Application
Filed:
March 20, 2008
Publication date:
September 11, 2008
Inventors:
G. R. Barrie Webster, Leonard P. Sarna, Raphael Mechoulam
Abstract: Methods of converting cannabidiol to &Dgr;8-tetrahydrocannabinol or &Dgr;9-tetrahydrocannabinol are described. The described methods produce higher yields and higher purity compared to prior art methods.
Type:
Application
Filed:
February 25, 2004
Publication date:
July 22, 2004
Inventors:
G. R. Barrie Webster, Leonard P. Sarna, Raphael Mechoulam
Abstract: Methods of converting cannabidiol to ?8-tetrahydrocannabinol or ?9-tetrahydrocannabinol are described. The described methods produce higher yields and higher purity compared to prior art methods.
Type:
Grant
Filed:
March 7, 2002
Date of Patent:
July 15, 2008
Inventors:
G. R. Barrie Webster, Leonard P. Sarna, Raphael Mechoulam
Abstract: A method for producing hemp oil, comprising decarboxylation of CBDA in hemp oil; short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil; selective THC to CBN conversion performed on the decarboxylated hemp oil.
Type:
Grant
Filed:
July 15, 2019
Date of Patent:
January 5, 2021
Assignee:
CV SCIENCES, INC.
Inventors:
Michael J. Mona, III, Joshua A. Hartsel, Greg Waterbury
Abstract: This disclosure provides a method for converting CBD to a tetrahydrocannabinol featuring the use of cheap and non-toxic aluminum isopropoxide as a catalyst. The method comprises (a) providing a reaction mixture comprising a catalyst in an organic solvent, wherein the catalyst comprises aluminum isopropoxide; (b) adding a reagent comprising CBD to the reaction mixture; (c) mixing the reaction mixture and allowing a reaction for converting CBD to a tetrahydrocannabinol to occur for a predetermine period of time; (d) removing the catalyst by filtration upon the completion of the reaction; (e) removing the organic solvent; and (f) eluting the tetrahydrocannabinol from the organic phase.
Abstract: The present invention is directed to methods of producing THC from CBD utilizing non-harsh methodology and resulting in substantially increased yields, as well as devices built upon these novel methods. The methods and devices are material efficient, and in certain embodiments, solvent-free. In particular, in certain embodiments, these methods and related devices are suitable for commercial production of THC from CBD. Furthermore, in certain embodiments, the present invention provides methods of producing THC from CBD in manner that affords tunability to select the ratio of THC-8 to THC-9.