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  • COMPOSITIONS FOR TISSUE REPAIR/REGENERATION
    Publication number: 20110071086
    Abstract: The invention provides compositions and methods for cardiac repair and/or regeneration of tissues such as myocardium.
    Type: Application
    Filed: November 4, 2008
    Publication date: March 24, 2011
    Inventors: Victor J. Dzau, Jian Guo
  • COMPOSITIONS AND METHODS FOR CONTROLLING BLOOD PRESSURE
    Publication number: 20230313160
    Abstract: The present disclosure describes compositions and methods for treating hypertension in a subject.
    Type: Application
    Filed: November 11, 2022
    Publication date: October 5, 2023
    Inventors: Conrad P. Hodgkinson, Hualing Sun, Richard Pratt, Victor J. Dzau
  • Methods of treating cardiac disorders
    Publication number: 20070258951
    Abstract: The invention feature methods and compositions for treating ischemic aand reperfusuin related injury such as cardiac disorders.
    Type: Application
    Filed: November 20, 2006
    Publication date: November 8, 2007
    Inventors: Victor Dzau, Luis Melo, Mark Perrella, Reitu Agrawal
  • Methods of treating cardiac disorders
    Publication number: 20030022870
    Abstract: The invention feature methods and compositions for treating ischemic aand reperfusuin related injury such as cardiac disorders.
    Type: Application
    Filed: June 3, 2002
    Publication date: January 30, 2003
    Inventors: Victor Dzau, Luis G. Melo, Mark A. Perrella, Reitu Agrawal
  • METHODS OF TREATING CARDIAC DISORDERS
    Publication number: 20110044947
    Abstract: The invention feature methods and compositions for treating ischemic and reperfusuin related injury such as cardiac disorders.
    Type: Application
    Filed: March 25, 2010
    Publication date: February 24, 2011
    Inventors: Victor Dzau, Luis G. Melo, Mark A. Perrella, Reitu Agrawal
  • Stem cell derived factors for treating pathologic conditions
    Publication number: 20080176207
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions.
    Type: Application
    Filed: January 11, 2008
    Publication date: July 24, 2008
    Inventors: Victor Dzau, Maria Mirotsou
  • STEM CELL DERIVED FACTORS FOR TREATING PATHOLOGIC CONDITIONS
    Publication number: 20110003743
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions.
    Type: Application
    Filed: March 18, 2010
    Publication date: January 6, 2011
    Inventors: Victor Dzau, Maria Mirotsou
  • Stem cell derived factors for treating pathologic conditions
    Publication number: 20070259425
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
    Type: Application
    Filed: August 21, 2006
    Publication date: November 8, 2007
    Inventors: Victor Dzau, Maria Mirotsou
  • STEM CELL DERIVED FACTORS FOR TREATING PATHOLOGIC CONDITIONS
    Publication number: 20170128526
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
    Type: Application
    Filed: May 27, 2016
    Publication date: May 11, 2017
    Inventors: Victor Dzau, Maria Mirotsou
  • Inhibition of Histone Methyltransferase for Cardiac Reprogramming
    Publication number: 20150297611
    Abstract: A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
    Type: Application
    Filed: November 4, 2013
    Publication date: October 22, 2015
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Stem cell-derived factors for treating pathologic conditions
    Publication number: 20060211600
    Abstract: Compositions and methods for cellular and tissue protection, repair, and regeneration are described. Mesenchymal cell-derived paracrine factors confer a therapeutic benefit to a variety of injured, compromised or diseased tissues such as myocardial tissue.
    Type: Application
    Filed: February 8, 2006
    Publication date: September 21, 2006
    Inventors: Victor Dzau, Maria Mirotsou
  • METHOD OF REDUCING CELL DEATH BY ADMINISTERING A PARACRINE FACTOR OF A MESENCHYMAL STEM CELL
    Publication number: 20120283183
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions.
    Type: Application
    Filed: March 18, 2010
    Publication date: November 8, 2012
    Inventors: Victor Dzau, Maria Mirotsou
  • Stem Cell Derived Factors for Treating Pathologic Conditions
    Publication number: 20140357703
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
    Type: Application
    Filed: April 18, 2014
    Publication date: December 4, 2014
    Inventors: Victor J. Dzau, Maria Mirotsou
  • INHIBITION OF HISTONE METHYLTRANSFERASE FOR CARDIAC REPROGRAMMING
    Publication number: 20190192533
    Abstract: A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
    Type: Application
    Filed: November 19, 2018
    Publication date: June 27, 2019
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Stem Cell Derived Factors for Treating Pathologic Conditions
    Publication number: 20140296152
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
    Type: Application
    Filed: April 18, 2014
    Publication date: October 2, 2014
    Applicants: DUKE UNIVERSITY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Victor J. Dzau, Maria Mirotsou
  • COMPOSITIONS AND METHODS FOR CELLULAR REPROGRAMMING
    Publication number: 20210017497
    Abstract: Disclosed herein are compositions and methods for cellular reprogramming. The compositions comprise one or more miRs and an activator of NF?B. Also provided are methods for enhancing or upregulating cardiomyocyte maturation in a cell or a subject and methods for inhibiting or downregulating cardiomyocyte maturation.
    Type: Application
    Filed: March 21, 2019
    Publication date: January 21, 2021
    Applicant: Duke University
    Inventors: Conrad HODGKINSON, Victor DZAU, Jaewoo Lee, Bruce A. SULLENGER
  • MULTICISTRONIC MIRNA DELIVERY FOR CARDIAC REPROGRAMMING
    Publication number: 20220175845
    Abstract: The invention provides a method of promoting reprogramming of a cardiac fibroblast into a cardiomyocyte by contacting the cardiac fibroblast with an isolated polynucleotide molecule comprising at least two functional miRNA sequences using a multicistronic expression system for reprogramming of fibroblasts into functional mature cardiomyocytes.
    Type: Application
    Filed: December 3, 2021
    Publication date: June 9, 2022
    Inventors: Conrad P. Hodgkinson, Victor J. Dzau
  • DIRECT REPROGRAMMING OF CELLS TO CARDIAC MYOCYTE FATE
    Publication number: 20200345786
    Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
    Type: Application
    Filed: June 29, 2020
    Publication date: November 5, 2020
    Inventors: Victor J. Dzau, Maria Mirotsou, Tilanthi Jayawardena
  • Direct Reprogramming of Cells to Cardiac Myocyte Fate
    Publication number: 20180344776
    Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
    Type: Application
    Filed: June 4, 2018
    Publication date: December 6, 2018
    Inventors: Victor J. Dzau, Maria Mirotsou, Tilanthi Jayawardena
  • Compositions and methods for cellular reprogramming
    Patent number: 11512290
    Abstract: Disclosed herein are compositions and methods for cellular reprogramming. The compositions comprise one or more miRs and an activator of NF?B. Also provided are methods for enhancing or upregulating cardiomyocyte maturation in a cell or a subject and methods for inhibiting or downregulating cardiomyocyte maturation.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: November 29, 2022
    Assignee: Duke University
    Inventors: Conrad Hodgkinson, Victor Dzau, Jaewoo Lee, Bruce A. Sullenger
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