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  • VEGF gene transfer into endothelial cells for vascular prosthesis
    Patent number: 5785965
    Abstract: Endothelial cells derived from subcutaneous adipose tissue are genetically modified to express the endothelial cell-specific angiogenic factor VEGF. The modified cells are sodded onto a vascular prosthesis for transplantation into an autologous or allogeneic recipient. The method accelerates endothelialization on the luminal surface of the vessel, and promotes collateral circulation in distal ischemic organs.
    Type: Grant
    Filed: May 15, 1996
    Date of Patent: July 28, 1998
    Assignee: The Board of Trustees of the Leland Stanford Junior Univ.
    Inventors: Richard E. Pratt, Victor J. Dzau
  • Compositions and methods based upon an isoform of p53
    Patent number: 6294384
    Abstract: The present invention is directed to an isoform of the p53 tumor suppressor and to polynucleotides that encode this isoform. The isoform may be used as a marker to indicate that cardiac cells have experienced hypoxia, as would occur during a myocardial infarction. In addition, vectors encoding the isoform may be transfected into cells as a means of regulating proliferation.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: September 25, 2001
    Assignee: The Brigham and Women's Hospital Inc.
    Inventors: Giorgio Dell'Acqua, Michael J. Mann, Victor J. Dzau
  • Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
    Patent number: 6642208
    Abstract: Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: November 4, 2003
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Victor J. Dzau, Gary H. Gibbons
  • Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
    Patent number: 6337321
    Abstract: Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: January 8, 2002
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Victor J. Dzau, Gary H. Gibbons