Abstract: Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes.
Type:
Application
Filed:
February 1, 2002
Publication date:
July 11, 2002
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
John P. Cooke, Victor J. Dzau, Gary H. Gibbons
Abstract: Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host.
Type:
Application
Filed:
July 15, 2003
Publication date:
April 29, 2004
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
John P. Cooke, Victor J. Dzau, Gary H. Gibbons
Abstract: Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes.
Type:
Grant
Filed:
February 1, 2002
Date of Patent:
November 11, 2003
Assignee:
The Board of Trustees of the Leland Stanford Junior
University
Inventors:
John P. Cooke, Victor J. Dzau, Gary H. Gibbons
Abstract: Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds, namely L-arginine, L-lysine, physiologically acceptable salts thereof, and polypeptide precursors thereof, which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. In or in combination, other compounds, such as B.sub.6, folate, B.sub.12, or an antioxidant, which provide for short term enhancement of nitric oxide, either directly or by physiological processes may be employed.
Type:
Application
Filed:
February 1, 2002
Publication date:
October 17, 2002
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
John
P.
COOKE
, Victor
J.
DZAU
, Gary
H.
GIBBONS
Abstract: Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds, namely L-arginine, L-lysine, physiologically acceptable salts thereof, and polypeptide precursors thereof, which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. In or in combination, other compounds, such as B.sub.6, folate, B.sub.12, or an antioxidant, which provide for short term enhancement of nitric oxide, either directly or by physiological processes may be employed.
Type:
Grant
Filed:
November 9, 1995
Date of Patent:
April 6, 1999
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
John P. Cooke, Victor J. Dzau, Gary H. Gibbons
Abstract: Atherogenesis and restenosis are treated by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes. In addition, cells may be genetically engineered to provide a component in the synthetic pathway to nitric oxide, so as to drive the process to enhance nitric oxide concentration, particularly in conjunction with the administration of a nitric oxide precursor.
Type:
Grant
Filed:
February 7, 1997
Date of Patent:
August 31, 1999
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
John P. Cooke, Victor J. Dzau, Gary H. Gibbons