Search Patents
  • COMPOSITIONS FOR TISSUE REPAIR/REGENERATION
    Publication number: 20110071086
    Abstract: The invention provides compositions and methods for cardiac repair and/or regeneration of tissues such as myocardium.
    Type: Application
    Filed: November 4, 2008
    Publication date: March 24, 2011
    Inventors: Victor J. Dzau, Jian Guo
  • Method of reducing cell death by administering a paracrine factor of a mesenchymal stem cell
    Patent number: 8703710
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death and/or tissue injury associated with ischemic conditions.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: April 22, 2014
    Assignees: The Brigham and Women's Hospital, Inc., Duke University
    Inventors: Victor J. Dzau, Maria Mirotsou
  • Method of reducing cell death by administering a Sfrp polypeptide
    Patent number: 8129344
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: March 6, 2012
    Assignees: Duke University, The Brigham and Women's Hospital, Inc.
    Inventors: Victor Dzau, Maria Mirotsou
  • Method of enhancing cardiac tissue repair by administering a SFRP polypeptide
    Patent number: 7638128
    Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: December 29, 2009
    Assignees: The Brigham and Women's Hospital, Inc., Duke University
    Inventors: Victor Dzau, Maria Mirotsou
  • Compositions and methods based upon an isoform of p53
    Patent number: 6294384
    Abstract: The present invention is directed to an isoform of the p53 tumor suppressor and to polynucleotides that encode this isoform. The isoform may be used as a marker to indicate that cardiac cells have experienced hypoxia, as would occur during a myocardial infarction. In addition, vectors encoding the isoform may be transfected into cells as a means of regulating proliferation.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: September 25, 2001
    Assignee: The Brigham and Women's Hospital Inc.
    Inventors: Giorgio Dell'Acqua, Michael J. Mann, Victor J. Dzau