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  • TREATMENT OF PROLIFERATIVE DISEASES
    Publication number: 20120172313
    Abstract: The present invention relates to methods for preventing or treating proliferative diseases. In particular, the present invention relates to the use of compositions derived or derivable from plants, such as plant defensins, particularly in methods for the prevention or treatment of proliferative diseases such as cancer. The present invention also relates to associated uses, systems and kits.
    Type: Application
    Filed: June 23, 2011
    Publication date: July 5, 2012
    Inventors: MARK DARREN HULETT, IVAN KA HO POON, AMY ALEXANDRA BAXTER, MARILYN ANDERSON, FUNG LAY
  • Defensin-encoding nucleic acid molecules, uses therefor and transgenic plants comprising same
    Publication number: 20060150276
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Application
    Filed: March 10, 2006
    Publication date: July 6, 2006
    Inventors: Marilyn Anderson, Fung Lay, Robyn Heath
  • Defensin-encoding nucleic acid molecules, uses therefor and transgenic plants comprising same
    Publication number: 20060156433
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Application
    Filed: March 10, 2006
    Publication date: July 13, 2006
    Inventors: Marilyn Anderson, Fung Lay, Robyn Heath
  • Defensin-encoding nucleic acid molecules derived from Nicotiana alata, uses therefor and transgenic plants comprising same
    Publication number: 20050150004
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Application
    Filed: February 22, 2005
    Publication date: July 7, 2005
    Inventors: Marilyn Anderson, Fung Lay, Robyn Heath
  • NOVEL PLANT DEFENSINS AND USE IN THE TREATMENT OF PROLIFERATIVE DISEASES
    Publication number: 20150158918
    Abstract: The present invention relates to compositions and methods for preventing or treating proliferative diseases. In particular, the present invention relates to the use of compositions derived or derivable from plants, such as plant defensins, particularly in methods for the prevention or treatment of proliferative diseases such as cancer. The present invention also relates to associated uses, systems and kits.
    Type: Application
    Filed: October 19, 2012
    Publication date: June 11, 2015
    Applicants: HEXIMA LIMITED, BALMORAL AUSTRALIA PTY LTD
    Inventors: Mark Darren Hulett, Fung Tso Lay
  • Plant defensins and use in the treatment of proliferative diseases
    Patent number: 9540423
    Abstract: The present invention relates to compositions and methods for preventing or treating proliferative diseases. In particular, the present invention relates to the use of compositions derived or derivable from plants, such as plant defensins, particularly in methods for the prevention or treatment of proliferative diseases such as cancer. The present invention also relates to associated uses, systems and kits.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: January 10, 2017
    Assignees: BALMORAL AUSTRALIA PTY LTD, HEXIMA LIMITED
    Inventors: Mark Darren Hulett, Fung Tso Lay
  • Defensin- specific antibodies
    Publication number: 20090069545
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Application
    Filed: July 30, 2007
    Publication date: March 12, 2009
    Applicant: HEXIMA LIMITED
    Inventors: MARILYN ANNE ANDERSON, FUNG TSO LAY, ROBYN LOUISE HEATH
  • Defensin-encoding nucleic acid molecules, uses therefor and transgenic plants comprising same
    Patent number: 7544861
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: June 9, 2009
    Assignee: Hexima Limited
    Inventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
  • Defensin-like amino acid molecules derived from , uses therefor and transgenic plants comprising same
    Patent number: 7297840
    Abstract: The present invention provides amino acid molecules derived from Nicotiana alata. The present invention contemplates the use of nucleic acids encoding such amino acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: November 20, 2007
    Assignee: Hexima Ltd.
    Inventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
  • Defensin-encoding nucleic acid molecules derived from nicotiana alata, uses therfor and transgenic plants comprising same
    Patent number: 7041877
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transcienic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transcienic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: May 9, 2006
    Assignee: Hexima, Ltd.
    Inventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
  • Defensin-encoding nucleic acid molecules derived from , uses therefor and transgenic plants comprising same
    Patent number: 9896697
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: February 20, 2018
    Assignee: Hexima Limited
    Inventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
  • DEFENSIN-ENCODING NUCLEIC ACID MOLECULES DERIVED FROM NICOTIANA ALATA, USES THEREFOR AND TRANSGENIC PLANTS COMPRISING SAME
    Publication number: 20140208461
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Application
    Filed: March 24, 2014
    Publication date: July 24, 2014
    Applicant: HEXIMA LIMITED
    Inventors: Marilyn Anne ANDERSON, Fung Tso LAY, Robyn Louise HEATH
  • Defensin-Encoding Nucleic Acid Molecules Derived From Nicotiana Alata, Uses Therefor And Transgenic Plants Comprising Same
    Publication number: 20130047299
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Application
    Filed: August 28, 2012
    Publication date: February 21, 2013
    Applicant: Hexima Limited
    Inventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
  • Defensin-encoding nucleic acid molecules derived from , uses therefor and transgenic plants comprising same
    Patent number: 8252898
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: August 28, 2012
    Assignee: Hexima Limited
    Inventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
  • Defensin-encoding nucleic acid molecules derived from , uses therefor and transgenic plants comprising same
    Patent number: 8722968
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: May 13, 2014
    Assignee: Hexima Limited
    Inventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
  • Defensin-Encoding Nucleic Acid Molecules Derived From Nicotiana Alata, Uses Therefor and Transgenic Plants Comprising Same
    Publication number: 20100218280
    Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.
    Type: Application
    Filed: February 18, 2010
    Publication date: August 26, 2010
    Applicant: HEXIMA LIMITED
    Inventors: MARILYN ANNE ANDERSON, FUNG TSO LAY, ROBYN LOUISE HEATH
  • MODIFIED PLANT DEFENSIN
    Publication number: 20090083880
    Abstract: The invention herein includes a general method for reducing or eliminating a toxic effect of transgenic defensin expression in a host plant. The invention also includes a method of modifying a nucleic acid encoding a defensin, a nucleic acid modified thereby and a modified defensin encoded by the modified nucleic acid sequence. The invention also includes a transgenic plant containing and expressing the modified defensin-coding nucleic acid sequence, the plant exhibiting reduced or eliminated toxic effects of defensin, compared with otherwise comparable transgenic plants expressing an unmodified defensin. The modified defensin is termed a chimeric defensin having a mature defensin domain of a first plant defensin combined with a C-terminal propeptide domain of a second plant defensin or a vacuolar translocation peptide.
    Type: Application
    Filed: April 18, 2008
    Publication date: March 26, 2009
    Applicant: HEXIMA LTD.
    Inventors: MARILYN ANNE ANDERSON, ROBYN LOUISE HEATH, FUNG TSO LAY, Simon Poon
  • Plant-derived molecules and genetic sequences encoding same and uses therefor
    Publication number: 20030217382
    Abstract: The present invention provides genetic molecules encoding plant floral defensin-like molecules and their use in generating transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The present invention further provides for the use of floral- and seed-derived defensins in the generation of insect resistance in plants. The plants may be monocotyledonous or dicotyledonous plants and are in particular, crop plants and ornamental flowering plants. The genetic molecules are also useful in generating recombinant defensin-like molecules for use in the topical application of compositions to prevent or otherwise retard pest-infestation of plants. The floral defensin-like molecules or genetic molecules encoding same of the present invention may be used alone or in combination with other agents such as a proteinase inhibitor precursor or a nucleic acid molecule encoding same or other molecules or their encoding nucleotide sequences.
    Type: Application
    Filed: February 8, 2002
    Publication date: November 20, 2003
    Inventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
  • ARRAY ULTRASOUND ENDOSCOPIC PROBE, A MANUFACTURE METHOD THEREOF AND A FIXING AND ROTATING DEVICE
    Publication number: 20120302888
    Abstract: This invention relates to a radial array ultrasound endoscopic probe and its manufacture method and a fixing and rotating device. The probe comprises: a metal cylinder located at the center; a plurality of piezoelectric elements which are cut from piezoelectric ceramic or single crystal rings and arranged around the metal cylinder, said piezoelectric elements and said metal cylinder being provided with a backing material layer for absorbing sound therebetween, said piezoelectric elements being covered with a matching material layer on the outer side thereof, and said piezoelectric elements are filled with decoupling material therebetween; a plurality of coaxial cables correspondingly connected with the plurality of piezoelectric elements; and a circular lattice in a gear shape which sleeves over said metal cylinder and functions to arrange and separate the coaxial cables.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 29, 2012
    Applicant: The Hong Kong Polytechnic University
    Inventors: Jiyan Dai, Kwok Fung Cheung, Dan Zhou, Yat Ching Chiu, Kwok Ho Lam, Yan Chen, Helen L. W. Chan
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