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  • Methods and compositions for enhancing the delivery of a nucleic acid to a cell
    Publication number: 20050080030
    Abstract: The present invention relates to methods and compositions useful for enhancing the efficiency of delivery of a nucleic acid to a cell. Preferably the cell is a mammalian cell. The method comprises providing to a cell an agent capable of enhancing the cytoskeletal permissiveness of the cell for transfection. The method also comprises providing to the cell a nucleic acid delivery system for the transfection of the cell, whereby the efficiency of delivery of a nucleic acid to the cell is enhanced.
    Type: Application
    Filed: September 5, 2003
    Publication date: April 14, 2005
    Inventors: Robert Levy, Peter Jones, Quanyi Li
  • Methods and compositions for enhancing the delivery of a nucleic acid to a cell
    Publication number: 20020034821
    Abstract: The present invention relates to methods and compositions useful for enhancing the efficiency of delivery of a nucleic acid to a cell. Preferably the cell is a mammalian cell. The method comprises providing to a cell an agent capable of enhancing the cytoskeletal permissiveness of the cell for transfection. The method also comprises providing to the cell a nucleic acid delivery system for the transfection of the cell, whereby the efficiency of delivery of a nucleic acid to the cell is enhanced.
    Type: Application
    Filed: May 9, 2001
    Publication date: March 21, 2002
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Peter L. Jones, Quanyi Li
  • Methods and compositions for enhancing the delivery of a nucleic acid to a cell
    Patent number: 6919208
    Abstract: The present invention relates to methods and compositions useful for enhancing the efficiency of delivery of a nucleic acid to a cell. Preferably the cell is a mammalian cell. The method comprises providing to a cell an agent capable of enhancing the cytoskeletal permissiveness of the cell for transfection. The method also comprises providing to the cell a nucleic acid delivery system for the transfection of the cell, whereby the efficiency of delivery of a nucleic acid to the cell is enhanced.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: July 19, 2005
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Peter L. Jones, Quanyi Li
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