Search Patents
  • TRPM8 antagonists and their use in treatments
    Patent number: 8778941
    Abstract: Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: July 15, 2014
    Assignee: AMGEN Inc.
    Inventors: James Brown, Jian J. Chen, Vijay Keshav Gore, Scott Harried, Daniel B. Horne, Matthew R. Kaller, Qingyian Liu, Holger Monenschein, Thomas T. Nguyen, Nobuko Nishimura, Wenge Zhong
  • System and method for transforming an in-use RAID array including migrating data using reserved extents
    Patent number: 9563359
    Abstract: A system is provided for transforming an in-use RAID array from a first array configuration having a first parameter to a second array configuration having a second parameter while preserving a logical data structure of the RAID array. The system includes an extent reservation component, and a data migration component for reading unmigrated data from an area of an array arranged according to the first array configuration and writing the data to an area of the array arranged according to the second array configuration using reserved extents to store migrated data. The system also includes a first I/O component for performing I/O according to the first array configuration on unmigrated data prior to its reading by the data migration component, and a second I/O component for performing I/O according to the second array configuration on the migrated data after writing the migrated data.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: February 7, 2017
    Assignee: International Business Machines Corporation
    Inventors: Joanna K. Brown, Matthew J. Fairhurst, William J. Scales, Mark B. Thomas
  • System and method for transforming an in-use raid array including migrating data using reserved extents
    Patent number: 9195412
    Abstract: A system is provided for transforming an in-use RAID array from a first array configuration having a first parameter to a second array configuration having a second parameter while preserving a logical data structure of the RAID array. The system includes an extent reservation component, and a data migration component for reading unmigrated data from an area of an array arranged according to the first array configuration and writing the data to an area of the array arranged according to the second array configuration using reserved extents to store migrated data. The system also includes a first I/O component for performing I/O according to the first array configuration on unmigrated data prior to its reading by the data migration component, and a second I/O component for performing I/O according to the second array configuration on the migrated data after writing the migrated data.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: November 24, 2015
    Assignee: International Business Machines Corporation
    Inventors: Joanna K. Brown, Matthew J. Fairhurst, William J. Scales, Mark B. Thomas
  • (Alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
    Patent number: 10603324
    Abstract: Provided herein are (alpha-substituted aralkylamino or heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: March 31, 2020
    Assignee: MEI Pharma, Inc.
    Inventors: S. David Brown, David J. Matthews
  • Analyzing the behavior of a storage system
    Publication number: 20070088861
    Abstract: In order to investigate the behaviour of a data storage system, the time differences between commands from an analysis device and the completion of the operations defined by those commands are analyzed. The method may use a factorial parameter table definition representing common threads of I/O events in a patterned, cyclic nature, using a host computer as the host application emulator and data logger. The workload definition is provided either from hypothetical proposed thread parameters, or by statistical and common factorial analysis of real application I/O traffic analysis, or a combination of both. The generated workloads can be run while measuring the I/O event completion timings and event queuing characteristics, facilitating engineering interpretation of results for the purpose of analysing the effects of workload and system architectural design factors, and optimisation or evaluation of total system configurations.
    Type: Application
    Filed: August 25, 2006
    Publication date: April 19, 2007
    Inventors: Martin Dudley, Nicholas Granger-Brown, Matthew Latter, Christopher Robert Smart
  • Artificial Intelligence Engine Having Various Algorithms to Build Different Concepts Contained Within a Same AI Model
    Publication number: 20180357552
    Abstract: The AI engine has a first module that chooses from a library of algorithms to use when automatically assembling and building different learning topologies to solve different concepts making up a resulting AI model. The AI engine may integrate both i) one or more dynamic programming training algorithms and ii) one or more policy optimization algorithms, to build the different learning topologies to solve the different concepts contained with an AI model in order to solve a wide variety of problem types. Each concept contained in the AI model can use a most appropriate approach for achieving a mission of that concept. A learning topology representing a first concept can be built by the first module with a first dynamic programming training algorithm, while a learning topology representing a second concept in the same AI model can be built by the first module with a first policy optimization algorithm.
    Type: Application
    Filed: August 16, 2018
    Publication date: December 13, 2018
    Applicant: Bonsai AI, Inc.
    Inventors: Marcos Campos, Aditya Gudimella, Ruofan Kong, Matthew Brown
  • C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents
    Publication number: 20120202777
    Abstract: The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, wherein the variables G, T, D, L, A, X, R1 and R2 are as described hereinabove, and their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.
    Type: Application
    Filed: October 4, 2010
    Publication date: August 9, 2012
    Inventors: Matthew Frank Brown, Anthony Marfat, Michael Joseph Melnick, Usa Reilly
  • (ALPHA-SUBSTITUTED CYCLOALKYLAMINO AND HETEROCYCLYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES
    Publication number: 20140088102
    Abstract: Provided herein are (alpha-substituted cycloalkylamino or heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases.
    Type: Application
    Filed: March 27, 2012
    Publication date: March 27, 2014
    Applicant: MEI PHARMA, INC.
    Inventors: S. David Brown, David J. Matthews
  • (FUSED RING ARYLAMINO AND HETEROCYCLYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES
    Publication number: 20140088103
    Abstract: Provided herein are (fused ring arylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula (I), and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases.
    Type: Application
    Filed: March 27, 2012
    Publication date: March 27, 2014
    Applicant: MEI PHARMA, INC.
    Inventors: S. David Brown, David J. Matthews
  • Hydroxamic Acid Derivatives Useful as Antibacterial Agents
    Publication number: 20110178042
    Abstract: The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II); and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B. L1-L4 A, B, R1-R4 and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.
    Type: Application
    Filed: September 1, 2009
    Publication date: July 21, 2011
    Applicant: Pfizer Inc.
    Inventors: Matthew F. Brown, Charles F. Donovan, Edmund L. Eilsworth, Denton W. Hoyer, Timothy A. Johnson, Manjinder S. Lall, Chris Lim-Berakis, Sean T. Murphy, Debra A. Sherry, Clarke B. Taylor, Joseph S. Warmus
  • Chemical compounds
    Patent number: 9605004
    Abstract: The invention relates to pyrrolone compounds of the formula (I), wherein X, Ra, Rb, Rc, R1, R2 and R3 are as defined in the specification. Furthermore, the present invention relates to processes and intermediates for making compounds of formula (I), to herbicidal compositions comprising these compounds and to methods of using these compounds to control plant growth.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: March 28, 2017
    Assignees: Syngenta Limited, Syngenta Participations AG
    Inventors: Alan John Dowling, Timothy Robert Desson, William Guy Whittingham, Anne Jacqueline Dalencon, James Alan Morris, Jutta Elisabeth Boehmer, Mangala Phadte, Adrian Longstaff, Matthew Brian Hotson, Paul John De Fraine, Alison Jane Thompson, Shuji Hachisu
  • KIF18A INHIBITORS
    Publication number: 20220073504
    Abstract: Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.
    Type: Application
    Filed: December 20, 2019
    Publication date: March 10, 2022
    Applicant: AMGEN INC.
    Inventors: NURIA A TAMAYO, ABHISEK BANERJEE, JAMES ALEXANDER BROWN, MICHAEL J FROHN, JIAN JEFFREY CHEN, KEXUE LI, QINGYIAN LIU, JONATHAN DANTE LOW, VU MA, LIPING H PETTUS, MARY CATHERINE WALTON, ANA ELENA MINATTI, MATTHEW PAUL BOURBEAU, LEI JIA, THOMAS T NGUYEN, NOBUKO NISHIMURA, QIUFEN MAY XUE, JOHN GORDON ALLEN
  • Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
    Publication number: 20030032657
    Abstract: Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: 1
    Type: Application
    Filed: April 16, 2002
    Publication date: February 13, 2003
    Applicant: Pharmacia Corporation
    Inventors: David L. Brown, Matthew J. Graneto, Cindy L. Ludwig, John M. Molyneaux, John J. Talley
  • Pyrrolo[2,3-d]pyrimidine compounds
    Patent number: 7687507
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: March 30, 2010
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Todd A. Blumenkopf, Mark E. Flanagan, Matthew F. Brown
  • Modulators of sphingosine phosphate receptors
    Patent number: 8466183
    Abstract: Compounds of the following generic structure are provided: Such compounds activate a sphingosine-I-phosphate receptor of the subtype 1 (S1P1), and have utility in the treatment of malconditions mediated by S1P1 activation. More specifically, such compounds are beneficial in the treatment of, for example, multiple sclerosis, transplant rejection and/or adult respiratory syndrome.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: June 18, 2013
    Assignee: The Scripps Research Institute
    Inventors: Edward Roberts, Hugh Rosen, Steven Brown, Miguel A. Guerrero, Xuemei Peng, Ramulu Poddutoori
  • Modulators of sphingosine phosphate receptors
    Patent number: 8530503
    Abstract: Compounds of the following generic structure are provided: Such compounds activate a sphingosine-I-phosphate receptor of the subtype 1 (S1P1), and have utility in the treatment of malconditions mediated by S1P1 activation. More specifically, such compounds are beneficial in the treatment of, for example, multiple sclerosis, transplant rejection and/or adult respiratory syndrome.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: September 10, 2013
    Assignee: The Scripps Research Institute
    Inventors: Edward Roberts, Hugh Rosen, Steven Brown, Miguel A. Guerrero, Xuemei Peng, Ramulu Poddutoori
  • Modulators of sphingosine phosphate receptors
    Patent number: 8481573
    Abstract: Compounds of the following generic structure are provided: Such compounds activate a sphingosine-I-phosphate receptor of the subtype 1 (S1P1), and have utility in the treatment of malconditions mediated by S1P1 activation. More specifically, such compounds are beneficial in the treatment of, for example, multiple sclerosis, transplant rejection and/or adult respiratory syndrome.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: July 9, 2013
    Assignee: The Scripps Research Institute
    Inventors: Edward Roberts, Hugh Rosen, Steven Brown, Miguel A. Guerrero, Xuemei Peng, Ramulu Poddutoori
  • Cycloalkylamino Acid Derivatives
    Publication number: 20100120794
    Abstract: The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R1, R2, R3, R4, R5, R8, m, n, p, q, r, s, t and u are as defined herein. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: January 4, 2010
    Publication date: May 13, 2010
    Inventors: Samit Kumar Bhattacharya, Matthew Frank Brown, Peter Hans Dorff, Susan LaGreca
  • SYSTEMS AND METHODS FOR POST-OPERATIVE OUTCOME MONITORING
    Publication number: 20170140121
    Abstract: A system including a range of motion module, a quality of sleep module, an overall module, and a control module. The range of motion module, subsequent to performing a procedure on a patient, determines a first range of motion score of the patient based on a signal generated by a sensor. The quality of sleep module, subsequent to performing the procedure on the patient, determines a first quality of sleep score or a first pain score based on the signal generated by the sensor. The overall module determines a combined score based on (i) the first range of motion score, and (ii) the first sleep score or the first pain score. The control module (i) determines whether an outcome of the procedure is positive based on the combined score, and (ii) stores the determined outcome and the combined score in a memory.
    Type: Application
    Filed: November 18, 2015
    Publication date: May 18, 2017
    Inventors: Randal Schulhauser, Richard L. Brown, Jeff R. Justis, Matthew M. Morrison, Jeff M. Cherry
  • Substituted benzopyran analogs for the treatment of inflammation
    Publication number: 20020010206
    Abstract: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders.
    Type: Application
    Filed: May 24, 2001
    Publication date: January 24, 2002
    Applicant: G.D. Searle & Co.
    Inventors: Jeffery S. Carter, Mark G. Obukowicz, Balekudru Devadas, John J. Talley, David L. Brown, Matthew J. Graneto, Stephen R. Bertenshaw, Donald J. Rogier,, Srinivasan Raj Nagarajan, Cathleen E. Hanau, Susan J. Hartmann, Cindy L. Ludwig, Suzanne Metz, Donald E. Korte
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