Search Patents
  • Yeast mutants useful for indentifying immunosupressants
    Patent number: 5324659
    Abstract: Disclosed is a process utilizing yeast mutants for identifying active FK-506 type immunosuppressants. The process utilizes Saccharomyces cerevisiae mutants containing an fkr1, fkr2, fkr3 mutant gene or mixture thereof, which are resistant to FK-506 but sensitive to rapamycin. These mutants can be used in a diagnostic procedure for identifying FK-506 and FK-506 type immunosuppressants and in screening assays for compounds and fermentation broths which exhibit FK-506 type immunosuppressive activity. Specifically disclosed are the new yeast mutants, Saccharomyces cerevisiae YKF093, (Merck Culture Collection No. MY 2088) ATCC No. 74055, containing an fkr3 mutant gene, Saccharomyces cerevisiae YKF 012, (Merck Culture Collection No. MY 2096) ATCC No. 74061, which contains an fkr1 mutant gene, Saccharomyces cerevisiae YFK 014, (Merck Culture Collection No. MY 2097) ATCC No. 74062 and YFK-023-17A (Merck Culture Collection No. MY 2098) ATCC No.
    Type: Grant
    Filed: July 31, 1992
    Date of Patent: June 28, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Stephen A. Parent, Leonardo E. Brizuela, Gary L. Chrebet, Keith A. Bostian
  • FORMULATIONS FOR CATHEPSIN K INHIBITORS
    Publication number: 20130217766
    Abstract: The instant invention relates to pharmaceutical compositions containing cathespin K inhibitors. Also disclosed are processes for making said pharmaceutical compositions.
    Type: Application
    Filed: March 20, 2013
    Publication date: August 22, 2013
    Applicant: Merck, Sharp & Dohme, Corp.
    Inventor: Merck, Sharp & Dohme, Corp.
  • Engineered Anti-IL-23p19 Antibodies
    Publication number: 20130122009
    Abstract: Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
    Type: Application
    Filed: December 17, 2012
    Publication date: May 16, 2013
    Applicant: MERCK SHARP & DOHME CORP.
    Inventor: MERCK SHARP & DOHME CORP.
  • SPIROBIFLUORENE DERIVATIVES FOR USE IN ELECTRONIC DEVICES
    Publication number: 20200212301
    Abstract: The present application relates to a spirobifluorene derivative of a specific formula (I) which is suitable for use in electronic devices.
    Type: Application
    Filed: July 25, 2018
    Publication date: July 2, 2020
    Applicants: Merck Patent GmbH, Merck Patent GmbH
    Inventors: Elvira MONTENEGRO, Teresa MUJICA-FERNAUD, Florian MAIER-FLAIG, Frank VOGES
  • ORGANIC ELECTROLUMINESCENT DEVICE
    Publication number: 20190372025
    Abstract: The present invention relates to an organic electroluminescent device comprising a hole-injection layer comprising a metal complex as a main component and a method for producing the organic electroluminescent device.
    Type: Application
    Filed: February 27, 2018
    Publication date: December 5, 2019
    Applicants: Merck Patent GmbH, Merck Patent GmbH
    Inventors: Ilona STENGEL, Frank VOGES, Teresa MUJICA-FERNAUD, Henning SEIM
  • Crystalline hydrochloride salts of c-Met kinase inhibitors
    Patent number: 8674105
    Abstract: The instant invention relates to crystalline forms of Compound A, an inhibitor of c-MET kinase. Specifically, the instant invention relates to hydrochloride salts of Compound A.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: March 18, 2014
    Assignees: Merck Sharp & Dohme Limited, Merck Sharp & Dohme Corp.
    Inventors: Paolo Avalle, Minhua Chen
  • 3-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases
    Publication number: 20110003862
    Abstract: Compounds of the formula (I), inhibit D-amino acid oxidase and hence find use in treating degenerative and psychiatric diseases.
    Type: Application
    Filed: February 15, 2007
    Publication date: January 6, 2011
    Applicants: MERCK SHARP & DOHME LIMITED, MERCK & CO., INC.
    Inventors: Philip E. Brandish, Nicholas Brandon, Alister Campbell, Timothy Sparey
  • LIQUID-CRYSTALLINE MEDIA
    Publication number: 20130183460
    Abstract: The invention relates to liquid-crystalline media which can be used, in particular, for electro-optical displays having active-matrix addressing based on the ECB effect and for IPS (in-plane switching) displays or FFS (fringe field switching) displays.
    Type: Application
    Filed: December 20, 2012
    Publication date: July 18, 2013
    Applicant: MERCK PATENT GMBH
    Inventor: MERCK PATENT GMBH
  • Methylene Urea Derivatives
    Publication number: 20130158076
    Abstract: The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: February 15, 2013
    Publication date: June 20, 2013
    Applicant: MERCK PATENT GMBH
    Inventor: Merck Patent GmbH
  • NOVEL SPECIFIC CASPASE-10 INHIBITORS
    Publication number: 20130090385
    Abstract: The invention relates to compounds of the general formula (I) wherein R1, R2, R3, R4, R5, R6, i and j have the meanings given in claim 1, and to the use thereof as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy.
    Type: Application
    Filed: November 28, 2012
    Publication date: April 11, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventor: Merck Patent Gesellschaft mit Beschrankter Haftu
  • Indole derivatives as CRTH2 receptor antagonists
    Patent number: 9023864
    Abstract: Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: May 5, 2015
    Assignees: Merck Sharp & Dohme Corp., Merck Canada Inc.
    Inventors: Carl Berthelette, Michael Boyd, John Colucci, Karine Villeneuve, Joey L. Methot
  • Oxadiazole Diaryl Compounds
    Publication number: 20130109676
    Abstract: The invention relates to compounds of formula (I): wherein R1, R2, Ra, Rb, Rc and W, have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
    Type: Application
    Filed: December 12, 2012
    Publication date: May 2, 2013
    Applicant: MERCK SERONO SA
    Inventor: Merck Serono SA
  • 2-(HETEROCYCLYLBENZYL)PYRIDAZINONE DERIVATIVES
    Publication number: 20130131037
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.
    Type: Application
    Filed: January 11, 2013
    Publication date: May 23, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
    Inventor: MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
  • PIGMENT MIXTURE, AND USE THEREOF IN COSMETICS, FOOD AND PHARMACEUTICALS
    Publication number: 20130108569
    Abstract: The invention relates to pigment mixtures comprising at least two components A and B. The inventive pigment mixtures are characterized in that component A is embodied as effect pigments while component B is embodied as coloring agents and fillers. Also disclosed is the use of said pigment mixtures in cosmetic formulations and for coloring food products and pharmaceutical products.
    Type: Application
    Filed: December 18, 2012
    Publication date: May 2, 2013
    Applicant: MERCK PATENT GESELLSCHAFT
    Inventor: Merck Patent Gesellschaft
  • Antibiotic compounds
    Patent number: 7745644
    Abstract: Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: June 29, 2010
    Assignees: Merck Sharp & Dohme Corp., Merck Sharp and Dohme de Espana, S.A.
    Inventors: Angela Basilio, Olga Genilloud, Pilar Hernandez, Sheo Bux Singh, Jose Rueben Tormo, Jun Wang
  • Antibiotic compound
    Patent number: 7807445
    Abstract: Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structural formula (I).
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: October 5, 2010
    Assignees: Merck Sharp and Dohme de Espana, S.A., Merck Sharp & Dohme Corp.
    Inventors: Angela Basilio, Olga Genilloud, Hiranthi Jayasuriya, Ignacio Gonzalez, Sheo B. Singh, Oscar Salazar, Jun Wang
  • Benzoxazines
    Patent number: 4349673
    Abstract: Compounds of the formula Het--O--CH.sub.2 --CHOR--CH.sub.2 -NHaralkyl where Het is a 10 membered N-containing ring are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: September 14, 1982
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Corp.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Crystal forms of a HCV protease inhibitor
    Patent number: 9242917
    Abstract: The present invention relates to different forms of a HCV inhibitory compound.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: January 26, 2016
    Assignees: Merck Sharp & Dohme Limited, Merck Sharp & Dohme Corp.
    Inventors: Gregory L Beutner, Robert M Wenslow, Jr., Eric J Choi, Clinton Scott Shultz, Jeremy Scott, Juan D Arredondo, Laura Artino
  • Process for making 2, 5-substituted pyridine
    Patent number: 6420565
    Abstract: 2-lithio-5-halopyridine is formed as a predominant component of a reaction mixture by reacting BuLi with 2,5-dihalopyridine in a non-coordinating solvent.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: July 16, 2002
    Assignees: Merck & Co., Inc., Merck Frosst Canada & Co
    Inventors: Paul O'Shea, Xin Wang, Richard Tillyer
  • MAMMALIAN CELL SURFACE ANTIGENS; RELATED REAGENTS
    Publication number: 20130123200
    Abstract: Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: January 15, 2013
    Publication date: May 16, 2013
    Applicant: Merck Sharp & Dohme Corp.
    Inventor: Merck Sharp & Dohme Corp.
Narrow Results

Filter by US Classification