Search Patents
  • MAMMALIAN CELL SURFACE ANTIGENS; RELATED REAGENTS
    Publication number: 20130123200
    Abstract: Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: January 15, 2013
    Publication date: May 16, 2013
    Applicant: Merck Sharp & Dohme Corp.
    Inventor: Merck Sharp & Dohme Corp.
  • MAMMALIAN GENES; RELATED REAGENTS
    Publication number: 20130203060
    Abstract: Nucleic acids encoding a new family of small cysteine rich soluble proteins, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Application
    Filed: April 1, 2013
    Publication date: August 8, 2013
    Applicant: Merck Sharp & Dohme Corp.
    Inventor: Merck Sharp & Dohme Corp.
  • 5-lipoxygenase activating protein
    Patent number: 5182367
    Abstract: An 18kD protein (FLAP) has been isolated from rat and human cells which is necessary for production of leukotrienes from arachidonic acid in mammalian cells containing 5-lipoxygenase. The gene (cDNA) encoding for FLAP has also been produced.
    Type: Grant
    Filed: November 30, 1990
    Date of Patent: January 26, 1993
    Assignees: Merck & Co., Inc., Merck Frosst Canada, Inc.
    Inventors: John W. Gillard, Jacques-Yves Gauthier, Jillian F. Evans, Rejean Fortin, Yvan Guinon, Richard A. F. Dixon, Douglas K. Miller
  • Conjugates of leukotrienes with proteins
    Patent number: 4767745
    Abstract: Leukotrienes may be conjugated with various proteins such as Bovine Serum Albumin (BSA) and Hemocyanin from Giant Keyhole Limpets (KLH) using 1,5-difluoro-2,4-dinitrobenzene or 6-N-maleimidohexanoic acid chloride as coupling agents.These conjugates are useful as reagents in a newly developed immunoassay for leukotrienes, as well as having potential utility as chemical immunotherapeutic agents in the treatment of various allergic and chronic inflammatory diseases of the skin, lung, and airways, including asthma, allergic rhinitis, rheumatoid arthritis, and skin diseases such as psoriasis and eczema.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: August 30, 1988
    Assignees: Merck Frosst Canada, Inc., Merck & Co., Inc.
    Inventors: Robert N. Young, Joshua Rokach, Edward C. Hayes
  • Soluble CD164 polypeptides
    Patent number: 7803910
    Abstract: The present invention relates to sCD164 variants and therapeutic uses thereof, in particular for treating or preventing inflammatory or autoimmune disorders.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: September 28, 2010
    Assignee: Merck Serono S.A.
    Inventors: Gabriela Saborio, Christine Power, Amanda Proudfoot
  • LH liquid formulations
    Patent number: 8664369
    Abstract: The invention relates to liquid pharmaceutical formulations of luteinizing hormone (LH) for single- or multi-dose administration.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: March 4, 2014
    Assignee: Merck Serono S.A.
    Inventors: Rita Agostinetto, Fabrizio Samaritani, Alessandra Del Rio, Joel Richard
  • Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
    Patent number: 7585840
    Abstract: The invention relates to the use of osteoprotegerin for treatment and/or prevention of fibrotic diseases, in particular of scleroderma.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: September 8, 2009
    Assignee: Merck Serono S.A.
    Inventors: Christine Power, Christine Plater-Zyberk
  • Method for treating liver cirrhosis or interstitial pulmonary fibrosis
    Patent number: 7655628
    Abstract: The invention relates to the use of SARP-1 for the preparation of a medicament for the treatment and/or prevention of scleroderma, in particular of systemic sclerosis.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: February 2, 2010
    Assignee: Merck Serono SA
    Inventors: Christine Plater-Zyberk, Christine Power, Jacques Colinge
  • Engineered anti-IL-23R antibodies
    Patent number: 8309085
    Abstract: Antibodies to human IL-23R are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: November 13, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Leonard G. Presta
  • Human vanilloid receptor-like receptor
    Patent number: 7179898
    Abstract: The present invention discloses a human vanilloid receptor-like (VR-L) receptor.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: February 20, 2007
    Assignee: Merck & Co., Inc.
    Inventor: Timothy Peter Bonnert
  • Nucleic acids encoding engineered anti-IL-23R antibodies
    Patent number: 8691532
    Abstract: Antibodies to human IL-23R are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: April 8, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Leonard G. Presta
  • Human EphA9 receptor polypeptides
    Patent number: 7074899
    Abstract: EphA9 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EphA9 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: July 11, 2006
    Assignee: Merck Patent GmbH
    Inventors: Bjoern Hock, Klaus Duecker
  • Synthetic HPV16 virus-like particles
    Patent number: 5922588
    Abstract: The invention is a series of synthetic virus-like particles useful in the characterization of human papillomavirus infection and assays employing the synthetic virus-like particles.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: July 13, 1999
    Assignee: Merck & Co., Inc.
    Inventor: Steven Ludmerer
  • Regulator of G protein signalling
    Patent number: 7087716
    Abstract: RGS8 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing RGS8 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: August 8, 2006
    Assignee: Merck Patent GmbH
    Inventors: Claudia Wilm, Michael Gassen
  • IL-7 fusion proteins
    Patent number: 7960514
    Abstract: The invention is directed to a fusion protein which includes a first portion including an immunoglobulin (Ig) chain and a second portion including interleukin-7 (IL-7).
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: June 14, 2011
    Assignee: Merck Patent GmbH
    Inventors: Scott Lauder, Stephen D. Gillies
  • IL-7 fusion proteins
    Patent number: 8338575
    Abstract: The invention is directed to a fusion protein which includes a first portion including an immunoglobulin (Ig) chain and a second portion including interleukin-7 (IL-7).
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: December 25, 2012
    Assignee: Merck Patent GmbH
    Inventors: Scott Lauder, Stephen D. Gillies
  • NK-2 homeobox transcription factor
    Patent number: 7183397
    Abstract: Nkx2-C4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Nkx2-C4 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: February 27, 2007
    Assignee: Merck Patent GmbH
    Inventor: Claudia Wilm
  • Lipid binding protein 4
    Patent number: 6924357
    Abstract: Lipid Binding Protein 4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Lipid Binding Protein 4 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: August 2, 2005
    Assignee: Merck Patent GmbH
    Inventors: Matthias Grell, Klaus Dücker
  • Mitogen activated kinase
    Patent number: 7091022
    Abstract: MEKK3b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MEKK3b polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: August 15, 2006
    Assignee: Merck Patent GmbH
    Inventor: Burkhard Scharm
  • Nucleic acid molecules encoding BANK1 splice variants
    Patent number: 8105816
    Abstract: The present invention relates to a new splice variant of BANK1, the use of SNPs in BANK1 for diagnostics and the use of antagonists to modulate BANK1 and/or the BANK1 pathway.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: January 31, 2012
    Assignee: Merck Serono S. A.
    Inventors: Hadi Abderrahim, Sergei V. Kozyrev