Search Patents
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Publication number: 20090292336Abstract: In one embodiment, a neural interface system includes an implantable neural probe having a flexible substrate, electrodes that extend from the substrate that are adapted to contact neural tissue of the brain, a signal processing circuit configured to process neural signals collected with the electrodes, and a wireless transmission circuit configured to wirelessly transmit the processed neural signals, and a backend computing device configured to wirelessly receive the processed neural signals, to process the received signals to reconstruct the collected neural signals, and to analyze the collected neural signals.Type: ApplicationFiled: May 22, 2009Publication date: November 26, 2009Inventors: Toshikazu Nishida, John Gregory Harris, Rizwan Bashirullah, Jose Principe, Justin Sanchez
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Patent number: 8073546Abstract: The following disclosure describes several methods and apparatus for electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. For example, the method can include selecting a stimulation site by generating an intended neural activity by triggering a neural signal in or from the impaired body part and detecting a region of the brain in which a response neural activity occurs in reaction to the neural signal.Type: GrantFiled: July 12, 2010Date of Patent: December 6, 2011Assignee: Advanced Neuromodulation Systems, Inc.Inventors: W. Douglas Sheffield, Andrew D. Firlik
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Patent number: 8428732Abstract: In one embodiment, a neural interface system includes an implantable neural probe having a flexible substrate, electrodes that extend from the substrate that are adapted to contact neural tissue of the brain, a signal processing circuit configured to process neural signals collected with the electrodes, and a wireless transmission circuit configured to wirelessly transmit the processed neural signals, and a backend computing device configured to wirelessly receive the processed neural signals, to process the received signals to reconstruct the collected neural signals, and to analyze the collected neural signals.Type: GrantFiled: May 22, 2009Date of Patent: April 23, 2013Assignee: University of Florida Research Foundation, Inc.Inventors: Toshikazu Nishida, John Gregory Harris, Rizwan Bashirullah, Jose Principe, Justin Sanchez
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Patent number: 10668287Abstract: In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.Type: GrantFiled: July 26, 2017Date of Patent: June 2, 2020Assignee: Cardiac Pacemakers, Inc.Inventors: Andrew P. Kramer, Jason J. Hamann
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Patent number: 11154716Abstract: According to an embodiment of a method for providing neural stimulation, activity is sensed, and neural stimulation is automatically controlled based on the sensed activity. An embodiment determines periods of rest and periods of exercise using the sensed activity, and applies neural stimulation during rest and withdrawing neural stimulation during exercise. Other embodiments are provided herein.Type: GrantFiled: June 19, 2019Date of Patent: October 26, 2021Assignee: Cardiac Pacemakers, Inc.Inventors: Imad Libbus, Andrew P. Kramer
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Publication number: 20120165899Abstract: A neural stimulation system responsive to collateral neural activity that may arise in association with a neural stimulation procedure includes a stimulation interface configured to deliver stimulation signals to a target neural population, a monitoring interface positioned to receive signals corresponding to a neural activity within the target neural population, a stimulus unit coupled to deliver stimulation singals to the stimulation interface, and a sensing unit coupled to the monitoring device and the stimulus unit. The neural stimulation procedure may be directed toward rehabilitating, restoring, and/or enhancing one or more neural functions by facilitating and/or effectuating a neuroplastic change or reorganization; and/or affecting a neurological condition that exists on a continuous or essentially continuous basis absent the stimulation procedure.Type: ApplicationFiled: March 7, 2012Publication date: June 28, 2012Inventor: Bradford Evan Gliner
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Publication number: 20030195584Abstract: A non-invasive system and process for converting sensory data, e.g., visual, audio, taste, smell or touch, to neural firing timing differences in a human brain and using acoustic signals to generate the neural firing time differences. Data related to neural firing time differences, the acoustic signals, and a user's response map may be stored in memory. The user's response map may be used to more accurately map the calculated neural firing time differences to the correct neural locations.Type: ApplicationFiled: May 20, 2003Publication date: October 16, 2003Inventor: Thomas P. Dawson
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Publication number: 20110054562Abstract: A neural stimulation system responsive to collateral neural activity that may arise in association with a neural stimulation procedure includes a stimulation interface configured to deliver stimulation signals to a target neural population, a monitoring interface positioned to receive signals corresponding to a neural activity within the target neural population, a stimulus unit coupled to deliver stimulation singals to the stimulation interface, and a sensing unit coupled to the monitoring device and the stimulus unit. The neural stimulation procedure may be directed toward rehabilitating, restoring, and/or enhancing one or more neural functions by facilitating and/or effectuating a neuroplastic change or reorganization; and/or affecting a neurological condition that exists on a continuous or essentially continuous basis absent the stimulation procedure.Type: ApplicationFiled: November 8, 2010Publication date: March 3, 2011Inventor: Bradford Evan Gliner
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Publication number: 20120109020Abstract: The invention generally relates to methods for modifying neural transmission patterns. In certain embodiments, methods of the invention involve noninvasively applying a first type of energy to a region of neural tissue, noninvasively applying a second type of energy to the region of tissue, such that the combined effect modifies a neural transmission pattern between cells of the neural tissue.Type: ApplicationFiled: October 26, 2011Publication date: May 3, 2012Applicant: HIGHLAND INSTRUMENTS, INC.Inventors: Timothy Andrew Wagner, Uri Tzvi Eden
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Publication number: 20030074032Abstract: A neural stimulation system responsive to collateral neural activity that may arise in association with a neural stimulation procedure includes a stimulation interface configured to deliver stimulation signals to a target neural population, a monitoring interface positioned to receive signals corresponding to a neural activity within the target neural population, a stimulus unit coupled to deliver stimulation singals to the stimulation interface, and a sensing unit coupled to the monitoring device and the stimulus unit. The neural stimulation procedure may be directed toward rehabilitating, restoring, and/or enhancing one or more neural functions by facilitating and/or effectuating a neuroplastic change or reorganization; and/or affecting a neurological condition that exists on a continuous or essentially continuous basis absent the stimulation procedure.Type: ApplicationFiled: October 15, 2002Publication date: April 17, 2003Inventor: Bradford Evan Gliner
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Patent number: 8433414Abstract: Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.Type: GrantFiled: February 17, 2012Date of Patent: April 30, 2013Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Bradford Evan Gliner, Kent Leyde
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Patent number: 7620456Abstract: Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.Type: GrantFiled: March 23, 2006Date of Patent: November 17, 2009Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Bradford Evan Gliner, Kent Leyde
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Patent number: 10226629Abstract: Embodiments are directed to a computer implemented neural stimulation system having a first module configured to derive neural data from muscle contractions or movements of a subject. The system further includes a second module configured to derive a neural state assessment of the subject based at least in part on the neural data. The system further includes a third module configured to derive at least one neural stimulation parameter based at least in part on the neural state assessment. The system further includes a fourth module configured to deliver neural stimulations to the subject based at least in part on the at least one neural stimulation parameter.Type: GrantFiled: June 19, 2015Date of Patent: March 12, 2019Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Guillermo A. Cecchi, James R. Kozloski, Clifford A. Pickover, Irina Rish
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Patent number: 7831305Abstract: A neural stimulation system responsive to collateral neural activity that may arise in association with a neural stimulation procedure includes a stimulation interface configured to deliver stimulation signals to a target neural population, a monitoring interface positioned to receive signals corresponding to a neural activity within the target neural population, a stimulus unit coupled to deliver stimulation signals to the stimulation interface, and a sensing unit coupled to the monitoring device and the stimulus unit. The neural stimulation procedure may be directed toward rehabilitating, restoring, and/or enhancing one or more neural functions by facilitating and/or effectuating a neuroplastic change or reorganization; and/or affecting a neurological condition that exists on a continuous or essentially continuous basis absent the stimulation procedure.Type: GrantFiled: October 15, 2002Date of Patent: November 9, 2010Assignee: Advanced Neuromodulation Systems, Inc.Inventor: Bradford Evan Gliner
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Patent number: 11857811Abstract: Systems and methods are disclosed related to using acoustic waves to detect neural activity in a brain and/or localize the neural activity in the brain. Sensors positioned outside of a skull encasing the brain can detect acoustic waves associated with the neural activity in the brain. From output signals of the sensors, a particular type of neural activity (e.g., a seizure) can be detected. A location of the neural activity can be determined based on outputs of the sensors. In some embodiments, the ultrasound energy can be applied to the location of the neural activity in response to detecting the neural activity.Type: GrantFiled: February 7, 2022Date of Patent: January 2, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Butrus T. Khuri-Yakub, Kamyar Firouzi, George Quintin Stedman
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Patent number: 10207111Abstract: Embodiments are directed to a computer implemented neural stimulation system having a first module configured to derive neural data from muscle contractions or movements of a subject. The system further includes a second module configured to derive a neural state assessment of the subject based at least in part on the neural data. The system further includes a third module configured to derive at least one neural stimulation parameter based at least in part on the neural state assessment. The system further includes a fourth module configured to deliver neural stimulations to the subject based at least in part on the at least one neural stimulation parameter.Type: GrantFiled: January 4, 2018Date of Patent: February 19, 2019Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Guillermo A. Cecchi, James R. Kozloski, Clifford A. Pickover, Irina Rish
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Patent number: 9943689Abstract: Embodiments are directed to a computer implemented neural stimulation system having a first module configured to derive neural data from muscle contractions or movements of a subject. The system further includes a second module configured to derive a neural state assessment of the subject based at least in part on the neural data. The system further includes a third module configured to derive at least one neural stimulation parameter based at least in part on the neural state assessment. The system further includes a fourth module configured to deliver neural stimulations to the subject based at least in part on the at least one neural stimulation parameter.Type: GrantFiled: March 4, 2015Date of Patent: April 17, 2018Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Guillermo A. Cecchi, James R. Kozloski, Clifford A. Pickover, Irina Rish
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Publication number: 20080058892Abstract: A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.Type: ApplicationFiled: August 30, 2006Publication date: March 6, 2008Inventors: Paul A. Haefner, Kristofer J. James, Kent Lee, Imad Libbus, Anthony V. Caparso, Jonathan Kwok, Yachuan Pu
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Patent number: 8121695Abstract: Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.Type: GrantFiled: November 16, 2009Date of Patent: February 21, 2012Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Bradford Evan Gliner, Jeffrey Balzer, Andrew D Firlik
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Publication number: 20040111127Abstract: Systems and methods for treating a neurological disorder comprising determining a first set of neural stimulation parameters capable of treating a first subset of symptoms, determining a second set of neural stimulation parameters capable of treating a second subset of symptoms, and applying a neural stimulation therapy based upon the first set of neural stimulation parameters and the second set of neural stimulation parameters to the patient. The first set of neural stimulation parameters can include electrical stimulation at a first frequency, and the second set of neural stimulation parameters can include electrical stimulation at a second frequency. In other embodiments, a treatment method comprises applying a first neural stimulation therapy to the patient in a continuous or generally continuous manner during a first time interval, and applying a second neural stimulation therapy to the patient in a noncontinuous or interrupted manner following the first time interval.Type: ApplicationFiled: December 10, 2002Publication date: June 10, 2004Inventor: Bradford Evan Gliner