Search Patents
  • Patent number: 10898267
    Abstract: Stenosis information is obtained by obtaining photographic image data (302) from a displayed image of a blood vessel (103, 203) containing the stenosis. Contours of the blood vessel and the stenosis are detected and dimensions are estimated from the photographic image data. A blood vessel model is reconstructed and fractional flow reserve data is calculated using the blood vessel model.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: January 26, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Holger Schmitt, Christian Haase, Hannes Nickisch, Sven Prevrhal
  • Patent number: 11195278
    Abstract: A computing system (118) includes a computer readable storage medium (122) with computer executable instructions (124), including a including a biophysical simulator (126) with a segmentor (202) and a boundary condition determiner (206). The computing system further includes a processor (120) configured to execute the biophysical simulator to compute a fractional flow reserve index with cardiac imaging data and at least one of an adapted coronary tree segmentation and an adapted boundary condition.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: December 7, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hannes Nickisch, Holger Schmitt
  • Publication number: 20180360405
    Abstract: A system (100) for a targeted perfusion scan includes a computed tomography (CT) scanner (120), a feeding territory map (132) and a targeted perfusion unit (140). The CT scanner (120) performs a perfusion scan of a portion of tissues of an organ. The feeding territory map (132) maps arterial locations of an arterial vessel tree to spatially located organ tissues of the organ fed by the arterial locations. The targeted perfusion unit (140) includes one or more processors (164) configured to determine targeted coverage (200) from a location of a stenosis (112, 210) and the feeding territory map, and to control the CT scanner to perform the perfusion scan according to the determined targeted coverage.
    Type: Application
    Filed: December 20, 2016
    Publication date: December 20, 2018
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Sven PREVRHAL, Holger SCHMITT, Hannes NICKISCH
  • Patent number: 9788807
    Abstract: The invention relates to a processing apparatus for processing cardiac data of a living being and to an imaging system comprising the processing apparatus. A distribution of Fractional flow reserve (FFR) values being indicative of the FFR of different coronary arteries of the living being, a distribution of myocardial perfusion values like values of an iodine map being indicative of the myocardial perfusion of different portions of the myocardium of the living being and assignments between coronary arteries and portions of the myocardium of the living being are used for determining degrees of correspondence between FFR values and myocardial perfusion values. This allows for, for example, a determination of the reliability of the FFR values, if the myocardial perfusion values are known to be reliable, based on the determined degrees of correspondence.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: October 17, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Holger Schmitt, Hannes Nickisch, Sven Prevrhal
  • Patent number: 11576637
    Abstract: A computing system (118) includes a computer readable storage medium (122) with computer executable instructions (124), including a biophysical simulator (126), and a reference location (128), and a processor (120) configured to the biophysical simulator and simulate a reference FFR value at a predetermined location along a segmented coronary vessel indicated by the reference location. A computer readable storage medium encoded with computer readable instructions, which, when executed by a processor of a computing system, causes the processor to simulate a reference FFR value at a predetermined location along a segmented coronary vessel indicated by a predetermined reference location. A method including simulating a reference FFR value at a predetermined location along a segmented coronary vessel indicated by a predetermined reference location.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: February 14, 2023
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Holger Schmitt, Hannes Nickisch, Manindranath Vembar
  • Patent number: 10111633
    Abstract: A system (IPS) and related method for fractional flow reserve, FFR, simulation. The simulation for a range of FFR values for a vasculature portion is based on a composite transfer function which is combined from a weighted sum of global effect transfer functions he, each representing a distinct physical effect that causes a pressure drop. The weights we are gotten from a previous training phase against pressure pi versus flow rate fi 5 sample measurements associated with respective vasculature geometries. The simulated range of FFR values is visualized in a graphics display (GD) as a function of pressure and flow rate values within respective intervals.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: October 30, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hannes Nickisch, Michael Grass, Holger Schmitt, Jan Timmer
  • Publication number: 20180365838
    Abstract: A system (100) for segmenting a coronary artery vessel tree (182) of a patient heart in a three dimensional (3D) cardiac image (120) includes a coronary volume definition unit (150) and a coronary artery segmentation unit (180). The coronary volume definition unit (150) sets a spatial boundary (210, 220) from internal and external surfaces of heart tissues in the 3D cardiac image based on a fitted heart model (200). The coronary artery segmentation unit (180) segments the coronary artery vessel tree (182) in the 3D cardiac image using a segmentation algorithm with a search space limited by the spatial boundary set from the internal and external surfaces of the heart tissues.
    Type: Application
    Filed: December 19, 2016
    Publication date: December 20, 2018
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Cristian LORENZ, Tobias KLINDER, Holger SCHMITT, Hannes NICKISCH
  • Patent number: 10902606
    Abstract: A system (100) for segmenting a coronary artery vessel tree (182) of a patient heart in a three dimensional (3D) cardiac image (120) includes a coronary volume definition unit (150) and a coronary artery segmentation unit (180). The coronary volume definition unit (150) sets a spatial boundary (210, 220) from internal and external surfaces of heart tissues in the 3D cardiac image based on a fitted heart model (200). The coronary artery segmentation unit (180) segments the coronary artery vessel tree (182) in the 3D cardiac image using a segmentation algorithm with a search space limited by the spatial boundary set from the internal and external surfaces of the heart tissues.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: January 26, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Cristian Lorenz, Tobias Klinder, Holger Schmitt, Hannes Nickisch
  • Patent number: 11301994
    Abstract: A system (100) includes a computer readable storage medium (122) with computer executable instructions (124), including: a predictor (126) configured to determine a baseline coronary state and a predicted coronary state from contrast enhanced cardiac computed tomography volumetric image data and a model of an effect of one or more substances on characteristics effecting the coronary state. The system further includes a processor (120) configured to execute the predictor to determine the baseline coronary state and the predicted coronary state from the contrast enhanced cardiac computed tomography volumetric image data and the model of the effect of one or more of the substances on the characteristics effecting the coronary state. The system further includes a display configured to display the baseline coronary state and the predicted coronary state.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: April 12, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Holger Schmitt, Hannes Nickisch, Tobias Wissel
  • Patent number: 10282846
    Abstract: A method is provided for generating a deformable model (300) for segmenting an anatomical structure in a medical image. The anatomical structure comprises a wall. The deformable model (300) is generated such that it comprises, in addition to two surface meshes (320, 360), an intermediate layer mesh (340) for being applied in-between a first surface layer of the wall and a second surface layer of the wall. In generating the intermediate layer mesh (340), the mesh topology of at least part (400) of the intermediate layer mesh is matched to the mesh topology of one of the surface meshes (320, 360), thereby establishing matching mesh topologies. The deformable model (300), as generated, better matches the composition of such walls, thereby providing a more accurate segmentation.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: May 7, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Alexandra Groth, Hannes Nickisch, Frank Michael Weber, Juergen Weese, Hans Barschdorf
  • Patent number: 11141123
    Abstract: The present invention relates to a device (1) for fractional flow reserve determination. The device (1) comprises a model generator (10) configured to generate a three-dimensional model (3DM) of a portion of an imaged vascular vessel tree (VVT) surrounding a stenosed vessel segment (SVS), based on a partial segmentation of the imaged vascular vessel tree (VVT). Further, the device comprises an image processor (20) configured to calculate a blood flow (Q) through the stenosed vessel segment (SVS) based on an analysis of a time-series of X-ray images of the vascular vessel tree (VVT). Still further, the device comprises a fractional-flow-reserve determiner (30) configured to determine a fractional flow reserve (FFR) based on the three-dimensional model (3DM) and the calculated blood flow.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: October 12, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hanno Heyke Homann, Michael Grass, Raoul Florent, Holger Schmitt, Odile Bonnefous, Hannes Nickisch
  • Patent number: 9842401
    Abstract: The present invention relates a segmentation apparatus (10) for interactively segmenting blood vessels (2) in angiographic image data (3). The segmentation apparatus (10) comprises a significant location determining unit (11) for determining one or more locations of a current segmentation (4) of the blood vessels (2) in the angiographic image data (3) as significant locations (5) at which the current segmentation (4) has a predetermined influence on a value of a blood flow parameter that is calculated based on the current segmentation (4), and a display unit (12) for displaying the significant locations (5) to an operator. Thereby, the operator can be guided to focus his/her segmentation efforts to those locations of the current segmentation (4) that are most relevant for the accuracy of the calculation of the value of the blood flow parameter. This may ease the burden on the operator during the segmentation procedure.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: December 12, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Sven Prevrhal, Hannes Nickisch, Holger Schmitt
  • Patent number: 11490867
    Abstract: The present invention relates to a device (1) for fractional flow reserve determination. The device (1) comprises a model generator (10) configured to generate a three-dimensional model (3DM) of a portion of an imaged vascular vessel tree (VVT) surrounding a stenosed vessel segment (SVS), based on a partial segmentation of the imaged vascular vessel tree (VVT). Further, the device comprises an image processor (20) configured to calculate a blood flow (Q) through the stenosed vessel segment (SVS) based on an analysis of a time-series of X-ray images of the vascular vessel tree (VVT). Still further, the device comprises a fractional-flow-reserve determiner (30) configured to determine a fractional flow reserve (FFR) based on the three-dimensional model (3DM) and the calculated blood flow.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: November 8, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hanno Heyke Homann, Michael Grass, Raoul Florent, Holger Schmitt, Odile Bonnefous, Hannes Nickisch
  • Publication number: 20170105694
    Abstract: The invention relates to an apparatus for determining a fractional flow reserve (FFR) value of the coronary artery system of a livingbeing (3). A fractional flow reserve value determination unit (13) determines the FFR value by using an FFR value determination algorithm that is adapted to determine the FFR value based on a boundary condition and a provided representation of the coronary artery system, wherein the boundary condition is specific for the living being and determined by a boundary condition determination unit (12). Since the boundary condition determination unit determines a boundary condition, which is specific for the living being, and since the fractional flow reserve value determination unit not only uses the provided representation of the coronary artery system, but also the living being specific boundary condition for determining the FFR value, the accuracy of the FFR value, which is non-invasively determined, can be improved.
    Type: Application
    Filed: June 24, 2015
    Publication date: April 20, 2017
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Michael GRASS, Yechiel LAMASH, Liran GOSHEN, Holger SCHMITT, Mordechay Pinchas FREIMAN, Hannes NICKISCH, Sven PREVRHAL
  • Patent number: 10258303
    Abstract: The invention relates to an apparatus for determining a fractional flow reserve (FFR) value of the coronary artery system of a living being (3). A fractional flow reserve value determination unit (13) determines the FFR value by using an FFR value determination algorithm that is adapted to determine the FFR value based on a boundary condition and a provided representation of the coronary artery system, wherein the boundary condition is specific for the living being and determined by a boundary condition determination unit (12). Since the boundary condition determination unit determines a boundary condition, which is specific for the living being, and since the fractional flow reserve value determination unit not only uses the provided representation of the coronary artery system, but also the living being specific boundary condition for determining the FFR value, the accuracy of the FFR value, which is non-invasively determined, can be improved.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: April 16, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Michael Grass, Yechiel Lamash, Liran Goshen, Holger Schmitt, Mordechay Pinchas Freiman, Hannes Nickisch, Sven Prevrhal
  • Patent number: 11055845
    Abstract: A computing system (126) includes a computer readable storage medium (130) with computer executable instructions (128), including: a segmentation standardizer (120) configured to determine a standardized vascular tree from a segmented vascular tree segmented of volumetric image data and a predetermined set of pruning rules (206), and a biophysical simulator (122) configured to perform a biophysical simulation based on the standardized vascular tree. The computing system further includes a processor (124) configured to execute the segmentation standardizer to determine the standardized vascular tree from the segmented vascular tree segmented of volumetric image data and the predetermined set of pruning rules, and configured to execute the biophysical simulator to perform a biophysical simulation based on the standardized vascular tree. The computing system further includes a display configured to display at least one of the standardized vascular tree and a result of the biophysical simulation.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: July 6, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hannes Nickisch, Holger Schmitt, Sven Prevrhal, Mordechay Pinchas Freiman, Liran Goshen
  • Patent number: 9867584
    Abstract: A method of determining the blood flow through coronary arteries comprises generating (S1) a 3D image data set of at least the coronary arteries and the myocardial muscle, generating (S2) a 3D marker data set of at least the myocardial muscle from a dual-energy or spectral 3D data set obtained after administration of a marker, said 3D marker data set indicating the amount of said marker contained within voxels of said myocardial muscle, subdividing (S3) the myocardial muscle into myocardial muscle segments, determining (S4) which coronary artery supplies the respective myocardial muscle segments, determining (S5) the volume of blood that flows into the respective myocardial muscle segments from said 3D marker data set, and determining (S6) the total volume of blood that flows into a coronary artery of interest by summing the volume of blood flowing into all myocardial muscle segments supplied by said coronary artery.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: January 16, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Michael Grass, Holger Schmitt, Hannes Nickisch
  • Patent number: 11721439
    Abstract: A system (SY) for determining a relative importance of each of a plurality of image features (Fn) of a vascular medical image impacting an overall diagnostic metric computed for the image from an automatically-generated diagnostic rule. A medical kin image database (MIDB) includes a plurality of vascular medical images (M1 . . . k). A rule generating unit (RGU) analyzes the plurality of C vascular medical images and automatically generates at least one diagnostic rule corresponding to a common diagnosis of a subset of the plurality of vascular medical images based on a plurality of image features common to the subset of vascular medical images. An image providing unit (IPU) provides a current vascular medical image (CVMI) including the plurality of image features. A diagnostic metric computation unit (DMCU) computes an overall diagnostic metric for the current vascular medical image by applying the at least one automatically-generated diagnostic rule to the current vascular medical image.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: August 8, 2023
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Tobias Wissel, Hannes Nickisch, Michael Grass
  • Patent number: 11039804
    Abstract: The present invention relates to an apparatus (26) and a method for determining a fractional flow reserve. For this purpose, a new personalized hyperemic boundary condition model is provided. The personalized hyperemic boundary condition model is used to condition a parametric model for a simulation of a blood flow in a coronary tree (34) of a human subject. As a basis for the personalized hyperemic boundary condition model, a predefined hyperemic boundary condition model is used, which represents empirical derived hyperemic boundary condition parameters. However, these empirical hyperemic boundary condition parameters are not specific for a human subject under examination. In order to achieve a specification of the respective predefined hyperemic boundary condition model, specific human subject features are derived from a volumetric image of the coronary tree of the human subject.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: June 22, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Mordechay Pinchas Freiman, Liran Goshen, Hannes Nickisch
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