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  • Therapeutic RNA
    Publication number: 20210290730
    Abstract: This disclosure relates to the field of therapeutic RNAs for treatment of solid tumor cancers.
    Type: Application
    Filed: April 30, 2021
    Publication date: September 23, 2021
    Applicant: Sanofi
    Inventors: Friederike Gieseke, Ugur Sahin, Timothy R. Wagenaar, Dmitri G. Wiederschain
  • Therapeutic RNA
    Publication number: 20200147176
    Abstract: This disclosure relates to the field of therapeutic RNAs for treatment of solid tumor cancers.
    Type: Application
    Filed: August 27, 2019
    Publication date: May 14, 2020
    Applicant: Sanofi
    Inventors: Friederike Gieseke, Ugur Sahin, Timothy R. Wagenaar, Dmitri G. Wiederschain
  • Therapeutic RNA
    Patent number: 11865159
    Abstract: This disclosure relates to the field of therapeutic RNAs for treatment of solid tumor cancers.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: January 9, 2024
    Assignee: Sanofi
    Inventors: Friederike Gieseke, Ugur Sahin, Timothy R. Wagenaar, Dmitri G. Wiederschain, Christian Hotz
  • Method for identifying biologically active structures of microbial pathogens
    Publication number: 20040132132
    Abstract: The present invention concerns a method for identifying biologically active structures which are coded by the genome of microbial pathogens, using genomic pathogen nucleic acids.
    Type: Application
    Filed: February 6, 2004
    Publication date: July 8, 2004
    Inventors: Ugur Sahin, Ozlem Tuereci, Burkhard Ludewig
  • METHODS AND KITS FOR THE DIAGNOSIS OF CANCER
    Publication number: 20190033316
    Abstract: The present invention relates to methods and kits for the diagnosis, prognosis and/or monitoring of cancer in a patient. The present invention further relates to isolated peptides, panels of isolated peptides and diagnostic devices.
    Type: Application
    Filed: April 15, 2015
    Publication date: January 31, 2019
    Inventors: Rainer Hipfel, Clara Werner, Andree Rothermel, Ugur Sahin, Yvonne Kuhne
  • Antibodies specific for SSX proteins
    Publication number: 20030023057
    Abstract: The invention relates to members of the SSX family of genes, as well as their uses.
    Type: Application
    Filed: October 11, 2001
    Publication date: January 30, 2003
    Inventors: Ali O. Gure, Ozlem Tureci, Ugur Sahin, Solam Tsang, Matthew J. Scanlan, Alexander Knuth, Michael Pfreundschuh, Lloyd J. Old, Yao-Tseng Chen
  • METHOD AND KIT FOR DETERMINING WHETHER A SUBJECT SHOWS AN IMMUNE RESPONSE
    Publication number: 20160265050
    Abstract: The present invention relates to a kit and a method for determining whether a subject shows an immune response against an antigen.
    Type: Application
    Filed: October 24, 2014
    Publication date: September 15, 2016
    Inventors: Ugur SAHIN, Michael SCHÄFER, Marta Magdalena FARYNA, Tana OMOKOKO, Lisa HEBICH, Petra SIMON, Annett REICHARDT, Özlem YILDIZ
  • RNA FOR TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20200061166
    Abstract: The present invention relates to non-immunogenic RNA. This RNA forms the basis for the development of therapeutic agents for inducing tolerance towards an autoantigen and thus, for the treatment of autoimmune diseases.
    Type: Application
    Filed: April 10, 2018
    Publication date: February 27, 2020
    Inventors: Ugur Sahin, Sebastian Kreiter, Christina Krienke, Jutta Petschenka, Lena Mareen Kranz, Mustafa Diken
  • Identification of Tumor-Associated Markers for Diagnosis and Therapy
    Publication number: 20160215351
    Abstract: The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Application
    Filed: January 21, 2016
    Publication date: July 28, 2016
    Inventors: Ugur Sahin, Ozlem Tureci, Michael Koslowski
  • Identification of Tumor-Associated Antigens for Diagnosis and Therapy
    Publication number: 20150197576
    Abstract: The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Application
    Filed: January 27, 2015
    Publication date: July 16, 2015
    Inventors: Ugur Sahin, Ozlem Tureci, Michael Koslowski, Dirk Usener
  • RNA FOR TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20230330198
    Abstract: The present invention relates to non-immunogenic RNA. This RNA forms the basis for the development of therapeutic agents for inducing tolerance towards an autoantigen and thus, for the treatment of autoimmune diseases.
    Type: Application
    Filed: June 12, 2023
    Publication date: October 19, 2023
    Inventors: Ugur Sahin, Sebastian Kreiter, Christina Krienke, Jutta Petschenka, Lena Mareen Kranz, Mustafa Diken
  • Method For Determining The Function Of Nucleic Acid Sequences And Expression Products Coded Thereby
    Publication number: 20080299552
    Abstract: The invention relates to a method for the investigation and determination of the function of nucleic acid sequences and nucleic acid expression products by the introduction of RNA into host cells.
    Type: Application
    Filed: December 22, 2005
    Publication date: December 4, 2008
    Applicant: Johannes Gutenberg-Universitat Mainz Vertreten Durch Den Prasidenten
    Inventors: Ugur Sahin, Ozlem Tureci, Carolin Bell
  • MULTISPECIFIC ANTIBODIES AGAINST CD40 AND CD137
    Publication number: 20230089969
    Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
    Type: Application
    Filed: August 3, 2022
    Publication date: March 23, 2023
    Inventors: Isil ALTINTAS, David SATIJN, Rik RADEMAKER, Paul PARREN, Friederike GIESEKE, Ugur SAHIN
  • MODIFICATION OF RNA, PRODUCING AN INCREASED TRANSCRIPT STABILITY AND TRANSLATION EFFICIENCY
    Publication number: 20230193296
    Abstract: It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be possible to obtain increased grades of expression by using said RNA in gene therapy approaches.
    Type: Application
    Filed: October 25, 2022
    Publication date: June 22, 2023
    Inventors: Ugur Sahin, Silke Holtkamp, Ozlem Tureci, Sebastian Kreiter
  • Monoclonal Antibodies for Treatment of Cancer
    Publication number: 20150175686
    Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
    Type: Application
    Filed: January 23, 2015
    Publication date: June 25, 2015
    Inventors: Ugur Sahin, Michael Koslowski, Ozlem Tureci
  • Identification of Tumor-Associated Markers for Diagnosis and Therapy
    Publication number: 20170314078
    Abstract: The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Application
    Filed: May 10, 2017
    Publication date: November 2, 2017
    Inventors: Ugur Sahin, Özlem Türeci, Michael Koslowski
  • Identification of Tumor-Associated Antigens for Diagnosis and Therapy
    Publication number: 20170080068
    Abstract: The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Application
    Filed: July 27, 2016
    Publication date: March 23, 2017
    Inventors: Ugur Sahin, Özlem Türeci, Michael Koslowski, Dirk Usener
  • MULTISPECIFIC ANTIBODIES AGAINST CD40 AND CD137
    Publication number: 20220064317
    Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
    Type: Application
    Filed: June 28, 2021
    Publication date: March 3, 2022
    Inventors: Isil ALTINTAS, David SATIJN, Rik RADEMAKER, Paul PARREN, Friederike GIESEKE, Ugur SAHIN
  • MULTISPECIFIC ANTIBODIES AGAINST CD40 AND CD137
    Publication number: 20200062853
    Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
    Type: Application
    Filed: July 14, 2017
    Publication date: February 27, 2020
    Inventors: Isil ALTINTAS, David SATIJN, Rik RADEMAKER, Paul PARREN, Friederike GIESEKE, Ugur SAHIN
  • Monoclonal Antibodies for Treatment of Cancer
    Publication number: 20170058044
    Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
    Type: Application
    Filed: September 6, 2016
    Publication date: March 2, 2017
    Inventors: Ugur Sahin, Michael Koslowski, Özlem Türeci
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