Search Patents
  • RECOMBINANT VACCINES AND USE THEREOF
    Publication number: 20140134201
    Abstract: The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In particular, said invention relates to fusion molecules, comprising an antigen and the trans-membrane region and cytoplasmic region of a MHC molecule and/or the cytoplasmic region of a MHC or a SNARE molecule.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 15, 2014
    Applicant: BioNTech AG
    Inventors: Ozlem Tureci, Ugur Sahin, Sebastian Kreiter
  • Identification of Tumor-Associated Antigens for Diagnosis and Therapy
    Publication number: 20140017254
    Abstract: The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 16, 2014
    Inventors: Ugur Sahin, Ozlem Tureci, Michael Koslowski, Dirk Usener
  • Identification of Tumor-Associated Markers for Diagnosis and Therapy
    Publication number: 20140134165
    Abstract: The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Application
    Filed: January 20, 2014
    Publication date: May 15, 2014
    Inventors: Ugur Sahin, Ozlem Tureci, Michael Koslowski
  • Isolated peptides which bind to MHC class II molecules, and uses thereof
    Publication number: 20040214284
    Abstract: Peptides which have an amino acid sequence identical to sequences found in tumor rejection antigen precursors, such as NY-ESO-1, and SSX-2, are disclosed. These peptides bind to MHC-Class II molecules, such as HLA-DR molecules, and provoke proliferation of CD4+ cells.
    Type: Application
    Filed: May 21, 2004
    Publication date: October 28, 2004
    Inventors: Ozlem Tureci, Ugur Sahin, Michael Pfreundschuh
  • Isolated nucleic acid molecules encoding SSX family members and thereof
    Patent number: 6291658
    Abstract: The invention relates to members of the SSX family of genes, as well as their uses.
    Type: Grant
    Filed: May 5, 1997
    Date of Patent: September 18, 2001
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Ali O. Gure, Ozlem Tureci, Ugur Sahin, Solam Tsang, Matthew J. Scanlan, Alexander Knuth, Michael Pfreundschuh, Lloyd J. Old, Yao-Tseng Chen
  • Identification of Tumor-Associated Antigens for Diagnosis and Therapy
    Publication number: 20110189179
    Abstract: The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Application
    Filed: April 13, 2011
    Publication date: August 4, 2011
    Inventors: Ugur Sahin, Özlzem Türeci, Michael Koslowski, Dirk Usener
  • Recombinant vaccines and use thereof
    Publication number: 20100111993
    Abstract: The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In particular, said invention relates to fusion molecules, comprising an antigen and the trans-membrane region and cytoplasmic region of a MHC molecule and/or the cytoplasmic region of a MHC or a SNARE molecule.
    Type: Application
    Filed: October 13, 2004
    Publication date: May 6, 2010
    Inventors: Özlem Türeci, Ugur Sahin, Sebastian Kreiter
  • Identification of Tumor-Associated Antigens for Diagnosis and Therapy
    Publication number: 20090202530
    Abstract: The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Application
    Filed: September 6, 2006
    Publication date: August 13, 2009
    Inventors: Ugur Sahin, Özlem Türeci, Michael Koslowski, Dirk Usener
  • Isolated peptides which bind to MHC Class II molecules, and uses thereof
    Patent number: 7385044
    Abstract: Peptides which have an amino acid sequence identical to sequences found in tumor rejection antigen precursors, such as NY-ESO-1, and SSX-2, are disclosed. These peptides bind to MHC-Class II molecules, such as HLA-DR molecules, and provoke proliferation of CD4+ cells.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: June 10, 2008
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Ozlem Tureci, Ugur Sahin, Michael Pfreundschuh
  • IDENTIFICATION OF TUMOR-ASSOCIATED MARKERS FOR DIAGNOSIS AND THERAPY
    Publication number: 20120070430
    Abstract: The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Application
    Filed: April 22, 2010
    Publication date: March 22, 2012
    Inventors: Ugur Sahin, Ozlem Tureci, Michael Koslowski
  • Recombinant Vaccines and Use Thereof
    Publication number: 20130011426
    Abstract: The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In particular, said invention relates to fusion molecules, comprising an antigen and the trans-membrane region and cytoplasmic region of a MHC molecule and/or the cytoplasmic region of a MHC or a SNARE molecule.
    Type: Application
    Filed: May 15, 2012
    Publication date: January 10, 2013
    Inventors: Özlem Türeci, Ugur Sahin, Sebastian Kreiter
  • GENETIC PRODUCTS DIFFERENTIALLY EXPRESSED IN TUMORS AND USE THEREOF
    Publication number: 20150031025
    Abstract: The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
    Type: Application
    Filed: May 2, 2014
    Publication date: January 29, 2015
    Applicant: GANYMED PHARMACEUTICALS AG
    Inventors: Ugur Sahin, Özlem Türeci, Michael Koslowski
  • Monoclonal Antibodies Against Claudin-18 for Treatment of Cancer
    Publication number: 20100166779
    Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD1 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
    Type: Application
    Filed: May 27, 2008
    Publication date: July 1, 2010
    Inventors: Ugur Sahin, Ozlem Tureci, Gunda Brandenburg, Dirk Usener
  • USE OF RNA FOR REPROGRAMMING SOMATIC CELLS
    Publication number: 20110065103
    Abstract: The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, by introducing RNA encoding factors inducing the de-differentiation of somatic cells into the somatic cells and culturing the somatic cells allowing the cells to de-differentiate.
    Type: Application
    Filed: December 12, 2008
    Publication date: March 17, 2011
    Inventors: Ugur Sahin, Marco Poleganov, Tim Beissert
  • IDENTIFICATION OF SURFACE-ASSOCIATED ANTIGENS FOR TUMOR DIAGNOSIS AND THERAPY
    Publication number: 20140017679
    Abstract: The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
    Type: Application
    Filed: April 17, 2013
    Publication date: January 16, 2014
    Applicant: BioNTech AG
    Inventors: Ugur Sahin, Ozlem Tureci, Michael Koslowski, Gerd Helftenbein, Dirk Usener, Volker Schluter
  • Vaccine Composition Comprising 5'-CAP Modified RNA
    Publication number: 20120195917
    Abstract: The present invention relates to modification of RNA with 5?-cap analogs in order to improve the stability and increase the expression of said RNA, in particular in immature antigen presenting cells. The present invention provides a vaccine composition comprising said stabilized RNA, immature antigen presenting cells comprising said stabilized RNA, and methods for stimulating and/or activating immune effector cells and for inducing an immune response in an individual using said stabilized RNA.
    Type: Application
    Filed: August 3, 2010
    Publication date: August 2, 2012
    Applicant: OCV Intellectual Capital , LLC
    Inventors: Ugur Sahin, Andreas Kuhn, Edward Darzynkiewicz, Jacek Jemielity, Joanna Kowalska
  • Genetic Products Which are Differentially Expressed in Tumors and Use Thereof
    Publication number: 20100203040
    Abstract: The invention relates to the identification of genetic products expressed in association with tumours and to coding nucleic acids for said products. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are aberrantly expressed in association with tumours, proteins, polypeptides and peptides which are expressed in association with tumours and to the coding nucleic acids for said proteins, polypeptides and peptides.
    Type: Application
    Filed: September 10, 2004
    Publication date: August 12, 2010
    Inventors: Oezlem Tuereci, Ugur Sahin, Michael Koslowski
  • Genetic Products Differentially Expressed in Tumors and the Use Thereof
    Publication number: 20080166350
    Abstract: According to the invention, gene products expressed in a tumor-associated manner and the nucleic acids coding therefor were identified. The invention relates to the therapy and diagnosis of diseases wherein said gene products expressed in a tumor-associated manner are aberrantly expressed. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumor associated manner and to nucleic acids coding therefor.
    Type: Application
    Filed: May 18, 2005
    Publication date: July 10, 2008
    Applicant: Ganymed Pharmaceuticals AG
    Inventors: Ozlem Tureci, Ugur Sahin, Michael Koslowski
  • GENETIC PRODUCTS DIFFERENTIALLY EXPRESSED IN TUMORS AND USE THEREOF
    Publication number: 20130243796
    Abstract: The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which the genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 19, 2013
    Inventors: Ugur Sahin, Özlem Türeci, Michael Koslowski
  • Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy
    Publication number: 20080193454
    Abstract: The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.
    Type: Application
    Filed: May 11, 2005
    Publication date: August 14, 2008
    Inventors: Ozlem Tureci, Ugur Sahin, Sandra Schneider, Gerd Helftenbein, Volker Schluter, Dirk Usener, Philippe Thiel