Search Patents
  • NOVEL INHIBITORS OF SECRETION OF HEPATITIS B VIRUS ANTIGENS
    Publication number: 20130303552
    Abstract: Pharmaceutical compositions of the invention comprise triazolopyrimidines useful for the treatment of hepatitis virus in a patient.
    Type: Application
    Filed: October 4, 2011
    Publication date: November 14, 2013
    Applicant: INSTITUTE FOR HEPALITIS AND VIRUS RESEARCH
    Inventors: Xiaodong Xu, Andrea Cuconati, Timothy M. Block, Tong Xiao
  • ENRICHMENT METHOD OF VIRUS
    Publication number: 20110053250
    Abstract: The present invention provides a novel method that can increase readily a virus or viral vector concentration in a solution having a low concentration and a kit for performing the method. Conventional methods require complicated operations, expensive equipment, or highly trained experts for efficiently concentrating viruses from low-concentration virus solutions. The method of the present invention can concentrate viral vectors readily while maintaining infection abilities of the viral vectors, and thus it can be used as a safe and simple technique for concentrating a vector useful in the field of a genetic therapy or a vaccine therapy using a viral vector.
    Type: Application
    Filed: March 31, 2009
    Publication date: March 3, 2011
    Applicants: Japan Tobacco Inc., Virus Ikagaku Kenkyusho Inc.
    Inventors: Yoshimitsu Takakura, Masako Ichikawa, Kazuhiro Kondo, Akihiro Shimizu
  • Peptide to detect several herpes virus infections
    Patent number: 5760175
    Abstract: A peptide is disclosed for detection of a herpe4s virus infection in an animal subject susceptible thereto, wherein the peptide comprises a compound of the Formula: ##STR1## designated Sequence ID 1.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: June 2, 1998
    Assignee: Bio-Virus Research Incorporated
    Inventors: Daniel B. Golubev, Alexander Chaihorsky
  • Pharmaceutical compositions against several herpes virus infections and/or atherosclerotic plaque
    Patent number: 5837262
    Abstract: A pharmaceutical composition is disclosed for the treatment against several herpes virus infections or atherosclerotic plaques in a mammalian subject suspectible thereto which comprises: (a) 10 to 30% by weight of the peptide of SEQ ID 2; (b) 10 to 30% by weight of the peptide of SEQ ID 4; 10 to 30% by weight of the peptide of SEQ ID 6; and (d) 10 to 30% by weight of the peptide of SEQ ID 8; in combination with a pharmaceutically acceptable inert carrier.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: November 17, 1998
    Assignee: Bio-Virus Research Incorporated
    Inventors: Daniel Golubev, Alexander Chaihorsky
  • Peptide composition generating an immune response against herpes virus
    Patent number: 6015566
    Abstract: A composition is disclosed for generating an immune response against a herpes virus in an animal subject susceptible thereto, wherein the vaccine comprises a compound of the Formula:Val Asn Pro Arg Gly Gly Cys Phe Leu Gly Gly Gly Ala Lys Ala Gly 5 10 - 15 Gly Gly Gly Gly Arg Ala Ala Gly Gln Pro Arg Ala 20 25designated Sequence ID 1. The composition is especially effective in generating an immune response against Kaposi's sarcoma herpesvirus.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: January 18, 2000
    Assignee: Bio-Virus Research Incorporated
    Inventors: Daniel B. Golubev, Alexander Chaihorsky
  • Recombinant virus vector originating in HHV-6 or HHV-7, method of producing the same, method of transforming host cell using the same, host cell transformed thereby and gene therapy method using the same
    Publication number: 20100247486
    Abstract: It is intended to provide a virus vector by which an exogenous nucleotide sequence can be inserted and easily transferred into a mammalian host cell and a gene encoded by the exogenous nucleotide sequence can be expressed in the host cell, and which has a low risk of pathogenicity and is appropriately usable in gene therapy of mammals. Namely, a recombinant vector originating in HHV-6 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U5, U6, U7, U8, U24, and U25 regions of HHV-6; or a recombinant vector originating in HHV-7 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U7, U8, U24, U24a, and U25 regions of HHV-7.
    Type: Application
    Filed: August 30, 2004
    Publication date: September 30, 2010
    Applicant: Virus Ikagaku Kenkyusho Inc.
    Inventor: Kazuhiro Kondo
  • Recombinant virus vector originating in HHV-6 or HHV-7, method of producing the same, method of transforming host cell using the same, host cell transformed thereby and gene therapy method using the same
    Patent number: 8642045
    Abstract: It is intended to provide a virus vector by which an exogenous nucleotide sequence can be inserted and easily transferred into a mammalian host cell and a gene encoded by the exogenous nucleotide sequence can be expressed in the host cell, and which has a low risk of pathogenicity and is appropriately usable in gene therapy of mammals. Namely, a recombinant vector originating in HHV-6 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U5, U6, U7, U8, U24, and U25 regions of HHV-6; or a recombinant vector originating in HHV-7 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U7, U8, U24, U24a, and U25 regions of HHV-7.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: February 4, 2014
    Assignee: Virus Ikagaku Kenkyusho Inc.
    Inventor: Kazuhiro Konda
  • System and method for efficiently managing computer virus definitions using a structured virus database
    Patent number: 6622150
    Abstract: A system and method for efficiently managing computer virus definitions using a structured virus database are described. One or more virus definition records are stored in a structured virus database. Each virus definition record includes an identifier uniquely identifying a computer virus, at least one virus name associated with the computer virus, a virus definition sentence including object code providing operations to detect the identified computer virus within a computer system, and a virus removal sentence including object code providing operations to clean the identified computer virus from the computer system. The virus definition records in the structured virus database are accessed indexed by the identifier and the at least one virus name for each virus definition record. The object code of the virus definition sentence and the virus removal sentence for each accessed virus definition record is interpreted.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: September 16, 2003
    Assignee: Networks Associates Technology, Inc.
    Inventors: Victor Kouznetsov, Andrei Ushakov
  • System and method for distributing portable computer virus definition records with binary file conversion
    Patent number: 7231440
    Abstract: A system and method for distributing portable computer virus definition records with binary file conversion are described. One or more virus definition records are stored into a structured virus database. Each virus definition record includes an identifier uniquely identifying a computer virus, at least one virus name associated with the computer virus, a virus definition sentence comprising object code providing operations to detect the identified computer virus within a computer system, and a virus removal sentence comprising object code providing operations to clean the identified computer virus from the computer system. At least one updated virus definition record is stored into the structured virus database indexed by the identifier and the at least one virus name for each virus definition record. The virus definition records stored in the structured virus database are converted into a virus data file. The virus data file includes virus definition sets.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: June 12, 2007
    Assignee: McAfee, Inc.
    Inventors: Victor Kouznetsov, Andrei Ushakov
  • Replication of hepatitis C virus genome and identification of virus having high infectivity
    Patent number: 5766919
    Abstract: A method for replication of hepatitis C virus genome comprising infecting animal cells that have been infected with mouse retrovirus, with hepatitis C virus, and then culturing those cells. The present invention further provides a method for distinguishing a hepatitis C virus with high infectivity and a hepatitis C virus with less infectivity, comprising centrifugating a sample comprising a virus to be tested in a liquid medium to determine the density of the virus, and assigning the virus to a hepatitis C virus with high infectivity it the density thereof is up to about 1.06 g/ml, and assigning the virus to a hepatitis C virus with less infectivity if the density thereof is at least 1.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: June 16, 1998
    Assignees: Hiroshi Yoshikura, Yohko Shimizu
    Inventors: Hiroshi Yoshikura, Yohko Shimizu, Aikichi Iwamoto, Minako Hijikata
  • Replication of hepatitis C virus genome and identification of virus having high infectivity
    Patent number: 5552310
    Abstract: A method for replication of hepatitis C virus genome comprising infecting animal cells that have been infected with mouse retrovirus, with hepatitis C virus, and then culturing those cells. The present invention further provides a method for distinguishing a hepatitis C virus with high infectivity and a hepatitis C virus with less infectivity, comprising centrifugating a sample comprising a virus to be tested in a liquid medium to determine the density of the virus, and assigning the virus to a hepatitis C virus with high infectivity if the density thereof is up to about 1.06 g/ml, and assigning the virus to a hepatitis C virus with less infectivity if the density thereof is at least 1.
    Type: Grant
    Filed: October 20, 1992
    Date of Patent: September 3, 1996
    Assignees: Hiroshi Yoshikura, Yohko Shimizu
    Inventors: Hiroshi Yoshikura, Yohko Shimizu, Aikichi Iwamoto, Minako Hijikata
  • METHOD AND DEVICE FOR SEARCHING FOR PARENT VIRUS
    Publication number: 20140373152
    Abstract: A method and a device for searching for a parent virus file are disclosed. The method includes: determining an arbitrary virus file as a child virus file; obtaining a computer containing the child virus file; identifying a time when the child virus file first appeared in the computer; identifying times when other virus files contained in the computer that are different from the child virus file are first executed; determining suspect parent virus files from among the other virus files, the suspect parent virus files being first executed within a predetermined time period before the time when the child virus file first appeared in the computer; and determining the parent virus file from among the suspect parent virus files. Based on a principle that the time when the parent virus file is first executed is earlier that the time when the child virus file first appears, the suspect parent virus files are determined, and the parent virus file is found from among the suspect parent virus files.
    Type: Application
    Filed: April 30, 2014
    Publication date: December 18, 2014
    Inventor: Youdi Shi
  • Method and device for obtaining virus signatures
    Patent number: 9633205
    Abstract: A method and a device for obtaining virus signatures in the field of computer security have been disclosed. The method includes: obtaining text strings contained in each virus sample within a virus sample set; selecting text strings for use as virus signatures candidate according to a first frequency at which each text string occurs in a non-virus sample set and a second frequency at which each text string occurs in the virus sample set; calculating an information entropy of the virus signatures candidate according to a quantity of virus samples containing the virus signatures candidate and a quantity of non-virus samples containing the virus signatures candidate; and selecting virus signatures from the virus signatures candidate according to the information entropy. The present disclosure may timely identify the latest virus signatures and ensure that the obtained virus signatures are optimal signatures and may identify a wide range of virus variants.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: April 25, 2017
    Assignee: Tencent Technology (Shenzhen) Co., Ltd.
    Inventor: Sheng Guan
  • Broad Spectrum Inhibitors of the Post Proline Cleaving Enzymes for Treatment of Hepatitis C Virus Infections
    Publication number: 20150202218
    Abstract: Disclosed are methods of treating, inhibiting, or preventing a viral infection in a mammal in need thereof by administering a therapeutically or prophylactically effective amount of an inhibitor of FAP, an inhibitor of DPPIV, an inhibitor of DPP8, or an inhibitor of DPP9. The inhibitor may act as both an inhibitor of DPPIV and an inhibitor of DPP8/9. The viral infection includes, but is not limited to, hepatitis B virus, hepatitis C virus, human immunodeficiency virus, Polio virus, Coxsackie A virus, Coxsackie B virus, Rhino virus, respiratory syncytial virus, dengue virus, equine infectious anemia virus, Echo virus, small pox virus, Ebola virus, and West Nile virus.
    Type: Application
    Filed: August 1, 2013
    Publication date: July 23, 2015
    Inventor: William W. Bachovchin
  • Method and device for obtaining virus signatures
    Patent number: 10055584
    Abstract: A method and a device for obtaining virus signatures in the field of computer security have been disclosed. The method includes: obtaining text strings contained in each virus sample within a virus sample set; selecting text strings for use as virus signatures candidate according to a first frequency at which each text string occurs in a non-virus sample set and a second frequency at which each text string occurs in the virus sample set; calculating an information entropy of the virus signatures candidate according to a quantity of virus samples containing the virus signatures candidate and a quantity of non-virus samples containing the virus signatures candidate; and selecting virus signatures from the virus signatures candidate according to the information entropy. The present disclosure may timely identify the latest virus signatures and ensure that the obtained virus signatures are optimal signatures and may identify a wide range of virus variants.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: August 21, 2018
    Assignee: Tencent Technology (Shenzhen) Co., Ltd.
    Inventor: Sheng Guan
  • Method and system for generating and using a virus free file certificate integrated within a file
    Patent number: 7055175
    Abstract: A method and system are disclosed for generating and using a virus-free file certificate integrated in a file.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: May 30, 2006
    Assignee: International Business Machines Corporation
    Inventors: Jean-François Le Pennec, Olivier Hericourt, Jacques Fieschi
  • METHOD AND DEVICE FOR OBTAINING VIRUS SIGNATURES
    Publication number: 20150135323
    Abstract: A method and a device for obtaining virus signatures in the field of computer security have been disclosed. The method includes: obtaining text strings contained in each virus sample within a virus sample set; selecting text strings for use as virus signatures candidate according to a first frequency at which each text string occurs in a non-virus sample set and a second frequency at which each text string occurs in the virus sample set; calculating an information entropy of the virus signatures candidate according to a quantity of virus samples containing the virus signatures candidate and a quantity of non-virus samples containing the virus signatures candidate; and selecting virus signatures from the virus signatures candidate according to the information entropy. The present disclosure may timely identify the latest virus signatures and ensure that the obtained virus signatures are optimal signatures and may identify a wide range of virus variants.
    Type: Application
    Filed: January 22, 2015
    Publication date: May 14, 2015
    Applicant: Tencent Technology (Shenzhen) Co., Ltd.
    Inventor: Sheng GUAN
  • METHOD AND DEVICE FOR OBTAINING VIRUS SIGNATURES
    Publication number: 20170147818
    Abstract: A method and a device for obtaining virus signatures in the field of computer security have been disclosed. The method includes: obtaining text strings contained in each virus sample within a virus sample set; selecting text strings for use as virus signatures candidate according to a first frequency at which each text string occurs in a non-virus sample set and a second frequency at which each text string occurs in the virus sample set; calculating an information entropy of the virus signatures candidate according to a quantity of virus samples containing the virus signatures candidate and a quantity of non-virus samples containing the virus signatures candidate; and selecting virus signatures from the virus signatures candidate according to the information entropy. The present disclosure may timely identify the latest virus signatures and ensure that the obtained virus signatures are optimal signatures and may identify a wide range of virus variants.
    Type: Application
    Filed: February 7, 2017
    Publication date: May 25, 2017
    Applicant: Tencent Technology (Shenzhen) Co., Ltd.
    Inventor: Sheng GUAN
  • Method and system for controlling and filtering files using a virus-free certificate
    Publication number: 20020016925
    Abstract: The present invention is directed to computer viruses and more particularly to a method and system for use in a virus-free certificate firewall, of controlling and filtering files using a virus-free certificate.
    Type: Application
    Filed: January 2, 2001
    Publication date: February 7, 2002
    Inventors: Jean-Francois Le Pennec, Olivier Hericourt
  • Method and system for controlling and filtering files using a virus-free certificate
    Patent number: 6986051
    Abstract: The present invention is directed to computer viruses and more particularly to a method and system for use in a virus-free certificate firewall, of controlling and filtering files using a virus-free certificate.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: January 10, 2006
    Assignee: International Business Machines Corporation
    Inventors: Jean-Francois Le Pennec, Olivier Hericourt
Narrow Results

Filter by US Classification