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  • Antibodies That Bind Selectively To P25 And Uses Therefor
    Publication number: 20120141490
    Abstract: The present invention relates to a monoclonal antibody or fragment thereof, which binds specifically to the cyclin-dependent kinase 5 (Cdk5) activating protein, p25 and not to p35, a hybridoma cell line producing the monoclonal antibody, and methods for the detection and/or isolation of p25, p25 fragments or homologs thereof from biological material. The invention further relates to the use of the monoclonal antibody or fragment thereof for detection and treatment of neuronal disorders and cancers.
    Type: Application
    Filed: June 3, 2010
    Publication date: June 7, 2012
    Inventors: James A. Bibb, Janice W. Kansy
  • Antibodies that bind selectively to P25 and uses therefor
    Patent number: 8728472
    Abstract: The present invention relates to a monoclonal antibody or fragment thereof, which binds specifically to the cyclin-dependent kinase 5 (Cdk5) activating protein, p25 and not to p35, a hybridoma cell line producing the monoclonal antibody, and methods for the detection and/or isolation of p25, p25 fragments or homologs thereof from biological material. The invention further relates to the use of the monoclonal antibody or fragment thereof for detection and treatment of neuronal disorders and cancers.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: May 20, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: James A. Bibb, Janice W. Kansy