Abstract: The invention provides immunogenic formulations comprising virus-like particles (VLPs) from two or more genoclusters and/or strains of norovirus in a pharmaceutically acceptable carrier. In representative embodiments, the formulation also comprises an adjuvant, for example, a viral adjuvant or CpG. The invention also provides methods of inducing an immune response to one or more noroviruses.
Type:
Application
Filed:
September 3, 2010
Publication date:
March 24, 2011
Inventors:
Ralph S. Baric, Anna LoBue, Robert Edward Johnston, Joseph Thompson, Lisa Lindesmith
Abstract: The present invention provides methods and compositions comprising a chimeric norovirus capsid protein comprising a norovirus VP1 major capsid protein backbone comprising a norovirus epitope selected from the group consisting of: a) Epitope A; b) Epitope B; c) Epitope C; d) Epitope D; e) Epitope E; f) Epitope F; and g) any combination of (a) through (f) above, wherein the norovirus epitope is from a norovirus strain that is different from the norovirus VP1 major capsid protein backbone.
Type:
Application
Filed:
March 14, 2014
Publication date:
September 18, 2014
Applicant:
The University of North Carolina at Chapel Hill
Inventors:
Ralph Steven Baric, Lisa Chon Lindesmith, Kari Moore Debbink, Eric Francis Donaldson, Jesica Anne Swanstrom
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