Abstract: The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.
Type:
Grant
Filed:
July 23, 2015
Date of Patent:
November 20, 2018
Assignee:
THE PIRBRIGHT INSTITUTE
Inventors:
Erica Bickerton, Sarah Keep, Paul Britton