Abstract: This invention describes a non-aqueous oral composition of molecular iodine in a stabilized hydrophobic environment containing a hydrophobe or combination of hydrophobes for treating different disease states.
Abstract: A stabilized solid oral pharmaceutical composition comprised of iodide and iodate as the active agents in the presence of one or more pharmaceutical excipients and a method for preparing these stabilized compositions.
Type:
Grant
Filed:
February 26, 1999
Date of Patent:
June 19, 2001
Assignee:
Symbollon Corporation
Inventors:
Yongjun Duan, Kirk Dinehart, John Hickey, Jack Kessler
Abstract: The invention is a method of administering therapeutic iodine for treating a disorder in a mammal. The invention comprises a step of feeding said mammal an effective amount of an oxidant for an iodine species and an iodine reductant which will cause oxidation-reduction reactions upon contact with the gastric juices present in the stomach of the mammal. This is done such that molecular iodine is generated in vivo at a ratio of molecular iodine to total iodine of above at least about 0.65. The invention also discloses a non-aqueous pharmaceutically acceptable carrier with said oxidant and reductant having the ability to cause oxidation-reduction reactions upon contact with the gastric juices present in the stomach of said mammal and in an amount sufficient to generate molecular iodine, in vivo, at a ratio of molecular iodine to total iodine of above at least about 0.65.
Type:
Grant
Filed:
October 29, 1997
Date of Patent:
March 23, 1999
Assignee:
Symbollon Corporation
Inventors:
Yongjun Duan, John Hickey, Rick Panicucci, Jack Kessler