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  • MICROFLUIDIC ASSAY IN IDEALIZED MICROVASCULAR NETWORK FOR SELECTION AND OPTIMIZATION OF DRUG DELIVERY VEHICLES TO SIMULATED TUMORS
    Publication number: 20130101991
    Abstract: An apparatus for assaying a tumor drug delivery vehicle and or drug can include an idealized microvascular network (IMN) of one or more interconnected idealized flow channels in fluid communication through a porous wall with a tissue space (e.g., idealized tissue space) containing animal cells and means for quantifying drug delivery through the IMN to the animal cells.
    Type: Application
    Filed: December 14, 2012
    Publication date: April 25, 2013
    Applicant: CFD Research Corporation
    Inventor: CFD Research Corporation
  • Synthetic Microfluidic Blood-Brain Barrier
    Publication number: 20110104658
    Abstract: An apparatus and method for assaying blood-brain barrier properties for drug and drug delivery vehicle screening comprising of a microfluidic apparatus with gaps separating lumen and tissue space enabling formation of tight junctions similar to in vivo conditions using endothelial cells and brain cells.
    Type: Application
    Filed: March 17, 2010
    Publication date: May 5, 2011
    Applicant: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant, Shivshankar Sundaram, Ketan Bhatt
  • Particle Adhesion Assay for Microfluidic Bifurcations
    Publication number: 20100227312
    Abstract: A method for characterizing particle adhesion in microfluidic bifurcations and junctions comprises at least one idealized bifurcation or junction. Multiple bifurcations and/or junctions can be combined on a single microfluidic chip to create microfluidic networks configured for assays specifically to characterize particle interactions at junctions or to screen particles for desired interactions with microfluidic bifurcations and/or junctions.
    Type: Application
    Filed: March 6, 2009
    Publication date: September 9, 2010
    Applicant: CFD RESEARCH CORPORATION
    Inventors: Kapil Pant, Balabhaskar Prabhakarpandian, Shivshankar Sundaram, Angela Irene Rea-Ramsey
  • Microfluidic Assay for Characterization of the Leukocyte Adhesion Cascade
    Publication number: 20100112550
    Abstract: An apparatus and method for identifying and screening for agents affecting the leukocyte adhesion cascade (LAC) encompassing rolling, adhesion and migration comprises an optically clear, plastic microfluidic chip comprising flow channels with diameters in the range of 10-500 ?m. The flow channels are coated with endothelial cells and at least a portion of the flow channels contains 1-30 ?m sized openings, optionally filled with a native or synthetic extracellular matrix, that allow leukocyte migration into one or more tissue spaces.
    Type: Application
    Filed: November 4, 2009
    Publication date: May 6, 2010
    Applicant: CFD RESEARCH CORPORATION
    Inventor: Shivshankar Sundaram